1. Grigory V. Gelikonov

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    1. Mentioned In 67 Articles

    2. Measurement and Compensation for the Amplitude and Phase Spectral Distortions of an Interference Signal in Optical Coherence Tomography for the Relative Optical-Spectrum Width Exceeding 10%

      Measurement and Compensation for the Amplitude and Phase Spectral Distortions of an Interference Signal in Optical Coherence Tomography for the Relative Optical-Spectrum Width Exceeding 10%
      We describe a universal method of compensating for the arbitrary dispersion in the spectral and time domain optical coherence tomography systems. In combination with the amplitude method of correcting the optical-spectrum irregularities, this approach allows one to obtain the spectrally determined resolution if the instrument function is close to the Gaussian one. The efficiency of the method is demonstrated in the time and spectral domain optical coherence tomographies with the ...
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    3. Digital refocusing in optical coherence tomography using finite impulse response filters

      Digital refocusing in optical coherence tomography using finite impulse response filters
      A finite impulse response filter, which shifts the focal plane in optical coherence tomography (OCT) images, is proposed. Since several OCT images with the focal plane in various positions can be fused into one image with increased lateral resolution, such a filter facilitates the creation of an OCT system with numerically increased lateral resolution, operating in real-time, i.e. showing one OCT B-scan with increased lateral resolution while collecting data ...
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    4. Time domain optical coherence tomography is a useful tool for diagnosing otitis media with effusion

      Time domain optical coherence tomography is a useful tool for diagnosing otitis media with effusion
      The usability of time-domain optical coherence tomography equipped with a flexible endoscopic probe for detecting effusion in the tympanic cavity is shown in the clinical environment. The possibility of assessing the dynamic properties of effusion, particularly its contained scatterers' mobility, is shown in real clinical cases. A method of comparative assessment of scatterers' mobility is proposed.
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    5. Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use
      This work is dedicated to the development of the OCT system with angiography for everyday clinical use. Two major problems were solved during the development: compensation of specific natural tissue displacements, induced by contact scanning mode and physiological motion of patients (eg, respiratory and cardiac motions) and online visualization of vessel cross‐sections to provide feedback for the system operator.
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    6. Cross-Polarization Optical Coherence Tomography with Active Maintenance of the Circular Polarization of a Sounding Wave in a Common Path System

      Cross-Polarization Optical Coherence Tomography with Active Maintenance of the Circular Polarization of a Sounding Wave in a Common Path System
      We consider a cross-polarization optical coherence tomography system with a common path for the sounding and reference waves and active maintenance of the circular polarization of a sounding wave. The system is based on the formation of birefringent characteristics of the total optical path, which are equivalent to a quarter-wave plate with a 45 orientation of its optical axes with respect to the linearly polarized reference wave. Conditions under which ...
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    7. Equidistant Recording of the Spectral Components in Ultra-Wideband Spectral-Domain Optical Coherence Tomography

      Equidistant Recording of the Spectral Components in Ultra-Wideband Spectral-Domain Optical Coherence Tomography
      We develop an effective method for reducing nonequidistance when recording the spectral components of an interference signal in ultra-wideband spectral-domain optical coherence tomography. For this purpose, a corrector consisting of two identical prisms is used in a diffraction-grating spectrometer. The corrector rotation with respect to the diffraction-grating plane and a variation in the angle between the corrector elements allow one to adjust the equidistant spatial distribution of the spectral components ...
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    8. Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study

      Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study
      Determining boundaries of infiltrative glial tumors remains a challenging problem in neurooncology. Optical coherence tomography (OCT) with cross-polarization (CP) visualization is a promising technique as a surgical guidance tool. However, the outcome of the procedures performed under OCT guidance strongly depends on the surgeons qualification. Thus, a quantitative method for assessing resection margins with OCT is required. The aim of this study was to develop a robust quantitative approach for ...
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    9. In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography

      In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography
      Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of oropharyngeal and nasopharyngeal cancer using multifunctional optical coherence tomography (OCT). A spectral domain OCT system with a specially-designed oral imaging ...
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    10. A data-acquisition and control system for spectral-domain optical coherence tomography with a speed of 91 912 A-scans/s based on a USB 3.0 interface

      A data-acquisition and control system for spectral-domain optical coherence tomography with a speed of 91 912 A-scans/s based on a USB 3.0 interface
      We describe a system of optical spectrum registration at the output of an interferometer with controlled phase shifts for an experimental device intended for visualizing the internal structure of an optically turbid specimen, using the method of spectral domain optical coherence tomography. A device for spectral domain optical coherence tomography based on a common-path optical scheme with a USB 3.0 interface for inputting data into a computer has been ...
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    11. Medium chromatic dispersion calculation and correction in spectral-domain optical coherence tomography

      Medium chromatic dispersion calculation and correction in spectral-domain optical coherence tomography
      A method for determining and correcting distortions in spectral-domain optical coherence tomography images caused by medium dispersion was developed. The method is based on analysis of the phase distribution of the interference signal recorded by an optical coherence tomography device using an iterative approach to find and compensate for the effect of a mediums chromatic dispersion on point-spread function broadening in optical coherence tomography. This enables compensation of the impact ...
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    12. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography
      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using ground truth OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with ...
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    13. Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape

      Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape
      We describe the use of elastographic processing in phase-sensitive optical coherence tomography (OCT) for visualizing dynamics of strain and tissue-shape changes during laser-induced photothermal corneal reshaping, for applications in the emerging field of non-destructive and non-ablative (non-LASIK) laser vision correction. The proposed phase-processing approach based on fairly sparse data acquisition enabled rapid data processing and near-real-time visualization of dynamic strains. The approach avoids conventional phase unwrapping, yet allows for mapping ...
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    14. Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping

      Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping
      Phase-sensitive optical coherence tomography (OCT) is used for visualizing dynamic and cumulative strains and corneashape changes during laser-produced tissue heating. Such non-destructive (non-ablative) cornea reshaping can be used as a basis of emerging technologies of laser vision correction. In experiments with cartilaginous samples, polyacrilamide phantoms and excised rabbit eyes we demonstrate ability of the developed OCT system to simultaneously characterize transient and cumulated strain distributions, surface displacements, scattering tissue properties ...
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    15. Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy

      Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy
      A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers ...
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    16. Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping

      Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping
      In the context of the development of emerging laser-assisted thermo-mechanical technologies for non-destructive reshaping of avascular collagenous tissues (cartilages and cornea), we report the first application of phase-sensitive optical coherence tomography (OCT) for visualizing transient strains involving supra-wavelength inter-frame displacements of scatterers. Usually phase-sensitive OCT assumes the visualization of sub-pixel and even sub-wavelength displacements of scatterers and fairly small strains (say, 10 3 ), which conventionally implies the necessity of averaging ...
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  2. About Grigory V. Gelikonov

    Grigory V. Gelikonov

    Grigory V. Gelikonov received his M.S. at the Radiophysical Department of the N.I. Lobachevsky State Nizhny Novgorod University in 1992 and his Ph.D. in 2005.Since 1992 he has been working as a research scientist at the Institute of Applied Physics of the Russian Academy of Science. In 2006 he became Director of BioMedTech Llc. His main scientific interests include the development and creation of single mode fiber elements, invention of new types of fiber couplers, fiber optic Gyro (FOG), and Optical Coherence Tomography (OCT) imaging of biotissues. He has participated in the development of software for automated data acquisition and image processing. Dr. Gelikonov invented a brand new fast in-depth scanning (Russian and US patents) OCT system, a micro lateral scanning probe for endoscopic OCT, and a number of modifications of the OCT technique, including cross-polarization OCT and two-wavelength OCT. Dr. Gelikonov received the State Prize of the Russian Federation in Science and Technology in 1999.