1. Giovanni Gregori

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    1. Mentioned In 45 Articles

    2. Widefield En Face Optical Coherence Tomography Imaging of Subretinal Drusenoid Deposits

      Widefield En Face Optical Coherence Tomography Imaging of Subretinal Drusenoid Deposits
      BACKGROUND AND OBJECTIVE: To determine whether subretinal drusenoid deposits (SDD) can be detected on widefield en face slab images derived from spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) volume scans. PATIENTS AND METHODS: Retrospective study of patients with dry age-related macular degeneration (AMD) enrolled prospectively in an OCT imaging study using SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) with a central wavelength of 840 nm, and a ...
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    3. In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography

      In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography
      The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches for in vivo cochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24hours as seen at 3.5hours after ...
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    4. Spectral-Domain Optical Coherence Tomography Measurements of Choroidal Thickness and Outer Retinal Disruption in Macular Telangiectasia Type 2

      Spectral-Domain Optical Coherence Tomography Measurements of Choroidal Thickness and Outer Retinal Disruption in Macular Telangiectasia Type 2
      To evaluate subfoveal choroidal thickness (CT) and the extent of outer retinal disruption in patients with macular telangiectasia type 2 (MacTel2) compared with healthy eyes. PATIENTS AND METHODS: In this prospective, observational, cohort study, 62 patients (62 eyes) with Mac-Tel2 and 130 healthy controls (130 eyes) underwent a complete ophthalmological examination, spectral-domain optical coherence tomography (SD-OCT) imaging, and axial length measurements. Patients in the study group also underwent color fundus ...
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    5. Optical Coherence Tomography Measurements of Choroidal Thickness in Healthy Eyes: Correlation With Age and Axial Length

      Optical Coherence Tomography Measurements of Choroidal Thickness in Healthy Eyes: Correlation With Age and Axial Length
      BACKGROUND AND OBJECTIVE: To evaluate subfoveal choroidal thickness (CT) in healthy eyes using spectral-domain optical coherence tomography (SD-OCT) and provide correlations between age and axial length. PATIENTS AND METHODS: Enhanced depth SD-OCT imaging was performed with Cirrus (Carl Zeiss Meditec, Dublin, CA) and Spectralis (Heidelberg Engineering, Heidelberg, Germany) instruments. CT was measured from the outer limit of the retinal pigment epithelium to the inner surface of the sclera. RESULTS: The ...
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    6. Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging
      Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the ...
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    7. Swept-Source OCT Angiography of Macular Telangiectasia Type 2

      Swept-Source OCT Angiography of Macular Telangiectasia Type 2
      BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en ...
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    8. Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms

      Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms
      To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-m SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 ...
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    9. OCT Minimum Intensity as a Predictor of Geographic Atrophy Enlargement

      OCT Minimum Intensity as a Predictor of Geographic Atrophy Enlargement
      Purpose:To determine whether the minimum intensity of the optical coherence tomography (OCT) A-scans within the retina can predict locations of growth at the margin of geographic atrophy (GA) and the growth rate outside the margin. Methods:OCT scans were analyzed at baseline and 52 weeks. Expert graders manually segmented OCT images of GA. The 52-week follow-up scans were registered to the baseline scan coordinates for comparison. OCT Minimum Intensity ...
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    10. Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina

      Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina
      BACKGROUND AND OBJECTIVE: Spectral-domain optical coherence tomography (SD-OCT) en face imaging was used to measure the growth of geographic atrophy (GA) and identify baseline anatomic changes in the outer retina in eyes with nonexudative age-related macular degeneration (AMD). PATIENTS AND METHODS: In this prospective study, eyes were imaged using 200 200 and 512 128 A-scan raster patterns. Outer retinal anatomy was visualized using en face imaging of a 20-m thick ...
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    11. Enhanced optical coherence tomography for anatomical mapping

      Enhanced optical coherence tomography for anatomical mapping
      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a ...
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    12. Spectral-Domain Optical Coherence Tomography Imaging of Drusenoid Pigment Epithelial Detachments

      Spectral-Domain Optical Coherence Tomography Imaging of Drusenoid Pigment Epithelial Detachments
      Purpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging. Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used ...
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    13. Comparison of Geographic Atrophy Measurements from the OCT Fundus Image and the Sub-RPE Slab Image

      Comparison of Geographic Atrophy Measurements from the OCT Fundus Image and the Sub-RPE Slab Image
      PURPOSE: To compare two different approaches to measuring areas of geographic atrophy (GA) using spectral-domain optical coherence tomography (SD-OCT). METHODS: Fifty eyes with GA were imaged with an SD-OCT instrument. OCT fundus images and sub retinal pigment epithelium (RPE) slab images were generated. Three graders manually drew the GA boundaries on both en face images. An automated algorithm was used to segment the GA boundaries from the sub-RPE slabs. RESULTS ...
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    14. Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

      Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging
      Purpose: To compare the measurements of drusen area from manual segmentation of color fundus photographs with those generated by an automated algorithm designed to detect elevations of the retinal pigment epithelium (RPE) on spectral domain optical coherence tomography (SDOCT) images. Methods: Fifty eyes with drusen secondary to non-exudative age-related macular degeneration (AMD) were enrolled. All eyes were imaged with the Cirrus HD-OCT instrument (Carl Zeiss Meditec, Dublin, CA) using a ...
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  2. About Giovanni Gregori

    Giovanni Gregori

    Giovanni Gregori is with the Center for Ophthalmic Imaging & Biomedical Engineering at the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine.

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    1. PCI as a procedure has been around for decades, but only recently has the procedure been optimized by new diagnostic tools that can improve clinical outcomes...On demand FFR and OCT can support clinical decision making by providing highly-detailed intracoronary arterial views, which improves PCI, especially in complex cases. Furthermore, the resolution of OCT over intravascular ultrasound can be imperative in reducing challenges such as stent fracture and edge dissection.
      In St. Jude Medical Announces Launch of OPTIS Integrated System