1. Giovanni Gregori

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    1. Mentioned In 69 Articles

    2. Quantification of choriocapillaris with OCTA: a comparison study

      Quantification of choriocapillaris with OCTA: a comparison study
      Purpose To demonstrate the variation in quantitative choriocapillaris (CC) metrics with various binarization approaches using optical coherence tomography angiography (OCTA). Design Retrospective, observational, cross-sectional case series. Methods 3x3 mm and 6x6 mm macular OCTA scans were obtained from normal eyes and from eyes with drusen secondary to AMD. The CC slab was extracted and the CC flow deficits (FDs) were segmented with two previously published algorithms: fuzzy C-means approach (FCM ...
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    3. Two-Year Risk of Exudation in Eyes with Non-Exudative AMD and Subclinical Neovascularization Detected with Swept Source OCT Angiography

      Two-Year Risk of Exudation in Eyes with Non-Exudative AMD and Subclinical Neovascularization Detected with Swept Source OCT Angiography
      Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to study the prevalence, incidence, and natural history of subclinical macular neovascularization (MNV) in eyes with unilateral non-exudative age-related macular degeneration (AMD). Design Prospective cohort study. Methods Patients were imaged using 3x3 mm and 6x6 mm SS-OCTA scan patterns. MNV was detected using the outer retina to choriocapillaris en face slab. Prevalence and incidence of subclinical MNV, Kaplan-Meier cumulative estimates ...
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    4. Imaging of Epiretinal Membranes Using En Face Widefield Swept-Source Optical Coherence Tomography

      Imaging of Epiretinal Membranes Using En Face Widefield Swept-Source Optical Coherence Tomography
      BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography (SS-OCT) imaging was performed on eyes with epiretinal membranes (ERMs), and the extent of the ERMs were compared between the 12 mm 12 mm scans and the more routine 6 mm 6 mm field of view (FOV). PATIENTS AND METHODS: Eyes containing ERMs were imaged using a 12 mm 12 mm SS-OCT scan. En face images derived from vitreoretinal interface (VRI) slabs were ...
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    5. Correlations Between Choriocapillaris Flow Deficits Around Geographic Atrophy and Enlargement Rates Based on Swept Source OCT Imaging

      Correlations Between Choriocapillaris Flow Deficits Around Geographic Atrophy and Enlargement Rates Based on Swept Source OCT Imaging
      Purpose To determine the possible correlation between the annual enlargement rates (ERs) of geographic atrophy (GA) with the percentage and size of the choriocapillaris (CC) flow deficits (FDs) surrounding GA, measured with swept source optical coherence tomography angiography (SS-OCTA) images. Design Prospective, observational case series. Participants Patients with GA secondary to non-exudative AMD. Methods Patients were imaged with a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec) using a ...
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    6. Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography

      Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography
      Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. Design A prospective, cross-sectional study. Methods Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec). Both 3x3 mm and 6x6 mm scans were used to image the macular ...
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    7. Anatomic Localization of Type 1 and Type 2 Macular Neovascularization Using Swept-Source OCT Angiography

      Anatomic Localization of Type 1 and Type 2 Macular Neovascularization Using Swept-Source OCT Angiography
      BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography angiography (SS-OCTA) and different boundary-specific segmentation strategies were used to distinguish type 1 macular neovascularization (MNV) from type 2 MNV in eyes with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Eyes with exudative AMD were enrolled in a prospective study. Segmentation strategies included a slab from the outer retina (OR) to the choriocapillaris (CC) for the entire MNV, a slab from the ...
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    8. Attenuation correction assisted automatic segmentation for assessing choroidal thickness and vasculature with swept-source OCT

      Attenuation correction assisted automatic segmentation for assessing choroidal thickness and vasculature with swept-source OCT
      Swept source optical coherence tomography (SS-OCT) is being used more widely in clinical studies to investigate the choroid due to its deeper penetration under the retinal pigment epithelium and improved image quality compared with spectral domain OCT. However, automatic methods to reliably assess choroidal thickness and vasculature are still limited. This paper reports an approach that applies attenuation correction on SS-OCT structural scans to facilitate accurate automatic segmentation of the ...
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    9. En Face Imaging of Geographic Atrophy Using Different Swept-Source Optical Coherence Tomography Scan Patterns

      En Face Imaging of Geographic Atrophy Using Different Swept-Source Optical Coherence Tomography Scan Patterns
      Purpose Different swept source optical coherence tomography (SS-OCT) scan patterns were used to image geographic atrophy (GA) to determine if they provided similar area and enlargement measurements in eyes with age-related macular degeneration (AMD). Design Prospective, observational case series. Participants Patients with GA secondary to non-exudative AMD Methods Patients were imaged using SS-OCT (PLEX Elite 9000 instrument, Carl Zeiss Meditec, Dublin, CA) with follow-up imaging performed after six months and ...
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    10. Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease

      Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease
      Background: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). Methods: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular ...
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    11. Swept-Source OCT Angiography Identifies Choroidal Neovascularization Arising From a Choroidal Nevus

      Swept-Source OCT Angiography Identifies Choroidal Neovascularization Arising From a Choroidal Nevus
      Swept-source optical coherence tomography angiography (SS-OCTA) was used to diagnose choroidal neovascularization (CNV) arising from a choroidal nevus. A 61-year-old woman initially presented with submacular hemorrhage. She was diagnosed with neovascular age-related macular degeneration (AMD) and received three injections of bevacizumab (Avastin; Genentech, South San Francisco, CA). At a follow-up visit, SS-OCTA showed that the CNV appeared to arise from an adjacent choroidal nevus. This is the first report of ...
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    12. Swept-Source OCT Angiographic Imaging of a Central Retinal Vein Occlusion During Pregnancy

      Swept-Source OCT Angiographic Imaging of a Central Retinal Vein Occlusion During Pregnancy
      To avoid fluorescein angiography in a pregnant woman diagnosed with a central retinal vein occlusion (CRVO), swept-source optical coherence tomography angiography (SS-OCTA) was performed and showed no evidence of decreased central retinal perfusion leading to the diagnosis of a nonischemic CRVO. Five months after an intravitreal injection of steroid, both her vision and the retinal appearance had returned to normal. This case demonstrates how a noninvasive, safe, 12 mm 12 ...
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    13. Detection of Choriocapillaris Loss in Alport Syndrome With Swept-Source OCT Angiography

      Detection of Choriocapillaris Loss in Alport Syndrome With Swept-Source OCT Angiography
      A patient previously diagnosed with Alport Syndrome was evaluated using multimodal imaging. Optical coherence tomography (OCT) demonstrated significant thinning of the inner retina within the macula, and inner retinal cysts were found in the peripheral macula. OCT angiography demonstrated loss of the choriocapillaris. Abnormal collagen appears to have multiple deleterious effects on the retinal and choroidal structure and vasculature.
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    14. Swept-Source OCT Angiography of Multiple Evanescent White Dot Syndrome With Inflammatory Retinal Pigment Epithelial Detachment

      Swept-Source OCT Angiography of Multiple Evanescent White Dot Syndrome With Inflammatory Retinal Pigment Epithelial Detachment
      A 30-year-old woman with photopsias and decreased vision was diagnosed with multiple evanescent white dot syndrome (MEWDS) with an atypical inflammatory subfoveal retinal pigment epithelial detachment (PED) and imaged using swept-source optical coherence tomography (SS-OCT) during several visits. SS-OCT imaging revealed a focal area of attenuated choriocapillaris underneath the PED. An attempt to treat the presumed macular inflammatory lesion with corticosteroids resulted in bilateral exudation consistent with central serous chorioretinopathy.
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    15. Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

      Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid
      The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT ...
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    16. Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal Neovascularization

      Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal Neovascularization
      Purpose : The purpose of this study was to compare imaging of choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA). Methods : Optical coherence tomography angiography was performed using a 100-kHz SS-OCT instrument and a 68-kHz SD-OCTA instrument (Carl Zeiss Meditec, Inc.). Both 3 3- and 6 6-mm 2 scans were obtained on both instruments. The 3 3-mm 2 SS-OCTA scans consisted of 300 A-scans per ...
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  2. About Giovanni Gregori

    Giovanni Gregori

    Giovanni Gregori is with the Center for Ophthalmic Imaging & Biomedical Engineering at the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine.

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    1. PCI as a procedure has been around for decades, but only recently has the procedure been optimized by new diagnostic tools that can improve clinical outcomes...On demand FFR and OCT can support clinical decision making by providing highly-detailed intracoronary arterial views, which improves PCI, especially in complex cases. Furthermore, the resolution of OCT over intravascular ultrasound can be imperative in reducing challenges such as stent fracture and edge dissection.
      In St. Jude Medical Announces Launch of OPTIS Integrated System