1. Giovanni Gregori

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    1. Mentioned In 36 Articles

    2. OCT Minimum Intensity as a Predictor of Geographic Atrophy Enlargement

      OCT Minimum Intensity as a Predictor of Geographic Atrophy Enlargement

      Purpose:To determine whether the minimum intensity of the optical coherence tomography (OCT) A-scans within the retina can predict locations of growth at the margin of geographic atrophy (GA) and the growth rate outside the margin. Methods:OCT scans were analyzed at baseline and 52 weeks. Expert graders manually segmented OCT images of GA. The 52-week follow-up scans were registered to the baseline scan coordinates for comparison. OCT Minimum Intensity (MI) values were studied within a 180-micron margin around the boundary of GA at baseline. Baseline MI values were compared in areas of progression and non-progression of the GA, and ...

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    3. Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina

      Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina

      BACKGROUND AND OBJECTIVE: Spectral-domain optical coherence tomography (SD-OCT) en face imaging was used to measure the growth of geographic atrophy (GA) and identify baseline anatomic changes in the outer retina in eyes with nonexudative age-related macular degeneration (AMD). PATIENTS AND METHODS: In this prospective study, eyes were imaged using 200 × 200 and 512 × 128 A-scan raster patterns. Outer retinal anatomy was visualized using en face imaging of a 20-μm thick slab encompassing the inner segment/outer segment (IS/OS) band. RESULTS: En face SD-OCT imaging of the IS/OS region revealed a bilaterally symmetrical pattern of outer retinal disruption ...

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    4. Enhanced optical coherence tomography for anatomical mapping

      Enhanced optical coherence tomography for anatomical mapping

      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ...

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    5. Spectral-Domain Optical Coherence Tomography Imaging of Drusenoid Pigment Epithelial Detachments

      Spectral-Domain Optical Coherence Tomography Imaging of Drusenoid Pigment Epithelial Detachments

      Purpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging. Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used to quantify volumetric changes in DPEDs and to detect the evolution and formation of geographic atrophy and choroidal neovascularization. Changes in DPED area and volume and development of the advanced ...

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    6. Comparison of Geographic Atrophy Measurements from the OCT Fundus Image and the Sub-RPE Slab Image

      Comparison of Geographic Atrophy Measurements from the OCT Fundus Image and the Sub-RPE Slab Image

      PURPOSE: To compare two different approaches to measuring areas of geographic atrophy (GA) using spectral-domain optical coherence tomography (SD-OCT). METHODS: Fifty eyes with GA were imaged with an SD-OCT instrument. OCT fundus images and sub– retinal pigment epithelium (RPE) slab images were generated. Three graders manually drew the GA boundaries on both en face images. An automated algorithm was used to segment the GA boundaries from the sub-RPE slabs. RESULTS: The agreement between the three manual measurements on both OCT fundus images (ICC = .998) and sub-RPE slabs (ICC = .999) was excellent. Area measurements from OCT fundus images and sub-RPE slabs ...

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    7. Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

      Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

      Purpose: To compare the measurements of drusen area from manual segmentation of color fundus photographs with those generated by an automated algorithm designed to detect elevations of the retinal pigment epithelium (RPE) on spectral domain optical coherence tomography (SDOCT) images. Methods: Fifty eyes with drusen secondary to non-exudative age-related macular degeneration (AMD) were enrolled. All eyes were imaged with the Cirrus HD-OCT instrument (Carl Zeiss Meditec, Dublin, CA) using a 200x200 A-scan raster pattern covering a 6mm X 6mm area centered on the fovea. Digital color fundus images were taken on the same day. Drusen were traced manually on the ...

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    8. Identifying the boundaries of retinal pigment epithelial detachments using two spectral-domain optical coherence tomography instruments

      Identifying the boundaries of retinal pigment epithelial detachments using two spectral-domain optical coherence tomography instruments
      ...naccurate retinal thickness measurements unless manual adjustments were performed Fernando M. Penha, MD, PhD; Giovanni Gregori, PhD; Zohar Yehoshua, MD; William J. Feuer, MS; Philip J. Rosenfeld, MD, PhD To compare two s...
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    9. Automated Detection of the Foveal Center Improves SD-OCT Measurements of Central Retinal Thickness

      Automated Detection of the Foveal Center Improves SD-OCT Measurements of Central Retinal Thickness

      BACKGROUND AND OBJECTIVE: To investigate the performance of an automated foveal center detection algorithm on spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Fifty normal eyes and 50 eyes with early stage dry age-related macular degeneration (AMD) were analyzed. The actual scan center (SC), automatically detected foveal center (AF), and manually identified foveal center (MF) were compared. RESULTS: The mean of the radial distances was 89 ± 120 μm from MF to SC and 54 ± 41 μm from MF to AF for normal eyes and 179 ± 125 μm from SC to MF and 104 ± 62 μm from AF to MF for ...

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    10. Spectral-domain Optical Coherence Tomography Imaging of Age-related Macular Degeneration

      Spectral-domain Optical Coherence Tomography Imaging of Age-related Macular Degeneration
      Spectral-domain optical coherence tomography (SD-OCT) high-speed, high-resolution imaging of the macula has become an essential tool for evaluating dry and wet age-related macular degeneration (AMD). This high-speed, high-resolution imaging strategy, combined with new innovative algorithms, permits reproducible measurements of the anatomic changes associated with AMD, which include drusen, geographic atrophy (GA), and choroidal neovascularization (CNV). To visualize drusen and larger retinal pigment epithelial detachments, an algorithm was developed for Cirrus HD-OCT (Carl Zeiss Meditec, Dublin CA) to detect elevations in the retinal pigment epithelium (RPE). To visualize GA, an algorithm was developed to provide en face visualization of the macula ...
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    11. Quantitative Imaging of Retinal Pigment Epithelial Detachments Using Spectral-Domain Optical Coherence Tomography

      Quantitative Imaging of Retinal Pigment Epithelial Detachments Using Spectral-Domain Optical Coherence Tomography
      ...es to Philip J. Rosenfeld, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136 email address , * Giovanni Gregori, * Manuel Falcão, * Zohar Yehoshua, * Fenghua Wang, * William J. Feuer Department of Ophthalm...
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    12. Natural History of Drusen Morphology in Age-Related Macular Degeneration Using Spectral Domain Optical Coherence Tomography

      Natural History of Drusen Morphology in Age-Related Macular Degeneration Using Spectral Domain Optical Coherence Tomography

      Purpose: To characterize the natural history of drusen using spectral-domain optical coherence tomography (SD-OCT) imaging of eyes from patients with nonexudative age-related macular degeneration (AMD).Design: Prospective, longitudinal, natural history study.Participants: We included 143 eyes of 100 patients with at least 6 months of follow-up.Methods: Patients with drusen secondary to nonexudative AMD were scanned using the Cirrus SD-OCT instrument. Eyes were imaged using the 200×200 A-scan raster pattern contained within a 6×6 mm area. Custom software was used to quantify volumetric changes in drusen over a period of ≥6 months and for as long as 24 ...

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    13. 1-15 of 36 1 2 3 »
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  2. About Giovanni Gregori

    Giovanni Gregori

    Giovanni Gregori is with the Center for Ophthalmic Imaging & Biomedical Engineering at the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine.