1. Gereon Hüttmann

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    1. Mentioned In 64 Articles

    2. Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Explore OSA | OSA Publishing
      Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations
      Computational adaptive optics (CAO) is emerging as a viable alternative to hardware-based adaptive opticsin particular when applied to optical coherence tomography of the retina. For this technique, algorithms are required that detect wavefront errors precisely and quickly. Here we propose an extension of the frequently used subaperture image correlation. By applying this algorithm iteratively and, more importantly, comparing each subaperture not to the central subaperture but to several randomly selected ...
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      Mentions: Gereon Hüttmann University of Lübeck Hendrik Spahr

    3. Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks

      Explore OSA | OSA Publishing Dermatology
      Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks
      Optical coherence tomography (OCT) enables the non-invasive acquisition of high-resolution three-dimensional cross-sectional images at micrometer scale and is mainly used in the field of ophthalmology for diagnosis as well as monitoring of eye diseases. Also in other areas, such as dermatology, OCT is already well established. Due to its non-invasive nature, OCT is also employed for research studies involving animal models. Manual evaluation of OCT images of animal models is ...
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      Mentions: Massachusetts General Hospital Gereon Hüttmann University of Lübeck

    4. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Explore SPIE Digital Library Dermatology
      Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture is mandatory. Only this makes it possible to reliably analyze large amounts of image data, to establish biomarkers, and to monitor disease developments. However, due to its optical properties, OCTA images of skin often suffer from a poor signal-to-noise ...
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      Mentions: Massachusetts General Hospital Harvard University Gereon Hüttmann

    5. Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion

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      Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion
      In optical coherence tomography (OCT), lateral motion is determined either by speckle tracking or by multi-aperture Doppler OCT. Here we show that both methods may provide incorrect results because, outside the focal plane, non-uniform axial motion is misinterpreted as lateral motion. First, we demonstrate the existence of this artifact by means of a simulation for speckle tracking. Then the physical origin of the artifact and its mathematical relation to defocus ...
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      Mentions: Gereon Hüttmann University of Lübeck Hendrik Spahr

    6. Method for filtering reflexes in full-field setups for ophthalmologic imaging by separated illumination and detection apertures

      Explore uspto.gov Ophthalmology , Patents
      Method for filtering reflexes in full-field setups for ophthalmologic imaging by separated illumination and detection apertures
      A parallel detecting optical coherence tomography (OCT) setup and method, in which the light paths of the illumination of the sample and of the detection of the backscattered light do not use the same apertures. The separation of illumination and detection apertures filters these disturbing reflexes from the backscattered light of the sample and significantly increases image quality.
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      Mentions: Thorlabs Gereon Hüttmann

    7. Simple approach for aberration-corrected OCT imaging of the human retina

      Explore OSA | OSA Publishing Ophthalmology
      Simple approach for aberration-corrected OCT imaging of the human retina
      Aberration-corrected imaging of human photoreceptor cells, whether hardware or software based, presently requires a complex and expensive setup. Here we use a simple and inexpensive off-axis full-field time-domain optical coherence tomography (OCT) approach to acquire volumetric data of an in vivo human retina. Full volumetric data are recorded in 1.3 s. After computationally correcting for aberrations, single photoreceptor cells were visualized. In addition, the numerical correction of ametropia is ...
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      Mentions: Gereon Hüttmann Reginald Birngruber University of Lübeck

    8. High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

      Explore OSA | OSA Publishing Probes
      High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography
      We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 m was achieved at a working distance of 1 ...
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      Mentions: Robert A. Huber Gereon Hüttmann University of Lübeck

    9. Interferometric detection of 3D motion using computational subapertures in optical coherence tomography

      Explore OSA | OSA Publishing
      Interferometric detection of 3D motion using computational subapertures in optical coherence tomography
      Doppler optical coherence tomography (OCT) quantifies axial motion with high precision, whereas lateral motion cannot be detected by a mere evaluation of phase changes. This problem was solved by the introduction of three-beam Doppler OCT, which, however, entails a high experimental effort. Here, we present the numerical analogue to this experimental approach. Phase-stable complex-valued OCT datasets, recorded with full-field swept-source OCT, are filtered in the Fourier domain to limit imaging ...
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      Mentions: Thorlabs Gereon Hüttmann University of Lübeck

    10. Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography

      Explore OSA | OSA Publishing Otolaryngology , Probes
      Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography
      Intravital microscopy (IVM) offers the opportunity to visualize static and dynamic changes of tissue on a cellular level. It is a valuable tool in research and may considerably improve clinical diagnosis. In contrast to confocal and non-linear microscopy, optical coherence tomography (OCT) with microscopic resolution (mOCT) provides intrinsically cross-sectional imaging. Changing focus position is not needed, which simplifies especially endoscopic imaging. For in-vivo imaging, here we are presenting endo-microscopic OCT ...
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      Mentions: Gereon Hüttmann University of Lübeck

    11. Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography

      Explore Wiley Online Library
      Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography
      In their latest publication on retinal pulse wave velocity measurement using optical co-herence tomography (OCT), Qian Li et al. propose a method to determine the pulse wave velocity in retinal arteries and veins [1]. This should enable a non-invasive determination of biomechanical properties of the vessel network, particularly the elasticity of the vessel walls [2].
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      Mentions: Gereon Hüttmann University of Lübeck Qian Li

    12. Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography

      Explore IOVS Journal
      Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography
      Purpose : Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT). Methods : Corneal neovascularization was induced by intrastromal placement of 11.0 nylon ...
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      Mentions: University of Cologne Gereon Hüttmann University of Lübeck

    13. An Approach for Needle Based Optical Coherence Elastography Measurements

      Explore Home - Springer
      An Approach for Needle Based Optical Coherence Elastography Measurements
      While navigation and interventional guidance are typically based on image data, the images do not necessarily reflect mechanical tissue properties. Optical coherence elastography (OCE) presents a modality with high sensitivity and very high spatial and temporal resolution. However, OCE has a limited field of view of only 25 mm depth. We present a side-facing needle probe to image externally induced shear waves from within soft tissue. A first method of ...
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      Mentions: Gereon Hüttmann University of Lübeck

    15. Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited]

      Explore OSA | OSA Publishing
      Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited]
      Full-field swept-source optical coherence tomography (FF-SS-OCT) was recently shown to allow new and exciting applications for imaging the human eye that were previously not possible using current scanning OCT systems. However, especially when using cameras that do not acquire data with hundreds of kHz frame rate, uncorrected phase errors due to axial motion of the eye lead to a drastic loss in image quality of the reconstructed volumes. Here we ...
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      Mentions: Thorlabs Gereon Hüttmann University of Lübeck

    16. In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography

      Explore OSA | OSA Publishing Ophthalmology
      In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography
      With a simple setup, mainly composed of a low coherence light source and a camera, full-field optical coherence tomography (FF-OCT) allows volumetric tissue imaging. However, fringe washout constrains its use in retinal imaging. Here, we present a novel motion-insensitive approach to FF-OCT, which introduces path-length differences between the reference and the sample light in neighboring pixels using an off-axis reference beam. The temporal carrier frequency in scanned time-domain OCT is ...
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      Mentions: Thorlabs Gereon Hüttmann Reginald Birngruber
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  4. About Gereon Hüttmann

    Gereon Hüttmann

    Gereon Hüttmann is with the Institute for Biomedical Optics at the University of Lübeck.

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