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Friedemann Paul

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1. Mentioned In 32 Articles
2. Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study
  
  Explore Journal of Neuroinflammation Jul 30 2019 Neurology , Ophthalmology
  
  Background Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. It is unclear, if neuro-axonal damage occurs only in an attack-dependent manner or also progressively. Therefore, this study aimed to investigate longitudinally intra-retinal layer changes in eyes without new optic neuritis (ON) in MOG-IgG-seropositive patients. Methods We included 38 eyes of 24 patients without ON during follow-up (F/U) [median years (IQR ...
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  Mentions: Friedemann Paul
3. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study
  
  Explore Wiley Online Library May 18 2019 Neurology , Ophthalmology
  
  Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical ...
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  Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer
4. Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study
  
  Explore Wiley Online Library Mar 14 2019 Neurology , Ophthalmology
  
  Objective To determine the optimal thresholds for inter‐eye differences in retinal nerve fiber and ganglion cell+inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Background Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multi‐center international study at ...
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  Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer
5. Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis
  
  Explore Taylor & Francis Online Jan 1 2019 Neurology , Ophthalmology
  
  Introduction : Multiple Sclerosis (MS) is the most common chronic autoimmune neuroinflammatory condition in young adults. It is often accompanied by optic neuritis (ON) and retinal neuro-axonal damage causing visual disturbances. Optical coherence tomography (OCT) is a sensitive non-invasive method for quantifying intraretinal layer volumes. Recently, OCT not only showed to be a reliable marker for ON-associated damage, but also proved its high prognostic value for functional outcome and disability accrual ...
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  Mentions: Friedemann Paul
6. Optical Coherence Tomography in Disorders of the Central Nervous System
  
  Explore Thieme Nov 27 2018 Neurology , Ophthalmology
  
  Retinal changes and visual symptoms are present in several inflammatory, degenerative and tumorous disorders of the central nervous system (CNS). Optical coherence tomography (OCT) is a method that can be used in clinical practice to detect and quantify the structural correlates of these visual symptoms in neurological disorders. OCT is a non-invasive imaging technique, based on interferometry, which can create high-resolution images of the retina and measure the thickness and ...
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  Mentions: UC Irvine Friedemann Paul
7. The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis
  
  Explore LWW Online Nov 13 2018 Neurology , Ophthalmology
  
  Background: The International Multiple Sclerosis Visual System Consortium (IMSVISUAL) was formed in November 2014 with the primary goal of improving research, care, and education regarding the role of the visual system in multiple sclerosis (MS) and related disorders. Methods: In this review, we describe the formation, goals, activities, and structure of IMSVISUAL, as well as the relationship of IMSVISUAL with the Americas Committee for Treatment and Research in MS (ACTRIMS ...
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  Mentions: Peter A. Calabresi Johns Hopkins University University College London
8. Optical coherence tomography in acute optic neuritis: A population‐based study
  
  Explore Wiley Online Library Aug 20 2018 Ophthalmology
  
  Objectives To measure early structural damage caused by autoimmune inflammatory optic neuritis (ON) by optical coherence tomography (OCT) in a population‐based cohort. Methods In a prospective population‐based study over 24 months in Southern Denmark, patients diagnosed with acute ON and without prior diagnosis of a chronic neuroinflammatory disorder were included and examined with OCT, visual evoked potentials (VEP), visual fields, high contrast visual acuity (HCVA), and low contrast ...
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  Mentions: UC Irvine Friedemann Paul
9. Multicenter reliability of semiautomatic retinal layer segmentation using OCT
  
  Explore Neurology Mar 18 2018 Neurology , Ophthalmology
  
  Objective To evaluate the inter-rater reliability of semiautomated segmentation of spectral domain optical coherence tomography (OCT) macular volume scans. Methods Macular OCT volume scans of left eyes from 17 subjects (8 patients with MS and 9 healthy controls) were automatically segmented by Heidelberg Eye Explorer (v1.9.3.0) beta-software (Spectralis Viewing Module v6.0.0.7), followed by manual correction by 5 experienced operators from 5 different academic centers ...
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  Mentions: University College London UCSF Friedemann Paul
10. The relationship between age, axial length and retinal nerve fiber layer thickness in the normal elderly population in Taiwan: The Chiayi eye study in Taiwan
  
  Explore Journals | PLOS Mar 9 2018 Ophthalmology
  
  ...he Chiayi eye study in Taiwan. PLoS ONE 13(3): e0194116. https://doi.org/10.1371/journal.pone.0194116 Editor: Friedemann Paul, Charite Universitatsmedizin Berlin, GERMANY Received: September 1, 2016; Accepted: February 2...
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  Mentions: Optovue Carl Zeiss Meditec Chang Gung University
11. Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy
  
  Explore Home - Springer Dec 26 2017 Ophthalmology
  
  Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing inflammatory disorders of the central nervous system (CNS). Optic neuritis (ON) is the first NMOSD-related clinical event in 55% of the patients, which causes damage to the optic nerve and leads to visual impairment. Retinal optical coherence tomography (OCT) has emerged as a promising method for diagnosis of NMOSD and potential individual monitoring of disease course and severity. OCT not only detects ...
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  Mentions: Friedemann Paul
12. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
  
  Explore TheLancet.com Dec 12 2017 Neurology , Ophthalmology
  
  Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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  Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer
13. The APOSTEL recommendations for reporting quantitative optical coherence tomography studies
  
  Explore Neurology May 25 2016 Neurology , Ophthalmology
  
  Objective: To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results. Methods: A panel of experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and 2 neuroscientists) discussed requirements for performing and reporting quantitative analyses of retinal morphology and developed a list of initial recommendations based on experience and previous studies. The list of recommendations was subsequently revised during several meetings of the coordinating group. Results: We ...
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  Mentions: Peter A. Calabresi Johns Hopkins University Joel S. Schuman
14. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
  
  Explore TheLancet.com Mar 19 2016 Neurology , Ophthalmology
  
  Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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  Mentions: Peter A. Calabresi Johns Hopkins University University College London
15. Retinal pathology in Susac syndrome detected by spectral-domain optical coherence tomography
  
  Explore Neurology Jul 26 2015 Neurology , Ophthalmology
  
  Objective: The aim of this non-interventional study was to characterize retinal layer pathology in Susac syndrome (SuS), a disease with presumably autoimmune-mediated microvessel occlusions in the retina, brain, and inner ear, in comparison to the most important differential diagnosis multiple sclerosis (MS). Methods: Seventeen patients with SuS and 17 age- and sex-matched patients with relapsing-remitting MS (RRMS) and healthy controls (HC) were prospectively investigated by spectral-domain optical coherence tomography (OCT ...
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  Mentions: University of Heidelberg Friedemann Paul James Muller
16. Retinal pathology in idiopathic moyamoya angiopathy detected by optical coherence tomography
  
  Explore Neurology Jul 21 2015 Neurology , Ophthalmology
  
  Objective: To investigate whether patients with moyamoya angiopathy without obvious retinal pathologies such as retinal infarctions or the congenital morning glory anomaly may have subtle subclinical retinal changes. Methods: In this cross-sectional study, spectral domain optical coherence tomography was used to analyze the retinal morphology of 25 patients with idiopathic moyamoya angiopathy and 25 age- and sex-matched healthy controls. We analyzed the retinal vasculature with blue laser autofluorescence, lipofuscin deposits ...
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  Mentions: Friedemann Paul
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