1. Frederique Vanholsbeeck

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    1. Mentioned In 26 Articles

    2. Optical coherence tomography complements confocal microscopy for investigation of multicellular tumour spheroids

      Optical coherence tomography complements confocal microscopy for investigation of multicellular tumour spheroids
      Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional (3D) in-vitro culture systems, of ...
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    3. Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size
      Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional in-vitro culture systems, of the ...
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    4. Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation

      Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation
      Recent studies have shown potential for using polarisation sensitive optical coherence tomography (PS-OCT) to study cartilage morphology, and to be potentially used as an in vivo , non-invasive tool for detecting osteoarthritic changes. However, there has been relatively limited ability of this method to quantify the subtle changes that occur in the early stages of cartilage degeneration. An established mechanical indenting technique that has previously been used to examine the microstructural ...
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    5. Extracting morphometric information from rat sciatic nerve using optical coherence tomography

      Extracting morphometric information from rat sciatic nerve using optical coherence tomography
      We apply three optical coherence tomography (OCT) image analysis techniques to extract morphometric information from OCT images obtained on peripheral nerves of rat. The accuracy of each technique is evaluated against histological measurements accurate to +/-1 m. The three OCT techniques are: 1) average depth resolved profile (ADRP); 2) autoregressive spectral estimation (AR-SE); and, 3) correlation of the derivative spectral estimation (CoD-SE). We introduce a scanning window to the ADRP ...
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    6. Using polarisation-sensitive optical coherence tomography and mechanical indentation to assess cartilage degeneration in the bovine model of early osteoarthritis

      Using polarisation-sensitive optical coherence tomography and mechanical indentation to assess cartilage degeneration in the bovine model of early osteoarthritis
      Recent studies have shown potential for using polarisation sensitive optical coherence tomography (PS-OCT) to study cartilage morphology, and this presents a useful real-time non-invasive tool for detecting osteoarthritic changes. However, there has been relatively limited ability of this method to quantify the subtle changes in the early stages of joint degeneration. In this study, we investigate the ability of PS-OCT to detect microscale degenerative changes in cartilage, following compression, using ...
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    7. Dispersion mapping as a simple postprocessing step for Fourier domain Optical Coherence Tomography data

      Dispersion mapping as a simple postprocessing step for Fourier domain Optical Coherence Tomography data
      Optical Coherence Tomography (OCT) was originally conceived as a volumetric imaging method. Quickly, OCT images went beyond structural data and started to provide functional information about an object enabling for example visualization of blood flow or tissue elasticity. Minimal or no need for system alterations make functional OCT techniques useful in performing multimodal imaging, where differently contrasted images are produced in a single examination. We propose a method that further ...
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    8. Dispersion measurements in ocular media using a dual-wavelength swept source optical coherence tomography system

      Dispersion measurements in ocular media using a dual-wavelength swept source optical coherence tomography system
      Optical coherence tomography (OCT) has proved to be a powerful tool for the detection of microstructure in tissue. Label-free tissue differentiation on a micron scale is a promising and powerful technique for segmentation. This Letter describes a technique using a dual-wavelength OCT system to image the eye. We measure the walk-off between interfaces in A-scans, taken at two different wavelengths, to calculate the average group velocity dispersion parameter of each ...
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    9. 4D imaging of cardiac trabeculae contracting in vitro using gated OCT

      4D imaging of cardiac trabeculae contracting in vitro using gated OCT
      Cardiac trabeculae are widely used as experimental muscle preparations for studying heart muscle. However, their geometry (diameter, length, and shape) can vary not only amongst samples, but also within a sample, leading to inaccuracies in estimating their stress production, volumetric energy output, and/or oxygen consumption. Hence, it is desirable to have a system that can accurately image each trabecula in vitro during an experiment. To this end, we constructed ...
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    10. Simple and versatile long range swept source for optical coherence tomography applications

      Simple and versatile long range swept source for optical coherence tomography applications
      We present a versatile long coherence length swept-source laser design for optical coherence tomography applications. This design consists of a polygonal spinning mirror and an optical gain chip in a modified LittmanMetcalf cavity. A narrowband intra-cavity filter is implemented through multiple passes off a diffraction grating set at grazing incidence. The key advantage of this design is that it can be readily adapted to any wavelength regions for which broadband ...
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    11. Optical coherence tomography imaging of cardiac trabeculae

      Optical coherence tomography imaging of cardiac trabeculae
      An integrated instrument is being developed to study live cardiac trabeculae, which is capable of stimulating the muscle under controlled conditions while measuring the heat production, force, and sarcomere length distribution. To improve the accuracy of estimation of stress, strain, and volumetric heat production, the geometry of the muscle must be known. A spectral domain optical coherence tomography system (SD-OCT) has been constructed and calibrated to image the trabecula mounted ...
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    12. Dispersion mapping at the micrometer scale using tri-band optical frequency domain imaging

      Dispersion mapping at the micrometer scale using tri-band optical frequency domain imaging
      Techniques to differentiate between materials are a powerful addition to the structural information traditionally available from optical coherence tomography images. We present label-free detection of water and lipid at a micrometer scale by evaluating their unique dispersion properties. Using a tri-band swept source configuration, we measure both 2 and 3 and show how to identify the two materials at sample thicknesses of 40 and 90 m, respectively.
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    13. Speckle suppression in Fourier domain optical coherence tomography by fractional Fourier domain compounding

      Speckle suppression in Fourier domain optical coherence tomography by fractional Fourier domain compounding
      We propose a new numerical method for speckle reduction in Fourier domain OCT based on incoherent averaging of fractional Fourier domains of a single A-scan. Fractional Fourier transforms represent projections in the time-frequency space and thus, this method simultaneously compensates for group velocity dispersion.
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    14. Dispersion mapping at the micron scale using tri-band optical frequency domain imaging

      Dispersion mapping at the micron scale using tri-band optical frequency domain imaging
      We present detection of water and lipid at a micron scale by evaluating their unique dispersion properties. Using a triband swept source configuration, we measure 2 and 3 and show how to identify the two materials at a sample thickness of 40m and 90m, respectively. This report reveals exciting new prospects for label free differentiation and segmentation using optical coherence tomography.
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    15. Single-shot speckle reduction and dispersion compensation in optical coherence tomography by compounding fractional Fourier domains

      Single-shot speckle reduction and dispersion compensation in optical coherence tomography by compounding fractional Fourier domains
      We present speckle suppression and dispersion compensation for Fourier-domain optical coherence tomography based on fractional Fourier transforms of a single A scan. A 1.54-fold reduction in speckle contrast was achieved with group velocity dispersion compensation. The method is demonstrated on biological samples using a swept source configuration at 1310nm and a spectral-domain system at 840nm
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    16. 1-15 of 26 1 2 »
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  2. About Frederique Vanholsbeeck

    Frederique Vanholsbeeck

    Frederique Vanholsbeeck is with the Department of Physics at the University of Auckland. Dr. Vanholsbeeck's principal research area is now biophotonics, i.e., using light to observe and to understand physiological processes.