1. Frank G. Holz

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    1. Mentioned In 41 Articles

    2. Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model

      Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model
      Purpose : The aim of the study was to investigate optical coherence tomography angiography (OCTA) as a high-resolution in vivo imaging modality for monitoring therapeutic response to different vascular endothelial growth factor inhibitors in the rat model of laser-induced choroidal neovascularization (CNV). Further, OCTA findings were compared with fluorescein angiography (FA) and fluorescence microscopy. Methods : Laser treatment at day (D)0 was followed by intravitreal injection of aflibercept, AF564, and NaCl ...
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    3. Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2

      Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2
      Purpose To evaluate the utility of optical coherence tomography-angiography (OCT-A) for monitoring activity, progression and response to therapy of neovascularisations (NVs) secondary to macular telangiectasia type 2 (MacTel). Methods In a retrospective analysis, eyes with NVs secondary to MacTel were reviewed over a period of 8 months. Examinations at monthly intervals included visual acuity testing, dilated funduscopy, spectral domain-OCT and OCT-A. Eyes were treated with intravitreal VEGF (vascular endothelial growth ...
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    4. Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography

      Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography
      Here, we investigate the extent to which re-implementing a previously published algorithm for OCT-based drusen quantification permits replicating the reported accuracy on an independent dataset. We refined that algorithm so that its accuracy is increased. Following a systematic literature search, an algorithm was selected based on its reported excellent results. Several steps were added to improve its accuracy. The replicated and refined algorithms were evaluated on an independent dataset with ...
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    5. Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis

      Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis
      Introduction For quantification of Optical Coherence Tomography Angiography (OCTA) images, Vessel Density (VD) and Vessel Skeleton Density (VSD) are well established parameters and different algorithms are in use for their calculation. However, comparability, reliability and ability to discriminate healthy and impaired macular perfusion of different algorithms are unclear, yet, of potential high clinical relevance. Hence, we assessed comparability and test-retest reliability of the most common approaches. Materials and methods Two ...
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    6. ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)

      ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)
      Background/aims The prospective, non-interventional ORCA module of the OCEAN study (Observation of Treatment Patterns with Lucentis in Approved Indications) evaluated the qualiy of spectral domain-optical coherence tomography (SD-OCT) image interpretation and treatment decisions by clinicians in Germany and the impact on visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD). Methods 2286 SD-OCT scans of 205 eyes were independently evaluated by clinicians and reading centres ...
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    7. Estimating Retinal Sensitivity Using Optical Coherence Tomography With Deep-Learning Algorithms in Macular Telangiectasia Type 2

      Estimating Retinal Sensitivity Using Optical Coherence Tomography With Deep-Learning Algorithms in Macular Telangiectasia Type 2
      Importance As currently used, microperimetry is a burdensome clinical testing modality for testing retinal sensitivity requiring long testing times and trained technicians. Objective To create a deep-learning network that could directly estimate function from structure de novo to provide an en face high-resolution map of estimated retinal sensitivity. Design, Setting, and Participants A cross-sectional imaging study using data collected between January 1, 2016, and November 30, 2017, from the Natural ...
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    8. Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

      Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum
      Importance The diagnostic accuracy of different retinal imaging modalities to detect active choroidal neovascularization (CNV) in pseudoxanthoma elasticum (PXE) is essential to enable a correct diagnosis but currently poorly understood. Background Optical coherence tomography (OCT), fluorescein angiography (FA) and optical coherence tomography angiography (OCT‐A) are employed in daily practice but a systematic comparison of these imaging techniques is lacking. Design Retrospective, observational study. Participants Twenty patients (31 eyes) with ...
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    9. Optical coherence tomography angiography in intermediate uveitis

      Optical coherence tomography angiography in intermediate uveitis
      Purpose To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A) Design Case-control study Methods Patients and age-matched controls were imaged with swept-source OCT-A (PLEX Elite 9000, Zeiss). Using ImageJ superficial and deep retinal vasculature were semi-automatically analyzed for vessel (VD) and skeleton density (SD), vessel diameter index (VDI) and fractal dimension (FD). Choriocapillaris layer was automatically graded for mean signal ...
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    10. Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns

      Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns
      Purpose: To evaluate two different spectral-domain optical coherence tomography (SD-OCT) scan patterns in eyes with intermediate age-related macular degeneration (AMD) for the longitudinal assessment of drusen volume. Methods: The data of 38 eyes of 38 AMD patients (age 69.97 6.08 years) were included. The longitudinal drusen volume over 4 years was analyzed by annual SD-OCT raster scanning (field size 20 15). Two raster scan patterns (A/B) differed ...
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    11. MINIMAL OPTICAL COHERENCE TOMOGRAPHY B-SCAN DENSITY FOR RELIABLE DETECTION OF INTRARETINAL AND SUBRETINAL FLUID IN MACULAR DISEASES

      MINIMAL OPTICAL COHERENCE TOMOGRAPHY B-SCAN DENSITY FOR RELIABLE DETECTION OF INTRARETINAL AND SUBRETINAL FLUID IN MACULAR DISEASES
      Purpose: To determine the minimal optical coherence tomography B-scan density for reliable detection of intraretinal and subretinal fluid. Methods: Spectral domain optical coherence tomography raster scanning (Spectralis; Heidelberg Engineering, Heidelberg, Germany) using a scan field of 20 20 of 97 B-scans with an interscan distance (ISD) of 60 m was performed in 150 eyes of 150 consecutive patients at monitoring visits for intravitreal antivascular endothelial growth factor therapy. Using custom ...
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    12. CNNs Enable Accurate and Fast Segmentation of Drusen in Optical Coherence Tomography

      CNNs Enable Accurate and Fast Segmentation of Drusen in Optical Coherence Tomography
      Optical coherence tomography (OCT) is used to diagnose and track progression of age-related macular degeneration (AMD). Drusen, which appear as bumps between Bruchs membrane (BM) and the retinal pigment epithelium (RPE) layer, are among the most important biomarkers for staging AMD. In this work, we develop and compare three automated methods for Drusen segmentation based on the U-Net convolutional neural network architecture. By cross-validating on more than 50, 000 annotated ...
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    13. Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review

      Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review
      Purpose : To assess the quality of optical coherence tomography (OCT) grading algorithms for retinal biomarkers of age-related macular degeneration (AMD). Methods : Following a systematic review of the literature data on detection and quantification of AMD retinal biomarkers by available algorithms were extracted and descriptively synthesized. Algorithm quality was assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies 2 checklist with a focus on accuracy against established ...
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    14. Structural Changes in Optical Coherence Tomography Underlying Spots of Increased Autofluorescence in the Perilesional Zone of Geographic Atrophy

      Structural Changes in Optical Coherence Tomography Underlying Spots of Increased Autofluorescence in the Perilesional Zone of Geographic Atrophy
      Purpose : To investigate structural correlates corresponding to the appearance of increased fundus autofluorescence (FAF) in the perilesional area of geographic atrophy (GA) secondary to age-related macular degeneration. Methods : Serial FAF images of 181 eyes with GA of 134 patients participating in the Directional Spread in Geographic Atrophy study (NCT02051998) were screened for increased FAF spots that had developed during the review period. Thickness and reflectivity of the retinal pigment epithelium ...
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    15. The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS)

      The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS)
      Purpose : To evaluate the impact of lens opacity on retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening (BMO) measurements. Methods : Fifty-nine randomly selected patients without any other relevant ocular pathology undergoing elective routine cataract surgery in two specialized eye clinics were enrolled. RNFLT, BMO area, and BMO minimum rim width (BMO-MRW) were assessed with the Heidelberg Engineering Spectralis OCT using the anatomical positioning system (APS) prior to ...
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  2. About Frank G. Holz

    Frank G. Holz

    Frank G. Holz is the director of University Eye Hosptial Bonn at the Department of Ophthalmology at the University of Bonn, Bonn Germany.