1. Frank D. Verbraak

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    1. Mentioned In 20 Articles

    2. Optical coherence tomography (OCT) to image active and inactive retinoblastomas as well as retinomas

      Optical coherence tomography (OCT) to image active and inactive retinoblastomas as well as retinomas
      Purpose To illustrate Optical Coherence Tomography (OCT) images of active and inactive retinoblastoma (Rb) tumours. Methods Current observational study included patients diagnosed with retinoblastoma and retinoma who were presented at Amsterdam UMC and Jules‐Gonin Eye Hospital, between November 2010 and October 2017. Patients aged between 0 and 4 years were imaged under general anaesthesia with handheld OCT in supine position. Patients older than 4 years were imaged with the ...
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    3. Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography

      Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography
      A new metric is used to improve the contrast of birefringent structures in biological tissue using polarization-sensitive optical coherence tomography. This metric, optic axis uniformity (OAxU), is based on the optic axis of birefringence and quantifies the uniformity of the optic axis direction. OAxU provides surprisingly strong contrast for fibrous structures such as muscle and the retinal nerve fiber layer (RNFL). We used OAxU for automatic segmentation of the RNFL ...
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    4. PREDICTIVE VALUE OF OPTICAL COHERENCE TOMOGRAPHIC FEATURES IN THE BEVACIZUMAB AND RANIBIZUMAB IN PATIENTS WITH DIABETIC MACULAR EDEMA (BRDME) STUDY

      PREDICTIVE VALUE OF OPTICAL COHERENCE TOMOGRAPHIC FEATURES IN THE BEVACIZUMAB AND RANIBIZUMAB IN PATIENTS WITH DIABETIC MACULAR EDEMA (BRDME) STUDY
      Purpose: To establish the predictive value of specific optical coherence tomography retinal features on visual outcomes and retinal thickness during anti-vascular endothelial growth factor treatment in patients with diabetic macular edema. Methods: Post hoc analysis of compound data of a prospective, 6-month, multicenter, randomized controlled trial of 119 patients with diabetic macular edema receiving either intravitreal bevacizumab or ranibizumab were analyzed to assess the associations between baseline retinal morphologic parameters ...
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    5. Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery

      Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery
      Purpose To describe the use of a novel intra-ocular side-scanning probe enabling the acquisition of spectral-domain optical coherence tomography (SD-OCT) images during surgery in a series of patients with complex forms of retinal detachment. Methods A 23-gauge, side-scanning SD-OCT probe (C7 System; LightLab Imaging, Inc/St Jude Medical, St. Paul, MN, USA) in a 20-gauge catheter, was used to acquire the intra-operative OCT images in seven patients with vitreoretinal diseases ...
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    6. Detecting signs of retinal leakage in exudative AMD using Cirrus OCT versus SL SCAN-1, a novel integrated FD-OCT into a common slit lamp

      Detecting signs of retinal leakage in exudative AMD using Cirrus OCT versus SL SCAN-1, a novel integrated FD-OCT into a common slit lamp
      Purpose The purpose is to evaluate the interdevice and interobserver agreements between the SL SCAN-1 (a FD-OCT integrated into a common slit lamp) and a standard stand-alone FD-OCT device (the Cirrus ) with regard to the presence or absence of signs of leakage in the retina in patients with exudative AMD and treated with anti- VEGF . Methods Fifty-six patients, known to have exudative AMD and under treatment with anti- VEGF agents ...
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    7. Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation

      Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation
      ... Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands ^* Correspondence: Frank D. Verbraak, MD, PhD Department of Ophthalmology Academic Medical Center D2 room 420 Meibergdreef 9 1105...
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    8. Clinical applications of functional optical coherence tomography (Thesis)

      Clinical applications of functional optical coherence tomography (Thesis)
      The purpose of the work presented in this thesis is to show the potential of functional optical coherence tomography (OCT) to discriminate pathological from normal tissues in several clinical settings, by means of the attenuation coefficient. To that end, several fundamental studies were carried out to increase the fundamental understanding of the measured signals (in phantoms, during apoptosis) and both ex and in vivo investigations are performed in the urological ...
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    9. Standardised disturbance of the optical coherence tomography signal has varying effects on the scan quality assessment when comparing four devices

      Standardised disturbance of the optical coherence tomography signal has varying effects on the scan quality assessment when comparing four devices
      Introduction Optical coherence tomography (OCT) has become a successful application in ophthalmology. Time-domain OCT (Stratus, Carl Zeiss Meditec) has been overtaken by spectral-domain OCT (SDOCT) which has major advances in imaging speed, sensitivity and image resolution. 1 , 2 Several SDOCT devices are commercially available. In this small study, we assessed the change in subjective image quality and image quality parameter (IQP) provided by four different SDOCT devices using artificial filters ...
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    10. Effect of Age on Individual Retinal Layer Thickness in Normal Eyes as Measured with Spectral-Domain Optical Coherence Tomography

      Effect of Age on Individual Retinal Layer Thickness in Normal Eyes as Measured with Spectral-Domain Optical Coherence Tomography
      Purpose. To determine the effect of age on the thickness of individual retinal layers, measured with spectral-domain optical coherence tomography (SD-OCT), in a population of healthy Caucasians. Methods. One hundred and twenty subjects with an age ranging between 18 and 81 years were examined with SD-OCT (Topcon, Mark II). Mean layer thickness was calculated for 7 retinal layers, in the fovea (region 1 of the 9 ETDRS regions), in the ...
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    11. The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography

      The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography
      Purpose: The purpose of this study was to model the influence of cataract on Spectral Domain Optical Coherence Tomography (SDOCT) image quality and Retinal Nerve Fibre Layer (RNFL) thickness measurements. Methods: SDOCT images, made with two different devices (3DOCT-1000, Topcon and Cirrus HD-OCT), before and after cataract surgery were compared and judged against measurements from normal subjects using artificial filters simulating the effects of cataract. Optical density of the images ...
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    12. Feature Of The Week 9/2/12: Academic Medical Center at The University of Amsterdam Investigates Comparison of RNFL Thickness Measurements by SD-OCT Systems Using a Phantom Eye Model

      Feature Of The Week 9/2/12: Academic Medical Center at The University of Amsterdam Investigates Comparison of RNFL Thickness Measurements by SD-OCT Systems Using a Phantom Eye Model
      We developed a multi-layered phantom eye model that distinguishes instrumental from biological variation, to quantify differences in retinal nerve fiber layer (RNFL) thickness measurements by various spectral-domain optical coherence tomography (SD-OCT) systems. The eye model comprised a glass lens, water as vitreous and silicone elastomer based layers mimicking the retina (top layer thickness = 49 m). We tested 3 RTVue OptoVue, 3 Cirrus Zeiss, 3 3DOCT-1000 Topcon and 3 Spectralis Heidelberg ...
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    13. Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina

      Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina
      ...oy de Kinkelder^1,^3, 2. Jeroen Kalkman^1, 3. Dirk J. Faber^1,^2, 4. Olaf Schraa^4, 5. Pauline H.B. Kok^2, 6. Frank D. Verbraak^1,^2 and 7. Ton G. van Leeuwen^1,^5 1. ^1 Department of Biomedical Engineering & Physics, Ac...
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    14. Scanning beyond the limits of standard OCT with a Fourier domain optical coherence tomography integrated into a slit lamp: the SL SCAN-1

      Scanning beyond the limits of standard OCT with a Fourier domain optical coherence tomography integrated into a slit lamp: the SL SCAN-1
      PurposeWith a new Fourier domain optical coherence tomography (FD OCT) device, SL SCAN-1 (Topcon Europe Medical BV, Capelle a/d IJssel, The Netherlands), integrated into a slit-lamp OCT, scans can be obtained through a handheld lens. The necessary adjustment of the reference arm is possible by fast Z-alignment. This study was performed to prove the capability of SL SCAN-1 to scan through a three-mirror contact lens, scanning the peripheral retina ...
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    15. Overlay of conventional angiographic and en-face OCT images enhances their interpretation

      Overlay of conventional angiographic and en-face OCT images enhances their interpretation
      Background Combining characteristic morphological and functional information in one image increases pathophysiologic understanding as well as diagnostic accuracy in most clinical settings. En-face optical coherence tomography (OCT) provides a high resolution, transversal OCT image of the macular area combined with a confocal image of the same area (OCT C-scans). Creating an overlay image of a conventional angiographic image onto an OCT image, using the confocal part to facilitate transformation, combines ...
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  2. About Frank D. Verbraak

    Frank D. Verbraak

    Frank D. Verbraak is from the Department of Biomedical Engineering & Physics and the Department of Ophthalmology, Academic Medical Center, University of Amsterdam.