1. Francisco E. Robles

    0 Comments Leave a Comment

    1-15 of 24 1 2 »
    1. Mentioned In 24 Articles

    2. Georgia Institute of Technology Receives NIH Grant for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology

      Georgia Institute of Technology Receives NIH Grant for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology
      Georgia Institute of Technology Receives a 2019 NIH Grant for $182,900 for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology. The principal investigator is Francisco Robels. The program began in 2018 and ends in 2021. Below is a summary of the proposed work. The extent of resection of brain tumors is one of the most important factors associated with prolonged survival ...
      Read Full Article
    3. Coherently broadened, high-repetition-rate laser for stimulated Raman scattering–spectroscopic optical coherence tomography

      Coherently broadened, high-repetition-rate laser for stimulated Raman scattering–spectroscopic optical coherence tomography
      We present a novel light source specifically tailored for stimulated Raman scatteringspectroscopic optical coherence tomography (SRS-SOCT), which is, to the best of our knowledge, a novel molecular imaging method that combines the molecular sensitivity of SRS with the spatial and spectral multiplexing capabilities of SOCT. The novel laser consists of an 8 W, 450 fs Yb:KGW oscillator, with a repetition rate of 40 MHz, which delivers the Stokes beam ...
      Read Full Article
    4. Multiple window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry

      Multiple window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution is provided. For example, optical resolution may relate to scattering ...
      Read Full Article
    5. Stimulated Raman scattering spectroscopic optical coherence tomography

      Stimulated Raman scattering spectroscopic optical coherence tomography
      We integrate spectroscopic optical coherence tomography (SOCT) with stimulated Raman scattering (SRS) to enable simultaneously multiplexed spatial and spectral imaging with sensitivity to many endogenous biochemical species that play an important role in biology and medicine. The combined approach, termed SRS-SOCT, overcomes the limitations of each individual method. Ultimately, SRS-SOCT has the potential to achieve fast, volumetric, and highly sensitive label-free molecular imaging. We demonstrate the approach by imaging excised ...
      Read Full Article
    6. Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry

      Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution may relate to scattering information about a sample, and temporal ...
      Read Full Article
    7. Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography

      Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography
      Stimulated Raman scattering (SRS) enables fast, high resolution imaging of chemical constituents important to biological structures and functional processes, both in a label-free manner and using exogenous biomarkers. While this technology has shown remarkable potential, it is currently limited to point scanning and can only probe a few Raman bands at a time (most often, only one). In this work we take a fundamentally different approach to detecting the small ...
      Read Full Article
    8. Dual Window Processing Schemes For Spectroscopic Optical Coherence Tomography (OCT) And Fourier Domain Low Coherence Interferometry

      Dual Window Processing Schemes For Spectroscopic Optical Coherence Tomography (OCT) And Fourier Domain Low Coherence Interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution may relate to scattering information about a sample, and temporal ...
      Read Full Article
    9. Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography

      Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography
      We have recently developed a novel dual window scheme for processing spectroscopic OCT images to provide spatially resolved true color imaging of chromophores in scattering samples. Here we apply this method to measure the extinction spectra of plasmonic nanoparticles at various concentrations for potential in vivo applications. We experimentally demonstrate sub-nanomolar sensitivity in the measurement of nanoparticle concentrations, and show that colorimetric imaging with multiple species of nanoparticles produces enhanced ...
      Read Full Article
    10. Feature Of The Week 1/28/12: Duke University Demonstrates Molecular Imaging of Endogenous and Exogenous Chromophores using a Novel Form of Spectroscopic OCT

      Feature Of The Week 1/28/12: Duke University Demonstrates Molecular Imaging of Endogenous and Exogenous Chromophores using a Novel Form of Spectroscopic OCT
      ...etection, and delivery and monitoring of therapeutic agents.For more information see recent Article. Courtesy Francisco E. Robles from Duke University. In this letter the authors demonstrate molecular imaging of endogeno...
      Read Full Article
    11. Molecular imaging true-colour spectroscopic optical coherence tomography

      Molecular imaging true-colour spectroscopic optical coherence tomography
      Molecular imaging holds a pivotal role in medicine due to its ability to provide invaluable insight into disease mechanisms at molecular and cellular levels. To this end, various techniques have been developed for molecular imaging, each with its own advantages and disadvantages1, 2, 3, 4. For example, fluorescence imaging achieves micrometre-scale resolution, but has low penetration depths and is mostly limited to exogenous agents. Here, we demonstrate molecular imaging of ...
      Read Full Article
    12. Multiple Window Processing Schemes For Spectroscopic Optical Coherence Tomography (OCT) And Fourier Domain Low Coherence Interferometry

      Multiple Window Processing Schemes For Spectroscopic Optical Coherence Tomography (OCT) And Fourier Domain Low Coherence Interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution may relate to scattering information about a sample, and temporal ...
      Read Full Article
    13. 1-15 of 24 1 2 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Francisco E. Robles

    Francisco E. Robles

    Francisco Robles is an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University. He runs the Optical Imaging and Spectroscopy (OIS) Lab which focuses on advancing optical technologies to help improve the understanding of biological processes and the ability to identify and stage disease. The team develops and applies novel label-free linear and nonlinear spectroscopic methods, along with advanced signal processing methods, to gain access to novel forms of functional and molecular contrast for a variety of applications, including cancer detection, tumor margin assessment, and hematology. Dr. Robles completed a Postdoctoral Fellowship in the Department of Chemistry at Duke University (2016), earned his Ph.D. in Medical Physics at Duke University (2011), and earned a B.S. in Physics and in Nuclear Engineering from North Carolina State University (2007

  3. Quotes

    1. While with conventional OCT we are able to see structures such as blood vessels and even capillaries, the main drawback is that it doesn’t provide some basic functional information, including absorption, which also gives the true color of the structures...Each point on the three-dimensional image that we collect contains a great deal of useful information that we can use to reconstruct what’s happening at the molecular level...data not only helps create three-dimensional images, but it also contains important spectral information.
      In Biomolecules Show Their True Colors