1. Francesco Prati

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    1. Mentioned In 61 Articles

    2. Methodology for fully automated segmentation and plaque characterization in intracoronary optical coherence tomography images

      Methodology for fully automated segmentation and plaque characterization in intracoronary optical coherence tomography images

      Optical coherence tomography (OCT) is a light-based intracoronary imaging modality that provides high-resolution cross-sectional images of the luminal and plaque morphology. Currently, the segmentation of OCT images and identification of the composition of plaque are mainly performed manually by expert observers. However, this process is laborious and time consuming and its accuracy relies on the expertise of the observer. To address these limitations, we present a methodology that is able to process the OCT data in a fully automated fashion. The proposed methodology is able to detect the lumen borders in the OCT frames, identify the plaque region, and detect ...

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    3. Stent-related defects in patients presenting with stent thrombosis: differences at optical coherence tomography between subacute and late/very late thrombosis in the Mechanism Of Stent Thrombosis (MOST) study

      Stent-related defects in patients presenting with stent thrombosis: differences at optical coherence tomography between subacute and late/very late thrombosis in the Mechanism Of Stent Thrombosis (MOST) study

      Aims: Subacute, late, and very late stent thrombosis (ST) may occur after stent implantation, but they are characterised by different underlying pathophysiological mechanisms. We sought to appraise differences between subacute and late/very late ST at the thrombus site by optical coherence tomography (OCT). The Mechanism Of Stent Thrombosis (MOST) study was a prospective multicentre non-randomised registry which enrolled six subacute ST and six controls (subacute ST study), and 17 late/very late ST and 17 controls (late/very late ST study). Methods and results: Patients with subacute ST had a minimum stent area at the thrombus site of 2 ...

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    4. Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses

      Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses

      Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real world, a variety of definitions are being used by different groups and by different core laboratories to analyze OCT findings because of different clinical/procedural contexts in which OCT research has been carried out. This comprehensive overview is aimed to summarize different applicable definitions used by different research groups in plaque and stent analysis using OCT. In addition ...

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    5. Fully automated calcium detection using optical coherence tomography

      Fully automated calcium detection using optical coherence tomography

      Optical Coherence Tomography (OCT) is a new invasive technology for performing high-resolution cross-sectional imaging of the coronary arteries. In OCT images only Calcified plaque (CA) components can be accurately depicted as light penetrates hard tissue. In this work we present an automated method for detecting CA in OCT images. The method is fully automated as no user intervention is needed and includes three steps. In the first step the region between the lumen and the maximum penetration depth of OCT from the lumen border is determined. In the second step the region is classified into 3 clusters using the K-means ...

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    6. Optical coherence tomography criteria for defining functional severity of intermediate lesions: a comparative study with FFR

      Optical coherence tomography criteria for defining functional severity of intermediate lesions: a comparative study with FFR

      Fractional flow reserve (FFR) is the gold standard in the assessment of severity of the coronary stenosis. The aim of the study was to compare optical coherence tomography (OCT) obtained intermediate coronary lesions lumen areas measurements with FFR assessments, with the goal to develop an OCT threshold to identify significant coronary stenosis. 48 patients (mean age 65 ± 10 years) was enrolled for the study. Within this population, 71 intermediate coronary lesions were investigated using both FFR and OCT. High dose bolus of Adenosine (120 μg) was used to obtain coronary hyperemia. OCT imaging was performed using non-occlusive technique to assess ...

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    7. OCT Guidance to Improve Clinical Outcome of Coronary Interventions: What Have We Learnt?

      OCT Guidance to Improve Clinical Outcome of Coronary Interventions: What Have We Learnt?

      Optical coherence tomography (OCT) is the current state-of-the-art intravascular imaging technique which so far has been mainly used for research purpose. The clinical impact of an OCT-guided percutaneous coronary intervention is a field of controversy, although recent non randomized data has shown its potential clinical benefit. Many features that are clearly visualized by OCT are missed by both angiography and other intravascular imaging techniques due to their limited resolution. On the contrary, OCT allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. This may translate in an improved clinical outcome of OCT-guided procedures. This article reviews the ...

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      Mentions: Francesco Prati
    8. Randomized trial of standard versus ClearWay-infused abciximab and thrombectomy in myocardial infarction: rationale and design of the COCTAIL II study

      Randomized trial of standard versus ClearWay-infused abciximab and thrombectomy in myocardial infarction: rationale and design of the COCTAIL II study

      Background: Patients with ST-elevation myocardial infarction (STEMI) are at substantial risk of suboptimal procedural results and late adverse events. Angiography and optical coherence tomography (OCT) studies have identified residual coronary thrombus and microcirculatory injury as potential culprits for these adverse outcomes. We hypothesized that coronary thrombectomy and local infusion of glycoprotein IIb/IIIa inhibitors by means of a dedicated infusion device can synergistically improve results of percutaneous coronary intervention (PCI) for STEMI, as appraised by OCT. Methods: A total of 128 patients with STEMI will be randomized, to one of the following: abciximab infusion with the ClearWay coronary catheter (C ...

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    9. Severity of coronary atherosclerosis in patients with a first acute coronary event: a diabetes paradox

      Severity of coronary atherosclerosis in patients with a first acute coronary event: a diabetes paradox

      Aims We aimed to compare coronary artery disease (CAD) at the time of a first acute coronary syndrome (ACS) in type II diabetic and non-diabetic patients by coronary angiography and by optical coherence tomography (OCT). Methods and results Two different patient populations with a first ACS were enrolled for the angiographic (167 patients) and the OCT (72 patients) substudy. Angiographic CAD severity was assessed by Bogaty, Gensini, and Sullivan scores, whereas collateral development towards the culprit vessel was assessed by the Rentrop score. Optical coherence tomography plaque features were evaluated at the site of the minimum lumen area (MLA) and ...

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      Mentions: Francesco Prati
    10. Optical coherence tomography guided in-stent thrombus removal in patients with acute coronary syndromes

      Optical coherence tomography guided in-stent thrombus removal in patients with acute coronary syndromes

      The persistence of thrombus inside stent struts is a frequent event in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI), and this phenomenon might be associated with an increased risk of stent thrombosis. We sought to quantify by means of optical coherence tomography (OCT) the presence of in-stent thrombus after achievement of an optimal angiographic result in patients with ACS undergoing PCI. In addition, we evaluated the feasibility and safety of an OCT-guided strategy of in-stent thrombus removal. Eighty consecutive patients with ACS undergoing PCI were treated with two different strategies equally divided into two groups: angio-guided ...

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  2. About Francesco Prati

    Francesco Prati, MD, is from the San Giovanni-Addolorata Hospital in Rome.

  3. Quotes

    1. The technique allows high-resolution arterial-wall imaging in the range of 10-20 microns, allowing penetrance into the arterial wall and visualisation of specific components of the atherosclerotic plaques, including calcification, fibrotic tissue, necrotic lipid pools and thrombotic components.
      In In search of the thrombosis-prone vulnerable plaque