1. Florida International University

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    1. Mentioned In 26 Articles

    2. Florida International University Receives NIH Grant for Imaging the Functional Biomarkers of Photoreceptors

      Florida International University Receives NIH Grant for Imaging the Functional Biomarkers of Photoreceptors
      Florida International University Receives a 2020 NIH Grant for $485,580 for Imaging the Functional Biomarkers of Photoreceptors. The principal investigator is Shuliang Jiao. Below is a summary of the proposed work. Vision is the most fundamental of our senses and it is perhaps the greatest tragedy of all when blindness robs us of this modality. Photoreceptors are light-detecting cells initiating vision. Loss of photoreceptor leads to loss of vision ...
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    3. Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging

      Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging
      Lipofuscin in the retinal pigment epithelium (RPE) is the major source of fundus autofluorescence (FAF). A technical challenge to accurately quantify the FAF intensities, thus the lipofuscin concentration, is to compensate the light attenuation of RPE melanin. We developed the VIS-OCT-FAF technology to accomplish optical coherence tomography (OCT) and FAF simultaneously with a single broadband visible light source. We demonstrated that light attenuation by RPE melanin can be assessed and ...
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    4. Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging

      Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging
      We have developed a multimodal imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography, optical coherence tomography angiography, and confocal fluorescence microscopy in one platform. The system is able to image complementary features of a biological sample by combining different contrast mechanisms. We achieved fast imaging and large field of view by combining optical scanning with mechanical scanning, similar to our previous publication. We have demonstrated the capability ...
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    5. NIH Intramural Research Receives a 2019 Grant for Quantitative Biophotonics for Tissue Characterization and Function

      NIH Intramural Research Receives a 2019 Grant for Quantitative Biophotonics for Tissue Characterization and Function
      NIH Intramural Research Receives a 2019 Grant for $753,097 for Quantitative Biophotonics for Tissue Characterization and Function. The principal investigator is Amir Gandjabkhche. Below is a summary of the proposed work. Monitoring the placental oxygenation is critical to ensure a healthy pregnancy outcome. Abnormalities in placental oxygenation has been associated with preeclampsia and intrauterine growth restriction, fetal hypoxia, asphyxia, and cerebral palsy. Quantifying placental oxygenation can help early detection ...
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    6. Deep learning-based automated detection of retinal diseases using optical coherence tomography images

      Deep learning-based automated detection of retinal diseases using optical coherence tomography images
      Retinal disease classification is a significant problem in computer-aided diagnosis (CAD) for medical applications. This paper is focused on a 4-class classification problem to automatically detect choroidal neovascularization (CNV), diabetic macular edema (DME), DRUSEN, and NORMAL in optical coherence tomography (OCT) images. The proposed classification algorithm adopted an ensemble of four classification model instances to identify retinal OCT images, each of which was based on an improved residual neural network ...
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    7. Optical Coherence Photoacoustic Microscopy (OC-PAM) for Multimodal Imaging (Thesis)

      Optical Coherence Photoacoustic Microscopy (OC-PAM) for Multimodal Imaging (Thesis)
      Optical coherence tomography (OCT) and Photoacoustic microscopy (PAM) are two noninvasive, high-resolution, three-dimensional, biomedical imaging modalities based on different contrast mechanisms. OCT detects the light backscattered from a biological sample either in the time or spectral domain using an interferometer to form an image. PAM is sensitive to optical absorption by detecting the light-induced acoustic waves to form an image. Due to their complementary contrast mechanisms, OCT and PAM are ...
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    8. Optical coherence tomography-guided dynamic focusing for combined optical and mechanical scanning multimodal photoacoustic microscopy

      Optical coherence tomography-guided dynamic focusing for combined optical and mechanical scanning multimodal photoacoustic microscopy
      To achieve fast imaging and large field of view (FOV), we improved our multimodal imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography (OCT), and confocal fluorescence microscopy in one platform, by combining optical scanning with mechanical scanning. To ensure good focusing of the objective lens over all the imaged area, we employed OCT-guided dynamic focusing. Different from our previous point-by-point dynamic focusing, we employed an area-by-area focusing ...
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    9. Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases

      Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases
      Glomus tumors are painful, benign perivascular neoplasms of the glomus body affecting the nail apparatus. Although diagnosis can be made clinically using Love's and Hildreth's tests, imaging is required to distinguish glomus tumors from other subungual vascular lesions. Clinical diagnosis is complicated when the nail has no visible abnormalities. 1 Magnetic resonance imaging (MRI) is the modality of choice for imaging but requires a dedicated small part coil ...
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    10. Optical phantoms for biomedical polarimetry: a review

      Optical phantoms for biomedical polarimetry: a review
      Calibration, quantification, and standardization of the polarimetric instrumentation, as well as interpretation and understanding of the obtained data, require the development and use of well-calibrated phantoms and standards. We reviewed the status of tissue phantoms for a variety of applications in polarimetry; more than 500 papers are considered. We divided the phantoms into five groups according to their origin (biological/nonbiological) and fundamental polarimetric properties of retardation, depolarization, and diattenuation ...
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    11. Eunice Kennedy Shriver National Institute of Child Health & Human Development receives a NIH Grant for Quantitative Biophontonics for Tissue Characterization and Function

      Eunice Kennedy Shriver National Institute of Child Health & Human Development receives a NIH Grant for Quantitative Biophontonics for Tissue Characterization and Function
      Eunice Kennedy Shriver National Institute of Child Health Human Development receives a 2018 NIH Grant for $741,019 for Quantitative Biophontonics for Tissue Characterization and Function. The principal investigator is Amir Gandjbakache. Below is a summary of the proposed work. Monitoring the placenta oxygenation is critical to ensure a healthy pregnancy outcome. Abnormalities in placental oxygenation has been associated with preeclampsia and intrauterine growth restriction, fetal hypoxia, asphyxia, and cerebral ...
      Read Full Article
    12. Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging

      Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging
      Fundus autofluorescence (FAF) imaging is commonly used in ophthalmic clinics for diagnosis and monitoring of retinal diseases. Lipofuscin in the retinal pigment epithelium (RPE), with A2E as its most abundant component and a visual cycle by-product, is the major fluorophore of FAF. Lipofuscin accumulates with age and is implicated in degenerative retinal diseases. The amount of lipofuscin in RPE can be assessed by quantitative measurement of FAF. However, the currently ...
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    13. A multimodal imaging platform with integrated simultaneous photoacoustic microscopy, optical coherence tomography, optical Doppler tomography and fluorescence microscopy

      A multimodal imaging platform with integrated simultaneous photoacoustic microscopy, optical coherence tomography, optical Doppler tomography and fluorescence microscopy
      Various optical imaging modalities with different optical contrast mechanisms have been developed over the past years. Although most of these imaging techniques are being used in many biomedical applications and researches, integration of these techniques will allow researchers to reach the full potential of these technologies. Nevertheless, combining different imaging techniques is always challenging due to the difference in optical and hardware requirements for different imaging systems. Here, we developed ...
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    14. Florida International University Receives NIH Grant for Imaging The Functional Biomarkers of Photoreceptors

      Florida International University Receives  NIH Grant  for Imaging The Functional Biomarkers of Photoreceptors
      Florida International University Receives a 2017 NIH Grant for $495,185 for Imaging The Functional Biomarkers of Photoreceptors. The principal investigator is Shuliang Jiao. The program began in 2017 and ends in 2021. Below is summary of the proposed work. Vision is the most fundamental of our senses and it is perhaps the greatest tragedy of all when blindness robs us of this modality. Photoreceptors are light-detecting cells initiating vision ...
      Read Full Article
    15. Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy

      Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy
      Preterm birth (PTB) presents a serious medical heath concern throughout the world. There is a high incidence of PTB in both developed and developing countries ranging from 11%-15%, respectively. Studies have shown there may be numerous precursors to PTB including infections, genetic predisposition, nutrition and various other morbidities which all lead to a premature disorganization in the cervical collagen resulting in the weakening of the structure designed to keep ...
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    16. Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification

      Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification
      We developed a spectral-domain visible-light optical coherence tomography (VIS-OCT) based multimodal imaging technique which can accomplish simultaneous OCT and fluorescence imaging with a single broadband light source. Phantom experiments showed that by using the simultaneously acquired OCT images as a reference, the effect of light attenuation on the intensity of the fluorescent images by materials in front of the fluorescent target can be compensated. This capability of the multimodal imaging ...
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  2. About Florida International University

    Florida International University

    Florida International University is Miami's first and only public research university, offering bachelor's, master's, and doctoral degrees , FIU is worlds ahead in its service to the academic and local community. Designated as a top-tier research institution, FIU emphasizes research as a major component in the university's mission. The Herbert Wertheim College of Medicine and the School of Computing and Information Sciences ' Discovery Lab , are just two of many colleges, schools, and centers that actively enhance the university’s ability to set new standards through research initiatives.