Quantitative measurement of dynamic responses of unstained living cells is of great importance in many applications ranging from investigation of fundamental cellular functions to drug discoveries. Conventional optical methods for label-free cell-based assay examine cellular structural changes proximal to sensor surfaces under external stimuli, but require dedicated nanostructure-patterned substrates for operation. Here, we present a quantitative imaging method, spectral-domain optical coherence phase microscopy (SD-OCPM), as a viable optical platform for label-free cell-based assay. The instrument is based on a low-coherence interferometric microscope that enables quantitative depth-resolved phase measurement of a transparent specimen with high phase stability. We demonstrate SD-OCPM measurement ...
Fianium is the world leading manufacturer of ultrafast fibre lasers, providing a product portfolio of unrivalled diversity, uncompromised performance and reliability, to customers in academia and industry. Fianium's team combines more than 100 years experience gained working at the forefront of the fibre laser industry. Its customers include key industry figures in bio-medical, material inspection and processing as well as leading professors from top universities around the world.