1. Felix I. Feldchtein

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    1. Mentioned In 28 Articles

    2. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography
      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using ground truth OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with ...
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    3. Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy

      Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy
      A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers ...
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    4. Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial ...
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    5. Multi-modal optical imaging characterization of atherosclerotic plaques

      Multi-modal optical imaging characterization of atherosclerotic plaques
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers and other vascular structures in the development of atherosclerosis, including identification of vulnerable plaques, which remains an important clinical problem and imaging application. CP OCT's ability to visualize tissue birefringence and cross-scattering adds new information about the microstructure and composition of the ...
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    6. Quantitative Evaluation of the Polarization Characteristics of Coronary Arteries Atherosclerotic Plaques at Different Development Stages

      Quantitative Evaluation of the Polarization Characteristics of Coronary Arteries Atherosclerotic Plaques at Different Development Stages
      The aim of the investigation was to develop an approach to quantitative evaluation of polarization properties (birefringence and cross-scattering) basing on cross-polarization OCT images (CP OCT) in order to characterize the development stages of atherosclerotic plaques and to reveal unstable ones. Materials and Methods. We report on quantitative analysis of CP OCT images of the seven development stages of atherosclerotic plaques ex vivo . Integral depolarization factor (IDF) and effective birefringence ...
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    7. Imalux Ceases Operation

      Imalux Ceases Operation
      Imalux Corporation has announced that it has ceased operations due to various challenges to become a profitable on-going business. Imalux Corporation was one of the earliest OCT startup companies and received its first seed funding in 2000. Imalux opened operations in Cleveland Ohio with a strong technology connection to the Institute of Applied Physics in Russia. With the visionary leadership of Paul Amazeen and Felix Feldchtein Imalux developed the Niris ...
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    8. Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography

      Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography
      The goal of the research was analysis of the effect of collagen condition in formation of cross-polarized CP OCT images. We used of the CP OCT technique for studying collagen condition on an example of oral mucosa. Special histologic picrosirius red (PSR) staining of cheek mucosa specimens was used with subsequent assessing of the result of collagen staining in polarized light. High correlation (r = 0.692, p = 0.0001) between ...
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    9. Optical coherence tomography device and method having improved boundary control and distortion correction

      Optical coherence tomography device and method having improved boundary control and distortion correction
      Variants of an interferometric device are developed for examining internal structures of objects by means of optical coherence tomography, which allow for controlling a boundary location of the observation range. The device also allows for correcting a distortion of the tomographic image of the object under study, caused by lateral scanning, due to aberrations of the optical path length for the low-coherence optical radiation directed towards the object. Embodiments of ...
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    10. Common path systems and methods for frequency domain and time domain optical coherence tomography using non-specular reference reflection and a delivering device for optical radiation with a partially optically transparent non-specular reference reflector

      Common path systems and methods for frequency domain and time domain optical coherence tomography using non-specular reference reflection and a delivering device for optical radiation with a partially optically transparent non-specular reference reflector
      Provided are common path frequency domain and time domain OCT systems and methods that use non-specular reference reflection for obtaining internal depth profiles and depth resolved images of samples. Further provided is a delivering device for optical radiation, preferably implemented as an optical fiber probe with a partially optically transparent non-specular reflector placed in the vicinity of an associated sample. High frequency fringes are substantially reduced and a stable power ...
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    11. Polarization-sensitive common path optical coherence reflectometry/tomography device

      Polarization-sensitive common path optical coherence reflectometry/tomography device
      Polarization sensitive common path OCT/OCR devices are presented. Optical radiation from a source is converted into two cross-polarized replicas propagating therethrough with a predetermined optical path length difference. The two cross-polarized replicas are then delivered to an associated sample by a delivering device, which is, preferably, an optical fiber probe. A combination optical radiation is produced in at least one secondary interferometer by combining a corresponding portion of an ...
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    12. Feature Of The Week 9/27/09: Collective Dynamics of Swimming Bacteria: OCT Studies

      Feature Of The Week 9/27/09: Collective Dynamics of Swimming Bacteria: OCT Studies
      Feature Of The Week 9/27/09: Physical mechanisms governing large-scale organization of self-propelled biological microparticles, such as motor proteins, swimming bacteria, and other motile cells, attract significant attention among physicists and biologists. Scientists from Argonne National Laboratory, Imalux, and Cambridge University, discovered that commonly found bacteria such as Bacillus Subtilis are in fact highly efficient mixers for the liquid they live in. Thanks to original non-invasive optical coherence tomography ...
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    13. Optoelectronic probe system with all-optical coupling

      An optoelectronic probe system with all-optical coupling includes an optoelectronic measuring console coupled with an optoelectronic probe via an optical connector. A supplemental optical signal having an operative wavelength other than an operative wavelength of the regular optical part of the optoelectronic measuring console is communicated to the optoelectronic probe along with the output signal from the optoelectronic measuring console. The supplemental optical signal is then selected by a wavelength-division ...
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    14. Common path time domain optical coherence reflectometry/tomography device

      In common path time domain OCT/OCR devices optical radiation from a source is first split into two replicas, which are then delivered to an associated sample by an optical fiber probe. The tip of the optical fiber probe serves as a reference reflector and also serves as a combining element that produces a combination optical radiation by combining an optical radiation returning from the associated sample with a reference ...
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  2. About Felix I. Feldchtein

    Felix I. Feldchtein

    Felix I. Feldchtein is one of the creators of the first optical coherence tomography device in the former Soviet Union and one of the original founders of Imalux (initially Optical Coherence Technologies Inc.). He has contributed to over 60 scientific publications and multiple patents. Dr. Feldchtein is the laureate of 1999 Russian State Prize in Science and Technology for work in optical coherence tomography.  Dr. Feldchtein is also with Institute of Applied Physics of the Russian Academy of Sciences.

  3. Quotes

    1. SBIR programs are often judged mainly by academically minded panels focusing on academic merit. As a result, scientifically innovative proposals with very questionable commercial potential are winning over innovative technologies which are ready for the market but have already lost academic attractiveness.
      In Optical Coherence Tomography Used $500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What’s to Come?