1. Evelyn Regar

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    1. Mentioned In 152 Articles

    2. Three-dimensional visualization of intracoronary thrombus during stent implantation using the second generation, Fourier domain optical coherence tomography

      ...g the second generation, Fourier domain optical coherence tomography Takayuki Okamura, Patrick W. Serruys and Evelyn Regar* Thoraxcenter, Erasmus MC, Bd 585, 's-Gravendijkwal 230, 3015-CE Rotterdam, The Netherlands * Cor...
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    3. Imaging atherosclerotic plaque composition with intracoronary optical coherence tomography

      Imaging atherosclerotic plaque composition with intracoronary optical coherence tomography
      Optical coherence tomography (OCT) allows highly accurate diagnosis of atherosclerotic plaques, including measurement of the thickness of fibrous caps, permitting an assessment of the risk of rupture. While the OCT image presents morphological information in highly resolved detail, it relies on interpretation by trained readers for the identification of tissue type. We developed a method for quantitative classification of atherosclerotic plaque constituents. The optical attenuation coefficient mu(t) distinguishes different ...
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    4. Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis

      Optical coherence tomography (OCT) is a novel intravascular imaging modality, based on infrared light emission, that enables a high resolution arterial wall imaging, in the range of 1020 microns. This feature of OCT allows the visualization of specific components of the atherosclerotic plaques. The aim of the present Expert Review Document is to address the methodology, terminology and clinical applications of OCT for qualitative and quantitative assessment of coronary arteries ...
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    5. An optical coherence tomography study of a biodegradable vs. durable polymer-coated limus-eluting stent: a LEADERS trial sub-study

      Aims: Incomplete endothelialization has been found to be associated with late stent thrombosis, a rare but devastating phenomenon, more frequent after drug-eluting stent implantation. Optical coherence tomography (OCT) has 10 times greater resolution than intravascular ultrasound and thus appears to be a valuable modality for the assessment of stent strut coverage. The LEADERS trial was a multi-centre, randomized comparison of a biolimus-eluting stent (BES) with biodegradable polymer with a sirolimus-eluting ...
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    6. Optical Coherence Tomography Assessment Of The Acute Effects Of Stent Implantation On The Vessel Wall. A Systematic Quantitative Approach

      Objective: To observe and characterise vessel injury post-stenting using optical coherence tomography (OCT), to propose a systematic OCT classification for periprocedural vessel trauma, to evaluate its frequency in stable vs unstable patients and to assess its clinical impact during the hospitalization period. Setting: stenting causes vessel injury. Design and interventions: All consecutive patients in whom OCT was performed after stent implantation were included in the study. Qualitative and quantitative assessment ...
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    7. Virtual histology and optical coherence tomography: from research to a broad clinical application

      Invasive coronary imaging techniques have improved our understanding of atherosclerosis and helped us to evaluate the effectiveness of new drugs and new intravascular devices. We have adopted and integrated them rapidly into our clinical decision making process in the catheterisation laboratory. So far, only significant lesions in the coronary angiogram have been treated either by percutaneous coronary intervention (PCI) or coronary bypass artery grafting (CABG), while normal looking coronary segments ...
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    8. Reproducibility of quantitative optical coherence tomography for stent analysis

      Aims: To assess the inter- and intra- observer reproducibility for strut count, strut apposition and strut tissue coverage measurements with optical coherence tomography (OCT).Methods and results: Ten drug-eluting stents (244 frames, 1712 struts) imaged with OCT nine months after implantation were analysed by two independent analysts. One of the analysts repeated the analysis of five stents (120 frames, 795 struts) one week later. Offline analysis was performed with the ...
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    9. Fully automatic three-dimensional quantitative analysis of intracoronary optical coherence tomography

      Objectives and background: Quantitative analysis of intracoronary optical coherence tomography (OCT) image data (QOCT) is currently performed by a time-consuming manual contour tracing process in individual OCT images acquired during a pullback procedure (frame-based method). To get an efficient quantitative analysis process, we developed a fully automatic three-dimensional (3D) lumen contour detection method and evaluated the results against those derived by expert human observers. Methods: The method was developed using ...
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    10. A Multicentre Evaluation of the Safety of Intra-Coronary Optical Coherence Tomography

      Optical coherence tomography (OCT) is increasingly being applied to the coronary arteries. However, the risks associated with the imaging procedure are not yet well defined. The purpose of the present multicentre registry was to access the acute complicaitons associated with the clinical use of intera-coronary OCT in a large number of patients.
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    11. Incomplete Stent Apposition and Delayed Tissue Coverage Are More Frequent in Drug-Eluting Stents Implanted During Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Than in Drug-Eluting Stents Implanted for Stable/Un

      ...* Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands * Reprint requests and correspondence: Dr. Evelyn Regar, Thoraxcenter, Bd 585, Dr. Molewaterplein 40, 3015-GD Rotterdam, the Netherlands (Email: Objectiv...
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    12. First case of stenting of a vulnerable plaque in the Secritt I trial—the dawn of a new era?

      Background. A 63-year-old man presented with class II anginal symptoms. Investigations. Cardiac catheterization, intravascular ultrasound (IVUS) virtual histology, optical coherence tomography and off-line palpography. Diagnosis. The patient was diagnosed as having a culprit lesion in the left circumflex artery and a vulnerable plaque in the left anterior descending artery. Management. The culprit lesion was treated with two overlapping drug-eluting stents. The vulnerable plaque was then treated with a self-expanding stent ...
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  2. About Evelyn Regar

    Evelyn Regar

    Evelyn Regar is a interventional cardiologist at the ThoraxCenter, Erasmus Medical Center in the Netherlands.  Dr. Regar did her preclinical studies at the University of Regensburg, Germany, for two years, before training at the Technical University of Munich. From there, she trained in internal medicine and cardiology at the University Hospital, also in Munich. Since 1999, she works as an interventional cardiologist at the Thoraxcenter and has the post of clinical head of the catheter laboratory.


    1. The ILUMIEN system provides me and my colleagues with an easy-to-use, flexible solution that combines OCT and FFR technology on one system... Having these two cutting edge technologies together is a welcome advancement for therapy guidance, allowing me to choose the right tools for each patient situation.
      In St. Jude Medical Announces European Approval of First and Only Combined FFR and OCT System