1. ESPCI ParisTech

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    1. Mentioned In 83 Articles

    2. Characterization and Analysis of Retinal Axial Motion at High Spatiotemporal Resolution and Its Implication for Real-Time Correction in Human Retinal Imaging

      Characterization and Analysis of Retinal Axial Motion at High Spatiotemporal Resolution and Its Implication for Real-Time Correction in Human Retinal Imaging
      High-resolution ophthalmic imaging devices including spectral-domain and full-field optical coherence tomography (SDOCT and FFOCT) are adversely affected by the presence of continuous involuntary retinal axial motion. Here, we thoroughly quantify and characterize retinal axial motion with both high temporal resolution (200,000 A-scans/s) and high axial resolution (4.5 m), recorded over a typical data acquisition duration of 3 s with an SDOCT device over 14 subjects. We demonstrate ...
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    3. Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model

      Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model
      Retinal degenerative diseases lead to the blindness of millions of people around the world. In case of age-related macular degeneration (AMD), the atrophy of retinal pigment epithelium (RPE) precedes neural dystrophy. But as crucial as understanding both healthy and pathological RPE cell physiology is for those diseases, no current technique allows subcellular in vivo or in vitro live observation of this critical cell layer. To fill this gap, we propose ...
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    4. Optical phase modulation by natural eye movements: application to time-domain FF-OCT image retrieval

      Optical phase modulation by natural eye movements: application to time-domain FF-OCT image retrieval
      Eye movements are commonly seen as an obstacle to high-resolution ophthalmic imaging. In this context we study the natural axial movements of the in vivo human eye and show that they can be used to modulate the optical phase and retrieve tomographic images via time-domain full-field optical coherence tomography (TD-FF-OCT). This approach opens a path to a simplified ophthalmic TD-FF-OCT device, operating without the usual piezo motor-camera synchronization. The device ...
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    5. Manifestation of aberrations in full-field optical coherence tomography

      Manifestation of aberrations in full-field optical coherence tomography
      We report on a theoretical model for image formation in full-field optical coherence tomography (FFOCT). Because the spatial incoherence of the illumination acts as a virtual confocal pinhole in FFOCT, its imaging performance is equivalent to a scanning time-gated coherent confocal microscope. In agreement with optical experiments enabling a precise control of aberrations, FFOCT is shown to have nearly twice the resolution of standard imaging at moderate aberration level. Beyond ...
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    6. Non invasive live imaging of a novel RPE stress model with Dynamic Full-Field OCT

      Non invasive live imaging of a novel RPE stress model with Dynamic Full-Field OCT
      Retinal degenerative diseases lead to the blindness of millions of people around the world. In case of age-related macular degeneration (AMD), the atrophy of retinal pigment epithelium (RPE) precedes neural dystrophy. But as crucial as understanding both healthy and pathological RPE cell physiology is for those diseases, no current technique allows subcellular in vivo or in vitro live observation of this critical cell layer. To fill this gap, we propose ...
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    7. Adaptive-glasses time-domain FFOCT for wide-field high-resolution retinal imaging with increased SNR

      Adaptive-glasses time-domain FFOCT for wide-field high-resolution retinal imaging with increased SNR
      The highest three-dimensional (3D) resolution possible in in vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics. However, this combination brings important limitations, such as small field-of-view and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. In this Letter, we mitigate these limitations by combining our compact time-domain full-field OCT (FFOCT) with a multi-actuator adaptive lens ...
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      Mentions: ESPCI ParisTech
    8. Coherence gate shaping for wide field high-resolution in vivo retinal imaging with full-field OCT

      Coherence gate shaping for wide field high-resolution in vivo retinal imaging with full-field OCT
      Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine, but it is particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is normally achieved with adaptive optics (AO) and scanning methods, which considerably reduce the useful FOV and increase the system complexity. An alternative technique is time-domain full-field optical coherence tomography (FF-OCT), which has already shown ...
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    9. Full-field interferential imaging systems and methods

      Full-field interferential imaging systems and methods
      A system for the full-field interferential imaging of a sample, includes an illumination path with a light source, an interferometer with at least one first objective, and a separating element for receiving incident light waves via an input face and for forming an object arm for receiving the sample and a reference arm on which a reflection device is arranged, the reflection device being used to reflect incident light waves ...
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    10. Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

      Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids
      Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue but lacks functional information. We present dynamic full-field optical coherence tomography as a technique to noninvasively image living human induced pluripotent stem cell-derived retinal organoids. Coloured images with an endogenous contrast linked to organelle motility are generated, with submicrometre spatial resolution and millisecond temporal resolution, creating a way to identify specific cell types in living tissue ...
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    11. Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves

      Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
      Cell-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers, and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in ...
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    12. Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies

      Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies
      Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as oesophageal papillae, gastric pits, duodenal villi and colonic crypts. In dynamic FFOCT mode, we imaged ...
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    13. Full-field optical coherence tomography for the diagnosis of giant cell arteritis

      Full-field optical coherence tomography for the diagnosis of giant cell arteritis
      Histopathological examination of temporal artery biopsy (TAB) remains the gold standard for the diagnosis of giant cell arteritis (GCA) but is associated with essential limitations that emphasize the need for an upgraded pathological process. This study pioneered the use of full-field optical coherence tomography (FF-OCT) for rapid and automated on-site pathological diagnosis of GCA. Sixteen TABs (12 negative and 4 positive for GCA) were selected according to major histopathological criteria ...
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      Mentions: ESPCI ParisTech
    14. Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves

      Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
      High-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in ...
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      Mentions: ESPCI ParisTech
    15. Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems

      Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems
      Optical tomographic cross-sectional images of biological samples were made possible by interferometric imaging techniques such as Optical Coherence Tomography (OCT) [1, 2, 3]. Owing to its unprecedented view of the sample, OCT has become a gold standard, namely for human retinal imaging in the clinical environment. In this Letter, we present Optical Incoherence Tomography (OIT): a completely digital method extending the possibility to generate tomographic retinal cross-sections to non-interferometric imaging ...
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  2. About ESPCI ParisTech

    ESPCI ParisTech

    ESPCI ParisTech is a major institution of higher education an internationally renowned research center, and a fertile ground of innovation for industry.  Founded by the City of Paris in 1882, for over a century the School has attracted leading scientific innovators like Nobel Prize laureates Pierre and Marie Curie, Paul Langevin, Frédéric Joliot-Curie, Pierre-Gilles de Gennes, and Georges Charpak, who continue to contribute to the institution’s international reputation.  The School’s culture of excellence remains as vibrant as ever. Fully 60% of graduates go on to complete a thesis and earn their PhD. The School’s teaching faculty and researchers are building tomorrow’s knowledge base, publishing an article a day in top international scientific journals ; inventing the industry of the future, filing for a patent every single week.  A model of excellence and an illustration of the "French exception", ESPCI ParisTech is a founding member of ParisTech, the Paris Institute of Science and Technology.  Also see Langevin Institute (L’institut Langevin).