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    1. Mentioned In 58 Articles

    2. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Explore OSA | OSA Publishing Ophthalmology
      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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      Mentions: University of Pittsburgh Claude Boccara Sun Yat-Sen University

    4. In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography

      Explore SPIE Digital Library Ophthalmology
      In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography
      Despite obvious improvements in visualization of the in vivo cornea through the faster imaging speeds and higher axial resolutions, cellular imaging stays unresolvable task for OCT, as en face viewing with a high lateral resolution is required. The latter is possible with FFOCT, a method that relies on a camera, moderate numerical aperture (NA) objectives and an incoherent light source to provide en face images with a micrometer-level resolution. Recently ...
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      Mentions: Claude Boccara LLTech ESPCI ParisTech

    5. In vivo high resolution human corneal imaging using full-field optical coherence tomography

      Explore OSA | OSA Publishing Ophthalmology
      In vivo high resolution human corneal imaging using full-field optical coherence tomography
      We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowmans layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemets membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 m and relatively large field-of-view of 1.26 mm x 1.26 ...
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      Mentions: University of Pittsburgh Johns Hopkins University Claude Boccara

    6. The multiple scattering limit in optical microscopy

      Explore arxiv.org
      The multiple scattering limit in optical microscopy
      Optical microscopy offers a unique insight of biological structures with a sub-micrometer resolution and a minimum invasiveness. However, the inhomogeneities of the specimen itself can induce multiple scattering of light and optical aberrations which limit the observation to depths close to the surface. To predict quantitatively the penetration depth in microscopy, we theoretically derive the single-to-multiple scattering ratio in reflection. From this key quantity, the multiple scattering limit is deduced ...
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      Mentions: Claude Boccara ESPCI ParisTech Mathias Fink

    7. Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

      Explore IOVS Journal Ophthalmology
      Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography
      Purpose : To use cell motility as a contrast agent in retinal explants. Methods : Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. Results : Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen ...
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      Mentions: Michel Pâques Claude Boccara ESPCI ParisTech

    8. Fast subsurface fingerprint imaging with full-field optical coherence tomography system equipped with a silicon camera

      Explore arxiv.org
      Fast subsurface fingerprint imaging with full-field optical coherence tomography system equipped with a silicon camera
      Images recorded below the surface of a finger can have more details and be of higher quality than conventional surface fingerprint images. This is particularly true when the quality of the surface fingerprints is compromised by, for example, moisture or surface damage. However, there is an unmet need for a cost effective fingerprint sensor that could record high-quality images at sufficient depth below the surface and in short-enough time. To ...
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      Mentions: Claude Boccara ESPCI ParisTech Egidijus Auksorius

    9. Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

      Explore MDPI Open Access Journals Platform
      Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging
      Full-field optical coherence tomography (FF-OCT) is a variant of OCT that is able to register 2D en face views of scattering samples at a given depth. Thanks to its superior resolution, it can quickly reveal information similar to histology without the need to physically section the sample. Sensitivity and specificity levels of diagnosis performed with FF-OCT are 80% to 95% of the equivalent histological diagnosis performances and could therefore benefit ...
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      Mentions: Claude Boccara LLTech ESPCI ParisTech

    10. Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning

      Explore Conference Proceedings
      Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning
      For a large number of cancer surgeries, the lack of reliable intraoperative diagnosis leads to reoperations or bad outcomes for the patients. To deliver better diagnosis, we developed Dynamic Full Field OCT (D-FFOCT) as a complement to FFOCT. FFOCT already presents interesting results for cancer diagnosis e.g. Mohs surgery and reaching 96% accuracy on prostate cancer. D-FFOCT accesses the dynamic processes of metabolism and gives new tools to diagnose ...
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      Mentions: Claude Boccara ESPCI ParisTech

    11. Retinal imaging with adaptive optics full-field OCT

      Explore Conference Proceedings
      Retinal imaging with adaptive optics full-field OCT
      Adaptive optics full-filed OCT (FFOCT) with a transmissive liquid crystal spatial light modulator (LCSLM) as wavefront corrector is used without strict plane conjugation for low order aberrations corrections. We validated experimentally that FFOCT resolution is independent of aberrations and only reduce the signal level. A signal based sensorless algorithm was thus applied for wavefront distortion compensation. Image quality improvements by the wavefront sensorless control of the LCSLM were evaluated on ...
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      Mentions: Claude Boccara ESPCI ParisTech Mathias Fink

    12. Dynamic multimodal full-field optical coherence tomography and fluorescence structured illumination microscopy

      Explore SPIE | Journal Developmental Biology
      Dynamic multimodal full-field optical coherence tomography and fluorescence structured illumination microscopy
      We report on the development of a configuration of a multimodal full-field optical coherence tomography (FF-OCT) and fluorescence microscope. Our system can simultaneously acquire FF-OCT and structured illumination microscopy images. Dynamic parallel evolution of tissue microstructures and biochemical environments can be visualized. We use high numerical aperture objectives to optimize the combination of the two modalities. We imaged the propagation of mechanical waves initiated by calcium waves in a heart ...
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      Mentions: Claude Boccara ESPCI ParisTech Mathias Fink

    13. En face coherence microscopy [Invited]

      Explore OSA | OSA Publishing Microscopy
      En face coherence microscopy [Invited]
      En face coherence microscopy or flying spot or full field optical coherence tomography or microscopy (FF-OCT/FF-OCM) belongs to the OCT family because the sectioning ability is mostly linked to the source coherence length. In this article we will focus our attention on the advantages and the drawbacks of the following approaches: en face versus B scan tomography in terms of resolution, coherent versus incoherent illumination and influence of aberrations ...
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      Mentions: Claude Boccara ESPCI ParisTech Kate Grieve

    14. Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography

      Explore SPIE | Journal
      Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography
      Optical coherence tomography (OCT) can map the stiffness of biological tissue by imaging mechanical perturbations (shear waves) propagating in the tissue. Most shear wave elastography (SWE) techniques rely on active shear sources to generate controlled displacements that are tracked at ultrafast imaging rates. Here, we propose a noise-correlation approach to retrieve stiffness information from the imaging of diffuse displacement fields using low-frame rate spectral-domain OCT. We demonstrated the method on ...
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      Mentions: Claude Boccara ESPCI ParisTech Thu-Mai Nguyen

    15. Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport

      Explore OSA | OSA Publishing Microscopy
      Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport
      Intracellular motion can be quantitatively monitored in tissues using coherence-gated microscopic techniques. With full-field optical coherence tomography (FFOCT), the use of high numerical aperture microscope objectives provides a high resolution mapping of intracellular dynamics that are probed with subwavelength sensitivity. In the upper temporal bandwidth that we have used (1-6 Hz) the main contribution to the dynamic signal arises from the overall dynamical, optically heterogeneous cytoplasm. We propose a method ...
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      Mentions: Claude Boccara ESPCI ParisTech

    16. Adaptive optics full-field optical coherence tomography

      Explore SPIE | Journal
      Adaptive optics full-field optical coherence tomography
      We describe a simple and compact full-field optical coherence tomography (FFOCT) setup coupled to a transmissive liquid crystal spatial light modulator (LCSLM) to induce or correct aberrations. To reduce the system complexity, strict pupil conjugation was abandoned because low-order aberrations are often dominant. We experimentally confirmed a recent theoretical and experimental demonstration that the image resolution was almost insensitive to aberrations that mostly induce a reduction of the signal level ...
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      Mentions: Claude Boccara ESPCI ParisTech Mathias Fink
    17. 1-15 of 58 1 2 3 4 »
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  4. About ESPCI ParisTech

    ESPCI ParisTech

    ESPCI ParisTech is a major institution of higher education an internationally renowned research center, and a fertile ground of innovation for industry.  Founded by the City of Paris in 1882, for over a century the School has attracted leading scientific innovators like Nobel Prize laureates Pierre and Marie Curie, Paul Langevin, Frédéric Joliot-Curie, Pierre-Gilles de Gennes, and Georges Charpak, who continue to contribute to the institution’s international reputation.  The School’s culture of excellence remains as vibrant as ever. Fully 60% of graduates go on to complete a thesis and earn their PhD. The School’s teaching faculty and researchers are building tomorrow’s knowledge base, publishing an article a day in top international scientific journals ; inventing the industry of the future, filing for a patent every single week.  A model of excellence and an illustration of the "French exception", ESPCI ParisTech is a founding member of ParisTech, the Paris Institute of Science and Technology.  Also see Langevin Institute (L’institut Langevin).

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