1. Ernest W. Chang

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    1. Mentioned In 16 Articles

    2. Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT

      Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT
      We report the development of a novel otoscopy probe for assessing middle ear anatomy and function. Video imaging and phase-sensitive optical coherence tomography are combined within the same optical path. A sound stimuli channel is incorporated as well to study middle ear function. Thus, besides visualizing the morphology of the middle ear, the vibration amplitude and frequency of the eardrum and ossicles are retrieved as well. Preliminary testing on cadaveric ...
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    3. Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

      Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study
      We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of 1 m 1m , OCT imaging delineates BCC depth spreading (margins) with resolution of 7 m 7m . When delineating margins in 20 specimens of ...
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    4. Low coherence interferometry approach for aiding fine needle aspiration biopsie

      Low coherence interferometry approach for aiding fine needle aspiration biopsie
      We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.
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    5. Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties

      Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties
      Most techniques measuring corneal biomechanics in vivo are biased by side factors. We demonstrate the ability of optical coherence tomographic (OCT) vibrography to determine corneal material parameters, while reducing current prevalent restrictions of other techniques (such as intraocular pressure (IOP) and thickness dependency). Modal analysis was performed in a finite-element (FE) model to study the oscillation response in isolated thin corneal flaps/eye globes and to analyse the dependency of ...
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    6. Physical Sciences Receives NIH Grant for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear

      Physical Sciences Receives NIH Grant for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear
      Physical Sciences Received at 2014 NIH Grant for $197,522 for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear. The principal investigator is Ernest Chang. The program begins and ends in 2014. Below is a summary of the proposed work. There is a growing clinical need for improving the non-invasive diagnostic capabilities of middle ear pathologies in vivo. To address this need, Physical Sciences Inc. (PSI), in collaboration with ...
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    7. Physical Sciences Incorporated Receives 2014 NIH Grant for Integrating Optical Coherence Tomography with Laryngeal High-Speed Videoendoscopy

      Physical Sciences Incorporated Receives 2014 NIH Grant for Integrating Optical Coherence Tomography with Laryngeal High-Speed Videoendoscopy
      Physical Sciences Incorporated Received a 2014 NIH Grant for $224,955 for Integrating Optical Coherence Tomography with Laryngeal High-Speed Videoendoscopy. The principal investigator is Ernest Chang. The program began in 2014 and ends in 2014. Below is a summary of the proposed work. There is a growing clinical need for improving the assessment of vocal fold tissue properties in vivo, especially dynamic properties measured during human voice production. To address ...
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    8. Fast and accurate metrology of multi-layered ceramic materials by an automated boundary detection algorithm developed for optical coherence tomography data

      Fast and accurate metrology of multi-layered ceramic materials by an automated boundary detection algorithm developed for optical coherence tomography data
      ...actured samples with high accuracy and robustness. © 2014 Optical Society of America Peter Ekberg, Rong Su, Ernest W. Chang, Seok Hyun Yun, and Lars Mattsson, "Fast and accurate metrology of multi-layered ceramic mater...
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    9. Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography

      Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography
      Optical coherence tomography (OCT) can provide high-resolution ([sim]10-15 [mu]m/pixel) images of vocal fold microanatomy, as demonstrated previously. We explored physiologically triggered Fourier-domain OCT for imaging vocal folds during phonation. The goal is to visualize dynamic histological cross sections and four-dimensional data sets where multiple planes are displayed in synchronized motion. If feasible, this approach could be a useful research tool and spur development of new clinical instrumentation ...
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    10. Long-wavelength optical coherence tomography at 1.7 μm for enhanced imaging depth

      Long-wavelength optical coherence tomography at 1.7 μm for enhanced imaging depth
      Multiple scattering in a sample presents a significant limitation to achieve meaningful structural information at deeper penetration depths in optical coherence tomography (OCT). Previous studies suggest that the spectral region around 1.7 m may exhibit reduced scattering coefficients in ... [Opt. Express 16, 19712-19723 (2008)]
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  2. About Ernest W. Chang

    Ernest W. Chang

    Ernest W. Chang is at Physical Sciences Incorporated.