1. Erling Falk

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    1. Mentioned In 7 Articles

    2. Update on acute coronary syndromes: the pathologists' view

      Update on acute coronary syndromes: the pathologists' view

      Although mortality rates from coronary heart disease in the western countries have declined in the last few decades, morbidity caused by this disease is increasing and a substantial number of patients still suffer acute coronary syndrome (ACS) and sudden cardiac death. Acute coronary syndrome occurs as a result of myocardial ischaemia and its manifestations include acute myocardial infarction and unstable angina. Culprit plaque morphology in these patients varies from thrombosis with or without coronary occlusion to sudden narrowing of the lumen from intraplaque haemorrhage. The coronary artery plaque morphologies primarily responsible for thrombosis are plaque rupture, and plaque erosion, with ...

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    3. Spatial orientation of cross-sectional images of coronary arteries: point of view in intracoronary imaging

      Spatial orientation of cross-sectional images of coronary arteries: point of view in intracoronary imaging

      Background In studies where cross-sectional images of coronary arteries obtained with different imaging modalities are compared, the importance of correct co-localization and matching of images along the coronary artery longitudinal axis is obvious. However, it appears neglected that correct spatial orientation of the cross-sectional plane may not be obtainable just by rotating the images to ensure co-localization of identifiable landmarks such as sidebranches. A cross-section has two sides, one facing proximally and the other distally, and pairs of images reconstructed corresponding to these opposite points of view are mirror images of each other and not superimposable. This may be difficult ...

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    4. Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Objectives: The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease.Background: Intravascular optical coherence tomography (IVOCT) is a catheter-based modality that acquires images at a resolution of 10 μm, enabling visualization of blood vessel wall microstructure in vivo at an unprecedented level of detail. IVOCT devices are now commercially available worldwide, there is an active user base, and ...

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    5. Non-invasive imaging of atherosclerosis

      Non-invasive imaging of atherosclerosis

      Atherosclerosis is an inflammatory disease that causes most myocardial infarctions, strokes, and acute coronary syndromes. Despite the identification of multiple risk factors and widespread use of drug therapies, it still remains a global health concern with associated costs. It is well known that the risks of atherosclerotic plaque rupture are not well correlated with stenosis severity. Lumenography has a central place for defining the site and severity of vascular stenosis as a prelude to intervention for relief of symptoms due to blood flow limitation. Atherosclerosis develops within the arterial wall; this is not imaged by lumenography and hence it provides ...

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    6. In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts?

      In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts?

      Intravascular optical coherence tomography (OCT) is increasingly being used to assess coronary vessel pathology in vivo due to its unrivalled high resolution of 10–20 µm. Previous reports have shown that OCT is capable of visualizing thin-cap fibroatheromas (TCFAs), 1 which are thought to be the precursor lesions of ruptured plaques responsible for the majority of thrombosis-mediated sudden death. 2 In addition, OCT is able to identify features that have been related to the advancement of atherosclerotic lesions, including neovascularization 3,4 and macrophage infiltration.5,6 It is against this background that Uemura and colleagues describe the baseline OCT ...

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    7. First In Vivo Demonstration of Coronary Edema in Culprit Lesion of Patient With Acute Coronary Syndrome by Cardiovascular Magnetic Resonance

      First In Vivo Demonstration of Coronary Edema in Culprit Lesion of Patient With Acute Coronary Syndrome by Cardiovascular Magnetic Resonance
      Atherosclerosis is a chronic, progressive, inflammatory disease causing multiple lesions in the intima of large and medium-sized arteries. 1 A minority of atherosclerotic lesions referred to as vulnerable plaques (VPs) may suddenly precipitate thrombosis, leading to life-threatening events such as acute myocardial infarction and ischemic stroke. The most common VP is the rupture-prone type, also known as thin-cap fibroatheromas, which are characterized by a large necrotic core with a thin and inflamed fibrous cap, outward remodeling mitigating luminal obstruction, neovascularization, plaque hemorrhage, adventitial inflammation, and a “spotty” pattern of calcifications. 2 Among these features, inflammation and angiogenesis are believed to ...
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  2. About Erling Falk

    Erling Falk

    Erling Falk is a cardiovascular pathologist from the University of Aarhus, Denmark.

  3. Quotes

    1. Atherosclerosis is a multifocal disease, there's never one single plaque, and the symptomatic plaques that do get treated today don't tend to be the dangerous ones.
      In In search of the thrombosis-prone vulnerable plaque
    2. While such tests don't distinguish between malignant and benign atherosclerosis.
      In In search of the thrombosis-prone vulnerable plaque