1. Eric J. Chaney

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    1. Mentioned In 32 Articles

    2. Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy

      Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy
      Impaired skin wound healing is a significant co-morbid condition of diabetes that is caused by poor microcirculation, among other factors. Studies have shown that angiogenesis, a critical step in the wound healing process in diabetic wounds, can be promoted under hypoxia. In this study, an angiogenesis-promoting topical treatment for diabetic wounds, which promotes angiogenesis by mimicking a hypoxic environment via inhibition of prolyl hydroxylase resulting in elevation or maintenance of ...
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    3. Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification
      Background and Objective Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from ...
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    4. Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

      Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer
      Background Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of macrometastasis , the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect micrometastasis , minimize or eliminate lymphatic ...
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    5. Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery
      Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of ...
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    6. Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas
      ...perlipidemic rabbit aortas 1. Jongsik Kim^1^1, 2. Adeel Ahmad^2, 3. Joanne Li^3, 4. Marina Marjanovic^1,3, 5. Eric J. Chaney^1, 6. Kenneth S. Suslick^1,4 and 7. Stephen A. Boppart^1,2,3,5,* Article first published online...
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    7. Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment

      Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment
      Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT ...
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    8. Comparison of a MEMS-Based Handheld OCT Scanner With a Commercial Desktop OCT System for Retinal Evaluation

      Comparison of a MEMS-Based Handheld OCT Scanner With a Commercial Desktop OCT System for Retinal Evaluation
      Purpose: The goal of this study was to evaluate the ability of our handheld optical coherence tomography (OCT) scanner to image the posterior and anterior structures of the human eye, and especially the individual layers of the retina, and to compare its diagnostic performance with that of a fixed desktop commercial ophthalmic OCT system. Methods: We compared the clinical imaging results of our handheld OCT with a leading commercial desktop ...
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    9. Segmentation And Correlation Of Optical Coherence Tomography And X-RAY Images For Breast Cancer Diagnostics.

      Segmentation And Correlation Of Optical Coherence Tomography And X-RAY Images For Breast Cancer Diagnostics.
      Pre-operative X-ray mammography and intraoperative X-ray specimen radiography are routinely used to identify breast cancer pathology. Recent advances in optical coherence tomography (OCT) have enabled its use for the intraoperative assessment of surgical margins during breast cancer surgery. While each modality offers distinct contrast of normal and pathological features, there is an essential need to correlate image -based features between the two modalities to take advantage of the diagnostic capabilities ...
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    10. Long-term time-lapse multimodal intravital imaging of regeneration and bone-marrow-derived cell dynamics in skin (World Scientific)

      Long-term time-lapse multimodal intravital imaging of regeneration and bone-marrow-derived cell dynamics in skin (World Scientific)
      ...omputer Engineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Avenue, Urbana, IL 61801, USA Eric J. Chaney Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champ...
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    11. Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ 3 Integrin-Targeted Microspheres

      Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ 3 Integrin-Targeted Microspheres
      Purpose We investigated the early-stage fatty streaks/plaques detection using magnetomotive optical coherence tomography (MM-OCT) in conjunction with v 3 integrin-targeted magnetic microspheres (MSs). The targeting of functionalized MSs was investigated by perfusing ex vivo aortas from an atherosclerotic rabbit model in a custom-designed flow chamber at physiologically relevant pulsatile flow rates and pressures. Procedures Aortas were extracted and placed in a flow chamber. Magnetic MS contrast agents were perfused ...
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    12. Three-dimensional Optical Coherence Tomography for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease

      Three-dimensional Optical Coherence Tomography for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease
      ...phy for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease Renu John PhD, Steven G. Adie PhD, Eric J. Chaney BS, Marina Marjanovic PhD, Krishnarao V. Tangella MD, Stephen A. Boppart MD, PhD Translational ...
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    13. Noninvasive in vivo optical detection of biofilm in the human middle ear

      Noninvasive in vivo optical detection of biofilm in the human middle ear
      Otitis media (OM), a middle-ear infection, is the most common childhood illness treated by pediatricians. If inadequately treated, OM can result in long-term chronic problems persisting into adulthood. Children with chronic OM or recurrent OM often have conductive hearing loss and communication difficulties and require surgical treatment. Tympanostomy tube insertion, the placement of a small drainage tube in the tympanic membrane (TM), is the most common surgical procedure performed in ...
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    14. Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin
      ...structural and functional imaging of engineered and natural skin 1. Youbo Zhao^1, 2. Benedikt W. Graf^1,2, 3. Eric J. Chaney^1, 4. Ziad Mahmassani^3, 5. Eleni Antoniadou^4, 6. Ross DeVolder^5, 7. Hyunjoon Kong^5, 8. Marn...
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  2. About Eric J. Chaney

    Eric J. Chaney

    Eric J. Chaney is a Biological Research Specialist in Dr. Bopparts research group at the Beckman Institute at University of Illinois at Urbana Champaign.