1. Erasmus University

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    1. Mentioned In 342 Articles

    2. Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study

      Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study
      Purpose This is the first study that evaluates the prevalence of retinal thinning and the correlation with papilledema and visual acuity (VA) in a large craniosynostosis population. Design Prospective clinical cohort study Methods All syndromic and complex craniosynostosis patients who visited the only national referral center between 2018-2020 were included. Retinal layers were segmented using optical coherence tomography (OCT). Patients were seen by an ophthalmologist for VA assessment and fundoscopy ...
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    3. Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT–FFR trial

      Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT–FFR trial
      Aims The aim of this study was to understand the impact of optical coherence tomography (OCT)-detected thin-cap fibroatheroma (TCFA) on clinical outcomes of diabetes mellitus (DM) patients with fractional flow reserve (FFR)-negative lesions. Methods and results COMBINE OCT-FFR study was a prospective, double-blind, international, natural history study. After FFR assessment, and revascularization of FFR-positive lesions, patients with 1 FFR-negative lesions (target lesions) were classified in two groups based ...
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    4. Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy and Optical Coherence Tomography Imaging Study Rationale and Des

      Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy and Optical Coherence Tomography Imaging Study Rationale and Des
      Background: The risk for cardiovascular adverse events after acute myocardial infarction (AMI) remains high despite potent medical treatment including low-density lipoprotein cholesterol (LDL-C) lowering with statins. Proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies substantially reduce LDL-C when added to statin. Alirocumab, a momoclonal antibody to PCSK9, reduces major adverse cardiovascular events after AMI. The effects of alirocumab on coronary atherosclerosis including plaque burden, plaque composition and fibrous cap thickness ...
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    5. Multi-modality intravascular imaging for guiding coronary intervention and assessing coronary atheroma: the Novasight Hybrid IVUS-OCT system

      Multi-modality intravascular imaging for guiding coronary intervention and assessing coronary atheroma: the Novasight Hybrid IVUS-OCT system
      Intravascular imaging has evolved alongside interventional cardiology as an adjunctive tool for assessing plaque pathology and for guiding and optimising percutaneous coronary intervention (PCI) in challenging lesions. The two modalities which have dominated the field are intravascular ultrasound (IVUS), which relies on sound waves and optical coherence tomography (OCT), relying on light waves. These approaches however have limited efficacy in assessing plaque morphology and vulnerability that are essential for guiding ...
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    6. Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Quantification of key retinal features in early and late age-related macular degeneration using deep learning
      Purpose To develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD). Design Development and validation of a deep-learning model for feature segmentation Methods Data for model development were obtained from 307 optical coherence tomography volumes. Eight experienced graders manually delineated all abnormalities in 2,712 B-scans. A deep neural network was trained with this data to perform voxel-level ...
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    7. Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging

      Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging
      Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) visualize the coronary artery wall and plaque morphology in great detail. The advent of these high-resolution intracoronary imaging modalities has propelled our understanding of coronary atherosclerosis and provided enhanced guidance for percutaneous coronary intervention. Yet, the lack of contrast between distinct tissue types and plaque compositions impedes further elucidation of the complex mechanisms that contribute to acute coronary syndrome (ACS ...
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    8. Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

      Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging
      Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been developed and improved as both diagnostic and guidance tools for interventional procedures over the past three decades. IVUS has a resolution of 100 m with a high tissue penetration and capability of assessing the entire structure of a coronary artery including the external elastic membrane, whereas OCT has a higher resolution of 1020 m to assess endoluminal structures with a ...
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    9. Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography.

      Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography.
      Despite significant advances in preventive, medical and interventional management, coronary artery disease remains the leading cause of death worldwide. We now know that in the majority of acute coronary syndromes, a thrombotic event is triggered either by the rupture or erosion of the so-called high-risk or vulnerable plaque. However, accurately identifying the individual who is at significant risk of acute event remains the holy grail of preventive cardiology. To better ...
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    10. Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

      Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation
      Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT ...
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    11. Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression

      Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression
      Objectives This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. Background There is robust evidence that intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether multimodality imaging and ESS mapping enable more accurate prediction of coronary plaque progression. Methods A total of ...
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  2. About Erasmus University

    Erasmus Medical Center is the largest and most versatile of the eight university medical centers in the Netherlands. Erasmus MC wants to further extend its international reputation and become one of the twenty best medical institutes in the world by 2013.  Also see The Thoraxcentrum of the Erasmus University Medical Center was founded in 1971 and is an integrated organization of the departments of Cardiology and Cardiothoracic Surgery. The Thoraxcentrum is divided into six medical units and three scientific units: Cardio-Thoracic Surgery, Cardiology, and Biomedical Engineering. The focus of Thoraxcenter Biomedical Engineering is the imaging and diagnosis of cardiovascular disorders. This department is led by Prof. Dr. Ir. A.F.W. van der Steen. The Biomedical Engineering department brings together two technical specialities of the Thoraxcenter, namely: The Experimental Echocardiography group, which investigates the physical and technical aspects of ultrasound for cardiac diagnosis.  Erasmus University Rotterdam is an international knowledge workshop for critical thinking and academic training, driven by a strong focus on current social issues.  The Erasmus MC (medical center) is the university hospital of the city of Rotterdam, The Netherlands. It is affiliated with the Erasmus University.