1. Emory University

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    1. Mentioned In 46 Articles

    2. In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

      In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
      Spectral-domain optical coherence tomography (SD-OCT) is useful for visualizing retinal and ocular structures in vivo . In research, SD-OCT is a valuable tool to evaluate and characterize changes in a variety of retinal and ocular disease and injury models. In light induced retinal degeneration models, SD-OCT can be used to track thinning of the photoreceptor layer over time. In glaucoma models, SD-OCT can be used to monitor decreased retinal nerve fiber ...
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      Mentions: Emory University
    3. Pentosan polysulfate maculopathy versus inherited macular dystrophies: comparative assessment with multimodal imaging

      Pentosan polysulfate maculopathy versus inherited macular dystrophies: comparative assessment with multimodal imaging
      Purpose To evaluate whether pentosan polysulfate maculopathy manifests distinctive characteristics that permit differentiation from hereditary maculopathies with multimodal fundus imaging. Design Retrospective Review Subjects Emory Eye Center databases were queried for the following International Classification of Diseases (ICD) codes between May 20, 2014 through October 22, 2019: 362.70 (unspecified hereditary retinal dystrophy), 362.74 + H35.52 (pigmentary retinal dystrophy), 362.76 +H35.54 (dystrophies primarily involving the retinal pigment ...
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      Mentions: Emory University
    4. Machine Leaning Model Comparison for Automatic Segmentation of Intracoronary Optical Coherence Tomography and Plaque Cap Thickness Quantification

      Machine Leaning Model Comparison for Automatic Segmentation of Intracoronary Optical Coherence Tomography and Plaque Cap Thickness Quantification
      ...ctor machine (SVM). In vivo OCT and intravascular ultrasound (IVUS) images were acquired from two patients at Emory University with informed consent obtained. Eighteen OCT image slices which included lipid core and with ...
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    5. Topography and pachymetry maps for mouse corneas using optical coherence tomography

      Topography and pachymetry maps for mouse corneas using optical coherence tomography
      The majority of the eye's refractive power lies in the cornea, and pathological changes in its shape can affect vision. Small animal models offer an unparalleled degree of control over genetic and environmental factors that can help elucidate mechanisms of diseases affecting corneal shape. However, there is not currently a method to characterize the corneal shape of small animal eyes with topography or pachymetry maps, as is done clinically ...
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    6. Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3-D Deformed Stent Geometry

      Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3-D Deformed Stent Geometry
      Percutaneous coronary intervention (PCI) is the prevalent treatment for coronary artery disease, with hundreds of thousands of stents implanted annually. Computational studies have demonstrated the role of biomechanics in the failure of vascular stents, but clinical studies is this area are limited by a lack of understanding of the deployed stent geometry, which is required to accurately model and predict the stent-induced in vivo biomechanical environment. Herein, we present an ...
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    7. Automatic Segmentation Methods Based on Machine Learning for Intracoronary Optical Coherence Tomography Image

      Automatic Segmentation Methods Based on Machine Learning for Intracoronary Optical Coherence Tomography Image
      ...characterize the plaque component. In vivo IVUS and OCT coronary plaque data from 5 patients were acquired at Emory University with patients consent obtained. Seventy-seven matched IVUS and OCT slices with good image qua...
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    8. Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3D Deformed Stent Geometry

      Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3D Deformed Stent Geometry
      Percutaneous coronary intervention (PCI) is the prevalent treatment for coronary artery disease, with hundreds of thousands of stents implanted annually. Computational studies have demonstrated the role of biomechanics in the failure of vascular stents, but clinical studies is this area are limited by a lack of understanding of the deployed stent geometry, which is required to accurately model and predict the stent induced in vivo biomechanical environment. Herein, we present ...
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    9. Ocular Morphological Changes in Patients with Restless Legs Syndrome Analyzed by Optical Coherence Tomography

      Ocular Morphological Changes in Patients with Restless Legs Syndrome Analyzed by Optical Coherence Tomography
      Background Two leading hypotheses for restless legs syndrome (RLS) pathophysiology are dopaminergic dysfunction and sympathetic overactivity. Ocular changes occur with both dopaminergic and sympathetic pathologies, and thus may provide unique insights into the pathophysiology of RLS. Methods Thirty-five patients with RLS and 35 healthy individuals were enrolled in the study. Peripapillary retinal nerve fiber layer (RNFL), macular, and choroidal thicknesses were measured by optical coherence tomography (OCT). Results There were ...
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      Mentions: Emory University
    10. Coherently broadened, high-repetition-rate laser for stimulated Raman scattering–spectroscopic optical coherence tomography

      Coherently broadened, high-repetition-rate laser for stimulated Raman scattering–spectroscopic optical coherence tomography
      We present a novel light source specifically tailored for stimulated Raman scatteringspectroscopic optical coherence tomography (SRS-SOCT), which is, to the best of our knowledge, a novel molecular imaging method that combines the molecular sensitivity of SRS with the spatial and spectral multiplexing capabilities of SOCT. The novel laser consists of an 8 W, 450 fs Yb:KGW oscillator, with a repetition rate of 40 MHz, which delivers the Stokes beam ...
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    11. Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3D Deformed Stent Geometry

      Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3D Deformed Stent Geometry
      Percutaneous coronary intervention (PCI) is the prevalent treatment for coronary artery disease, with hundreds of thousands of stents implanted annually. Computational studies have demonstrated the role of biomechanics in the failure of vascular stents, but clinical studies is this area are limited by a lack of understanding of the deployed stent geometry, which is required to accurately model and predict the stent induced in vivo biomechanical environment. Herein, we present ...
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    12. Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression

      Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression
      Purpose To report patients with sellar tumors and chiasmal compression with normal visual fields, who demonstrate damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) on optical coherence tomography (OCT). Methods Seven patients with sellar tumors causing mass effect on the optic chiasm without definite visual field defect, but abnormal GCC are described. GCC/RNFL analyses using Cirrus-OCT were classified into centiles based on the manufacturers ...
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      Mentions: Emory University
    13. Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach

      Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach
      Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets cap thickness to zero when cap is under resolution limit and IVUS does not see it. An innovative modeling approach combining IVUS and optical coherence tomography (OCT) is introduced for cap thickness quantification and more accurate cap stress/strain calculations. In vivo IVUS and OCT coronary plaque data were ...
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    14. Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis

      Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis
      Optical coherence tomography (OCT) is a non-invasive imaging technique routinely used in ophthalmology to visualize and quantify the layers of the retina. It also provides information on optic nerve head topography, peripapillary retinal nerve fiber layer thickness, and macular volume, which correlate with axonal loss. These measurements are of particular interest in optic neuropathies and in multiple sclerosis, and OCT parameters are now used as endpoints in neurologic clinical trials.
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      Mentions: Emory University
    15. Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography

      Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography
      The choriocapillaris plays an important role in supporting the metabolic demands of the retina. Studies of the choriocapillaris in disease states with optical coherence tomography angiography (OCTA) have proven insightful. However, image artifacts complicate the identification and quantification of the choriocapillaris in degenerative diseases such as choroideremia. Here, we demonstrate a supervised machine learning approach to detect intact choriocapillaris based on training with results from an expert grader. We trained ...
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  2. About Emory University

    Emory University

    Emory University, a top 20 research university located in Atlanta, Georgia, is an inquiry-driven, ethically engaged and diverse community whose members work collaboratively for positive transformation in the world through courageous leadership in teaching, research, scholarship, health care and social action.  The university is recognized internationally for its outstanding liberal arts college, superb professional schools and one of the Southeast's leading health care systems.  Also see Emory University School of Medicine.