1. Emory University

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    1. Mentioned In 34 Articles

    2. Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis

      Explore ScienceDirect Neurology , Ophthalmology
      Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis
      Optical coherence tomography (OCT) is a non-invasive imaging technique routinely used in ophthalmology to visualize and quantify the layers of the retina. It also provides information on optic nerve head topography, peripapillary retinal nerve fiber layer thickness, and macular volume, which correlate with axonal loss. These measurements are of particular interest in optic neuropathies and in multiple sclerosis, and OCT parameters are now used as endpoints in neurologic clinical trials.
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      Mentions: Emory University

    4. Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography

      Explore OSA | OSA Publishing Ophthalmology
      Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography
      The choriocapillaris plays an important role in supporting the metabolic demands of the retina. Studies of the choriocapillaris in disease states with optical coherence tomography angiography (OCTA) have proven insightful. However, image artifacts complicate the identification and quantification of the choriocapillaris in degenerative diseases such as choroideremia. Here, we demonstrate a supervised machine learning approach to detect intact choriocapillaris based on training with results from an expert grader. We trained ...
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      Mentions: David Huang Emory University Oregon Health & Science University

    5. Optical Coherence Tomography Angiography in Choroideremia: Correlating Choriocapillaris Loss With Overlying Degeneration

      Explore JAMA Network Ophthalmology
      Optical Coherence Tomography Angiography in Choroideremia: Correlating Choriocapillaris Loss With Overlying Degeneration
      Importance Novel therapies for choroideremia, an X-linked recessive chorioretinal degeneration, demand a better understanding of the primary site(s) of cellular degeneration. Optical coherence tomography angiography allows for choriocapillaris (CC) imaging. We compared the extent of structural alterations of the CC, retinal pigment epithelium, and photoreceptors with multimodal imaging. Observations In a clinical case series conducted from September 15, 2014, through February 5, 2015, 14 eyes of 7 male patients ...
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      Mentions: David Huang Emory University Oregon Health & Science University

    7. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy

      Explore ajplung.physiology.org Pulmonology
      Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy
      Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism when used in combination have not been consistent with clinical results. We employed Micro-Optical Coherence Tomography (OCT) as a novel means to assess the mechanism of action of CFTR modulators, focusing on the effects on mucociliary clearance. Primary human airway monolayers from patients with a G551D mutation responded to ivacaftor treatment ...
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      Mentions: Guillermo J. Tearney Johns Hopkins University Emory University

    8. Temporal Trends in Strut-Level Optical Coherence Tomography Evaluation of Coronary Stent Coverage

      Explore Wiley Online Library Cardiology
      Temporal Trends in Strut-Level Optical Coherence Tomography Evaluation of Coronary Stent Coverage
      Objectives We sought to pool data from all studies with reported strut-level data in human subjects evaluated by optical coherence tomography (OCT) surveillance and to compare the aggregate data of stent strut coverage on a longitudinal temporal timeline from initial implantation for different coronary stent subtypes. Background Delayed strut coverage following drug-eluting stent (DES) implantation is an important contributor to late stent thrombosis (LST). OCT can detect stent strut coverage ...
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      Mentions: Emory University University of Arizona Habib Samady

    9. MULTIMODAL IMAGING OF A FAMILY WITH SPINOCEREBELLAR ATAXIA TYPE 7 DEMONSTRATING PHENOTYPIC VARIATION AND PROGRESSION OF RETINAL DEGENERATION

      Explore LWW Online Ophthalmology
      MULTIMODAL IMAGING OF A FAMILY WITH SPINOCEREBELLAR ATAXIA TYPE 7 DEMONSTRATING PHENOTYPIC VARIATION AND PROGRESSION OF RETINAL DEGENERATION
      Purpose: To report the variability and progression of clinical presentation in three family members with spinocerebellar ataxia Type 7 including early recognizable features on retinal imaging and magnetic resonance imaging. Methods: Retrospective case series. Results: The proband, Patient 1 (mother) presented at age 26 with light perception vision. Initial examination was significant for optic disc pallor, vascular attenuation, and central macular atrophy. Two years later, her vision declined to no ...
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      Mentions: Emory University

    10. Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

      Explore ScienceDirect Cardiology
      Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights
      Coronary atherosclerosis continues to be major cause of death in the developed world ( (1) ). Although we have known for at least a century that fissures and ruptures of coronary arteries are the cause of coronary thrombosis and, in the last 2 decades, that plaque erosion and calcified nodule are additional causes of thrombosis, our ability to use this knowledge in a real-time fashion to affect the treatment of patients with ...
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      Mentions: Emory University

    12. OPTICAL COHERENCE TOMOGRAPHY-GUIDED RANIBIZUMAB INJECTION FOR CYSTOID MACULAR EDEMA IN WELL-CONTROLLED UVEITIS: Twelve-Month Outcomes

      Explore LWW Online Ophthalmology
      OPTICAL COHERENCE TOMOGRAPHY-GUIDED RANIBIZUMAB INJECTION FOR CYSTOID MACULAR EDEMA IN WELL-CONTROLLED UVEITIS: Twelve-Month Outcomes
      Purpose: To determine whether serial ranibizumab injections are effective in the treatment of cystoid macular edema in patients with chronic controlled noninfectious uveitis. Methods: Five eyes of 5 patients were included in a prospective noncomparative therapeutic trial. They received intravitreal injections of ranibizumab at Day 0 and were followed monthly for 1 year. Injections were repeated monthly if persistent or new cystic edema manifested on optical coherence tomography. The primary ...
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      Mentions: Emory University University of Miami

    13. Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis An OCT, IVUS, and Angiographic Study

      Explore JACC Cardiology
      Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis An OCT, IVUS, and Angiographic Study
      Background The relationship between features of vulnerable plaque and angiographic coronary stenosis is unknown. Objectives The purpose of this study was to systematically investigate the absolute number, relative prevalence, and characteristics of thin-cap fibroatheroma (TCFA) at different degrees of stenosis using optical coherence tomography (OCT), intravascular ultrasound, and coronary angiography. Methods We identified 643 plaques from 255 subjects who underwent OCT imaging in all 3 coronary arteries. They were divided ...
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      Mentions: University of Pittsburgh Emory University Massachusetts General Hospital

    14. Refractive index measurement of the mouse crystalline lens using optical coherence tomography

      Explore ScienceDirect Ophthalmology
      Refractive index measurement of the mouse crystalline lens using optical coherence tomography
      In recent years, there has been a growing interest for using mouse models in refractive development and myopia research. The crystalline lens is a critical optical component of the mouse eye that occupies greater than 50% of the ocular space, and significant increases in thickness with age. However, changes in refractive index of the mouse crystalline lens are less known. In this study, we examined the changes in thickness and ...
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      Mentions: Emory University
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