1. Elliot M. Frohman

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    1. Mentioned In 37 Articles

    2. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study
      Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical ...
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    3. Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study

      Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study
      Objective To determine the optimal thresholds for inter‐eye differences in retinal nerve fiber and ganglion cell+inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Background Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multi‐center international study at ...
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    4. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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    5. Optical Coherence Tomography in Neurologic Disease (Textbook)

      Optical Coherence Tomography in Neurologic Disease (Textbook)
      Shortly after the invention of the first two-dimensional optical coherence tomography (OCT) scans by James Fujimoto and colleagues at the Massachusetts Institute of Technology in 1991, ophthalmologists recognized the extraordinary potential for OCT to facilitate quantitative assessment of the neuroretina. OCT rapidly became a commonplace tool in ophthalmologic practice to identify both inflammatory and degenerative conditions affecting the optic nerve and retina. The utility of OCT to detect and quantify ...
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    6. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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    7. Leading Edge Collaboration in Eye-Related Research Earns Investigators at NYU Langone Medical Center, Johns Hopkins, and the UT Southwestern Medical Center the 2015 Barancik Prize for Innovation in MS Research

      Leading Edge Collaboration in Eye-Related Research Earns Investigators at NYU Langone Medical Center, Johns Hopkins, and the UT Southwestern Medical Center the 2015 Barancik Prize for Innovation in MS Research
      ...oke. He currently serves as chair of the National MS Society's Clinical and Translational Research Committee. Elliot Frohman , MD, PhD, FAAN, FANA is Professor of Neurology Neurotherapeutics and Ophthalmology. He is a D...
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    8. Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study

      Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study
      Objective The aim of this work was to determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS). Methods Cirrus high-definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46 months). Three-Tesla magnetic resonance imaging ...
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    9. Optical coherence tomography reflects brain atrophy in MS: A four year study

      Optical coherence tomography reflects brain atrophy in MS: A four year study
      Objective : To determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS). Methods : Cirrus high definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46-months). Three-tesla magnetic resonance imaging brain scans (including brain-substructure volumetrics) were ...
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    10. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria
      Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. Objective: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. Methods: A prospective multi-centre ( n = 13 ...
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    11. Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis
      Background Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population. Objectives To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and ...
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    12. Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis

      Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis
      Post-mortem ganglion cell dropout has been observed in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis remains largely unexplored. Peripapillary retinal nerve fibre layer thickness, measured by optical coherence tomography, has been proposed as an outcome measure in studies of neuroprotective agents in multiple sclerosis, yet potential swelling during the acute stages of optic neuritis may confound baseline measurements. The objective of this ...
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    13. Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness

      Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness
      Background: Post-mortem analyses of multiple sclerosis (MS) eyes demonstrate prominent retinal neuronal ganglion cell layer (GCL) loss, in addition to related axonal retinal nerve fiber layer (RNFL) loss. Despite this, clinical correlations of retinal neuronal layers remain largely unexplored in MS. Objectives: To determine if MS patients exhibit in vivo retinal neuronal GCL loss, deeper retinal neuronal loss, and investigate correlations between retinal layer thicknesses, MS clinical subtype and validated ...
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    14. The Impact of Utilizing Different Optical Coherence Tomography Devices for Clinical Purposes and in Multiple Sclerosis Trials

      The Impact of Utilizing Different Optical Coherence Tomography Devices for Clinical Purposes and in Multiple Sclerosis Trials
      ...tcome measures for MS trials. She is also on the advisory board for an MS trial sponsored by Biogen Idec. Dr. Elliot Frohman has received speaker honoraria and consulting fees from Biogen Idec, TEVA, and Athena. He has a...
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  2. About Elliot M. Frohman

    Elliot M. Frohman

    Elliot Frohman is a professor of neurology and ophthalmology and director of the Multiple Sclerosis Clinical Center at University of Texas Southwestern Medical Center.  Dr. Frohman’s research is focused on the development of ophthalmological models from which to characterize the processes of neurodegeneration, neuroprotection, and neurorestoration in multiple sclerosis (MS). These studies utilize advanced retinal imaging techniques such as optical coherence tomography (OCT) and laser polarimetry (GDx) and non-conventional MRI techniques such as diffusion tensor and magnetization transfer imaging. Neuroprotection clinical trials aimed at demonstrating preservation of neurons and axons within the retina after acute optic neuritis in MS patients are currently underway.

  3. Quotes

    1. This technique has the potential to provide a powerful and reliable assessment strategy to measure structural changes in the central nervous system, both for diagnostic purposes and in clinical trials to monitor whether potential treatments can prevent deterioration or restore nerve function...An ophthalmologist might someday be able to use OCT to identify retinal thinning during a routine eye exam and consider MS as a prime diagnosis.
      In Simple Eye Test Measures Damage from Multiple Sclerosis