1. Edmund Koch

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    1. Mentioned In 90 Articles

    2. Improved Imaging of Magnetically Labeled Cells Using Rotational Magnetomotive Optical Coherence Tomography

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      Improved Imaging of Magnetically Labeled Cells Using Rotational Magnetomotive Optical Coherence Tomography
      Abstract In this paper, we present a reliable and robust method for magnetomotive optical coherence tomography (MM-OCT) imaging of single cells labeled with iron oxide particles. This method employs modulated longitudinal and transverse magnetic fields to evoke alignment and rotation of anisotropic magnetic structures in the sample volume. Experimental evidence suggests that magnetic particles assemble themselves in elongated chains when exposed to a permanent magnetic field. Magnetomotion in the intracellular ...
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      Mentions: Dresden University of Technology Edmund Koch

    3. Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain

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      Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain
      In spectral domain optical coherence tomography (SD-OCT), any transverse motion component of a detected obliquely moving sample results in a nonlinear relationship between the Doppler phase shift and the axial sample velocity restricting phase-resolved Doppler OCT (PR-DOCT). The size of the deviation from the linear relation depends on the amount of the transverse velocity component, given by the Doppler angle, and the height of the absolute sample velocity. Especially for ...
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      Mentions: Julia Walther Dresden University of Technology Edmund Koch

    4. Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats

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      Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats
      Though artificial ventilation is an essential life-saving treatment, the mechanical behavior of lung tissue at the alveolar level is still unknown. Therefore, we need to understand the tissue response during artificial ventilation at this microscale in order to develop new and more protective ventilation methods. Optical coherence tomography (OCT) combined with intravital microscopy (IVM) is a promising tool for visualizing lung tissue dynamics with a high spatial and temporal resolution ...
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      Mentions: Dresden University of Technology Edmund Koch Maria Gaertner

    5. Impact of a detector dead time in phase-resolved Doppler analysis using spectral domain optical coherence tomography

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      Impact of a detector dead time in phase-resolved Doppler analysis using spectral domain optical coherence tomography
      For any oblique sample movement containing a transverse velocity component, the commonly used linear relationship between the phase shift and the axial velocity component is erroneous for spectrometer-based optical coherence tomography (spectral domain OCT, SD-OCT). We recently proposed a new Doppler model that assumes a continuous integration of the photocurrent. In this research, we extend the model for detectors with a shutter control by taking detector dead time into account ...
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      Mentions: Julia Walther Dresden University of Technology Edmund Koch

    6. Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear

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      Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear
      The treatment of otitis media requires classifying the effusion in the tympanic cavity for choosing appropriate therapeutic strategies. Otoscopic examination of the middle ear depends on the expertise of the physician and is often hampered in case of inflammatory alterations of the tympanic membrane. In otologic research, optical coherence tomography is an innovative non-invasive imaging technique utilized for visualizing the tympanic membrane. This ex vivo study presents the possibility of ...
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      Mentions: Dresden University of Technology Edmund Koch Lars Kirsten

    8. Improved non-invasive Optical Coherence Tomography detection of different engineered nanoparticles in food-mimicking matrices

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      Improved non-invasive Optical Coherence Tomography detection of different engineered nanoparticles in food-mimicking matrices
      Food industry and regulators require fast and reliable analytical methods for quality control. This especially counts for the detection of engineered nanomaterials (ENMs) in food products. Respective EU regulation is in force, but the development of appropriate methods is still underway. This paper updates the scope of Optical Coherence Tomography (OCT) for ENM/food matrix analysis. A range of nanomaterials and composites Au@SiO 2 , Ag, Ag@SiO 2 and ...
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      Mentions: Dresden University of Technology Edmund Koch Lars Kirsten

    9. NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

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      NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice
      Aims Endothelial dysfunction is an early step in the development of atherosclerosis. Increased formation of superoxide anions by NADPH oxidase Nox1, 2, and 5 reduces nitric oxide availability and can promote endothelial dysfunction. In contrast, recent evidence supports a vasoprotective role of H 2 O 2 produced by main endothelial isoform Nox4. Therefore, we analysed the impact of genetic deletion of Nox4 on endothelial dysfunction and atherosclerosis in the low-density ...
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      Mentions: Dresden University of Technology Henning Morawietz Edmund Koch

    10. Imaging of aortic valve dynamics in 4D OCT New insights into murine aortic valve diseases

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      Imaging of aortic valve dynamics in 4D OCT New insights into murine aortic valve diseases
      The mechanical components of the heart, especially the valves and leaflets, are enormous stressed during lifetime. Therefore, those structures undergo different pathophysiological tissue transformations which affect cardiac output and in consequence living comfort of affected patients. These changes may lead to calcific aortic valve stenosis (AVS), the major heart valve disease in humans. The knowledge about changes of the dynamic behaviour during the course of this disease and the possibility ...
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      Mentions: Dresden University of Technology Edmund Koch

    11. Optimal processing of Doppler signals in OCT

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      Optimal processing of Doppler signals in OCT
      Besides structural imaging, OCT can be used to estimate axial velocities of the sample resolved in depth by Doppler processing. In Fourier domain OCT (FD-OCT), this is accomplished by measuring the phase difference (i.e. phase shift) between timely separated A-scans at the same depth. In most cases, these data are disturbed by noise caused by intrinsic noise of the OCT system, specified by the SNR, and decorrelation noise caused ...
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      Mentions: Julia Walther Dresden University of Technology Edmund Koch

    12. Imaging the tympanic membrane oscillation ex vivo with Doppler optical coherence tomography during simulated Eustachian catarrh

      Explore Conference Proceedings Otolaryngology
      Imaging the tympanic membrane oscillation ex vivo with Doppler optical coherence tomography during simulated Eustachian catarrh
      Recently, optical coherence tomography (OCT) was utilized in multiple studies for structural and functional imaging of the middle ear and the tympanic membrane. Since Doppler OCT allows both, the spatially resolved measurement of the tympanic membrane oscillation and high-resolution imaging, it is regarded as a promising tool for future in vivo applications. In this study, Doppler OCT is utilized for the visualization of the tympanic membrane oscillation in temporal bones ...
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      Mentions: Julia Walther Dresden University of Technology Edmund Koch

    13. 4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo

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      4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo
      The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain during lifetime. Like all highly stressed materials, also these biological components undergo fatigue and signs of wear, which impinge upon cardiac output and in the end on health and living comfort of affected patients. Thereby pathophysiological changes of the aortic valve leading to calcific aortic valve stenosis (AVS) as most frequent heart valve disease ...
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      Mentions: Dresden University of Technology Edmund Koch

    14. Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy

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      Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy
      Cell transplantation and stem cell therapy are promising approaches for regenerative medicine and are of interest to researchers and clinicians worldwide. However, currently, no imaging technique that allows three-dimensional in vivo inspection of therapeutically administered cells in host tissues is available. Therefore, we investigate magnetomotive optical coherence tomography (MM-OCT) of cells labeled with magnetic particles as a potential noninvasive cell tracking method. We develop magnetomotive imaging of mesenchymal stem cells ...
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      Mentions: Julia Walther Dresden University of Technology Edmund Koch

    15. Visualization of dynamic boiling processes using high-speed optical coherence tomography

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      Visualization of dynamic boiling processes using high-speed optical coherence tomography
      Investigating microscale nucleate boiling processes with high heat flux requires experimental visualization and quantification with high spatial resolution in the micrometer range as well as a sufficient temporal resolution. Numerous measurement techniques are employed for providing comprehensive experimental data on microscale boiling processes and other multiphase flows. In this context, optical coherence tomography (OCT) has been introduced recently for the visualization of quasistatic growing vapor bubbles in turbid fluids with ...
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      Mentions: National Institutes of Health Julia Walther Sven Meissner
    17. 1-15 of 90 1 2 3 4 5 6 »
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  4. About Edmund Koch

    Edmund Koch

    Edmund Koch is with the Department of Clinical Sensoring and Monitoring, Medical Faculty Carl Gustav Carus at the University of Technology in Dresden Germany.  Also see Dr. Koch's Optical Sensors and Monitors for Biomedical applications website.

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