1. Edmund Koch

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    1. Mentioned In 91 Articles

    2. Advanced analysis of domain walls in Mg doped LiNbO3 crystals with high resolution OCT

      Advanced analysis of domain walls in Mg doped LiNbO3 crystals with high resolution OCT
      The structure of domain walls (DW) in ferroelectric media is of great interest as this material is used for frequency doublers and other applications. We show that the structure of the DWs can nicely be visualized by high resolution optical coherence tomography (OCT). While the high group refractive index of lithium niobate allows a resolution much better than 1 m, the large dispersion can blur the image and has to ...
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    3. Improved Imaging of Magnetically Labeled Cells Using Rotational Magnetomotive Optical Coherence Tomography

      Improved Imaging of Magnetically Labeled Cells Using Rotational Magnetomotive Optical Coherence Tomography
      Abstract In this paper, we present a reliable and robust method for magnetomotive optical coherence tomography (MM-OCT) imaging of single cells labeled with iron oxide particles. This method employs modulated longitudinal and transverse magnetic fields to evoke alignment and rotation of anisotropic magnetic structures in the sample volume. Experimental evidence suggests that magnetic particles assemble themselves in elongated chains when exposed to a permanent magnetic field. Magnetomotion in the intracellular ...
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    4. Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain

      Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain
      In spectral domain optical coherence tomography (SD-OCT), any transverse motion component of a detected obliquely moving sample results in a nonlinear relationship between the Doppler phase shift and the axial sample velocity restricting phase-resolved Doppler OCT (PR-DOCT). The size of the deviation from the linear relation depends on the amount of the transverse velocity component, given by the Doppler angle, and the height of the absolute sample velocity. Especially for ...
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    5. Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats

      Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats
      Though artificial ventilation is an essential life-saving treatment, the mechanical behavior of lung tissue at the alveolar level is still unknown. Therefore, we need to understand the tissue response during artificial ventilation at this microscale in order to develop new and more protective ventilation methods. Optical coherence tomography (OCT) combined with intravital microscopy (IVM) is a promising tool for visualizing lung tissue dynamics with a high spatial and temporal resolution ...
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    6. Impact of a detector dead time in phase-resolved Doppler analysis using spectral domain optical coherence tomography

      Impact of a detector dead time in phase-resolved Doppler analysis using spectral domain optical coherence tomography
      For any oblique sample movement containing a transverse velocity component, the commonly used linear relationship between the phase shift and the axial velocity component is erroneous for spectrometer-based optical coherence tomography (spectral domain OCT, SD-OCT). We recently proposed a new Doppler model that assumes a continuous integration of the photocurrent. In this research, we extend the model for detectors with a shutter control by taking detector dead time into account ...
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    7. Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear

      Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear
      The treatment of otitis media requires classifying the effusion in the tympanic cavity for choosing appropriate therapeutic strategies. Otoscopic examination of the middle ear depends on the expertise of the physician and is often hampered in case of inflammatory alterations of the tympanic membrane. In otologic research, optical coherence tomography is an innovative non-invasive imaging technique utilized for visualizing the tympanic membrane. This ex vivo study presents the possibility of ...
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    8. Improved non-invasive Optical Coherence Tomography detection of different engineered nanoparticles in food-mimicking matrices

      Improved non-invasive Optical Coherence Tomography detection of different engineered nanoparticles in food-mimicking matrices
      Food industry and regulators require fast and reliable analytical methods for quality control. This especially counts for the detection of engineered nanomaterials (ENMs) in food products. Respective EU regulation is in force, but the development of appropriate methods is still underway. This paper updates the scope of Optical Coherence Tomography (OCT) for ENM/food matrix analysis. A range of nanomaterials and composites Au@SiO 2 , Ag, Ag@SiO 2 and ...
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    9. NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

      NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice
      Aims Endothelial dysfunction is an early step in the development of atherosclerosis. Increased formation of superoxide anions by NADPH oxidase Nox1, 2, and 5 reduces nitric oxide availability and can promote endothelial dysfunction. In contrast, recent evidence supports a vasoprotective role of H 2 O 2 produced by main endothelial isoform Nox4. Therefore, we analysed the impact of genetic deletion of Nox4 on endothelial dysfunction and atherosclerosis in the low-density ...
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    10. Imaging of aortic valve dynamics in 4D OCT New insights into murine aortic valve diseases

      Imaging of aortic valve dynamics in 4D OCT  New insights into murine aortic valve diseases
      The mechanical components of the heart, especially the valves and leaflets, are enormous stressed during lifetime. Therefore, those structures undergo different pathophysiological tissue transformations which affect cardiac output and in consequence living comfort of affected patients. These changes may lead to calcific aortic valve stenosis (AVS), the major heart valve disease in humans. The knowledge about changes of the dynamic behaviour during the course of this disease and the possibility ...
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    11. Optimal processing of Doppler signals in OCT

      Optimal processing of Doppler signals in OCT
      Besides structural imaging, OCT can be used to estimate axial velocities of the sample resolved in depth by Doppler processing. In Fourier domain OCT (FD-OCT), this is accomplished by measuring the phase difference (i.e. phase shift) between timely separated A-scans at the same depth. In most cases, these data are disturbed by noise caused by intrinsic noise of the OCT system, specified by the SNR, and decorrelation noise caused ...
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    12. Imaging the tympanic membrane oscillation ex vivo with Doppler optical coherence tomography during simulated Eustachian catarrh

      Imaging the tympanic membrane oscillation ex vivo with Doppler optical coherence tomography during simulated Eustachian catarrh
      Recently, optical coherence tomography (OCT) was utilized in multiple studies for structural and functional imaging of the middle ear and the tympanic membrane. Since Doppler OCT allows both, the spatially resolved measurement of the tympanic membrane oscillation and high-resolution imaging, it is regarded as a promising tool for future in vivo applications. In this study, Doppler OCT is utilized for the visualization of the tympanic membrane oscillation in temporal bones ...
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    13. 4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo

      4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo
      The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain during lifetime. Like all highly stressed materials, also these biological components undergo fatigue and signs of wear, which impinge upon cardiac output and in the end on health and living comfort of affected patients. Thereby pathophysiological changes of the aortic valve leading to calcific aortic valve stenosis (AVS) as most frequent heart valve disease ...
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    14. Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy

      Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy
      Cell transplantation and stem cell therapy are promising approaches for regenerative medicine and are of interest to researchers and clinicians worldwide. However, currently, no imaging technique that allows three-dimensional in vivo inspection of therapeutically administered cells in host tissues is available. Therefore, we investigate magnetomotive optical coherence tomography (MM-OCT) of cells labeled with magnetic particles as a potential noninvasive cell tracking method. We develop magnetomotive imaging of mesenchymal stem cells ...
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    15. Visualization of dynamic boiling processes using high-speed optical coherence tomography

      Visualization of dynamic boiling processes using high-speed optical coherence tomography
      Investigating microscale nucleate boiling processes with high heat flux requires experimental visualization and quantification with high spatial resolution in the micrometer range as well as a sufficient temporal resolution. Numerous measurement techniques are employed for providing comprehensive experimental data on microscale boiling processes and other multiphase flows. In this context, optical coherence tomography (OCT) has been introduced recently for the visualization of quasistatic growing vapor bubbles in turbid fluids with ...
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    16. 1-15 of 91 1 2 3 4 5 6 »
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  2. About Edmund Koch

    Edmund Koch

    Edmund Koch is with the Department of Clinical Sensoring and Monitoring, Medical Faculty Carl Gustav Carus at the University of Technology in Dresden Germany.  Also see Dr. Koch's Optical Sensors and Monitors for Biomedical applications website.