1. Duke University

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    1. Mentioned In 347 Articles

    2. Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research

      Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research

      The ability to conduct highly localized delivery of contrast agents, viral vectors, therapeutic or pharmacological agents, and signaling molecules or dyes to live mammalian embryos is greatly desired to enable a variety of studies in the field of developmental biology, such as investigating the molecular regulation of cardiovascular morphogenesis. To meet such a demand, we introduce, for the first time, the concept of employing optical coherence tomography (OCT)-guide microinjections in live mouse embryos, which provides precisely targeted manipulation with spatial resolution at the micrometer scale. The feasibility demonstration is performed with experimental studies on cultured live mouse embryos at ...

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    3. Duke University Receives NIH Grant for Developing Inoperative OCT Guidance of Intraocular Surgery.

      Duke University Receives NIH Grant  for Developing Inoperative OCT Guidance of Intraocular Surgery.
      ...ophthalmic surgery. The proposed Biomedical Research Partnership comprises academic and clinical faculty from Duke University Biomedical Engineering Department (BME) and Duke Eye Center (DEC), faculty at the Cole Eye Ins...
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    4. 3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography

      3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography

      We present a novel general-purpose compression method for tomographic images, termed 3D adaptive sparse representation based compression (3D-ASRC). In this paper, we focus on applications of 3D-ASRC for the compression of ophthalmic 3D optical coherence tomography (OCT) images. The 3D-ASRC algorithm exploits correlations among adjacent OCT images to improve compression performance, yet is sensitive to preserving their differences. Due to the inherent denoising mechanism of the sparsity based 3D-ASRC, the quality of the compressed images are often better than the raw images they are based on. Experiments on clinical-grade retinal OCT images demonstrate the superiority of the proposed 3D-ASRC over ...

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    5. Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.

      Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.
      ... and cost barriers with MRI limit the widespread use and investigation of these posterior eye measures. These Duke University Receives a 2014 NIH Grant for $372,968 for Whole Eye Optical Coherence Tomography to Improve R...
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    6. Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

      Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

      Neurodegeneration in dementia is mainly evaluated by assessing cerebral atrophy, while retinal neurodegeneration can be quantified in vivo using optical coherence tomography (OCT). We examined the association of retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC–IPL) thinning with global and regional cerebral atrophy on magnetic resonance imaging (MRI). Malay participants aged 60–80 years from the Epidemiology of Dementia in Singapore Study underwent comprehensive examinations, including 3-Tesla cranial MRI. RNFL and GC-IPL thicknesses were obtained from spectral domain-OCT; and cerebral grey and white matter volumes were obtained from MRI scans using a validated segmentation tool. Linear ...

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    7. Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images

      Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images
      ...1Department of Biomedical Engineering, Duke University, Durham 27708, USA ^2Department of Computer Science, Duke University, Durham 27708, USA ^3Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, H...
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.