1. Duke University

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    1. Mentioned In 385 Articles

    2. 4D microscope-integrated OCT improves accuracy of ophthalmic surgical maneuvers

      4D microscope-integrated OCT improves accuracy of ophthalmic surgical maneuvers
      Ophthalmic surgeons manipulate micron-scale tissues using stereopsis through an operating microscope and instrument shadowing for depth perception. While ophthalmic microsurgery has benefitted from rapid advances in instrumentation and techniques, the basic principles of the stereo operating microscope have not changed since the 1930s. Optical Coherence Tomography (OCT) has revolutionized ophthalmic imaging and is now the gold standard for preoperative and postoperative evaluation of most retinal and many corneal procedures. We ...
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    3. Systems and methods for complex conjugate artifact resolved optical coherence tomography

      Systems and methods for complex conjugate artifact resolved optical coherence tomography
      Systems and methods are disclosed for optical coherence tomography (OCT). For example, imaging can use optical phase modulators based on optical delay lines that, in conjunction with a swept-source laser, can be used to achieve heterodyne swept source optical coherence tomography (SSOCT). These techniques resolve the complex conjugate ambiguity in SSOCT, thereby doubling the usable imaging range. This increased imaging range has numerous important clinical applications in ophthalmology, cardiology and ...
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    4. At Duke, sibling sleuths try to unlock mummy mystery

      At Duke, sibling sleuths try to unlock mummy mystery
      Mike Toth is trying to make mummies talk. In ancient Egypt, middle-class dead were mummified with a mask made of papyrus scraps papyrus mch, he calls it and finished off with layers of primer and paint. Toth hopes to look under those layers and see if these reused papyrus scraps have text on them. The laws of physics are against us, he said. We have to penetrate these layers paint ...
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    5. Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry

      Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution may relate to scattering information about a sample, and temporal ...
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    6. Wide field of view swept-source optical coherence tomography for peripheral retinal disease

      Wide field of view swept-source optical coherence tomography for peripheral retinal disease
      Background/aims To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. Methods A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-source laser and a custom sample arm consisting of two indirect ophthalmic lenses. Twenty-seven subjects with peripheral lesions (choroidal melanomas, choroidal naevi, sclerochoroidal calcification, retinitis pigmentosa, diabetic retinopathy, retinoschisis and uveitis) were imaged with ...
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    7. Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography

      Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography
      Stimulated Raman scattering (SRS) enables fast, high resolution imaging of chemical constituents important to biological structures and functional processes, both in a label-free manner and using exogenous biomarkers. While this technology has shown remarkable potential, it is currently limited to point scanning and can only probe a few Raman bands at a time (most often, only one). In this work we take a fundamentally different approach to detecting the small ...
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    8. MACULAR PSEUDO-HOLE IN SHAKEN BABY SYNDROME: UNDERSCORING THE UTILITY OF OPTICAL COHERENCE TOMOGRAPHY UNDER ANESTHESIA

      MACULAR PSEUDO-HOLE IN SHAKEN BABY SYNDROME: UNDERSCORING THE UTILITY OF OPTICAL COHERENCE TOMOGRAPHY UNDER ANESTHESIA
      Purpose: To describe a case of vitrectomy for nonclearing vitreous hemorrhage in shaken baby syndrome and the utility of intraoperative hand-held optical coherence tomography to distinguish a macular hole from a pseudo-hole. Methods: Case report of a 4-month-old girl. Results: After clearing of media opacity by vitrectomy, an apparent macular hole was seen with the operating microscope. However, this was shown to be only a pseudo-hole by intraoperative hand-held optical ...
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    9. Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.

      Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.
      ...ng the specified measures as well as future implications for spatial measurements of the eye from OCT images. Duke University Receives a 2015 NIH Grant for $344,421 for Whole Eye Optical Coherence Tomography to Improve R...
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    10. Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy

      Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy
      Purpose: To report the intraoperative use of microscope-integrated optical coherence tomography (MIOCT) to enable visualization for Descemet's stripping automated endothelial keratoplasty (DSAEK) in 2 patients with advanced bullous keratopathy. Methods: Patient 1 was an 83-year-old female and patient 2 was a 28-year-old male both with limited vision and significant pain from bullous keratopathy who underwent palliative DSAEK. Because of the severity and chronicity of the corneal decompensation in both ...
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    11. Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe

      Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe
      We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for both imaging modes, and the optical paths for each imaging mode were optimized for their respective application using a combination of commercial and custom optics. The system has a working distance of 26 ...
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    12. Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography

      Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography
      Purpose : To differentiate diabetic macular edema (DME) from pseudophakic cystoid macular edema (PCME) based solely on spectral-domain optical coherence tomography (SD-OCT). Methods : This cross-sectional study included 134 participants: 49 with PCME, 60 with DME, and 25 with diabetic retinopathy (DR) and ME after cataract surgery. First, two unmasked experts classified the 25 DR patients after cataract surgery as either DME, PCME, or mixed-pattern based on SD-OCT and color-fundus photography. Then ...
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    13. Pupil tracking optical coherence tomography for precise control of pupil entry position

      Pupil tracking optical coherence tomography for precise control of pupil entry position
      To maximize the collection efficiency of back-scattered light, and to minimize aberrations and vignetting, the lateral position of the scan pivot of an optical coherence tomography (OCT) retinal scanner should be imaged to the center of the ocular pupil. Additionally, several retinal structures including Henles Fiber Layer (HFL) exhibit reflectivities that depend on illumination angle, which can be controlled by varying the pupil entry position of the OCT beam. In ...
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    14. 16-30 of 385 « 1 2 3 4 5 ... 24 25 26 »
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.

  3. Quotes about Duke University

    1. We are excited to be working with an institution as prestigious as Duke University to advance medical diagnostics.
      In SpectraScience Announces Licensing of Key Technology From Duke University