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2. Multiple window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry
  
  Explore uspto.gov Jun 27 2017 Patents
  
  Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution is provided. For example, optical resolution may relate to scattering ...
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  Mentions: Duke University Adam Wax Robert N. Graf
3. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
  
  Explore OSA | OSA Publishing Jun 20 2017
  
  This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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  Mentions: Brett E. Bouma Johannes F. de Boer Joseph A. Izatt
4. Dual-axis optical coherence tomography for deep tissue imaging
  
  Explore OSA | OSA Publishing Jun 8 2017
  
  We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a ...
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  Mentions: Duke University Adam Wax Mohamed A. Ibrahim
5. HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS
  
  Explore LWW Online Jun 3 2017 Ophthalmology
  
  Purpose: The authors investigated feasibility of undilated handheld spectral domain optical coherence tomography (SDOCT) retinal imaging in preterm infants and children with neurologic abnormalities. Methods: Under an institutional review board-approved protocol, the authors attempted handheld SDOCT imaging of the retina, choroid, and optic nerve in infants and young children without pupil dilation. Scans were analyzed for quality and successful capture of foveal, optic nerve, and retinal structural parameters and abnormalities ...
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  Mentions: Duke University Cynthia A. Toth Ramiro S. Maldonado
6. When pressure meets light: detecting the photoacoustic effect at the origin
  
  Explore Nature Publishing Group Jun 1 2017 Microscopy
  
  Modern optical microscopy1, including confocal microscopy, two-photon microscopy and optical coherence tomography (OCT), has revolutionized life sciences by providing detailed information of biological samples with cellular and subcellular resolutions, and has become an essential tool for biomedical research labs. However, optical microscopy typically has a limited penetration depth of ~1mm in biological tissue due to strong optical scattering2,3. Moreover, with respective contrast mechanisms, confocal and two-photon microscopy usually rely ...
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7. Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
  
  Explore Optical Coherence Tomography News May 28 2017 Ophthalmology
  
  Glaucoma is characterized by an irreversible damage of retinal ganglion cells within the optic nerve head (ONH) at the back of the eye. Currently we know that elevated intraocular pressure (IOP) is associated with increased prevalence of glaucoma but not all glaucoma patients have an elevated IOP. The biomechanical theory of glaucoma hypothesizes that elevated (or fluctuating) IOP deforms the ONH tissues, including the lamina cribrosa (LC), and that these ...
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  Mentions: Duke University University College London National University of Singapore
8. Comparison of Anterior Segment Optical Coherence Tomography Bleb Grading, Moorfields Bleb Grading System, and Intraocular Pressure After Trabeculectomy
  
  Explore LWW Online May 1 2017 Ophthalmology
  
  Purpose: To compare a novel anterior segment optical coherence tomography (AS-OCT) bleb grading system with a clinical bleb grading system and both with intraocular pressure (IOP) following trabeculectomy surgery. Materials and Methods: A novel AS-OCT grading system based on bleb size and internal reflectivity was developed. An imaging center was tasked with masked grading of AS-OCT images acquired by multiple surgical sites at postoperative week (POW) 2, postoperative month (POM ...
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  Mentions: Duke University University of Washington Sanjay G. Asrani
9. Role of Disorganization of Retinal Inner Layers as an Optical Coherence Tomography Biomarker in Diabetic and Uveitic Macular Edema
  
  Explore Healio.com Apr 20 2017 Ophthalmology
  
  The role of optical coherence tomography (OCT) in characterizing normal and pathologic retinal architecture is still evolving. Numerous groups have tried to use OCT findings of retinal features as a surrogate for visual acuity in macular edema, but no traditional measure consistently accounts for visual outcomes. Retina specialists are still trying to process the data in the literature regarding this topic, as no good review currently exists. Dilraj S. Grewal ...
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10. Optical Coherence Tomography and Wide-Field Fluorescein Angiography in Retinopathy of Prematurity (Book Chapter)
  
  Explore Home - Springer Apr 17 2017 Ophthalmology , Textbooks
  
  The advent and adaptation of many imaging modalities promise to revolutionize our understanding of retinopathy of prematurity (ROP) by improving the detection, diagnosis, and monitoring of response to treatment of this disease. Diagnosis and classification of ROP traditionally relies on an eye exam by an ophthalmologist expert in this area who characterizes extent and character of retinal vascularization via indirect ophthalmoscopy. Many tools now exist that allow for data acquisition ...
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  Mentions: Duke University Cynthia A. Toth Ramiro S. Maldonado
11. Emerging Applications of Optical Coherence Tomography in Pediatric Optic Neuropathies
  
  Explore ScienceDirect Apr 17 2017 Ophthalmology
  
  Limited cooperation and attention span often lead to poorly reliable assessments of visual acuity and visual fields in children, making diagnosis and monitoring of pediatric optic neuropathies challenging. As a noninvasive imaging modality, optical coherence tomography (OCT) could offer particular utility in this patient population. OCT provides high-resolution characterization of the optic nerve head, peripapillary retinal nerve fiber layer, and cellular layers of the macula, all of which can be ...
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12. Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease
  
  Explore The JAMA Network Apr 12 2017 Ophthalmology
  
  Importance Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal diseases. To date, these two technologies have not been applied in combination to evaluate retinal vascular disease in the operating suite. Objective To conduct microscope-integrated, swept-source OCTA (MIOCTA) in children with retinal vascular disease. Design, Setting, and ...
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  Mentions: Joseph A. Izatt Duke University Cynthia A. Toth
13. Intraoperative 4-Dimensional Microscope-Integrated Optical Coherence TomographyGuided 27-Gauge Transvitreal Choroidal Biopsy for Choroidal Melanoma
  
  Explore LWW Online Mar 24 2017 Dermatology , Microscopy , Oncology , Ophthalmology
  
  Tissue sampling is desireable to understand prognostic genetic alternations in uveal melanoma...
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  Mentions: Joseph A. Izatt Duke University Cynthia A. Toth
14. Optical Coherence Tomography: Advances in functional OCT
  
  Explore BioOptics World Mar 8 2017
  
  ...xtending the utility of this powerful imaging technique. Adam Wax is a professor of biomedical engineering at Duke University, Durham, NC; e-mail: a.wax@duke.edu; http://bios.bme.duke.edu....
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  Mentions: Duke University Adam Wax
15. Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries
  
  Explore Indian Journal of Ophthalmology (IJO) Mar 1 2017 Ophthalmology
  
  ..., USA 2 Department of Biomedical Engineering, Duke University, Durham, NC, USA 3 Department of Ophthalmology, Duke University School of Medicine; Department of Biomedical Engineering, Duke University, Durham, NC, USA Cor...
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  Mentions: Joseph A. Izatt Duke University Cynthia A. Toth
16. Review of intraoperative optical coherence tomography: technology and applications [Invited]
  
  Explore OSA | OSA Publishing Feb 22 2017
  
  During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeons depth perception and visualization of instruments and sub-surface anatomy. Surgical procedures outside microsurgery, such as breast tumor resections, may also benefit from visualization of the sub-surface tissue structures. The widespread clinical adoption of optical coherence tomography (OCT) in ophthalmology and its growing prominence in other fields, such as cancer imaging, has motivated the development ...
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  Mentions: Joseph A. Izatt Duke University Cynthia A. Toth
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