1. Duke University

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    1. Mentioned In 366 Articles

    2. Wide field of view swept-source optical coherence tomography for peripheral retinal disease

      Wide field of view swept-source optical coherence tomography for peripheral retinal disease
      Background/aims To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. Methods A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-source laser and a custom sample arm consisting of two indirect ophthalmic lenses. Twenty-seven subjects with peripheral lesions (choroidal melanomas, choroidal naevi, sclerochoroidal calcification, retinitis pigmentosa, diabetic retinopathy, retinoschisis and uveitis) were imaged with ...
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    3. Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography

      Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography
      Stimulated Raman scattering (SRS) enables fast, high resolution imaging of chemical constituents important to biological structures and functional processes, both in a label-free manner and using exogenous biomarkers. While this technology has shown remarkable potential, it is currently limited to point scanning and can only probe a few Raman bands at a time (most often, only one). In this work we take a fundamentally different approach to detecting the small ...
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    4. MACULAR PSEUDO-HOLE IN SHAKEN BABY SYNDROME: UNDERSCORING THE UTILITY OF OPTICAL COHERENCE TOMOGRAPHY UNDER ANESTHESIA

      MACULAR PSEUDO-HOLE IN SHAKEN BABY SYNDROME: UNDERSCORING THE UTILITY OF OPTICAL COHERENCE TOMOGRAPHY UNDER ANESTHESIA
      Purpose: To describe a case of vitrectomy for nonclearing vitreous hemorrhage in shaken baby syndrome and the utility of intraoperative hand-held optical coherence tomography to distinguish a macular hole from a pseudo-hole. Methods: Case report of a 4-month-old girl. Results: After clearing of media opacity by vitrectomy, an apparent macular hole was seen with the operating microscope. However, this was shown to be only a pseudo-hole by intraoperative hand-held optical ...
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    5. Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.

      Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.
      ...ng the specified measures as well as future implications for spatial measurements of the eye from OCT images. Duke University Receives a 2015 NIH Grant for $344,421 for Whole Eye Optical Coherence Tomography to Improve R...
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    6. Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy

      Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy
      Purpose: To report the intraoperative use of microscope-integrated optical coherence tomography (MIOCT) to enable visualization for Descemet's stripping automated endothelial keratoplasty (DSAEK) in 2 patients with advanced bullous keratopathy. Methods: Patient 1 was an 83-year-old female and patient 2 was a 28-year-old male both with limited vision and significant pain from bullous keratopathy who underwent palliative DSAEK. Because of the severity and chronicity of the corneal decompensation in both ...
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    7. Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe

      Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe
      We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for both imaging modes, and the optical paths for each imaging mode were optimized for their respective application using a combination of commercial and custom optics. The system has a working distance of 26 ...
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    8. Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography

      Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography
      Purpose : To differentiate diabetic macular edema (DME) from pseudophakic cystoid macular edema (PCME) based solely on spectral-domain optical coherence tomography (SD-OCT). Methods : This cross-sectional study included 134 participants: 49 with PCME, 60 with DME, and 25 with diabetic retinopathy (DR) and ME after cataract surgery. First, two unmasked experts classified the 25 DR patients after cataract surgery as either DME, PCME, or mixed-pattern based on SD-OCT and color-fundus photography. Then ...
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    9. Pupil tracking optical coherence tomography for precise control of pupil entry position

      Pupil tracking optical coherence tomography for precise control of pupil entry position
      To maximize the collection efficiency of back-scattered light, and to minimize aberrations and vignetting, the lateral position of the scan pivot of an optical coherence tomography (OCT) retinal scanner should be imaged to the center of the ocular pupil. Additionally, several retinal structures including Henles Fiber Layer (HFL) exhibit reflectivities that depend on illumination angle, which can be controlled by varying the pupil entry position of the OCT beam. In ...
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    10. Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography

      Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography
      Clinical management of burn injuries depends upon an accurate assessment of the depth of the wound. Current diagnostic methods rely primarily on subjective visual inspection, which can produce variable results. In this study, spectroscopic optical coherence tomography was used to objectively evaluate burn injuries in vivo in a mouse model. Significant spectral differences were observed and correlated with the depth of the injury as determined by histopathology. The relevance of ...
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    11. Systems And Methods For Eye Tracking For Motion Corrected Ophthalmic Optical Coherenece Tomography

      Systems And Methods For Eye Tracking For Motion Corrected Ophthalmic Optical Coherenece Tomography
      Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. The imaging system also includes an OCT apparatus configured to generate OCT images of a retina of the eye. The OCT apparatus includes a scanner operable to be moved for relocating an OCT scan pivot ...
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    12. SD-OCT Angiography

      SD-OCT Angiography
      The objective of this study is to image retinal vascular alterations in patients with retinal disease using the AngioVue OCT-A system and understand the information these images provide. The investigators will image study participants who have retinal diseases with the AngioVue unit (Optovue) and will collect relevant clinical data to understand the nature of the information contained in images obtained on AngioVue. This study being conducted under an abbreviated IDE ...
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.