1. Duke University

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    1. Mentioned In 314 Articles

    2. Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu wants to figure out how to peer into your soul . . . or at least your brain. An expert in designing computer image processing algorithms, Farsiu is an assistant professor of ophthalmology at Duke Medicine who recently accepted a primary appointment in the Pratt biomedical engineering department with the hopes of strengthening collaborations across the university. “When President Bush said he looked Vladimir Putin in the eye and got a sense of his soul, he was actually on to something,” said Farsiu, who has a long history of collaborating with peers in Duke’s engineering school. “The retina is part ...

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    3. Segmentation and identification of layered structures in images

      Segmentation and identification of layered structures in images

      Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning ...

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    4. Methods for single-pass volumetric bidirectional blood flow imaging spectral domain optical coherence tomography using a modified hilbert transform

      Methods for single-pass volumetric bidirectional blood flow imaging spectral domain optical coherence tomography using a modified hilbert transform

      The present subject matter relates to in vivo volumetric bidirectional blood flow imaging using single-pass flow imaging spectral domain optical coherence tomography. This technique uses a modified Hilbert transform algorithm to separate moving and non-moving scatterers within a depth. The resulting reconstructed image maps the components of moving scatterers flowing into and out of the imaging axis onto opposite image halfplanes, enabling volumetric bidirectional flow mapping without manual segmentation.

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    5. Expanding OCT: Quanitifying the Cornea’s Optical Performance

      Expanding OCT: Quanitifying the Cornea’s Optical Performance

      Optical coherence tomography, a well-known method for imaging the retina, may allow physicians to perform quantitative metrology of the eye’s own optics. Swept-source OCT allows for simultaneous imaging of the cornea, iris and retina in living patients. Laser refractive surgeries such as laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) have brought better vision to tens of millions worldwide. But these techniques also exact a cost: because they work by reshaping the eye’s cornea, they make accurate measurement of the cornea’s optical parameters after surgery unreliable using conventional tools. That’s important, not only because inaccurate ...

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    6. Spectral Domain Optical Coherence Tomography Characterization of Pediatric Epiretinal Membranes

      Spectral Domain Optical Coherence Tomography Characterization of Pediatric Epiretinal Membranes

      Purpose: To compare the macular morphology of pediatric versus adult eyes with epiretinal membrane (ERM) using spectral domain optical coherence tomography and identify characteristics associated with postoperative visual acuity. Methods: This retrospective study analyzed spectral domain optical coherence tomography from pediatric subjects and a randomly selected cohort of adult subjects with ERM. Morphologic retinal and ERM features were graded by two masked spectral domain optical coherence tomography readers and compared with a postoperative change in visual acuity. Results: Pediatric ERMs (age, 0.3-16.5 years) were more confluently attached to the retina than adult ERMs (age, 40-88 years; P = 0 ...

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    7. Spectral Domain Optical Coherence Tomography Findings in CNGB3-Associated Achromatopsia and Therapeutic Implications

      Spectral Domain Optical Coherence Tomography Findings in CNGB3-Associated Achromatopsia and Therapeutic Implications

      We describe the spectral domain OCT findings in two siblings with CNGB3-associated achromatopsia. A 33-year-old female and her 31-year-old sibling were evaluated for mild nystagmus and decreased visual acuity which had been present since childhood. They were each evaluated with full field Ganzfeld electroretinography which demonstrated flat photopic responses and preserved rod function. Genetic testing performed at Carver lab at the University of Iowa confirmed a diagnosis of achromatopsia with identical mutations in the CNGB3 gene. Spectral domain optical coherence tomography was performed which revealed foveal changes in both siblings, with slight phenotypic variations in these genotypically identical siblings. OCT ...

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    8. Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT

      Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT
      ... Biomedical Engineering, Elcetrical and Computer Engineering, Computer Science, Duke University, Box 3802, Duke University Medical Center, AERI 5014, Durham, NC, NC, United States 3. ^3Department of Biomedical Eng...
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.