1. Duke University

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    1. Mentioned In 624 Articles

    2. Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT)

      Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT)
      Ocular deformation may be associated with biomechanical alterations in the structures of the eye, especially the cornea and sclera in conditions such as keratoconus, congenital glaucoma, and pathological myopia. Here, we propose a method to estimate ocular shape using an ultra-wide field MHz swept-source optical coherence tomography (SS-OCT) with a Fourier Domain Mode-Locked (FDML) laser and distortion correction of the images. The ocular biometrics for distortion correction was collected by ...
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    3. Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography

      Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography
      Purpose: To establish methods to visualize depth-resolved perifoveal retinal vasculature in preterm infants using handheld optical coherence tomography angiography (OCT-A). Methods: In this exploratory study, eyes of preterm infants were imaged using an investigational noncontact, handheld swept-source OCT-A device as part of the prospective BabySTEPS infant retinal imaging study. We selected high-quality OCT-A volumes at two developmental stages for analysis. Customized MATLAB scripts were used to segment retinal layers, test ...
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      Mentions: Duke University
    4. Retinal Microanatomy in Retinopathy of Prematurity

      Retinal Microanatomy in Retinopathy of Prematurity
      Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime. This study tests high-speed optical coherence tomography (OCT) technology compared to conventional color photographs at the bedside of very preterm infants in the intensive care nursery, to characterize previously unseen abnormalities that can predict a need for referral for ROP treatment, or poor ...
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    5. Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner

      Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner
      Clinical systems for optical coherence tomography (OCT) are used routinely to diagnose and monitor patients with a range of ocular diseases. They are large tabletop instruments operated by trained staff, and require mechanical stabilization of the head of the patient for positioning and motion reduction. Here we report the development and performance of a robot-mounted OCT scanner for the autonomous contactless imaging, at safe distances, of the eyes of freestanding ...
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      Mentions: Duke University
    6. Reproducibility of Retinal Vascular Phenotypes Obtained with Optical Coherence Tomography Angiography: Importance of Vessel Segmentation

      Reproducibility of Retinal Vascular Phenotypes Obtained with Optical Coherence Tomography Angiography: Importance of Vessel Segmentation
      Optical coherence tomography angiography (OCTA) is a non-invasive imaging method that can visualize the finest vascular networks in the human retina. OCTA image analysis has been successfully applied to the investigation of retinal vascular diseases of the eye and other systemic conditions that may manifest in the eye. To characterize and distinguish OCTA images from different pathologies, it is important to identify quantitative metrics and phenotypes that have high reproducibility ...
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      Mentions: Duke University
    7. Unified k-space theory of optical coherence tomography

      Unified k-space theory of optical coherence tomography
      We present a general theory of optical coherence tomography (OCT), which synthesizes the fundamental concepts and implementations of OCT under a common 3D k -space framework. At the heart of this analysis is the Fourier diffraction theorem, which relates the coherent interaction between a sample and plane wave to the Ewald sphere in the 3D k space representation of the sample. While only the axial dimension of OCT is typically ...
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      Mentions: Duke University
    8. Agreement Between Trend-Based and Qualitative Analysis of the Retinal Nerve Fiber Layer Thickness for Glaucoma Progression on Spectral-Domain Optical Coherence Tomography

      Agreement Between Trend-Based and Qualitative Analysis of the Retinal Nerve Fiber Layer Thickness for Glaucoma Progression on Spectral-Domain Optical Coherence Tomography
      Introduction: To evaluate the agreement between trend-based analysis and qualitative assessment of the retinal nerve fiber layer (RNFL) thickness for glaucomatous progression on spectral-domain optical coherence tomography (SDOCT). Methods: Retrospective review of 190 eyes from 103 patients with glaucoma or suspected glaucoma that underwent SDOCT imaging during four consecutive clinic visits. Trend-based progression was characterized by a significantly negative slope. Progression by qualitative analysis was determined by review of raw ...
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      Mentions: Duke University
    9. Microscope-Integrated OCT-Guided Volumetric Measurements of Subretinal Blebs Created by a Suprachoroidal Approach

      Microscope-Integrated OCT-Guided Volumetric Measurements of Subretinal Blebs Created by a Suprachoroidal Approach
      Purpose: To investigate the use of imaging modalities in the volumetric measurement of the subretinal space and examine the volume of subretinal blebs created by a subretinal drug delivery device utilizing microscope-integrated optical coherence tomography (MIOCT). Methods: An MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging ceramic spheres of known size that were surgically implanted into ex vivo porcine eyes. This method was ...
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      Mentions: Duke University
    10. Automated Identification of Referable Retinal Pathology in Teleophthalmology Setting

      Automated Identification of Referable Retinal Pathology in Teleophthalmology Setting
      Purpose : This study aims to meet a growing need for a fully automated, learning-based interpretation tool for retinal images obtained remotely (e.g. teleophthalmology) through different imaging modalities that may include imperfect (uninterpretable) images. Methods : A retrospective study of 1148 optical coherence tomography (OCT) and color fundus photography (CFP) retinal images obtained using Topcon's Maestro care unit on 647 patients with diabetes. To identify retinal pathology, a Convolutional Neural ...
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    11. A review of low-cost and portable optical coherence tomography

      A review of low-cost and portable optical coherence tomography
      Optical coherence tomography (OCT) is a powerful optical imaging technique capable of visualizing the internal structure of biological tissues at near cellular resolution. For years, OCT has been regarded as the standard of care in ophthalmology, acting as an invaluable tool for the assessment of retinal pathology. However, the costly nature of most current commercial OCT systems has limited its general accessibility, especially in low-resource environments. It is therefore timely ...
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    12. 1-15 of 624 1 2 3 4 ... 40 41 42 »
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.

  3. Quotes about Duke University

    1. We are excited to be working with an institution as prestigious as Duke University to advance medical diagnostics.
      In SpectraScience Announces Licensing of Key Technology From Duke University