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2. Spectroscopic optical coherence refraction tomography
  
  Explore OSA | OSA Publishing Apr 3 2020
  
  $Spectroscopic optical coherence refraction tomography$
  In optical coherence tomography (OCT), the axial resolution is often superior to the lateral resolution, which is sacrificed for long imaging depths. To address this anisotropy, we previously developed optical coherence refraction tomography (OCRT), which uses images from multiple angles to computationally reconstruct an image with isotropic resolution, given by the OCT axial resolution. On the other hand, spectroscopic OCT (SOCT), an extension of OCT, trades axial resolution for spectral ...
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  Mentions: Joseph A. Izatt Duke University Sina Farsiu
3. OCULAR MANIFESTATIONS OF PORETTI-BOLTSHAUSER SYNDROME: FINDINGS FROM MULTIMODAL IMAGING AND ELECTROPHYSIOLOG
  
  Explore LWW Online Mar 26 2020 Ophthalmology
  
  Background/Purpose: Poretti-Boltshauser syndrome is a rare, nonprogressive neurologic syndrome with characteristic cerebellar cysts on neuroimaging due to mutations in LAMA1 . The ophthalmic findings in Poretti-Boltshauser syndrome are not well described. Here, we report the ophthalmic findings from multimodal imaging and electrophysiology of a patient with genetically confirmed Poretti-Boltshauser syndrome . Methods: A 3-year-old boy with confirmed mutations in LAMA1 underwent examination under anesthesia with electroretinography and multimodal imaging including fundus ...
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  Mentions: Duke University Cynthia A. Toth
4. INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY AND ENDOSCOPY-GUIDED EXPLANTATION OF ARGUS II DEVIC
  
  Explore LWW Online Mar 22 2020 Ophthalmology
  
  Purpose: To describe a surgical approach using intraoperative optical coherence tomography and endoscopy for successful Argus II retinal prosthesis system removal. Methods: Retrospective review of a patient undergoing Argus II explantation 8 months after initial implantation. Results: Successful explantation of the Argus II device was performed in this patient. Conclusion: Explantation of the Argus II device can be a difficult surgery, and intraoperative optical coherence tomography and endoscopy can be ...
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  Mentions: Duke University
5. Recent developments in pediatric retina
  
  Explore LWW Online Mar 19 2020 Ophthalmology
  
  Purpose of review Pediatric retina is an exciting, but also challenging field, where patient age and cooperation can limit ease of diagnosis of a broad range of congenital and acquired diseases, inherited retinal degenerations are mostly untreatable and surgical outcomes can be quite different from those for adults. This review aims to highlight some recent advances and trends that are improving our ability to care for children with retinal conditions ...
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  Mentions: Duke University
6. Towards Label-Free 3D Segmentation of Optical Coherence Tomography Images of the Optic Nerve Head Using Deep Learning
  
  Explore arxiv.org Mar 1 2020 Ophthalmology
  
  Since the introduction of optical coherence tomography (OCT), it has been possible to study the complex 3D morphological changes of the optic nerve head (ONH) tissues that occur along with the progression of glaucoma. Although several deep learning (DL) techniques have been recently proposed for the automated extraction (segmentation) and quantification of these morphological changes, the device-specific nature and the difficulty in preparing manual segmentations (training data) limit their clinical ...
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  Mentions: Duke University Medical University of Vienna Singapore Eye Research Institute
7. Consolidation of Imaging Modalities Utilizing Digitally Assisted Visualization Systems: The Development of a Surgical Information Handling Cockpit
  
  Explore Medical Journals Publisher Feb 27 2020 Ophthalmology
  
  ...Cincinnati Eye Institute, Cincinnati, OH, USA Correspondence: Cassandra C Brooks Department of Ophthalmology, Duke University, 2351 Erwin Drive, Durham, NC 27705, USA Email Cassandra.brooks@duke.edu Abstract: The managem...
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  Mentions: Duke University FDA University of Cincinnati
8. Deep learning segmentation for optical coherence tomography measurements of the lower tear meniscus
  
  Explore OSA | OSA Publishing Feb 26 2020 Ophthalmology
  
  The tear meniscus contains most of the tear fluid and therefore is a good indicator for the state of the tear film. Previously, we used a custom-built optical coherence tomography (OCT) system to study the lower tear meniscus by automatically segmenting the image data with a thresholding-based segmentation algorithm (TBSA). In this report, we investigate whether the results of this image segmentation algorithm are suitable to train a neural network ...
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  Mentions: Duke University Medical University of Vienna Singapore Eye Research Institute
9. Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging
  
  Explore Nature Publishing Group Feb 22 2020 Ophthalmology
  
  Lipofuscin in the retinal pigment epithelium (RPE) is the major source of fundus autofluorescence (FAF). A technical challenge to accurately quantify the FAF intensities, thus the lipofuscin concentration, is to compensate the light attenuation of RPE melanin. We developed the VIS-OCT-FAF technology to accomplish optical coherence tomography (OCT) and FAF simultaneously with a single broadband visible light source. We demonstrated that light attenuation by RPE melanin can be assessed and ...
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  Mentions: Shuliang Jiao Duke University University of Miami
10. Faster. Stronger. Smarter.
  
  Explore pratt.duke.edu Feb 20 2020 Ophthalmology
  
  ... image analysis tools that are freely shared online and used in multicenter clinical trials around the world. Duke University is also finding innovative ways to apply AI to a range of disciplines. In 2019, Duke appointed...
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  Mentions: Duke University Cynthia A. Toth FDA
11. Toward Autonomous Robotic Micro-Suturing using Optical Coherence Tomography Calibration and Path Planning
  
  Explore arxiv.org Feb 9 2020
  
  Robotic automation has the potential to assist human surgeons in performing suturing tasks in microsurgery, and in order to do so a robot must be able to guide a needle with sub-millimeter precision through soft tissue. This paper presents a robotic suturing system that uses 3D optical coherence tomography (OCT) system for imaging feedback. Calibration of the robot-OCT and robot-needle transforms, wound detection, keypoint identification, and path planning are all ...
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  Mentions: Joseph A. Izatt Duke University Anthony N. Kuo
12. Duke University Receives NIH Grant for Handheld Portable Adaptive Optics optical Coherence Tomography for Imaging in Young Children
  
  Explore Optical Coherence Tomography News Feb 4 2020 Ophthalmology , Funding
  
  ...ren based on accurate quantitative measurement of disease imaging biomarkers.
  Duke University Receives a 2020 NIH Grant for $192,944 for Handheld Portable Adaptive Optics optical Coherence...
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  Mentions: National Institutes of Health Duke University Sina Farsiu
13. Deep learning-based single-shot prediction of differential effects of anti-VEGF treatment in patients with diabetic macular edema
  
  Explore OSA | OSA Publishing Jan 28 2020 Ophthalmology
  
  Anti-vascular endothelial growth factor (VEGF) agents are widely regarded as the first line of therapy for diabetic macular edema (DME) but are not universally effective. An automatic method that can predict whether a patient is likely to respond to anti-VEGF therapy can avoid unnecessary trial and error treatment strategies and promote the selection of more effective first-line therapies. The objective of this study is to automatically predict the efficacy of ...
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  Mentions: Duke University Sina Farsiu
14. Artificial intelligence predicts treatment outcome for diabetes-related vision loss
  
  Explore EurekAlert! Jan 28 2020
  
  ...t whether a patient is likely to respond to anti-VEGF treatments," said research team leader Sina Farsiu from Duke University. "This research represents a step toward precision medicine, in which such predictions help cl...
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  Mentions: Duke University Sina Farsiu
15. Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA
  
  Explore Healio.com Jan 22 2020 Ophthalmology
  
  BACKGROUND AND OBJECTIVE: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. PATIENTS AND METHODS: Single-center, prospective, cross-sectional, consecutive case-series of children with previously treated retinoblastoma who underwent portable OCTA of posterior retinoblastoma lesions. RESULTS: Eight tumors from seven eyes of five children with retinoblastoma were included. Tumors with types 1 (calcified remnant, n = 3), 2 ...
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  Mentions: Duke University Cynthia A. Toth Miguel A. Materin
16. Noninvasive optical coherence tomography imaging correlates with anatomic and physiologic end-organ changes in healthy normotensives with systemic blood pressure variability
  
  Explore LWW Online Jan 16 2020 Cardiology
  
  Objective Blood pressure variability (BPV) is considered as a novel risk factor for cardiovascular disease including left ventricular hypertrophy, vascular stiffness, and renal dysfunction. In this study, we aimed to determine the relationship between ambulatory BPV with subclinical organ damage and vascular stiffness parameters in normotensive healthy subjects. Methods A total of 100 healthy subjects over 18 years of age were included in this cross-sectional study. We divided the participants ...
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  Mentions: Duke University
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