1. Duke University

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    1. Mentioned In 391 Articles

    2. Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model

      Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model
      Recent developments in optical coherence tomography (OCT) systems for the cornea have limited resolution or acquisition speed. In this study we aim to evaluate the use of a micro-OCT (OCT ~1m axial resolution) compared to existing imaging modalities using animal models of corneal endothelial disease. We used established cryoinjury and bullous keratopathy models in Sprague Dawley rats comparing ex vivo OCT imaging in normal and diseased eyes to (1) histology ...
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    3. Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes

      Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes
      Purpose : The integration of swept-source optical coherence tomography (SS-OCT) into the operating microscope enables real-time, tissue-level three-dimensional (3D) imaging to aid in ophthalmic microsurgery. In this prospective randomized controlled study, we evaluated the impact of SS microscope-integrated OCT (MI-OCT) on ophthalmology residents' performance of ophthalmic microsurgical maneuvers. Methods : Fourteen ophthalmology residents from a single institution were stratified by year of training and randomized to perform four anterior segment surgical maneuvers ...
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    4. Posterior Eye Shape Measurement With Retinal OCT Compared to MRI

      Posterior Eye Shape Measurement With Retinal OCT Compared to MRI
      Purpose : Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. Methods : Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical ...
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    5. Optical Coherence Tomography for Retinal Surgery: Perioperative Analysis to Real-Time Four-Dimensional Image-Guided Surgery

      Optical Coherence Tomography for Retinal Surgery: Perioperative Analysis to Real-Time Four-Dimensional Image-Guided Surgery
      Magnification of the surgical field using the operating microscope facilitated profound innovations in retinal surgery in the 1970s, such as pars plana vitrectomy. Although surgical instrumentation and illumination techniques are continually developing, the operating microscope for vitreoretinal procedures has remained essentially unchanged and currently limits the surgeon's depth perception and assessment of subtle microanatomy. Optical coherence tomography (OCT) has revolutionized clinical management of retinal pathology, and its introduction into ...
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    6. Optical coherence tomography angiography in dural carotid-cavernous sinus fistula

      Optical coherence tomography angiography in dural carotid-cavernous sinus fistula
      Background Recently, applications of optical coherence tomography angiography (OCTA) have been limited to the retina and posterior segment. Although early studies have described its use for other clinical applications, its role in anterior segment vasculature and optic disc imaging has been limited thus far. Case presentation We describe a novel clinical application of OCTA in a patient with dural carotid-cavernous sinus fistula (CCF), which was complicated by increased intra-ocular pressure ...
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    7. Methods and computer program products for quantitative three-dimensional image correction and clinical parameter computation in optical coherence tomography

      Methods and computer program products for quantitative three-dimensional image correction and clinical parameter computation in optical coherence tomography
      Methods and computer program products for quantitative three-dimensional ("3D") image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography ("OCT") dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image ...
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    8. Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging OCT using Different Posterior Boundaries

      Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging OCT using Different Posterior Boundaries
      Purpose To assess the reliability of manual choroidal thickness measurements by comparing different posterior boundary definitions of the choroidal-scleral junction on enhanced depth imaging optical coherence tomography (EDI-OCT). Design Reliability analysis Methods Two graders marked the choroidal-scleral junction with segmentation software using different posterior boundaries: 1) the outer border of the choroidal vessel lumen, 2) the outer border of the choroid stroma, and 3) the inner border of the sclera ...
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    9. Development of Swept Source Optical Coherence Tomography and Adaptive Optics Scanning Laser Ophthalmoscopy: Improved Imaging Speed and Handheld Applications (Thesis)

      Development of Swept Source Optical Coherence Tomography and Adaptive Optics Scanning Laser Ophthalmoscopy: Improved Imaging Speed and Handheld Applications (Thesis)
      Optical coherence tomography (OCT) is a noninvasive three-dimensional interferometric imaging technique capable of achieving micrometer scale resolution. It is now a standard of care in ophthalmology, where it is used to improve the accuracy of early diagnosis, to better understand the source of pathophysiology, and to monitor disease progression and response to therapy. In particular, retinal imaging has been the most prevalent clinical application of OCT, but researchers and companies ...
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      Mentions: Duke University
    10. Postdoctoral Research Fellowship in ophthalmic adaptive optics optical coherence tomography imaging at Duke University

      Postdoctoral Research Fellowship in ophthalmic adaptive optics optical coherence tomography imaging at Duke University
      ...rmat and link to Google Scholar webpage to jizatt@duke.edu and sina.farsiu@duke.edu .

      Immediate opening at Duke University Biomedical Engineering Department for a Postdoctoral Research Associate interested in developm...

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    11. Systems and methods of angle-resolved low coherence interferometry based optical correlation

      Systems and methods of angle-resolved low coherence interferometry based optical correlation
      Systems and methods of angle-resolved low coherence interferometry based optical correlation are disclosed. According to an aspect, a method includes directing a sample beam towards a sample for producing a scattered sample beam from the sample. The method also includes receiving the scattered sample beam at a multitude of scattering angles in at least two directions. Further, the method includes cross-correlating the scattered sample beam with a reference beam to ...
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.

  3. Quotes about Duke University

    1. We are excited to be working with an institution as prestigious as Duke University to advance medical diagnostics.
      In SpectraScience Announces Licensing of Key Technology From Duke University