1. Duke University

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    1. Mentioned In 347 Articles

    2. Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

      Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

      We report the development of a combined confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) instrument (CRS-OCT) capable of measuring analytes in targeted biological tissues with sub-100-micron spatial resolution. The OCT subsystem was used to measure depth-resolved tissue morphology and guide the acquisition of chemically-specific Raman spectra. To demonstrate its utility, the instrument was used to accurately measure depth-resolved, physiologically-relevant concentrations of Tenofovir, a microbicide drug used to prevent the sexual transmission of HIV, in ex vivo tissue samples.

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    3. Functional optical coherence tomography: principles and progress

      Functional optical coherence tomography: principles and progress

      In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the ...

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    4. INTRAOPERATIVE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING AFTER INTERNAL LIMITING MEMBRANE PEELING IN IDIOPATHIC EPIRETINAL MEMBRANE WITH CONNECTING STRANDS

      INTRAOPERATIVE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING AFTER INTERNAL LIMITING MEMBRANE PEELING IN IDIOPATHIC EPIRETINAL MEMBRANE WITH CONNECTING STRANDS

      Purpose: To report the intraoperative optical coherence tomography findings in idiopathic epiretinal membrane (ERM) with connecting strands and to describe the postoperative outcomes. Methods: A retrospective, case series study within a prospective observational intraoperative optical coherence tomography imaging study was performed. Epiretinal membranes with connecting strands were characterized on preoperative spectral domain optical coherence tomography images and assessed against corresponding intraoperative (after internal limiting membrane [ILM] peeling) and postoperative spectral domain optical coherence tomography images. Results: Eleven locations of the connecting strands in 7 eyes were studied. The connecting strands had visible connections from the inner retinal surface to the ...

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    5. Method And System For Improving Aiming During Optical Coherence Tomography On Young Children By Synchronization With Retinal Bifringence Scanning

      Method And System For Improving Aiming During Optical Coherence Tomography On Young Children By Synchronization With Retinal Bifringence Scanning

      The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by synchronization with retinal birefringence scanning (RBS). OCT is performed without knowing whether or not the subject is looking at the intended target.

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    6. Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema

      Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema

      We present a fully automatic algorithm to identify fluid-filled regions and seven retinal layers on spectral domain optical coherence tomography images of eyes with diabetic macular edema (DME). To achieve this, we developed a kernel regression (KR)-based classification method to estimate fluid and retinal layer positions. We then used these classification estimates as a guide to more accurately segment the retinal layer boundaries using our previously described graph theory and dynamic programming (GTDP) framework. We validated our algorithm on 110 Bscans from ten patients with severe DME pathology, showing an overall mean Dice coefficient of 0.78 when comparing ...

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    7. Novel microscope-integrated stereoscopic display for intrasurgical optical coherence tomography

      Novel microscope-integrated stereoscopic display for intrasurgical optical coherence tomography

      The first generation of intrasurgical optical coherence tomography (OCT) systems displayed OCT data onto a separate computer monitor, requiring surgeons to look away from the surgical microscope. In order to provide real-time OCT feedback without requiring surgeons to look away during surgeries, recent prototype research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) systems into the surgical microscopes to allow the surgeons to access the OCT data and the surgical field through the oculars concurrently. However, all current intrasurgical OCT systems with a HUD are only capable of imaging through one ocular limiting the surgeon’s depth perception ...

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    8. IDENTIFICATION OF FLUID ON OPTICAL COHERENCE TOMOGRAPHY BY TREATING OPHTHALMOLOGISTS VERSUS A READING CENTER IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS

      IDENTIFICATION OF FLUID ON OPTICAL COHERENCE TOMOGRAPHY BY TREATING OPHTHALMOLOGISTS VERSUS A READING CENTER IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS

      Purpose: To examine treatment decisions by ophthalmologists versus reading center fluid identification from optical coherence tomography in Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Methods: Fluid in 6,210 optical coherence tomography scans (598 patients) in "as needed treatment" arm of CATT Year 1 was compared with ophthalmologist's treatment: positive fluid agreement (PFA, fluid+, treatment+) and positive fluid discrepancy (PFD, fluid+, treatment-), negative fluid agreement (fluid-, treatment-) and negative fluid discrepancy (fluid-, treatment+). For PFDs, fluid location and visual acuity were characterized. Results: Treatment and reading center fluid determination agreed in 72.1% (53.0% PFA, 19.1 ...

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    9. Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Background: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. Methods: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuro-ophthalmology clinic between November 2010 and October 2011 were reviewed. Excluded were eyes with papilledema with Frisen grade >2, other optic neuropathies or retinopathies, and those that did not have SD-OCT imaging. The remaining 43 patients were split into 2 groups: non-atrophic papilledema and atrophic papilledema. Automated SD-OCT segmentation was performed on patients with non-atrophic papilledema and age-matched controls for each of the 9 regions of the Early Treatment Diabetic Retinopathy ...

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    10. Adaptive Optics Microperimetry and OCT Images Show Preserved Function and Recovery of Cone Visibility in Macular Telangiectasia Type 2 Retinal Lesions

      Adaptive Optics Microperimetry and OCT Images Show Preserved Function and Recovery of Cone Visibility in Macular Telangiectasia Type 2 Retinal Lesions

      Purpose. To evaluate visual function and disease progression in the retinal structural abnormalities of three patients from two unrelated families with macular telangiectasia (MacTel) type 2. Methods. Adaptive optics scanning laser ophthalmoscopy (AOSLO) and AOSLO microperimetry (AOMP) were used to evaluate the structure and function of macular cones in three eyes with MacTel type 2. Cone spacing was estimated using histogram analysis of intercone distances, and registered spectral-domain optical coherence tomography (SD-OCT) scans were used to evaluate retinal anatomy. AOMP was used to assess visual sensitivity in and around areas of apparent cone loss. Results. Although overall lesion surface area ...

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    11. Reproducibility of Optovue RTVue Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Zeiss Stratus Metrics in Diabetic Macular Edema

      Reproducibility of Optovue RTVue Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Zeiss Stratus Metrics in Diabetic Macular Edema
      ...enry Ford Health System, Department of Ophthalmology and Eye Care Services ^5Department of Ophthalmology, Duke University, Durham, NC, USA ^6Department of Ophthalmology, Joslin Diabetes Center, Beetham Eye Inst...
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.