1. Duke University

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    1. Mentioned In 376 Articles

    2. Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography

      Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography
      Intra-operative optical coherence tomography (OCT) requires a display technology which allows surgeons to visualize OCT data without disrupting surgery. Previous research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) systems into surgical microscopes to provide monoscopic viewing of OCT data through one microscope ocular. To take full advantage of our previously reported real-time volumetric microscope-integrated OCT (4D MIOCT) system, we describe a stereoscopic HUD which projects a stereo ...
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    3. Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy

      Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy
      A 57-year-old white woman developed autoimmune retinopathy (AIR) in both eyes associated with bilateral autoimmune sensorineural hearing loss. Laboratory testing was positive for 68kDa (heat-shock protein) and 136kDa (human interstitial retinoid-binding protein). Extensive cancer screening was negative. Spectral-domain optical coherence tomography enhanced depth imaging demonstrated a markedly thickened choroid in both eyes. En face imaging showed a distinctive pattern of granular hyperreflective foveal dots. The concurrent sensorineural hearing loss was ...
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      Mentions: Duke University
    4. Prevalence of vitreomacular adhesion: an optical coherence tomography analysis in the retina clinic setting

      Prevalence of vitreomacular adhesion: an optical coherence tomography analysis in the retina clinic setting
      Purpose: The aims of this study were to determine the prevalence of vitreomacular adhesion (VMA) in a random sample of clinical patients at three US retina clinics and to assess comorbid retinal conditions, ocular diseases, prior treatment history, and other medical histories. Patients and methods: This observational, retrospective cohort study was based on patients from the Doheny Eye Centers, Duke Eye Center, and Tufts Medical Center who received a bilateral ...
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    5. Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography
      Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ . However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which ...
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    6. 4D microscope-integrated OCT improves accuracy of ophthalmic surgical maneuvers

      4D microscope-integrated OCT improves accuracy of ophthalmic surgical maneuvers
      Ophthalmic surgeons manipulate micron-scale tissues using stereopsis through an operating microscope and instrument shadowing for depth perception. While ophthalmic microsurgery has benefitted from rapid advances in instrumentation and techniques, the basic principles of the stereo operating microscope have not changed since the 1930s. Optical Coherence Tomography (OCT) has revolutionized ophthalmic imaging and is now the gold standard for preoperative and postoperative evaluation of most retinal and many corneal procedures. We ...
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    7. Systems and methods for complex conjugate artifact resolved optical coherence tomography

      Systems and methods for complex conjugate artifact resolved optical coherence tomography
      Systems and methods are disclosed for optical coherence tomography (OCT). For example, imaging can use optical phase modulators based on optical delay lines that, in conjunction with a swept-source laser, can be used to achieve heterodyne swept source optical coherence tomography (SSOCT). These techniques resolve the complex conjugate ambiguity in SSOCT, thereby doubling the usable imaging range. This increased imaging range has numerous important clinical applications in ophthalmology, cardiology and ...
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    8. At Duke, sibling sleuths try to unlock mummy mystery

      At Duke, sibling sleuths try to unlock mummy mystery
      Mike Toth is trying to make mummies talk. In ancient Egypt, middle-class dead were mummified with a mask made of papyrus scraps papyrus mch, he calls it and finished off with layers of primer and paint. Toth hopes to look under those layers and see if these reused papyrus scraps have text on them. The laws of physics are against us, he said. We have to penetrate these layers paint ...
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    9. Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry

      Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution may relate to scattering information about a sample, and temporal ...
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    10. Wide field of view swept-source optical coherence tomography for peripheral retinal disease

      Wide field of view swept-source optical coherence tomography for peripheral retinal disease
      Background/aims To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. Methods A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-source laser and a custom sample arm consisting of two indirect ophthalmic lenses. Twenty-seven subjects with peripheral lesions (choroidal melanomas, choroidal naevi, sclerochoroidal calcification, retinitis pigmentosa, diabetic retinopathy, retinoschisis and uveitis) were imaged with ...
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    11. Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography

      Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography
      Stimulated Raman scattering (SRS) enables fast, high resolution imaging of chemical constituents important to biological structures and functional processes, both in a label-free manner and using exogenous biomarkers. While this technology has shown remarkable potential, it is currently limited to point scanning and can only probe a few Raman bands at a time (most often, only one). In this work we take a fundamentally different approach to detecting the small ...
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    12. MACULAR PSEUDO-HOLE IN SHAKEN BABY SYNDROME: UNDERSCORING THE UTILITY OF OPTICAL COHERENCE TOMOGRAPHY UNDER ANESTHESIA

      MACULAR PSEUDO-HOLE IN SHAKEN BABY SYNDROME: UNDERSCORING THE UTILITY OF OPTICAL COHERENCE TOMOGRAPHY UNDER ANESTHESIA
      Purpose: To describe a case of vitrectomy for nonclearing vitreous hemorrhage in shaken baby syndrome and the utility of intraoperative hand-held optical coherence tomography to distinguish a macular hole from a pseudo-hole. Methods: Case report of a 4-month-old girl. Results: After clearing of media opacity by vitrectomy, an apparent macular hole was seen with the operating microscope. However, this was shown to be only a pseudo-hole by intraoperative hand-held optical ...
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.