1. Duke University

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    1. Mentioned In 591 Articles

    2. Deep learning-based classification and segmentation of retinal cavitations on optical coherence tomography images of macular telangiectasia type 2

      Deep learning-based classification and segmentation of retinal cavitations on optical coherence tomography images of macular telangiectasia type 2
      Aim: To develop a fully automatic algorithm to segment retinal cavitations on optical coherence tomography (OCT) images of macular telangiectasia type 2 (MacTel2). Methods: The dataset consisted of 99 eyes from 67 participants enrolled in an international, multicentre, phase 2 MacTel2 clinical trial ( NCT01949324 ). Each eye was imaged with spectral-domain OCT at three time points over 2 years. Retinal cavitations were manually segmented by a trained Reader and the retinal ...
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    3. Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials
      Purpose To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-VEGF through pixel-mapping analysis of baseline OCT. Design Cross-sectional analysis. Setting Multicenter clinical trial. Patient population 68 eyes from the Comparison of Age-Related Macular Degeneration Treatments Trials. Intervention Treatment with anti-VEGF agents. Main outcome measure The percentage of MA or FS pixels with each OCT feature at baseline, and the odds ratio (OR ...
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    4. Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System

      Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System
      Purpose : To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods : Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thickness on OCT scans of the right eye of 10 healthy adults. Three OCT systems were used: handheld Leica Envisu, investigational handheld swept-source OCT (UC3), and Heidelberg Spectralis ...
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    5. Farsiu Named Fellow of the Optical Society

      Farsiu Named Fellow of the Optical Society
      Sina Farsiu, the Paul Ruffin Scarborough Distinguished Associate Professor of Engineering, has been named a Fellow of the Optical Society of America (OSA). Farsiu was cited for his outstanding contributions to optical image processing and biophotonics. Farsiu is the director of the Vision and Image Processing Laboratory in Dukes Departments of Biomedical Engineering and Ophthalmology, where he has been instrumental in introducing modern image processing and computation methods into the ...
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    6. Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults

      Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults
      Purpose: This work assesses the intrasession repeatability of capillary perfusion density (CPD) and capillary flux index (CFI) measurements on peripapillary optical coherence tomography angiography (OCTA) in healthy eyes of older adults. Methods: In this cross-sectional study, healthy volunteers aged 50 years or older underwent 4.5 4.5 mm OCTA imaging centered on the optic nerve head using Zeiss Cirrus HD-5000 AngioPlex (Carl Zeiss Meditec). Two consecutive images were acquired ...
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    7. Macular Optical Coherence Tomography Characteristics at 36 weeks Postmenstrual Age in Infants Examined for Retinopathy of Prematurity

      Macular Optical Coherence Tomography Characteristics at 36 weeks Postmenstrual Age in Infants Examined for Retinopathy of Prematurity
      Objective To report our ability to capture, grade reliably and analyze bedside macular optical coherence tomography (OCT) images from preterm infants and relate OCT findings to biological factors and retinopathy of prematurity (ROP) status at a single time window in the STudy of Eye imaging in Preterm infantS (BabySTEPS). Design Prospective observational study Participants Preterm infants eligible for ROP screening, with parental consent for research and a 361 weeks postmenstrual ...
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    8. A Review of Deep Learning for Screening, Diagnosis, and Detection of Glaucoma Progression

      A Review of Deep Learning for Screening, Diagnosis, and Detection of Glaucoma Progression
      Because of recent advances in computing technology and the availability of large datasets, deep learning has risen to the forefront of artificial intelligence, with performances that often equal, or sometimes even exceed, those of human subjects on a variety of tasks, especially those related to image classification and pattern recognition. As one of the medical fields that is highly dependent on ancillary imaging tests, ophthalmology has been in a prime ...
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    9. Artificial Intelligence Mapping of Structure to Function in Glaucoma

      Artificial Intelligence Mapping of Structure to Function in Glaucoma
      Purpose : To develop an artificial intelligence (AI)based structure-function (SF) map relating retinal nerve fiber layer (RNFL) damage on spectral domain optical coherence tomography (SDOCT) to functional loss on standard automated perimetry (SAP). Methods : The study included 26,499 pairs of SAP and SDOCT from 15,173 eyes of 8878 patients with glaucoma or suspected of having the disease extracted from the Duke Glaucoma Registry. The data set was randomly ...
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    10. Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

      Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity
      Abstract Purpose : To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (ROP). Methods : In this exploratory study, we selected images from eyes with a range of ROP vascular disease, prospectively acquired from preterm infants using an investigational, noncontact, handheld, bedside swept-source OCT ...
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    11. Clustering Spectral-Domain Optical Coherence Tomography Images using a Deep Variational Auto-encoder

      Clustering Spectral-Domain Optical Coherence Tomography Images using a Deep Variational Auto-encoder
      Purpose : To learn a low-dimensional representation of spectral-domain optical coherence tomography (SD OCT) peripapillary images that can be used to classify images into glaucoma versus healthy eyes. Methods : The study included 23,992 Spectralis SD OCT images from 1,336 eyes, of which 30% were healthy and the remaining were glaucoma or glaucoma suspects. The definition of groups was based on visual fields and inspection of the optic nerve. In ...
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      Mentions: Duke University
    12. Lightweight Learning-based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images

      Lightweight Learning-based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images
      Purpose Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available to measure the volume of therapeutics successfully administered to the subretinal location during surgery. Here we introduce the first automatic method for quantifying the volume of subretinal blebs, using porcine eyes injected with ...
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    13. Robotics and Virtual Reality for Optical Coherence Tomography-Guided Ophthalmic Surgery and Diagnostics (Thesis)

      Robotics and Virtual Reality for Optical Coherence Tomography-Guided Ophthalmic Surgery and Diagnostics (Thesis)
      Ophthalmology is the only surgical specialty that routinely employs both microsurgical techniques and live intraoperative imaging, especially optical coherence tomography (OCT). Consequently, ophthalmic surgeons routinely face challenges in visualization and manipulation of small ocular tissues or in interpreting intraoperative imaging to guide their actions. This dissertation therefore seeks to advance the state-of-the-art in ophthalmic surgery with regards to manipulation, visualization, and interpretation. First, we address the interpretation challenge in ophthalmic ...
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    14. A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma

      A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma
      Purpose To compare retinal nerve fiber layer thickness (RNFLT) and Bruchs membrane opening (BMO) minimum rim width (MRW) measured by spectral-domain (SD) OCT for diagnosing glaucoma in those suspected of having the disease. Design Observational cohort study. Participants One hundred thirteen eyes from 81 patients suspected of having glaucoma based on optic nerve appearance. Methods Participants were imaged using SD OCT, and RNFLT and BMO MRW were measured. All participants ...
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    15. Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients

      Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients
      Handheld optical coherence tomography (OCT) makes it possible to acquire intraoperative and clinical imaging in infants and children for whom standard OCT is not possible. In patients with a retinal pathology who are left aphakic after surgery, however, image clarity is affected by insufficient refractive correction with handheld OCT. We describe a technique for supplementing the refractive power of the handheld OCT device with an aphakic contact lens to improve ...
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    16. 1-15 of 591 1 2 3 4 ... 38 39 40 »
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  2. About Duke University

    Duke University

    Duke University is a private research university located in Durham, North Carolina, USA. Duke University Medical CenterFor more than 75 years, our community of scholars and students has been devoted to understanding the causes, prevention and treatment of human disease. Duke University Eye Center is part of the Medical School.  Duke University's Pratt School of Engineering established The Fitzpatrick Center for Photonics and Communications Systems in December 2000 to help turn North Carolina into a "photon forest" where research and development in photonics would create the kind of technological advance and economic growth found in California's Silicon Valley.

  3. Quotes about Duke University

    1. We are excited to be working with an institution as prestigious as Duke University to advance medical diagnostics.
      In SpectraScience Announces Licensing of Key Technology From Duke University