1. Dresden University of Technology

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    1. Mentioned In 114 Articles

    2. Three-dimensional simultaneous optical coherence tomography and confocal fluorescence microscopy for investigation of lung tissue

      Three-dimensional simultaneous optical coherence tomography and confocal fluorescence microscopy for investigation of lung tissue
      Although several strategies exist for a minimal-invasive treatment of patients with lung failure, the mortality rate of acute respiratory distress syndrome still reaches 30% at minimum. This striking number indicates the necessity of understanding lung dynamics on an alveolar level. To investigate the dynamical behavior on a microscale, we used three-dimensional geometrical and functional imaging to observe tissue parameters including alveolar size and length of embedded elastic fibers during ventilation ...
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    3. Feature Of The Week 5/20/12: Dresden University of Technology Investigates Precision Lung Dynamics Using Four-Dimensional OCT

      Feature Of The Week 5/20/12: Dresden University of Technology Investigates Precision Lung Dynamics Using Four-Dimensional OCT
      ...olar tissue dynamics in animal models.For more information see recent Article. Courtesy Lars Kirsten from the Dresden University of Technology. The treatment of urgent lung diseases, such as the acute respiratory distres...
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    4. Endoscopic optical coherence tomography device for forward imaging with broad field of view

      Endoscopic optical coherence tomography device for forward imaging with broad field of view
      One current challenge of studying human tympanic membranes (TM) with optical coherence tomography (OCT) is the implementation of optics that avoid direct contact with the inflamed tissue. At the moment, no commercial device is available. We report an optics design for contactless forward imaging endoscopic optical coherence tomography (EOCT) with a large working distance (WD) and a broad field of view (FOV) by restricting the overall diameter of the probe ...
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    5. Four-dimensional imaging of murine subpleural alveoli using high-speed optical coherence tomography

      Four-dimensional imaging of murine subpleural alveoli using high-speed optical coherence tomography
      The investigation of lung dynamics on alveolar scale is crucial for the understanding and treatment of lung diseases, such as acute lung injury and ventilator induced lung injury, and to promote the development of protective ventilation strategies. One approach to this is the establishment of numerical simulations of lung tissue mechanics where detailed knowledge about three-dimensional alveolar structure changes during the ventilation cycle is required. We suggest four-dimensional optical coherence ...
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    6. Multimodal imaging of lung tissue using optical coherence tomography and two photon microscopy

      Multimodal imaging of lung tissue using optical coherence tomography and two photon microscopy
      In the context of protective artificial ventilation strategies for patients with severe lung diseases, the contribution of ventilator settings to tissue changes on the alveolar level of the lung is still a question under debate. To understand the impact of respiratory settings as well as the dynamic process of respiration, high-resolution monitoring and visualization of the dynamics of lung alveoli are essential. An instrument allowing 3D imaging of lung tissue ...
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    7. Quantitative investigation of alveolar structures with OCT using total liquid ventilation during mechanical ventilation

      Quantitative investigation of alveolar structures with OCT using total liquid ventilation during mechanical ventilation
      To develop new treatment possibilities for patients with severe lung diseases it is crucial to understand the lung function on an alveolar level. Optical coherence tomography (OCT) in combination with intravital microscopy (IVM) are used for imaging subpleural alveoli in animal models to gain information about dynamic and morphological changes of lung tissue during mechanical ventilation. The image content suitable for further analysis is influenced by image artifacts caused by ...
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    8. Shear flow-induced optical inhomogeneity of blood assessed in vivo and in vitro by spectral domain optical coherence tomography in the 1.3 um wavelength range

      Shear flow-induced optical inhomogeneity of blood assessed in vivo and in vitro by spectral domain optical coherence tomography in the 1.3 um wavelength range
      The optical inhomogeneity of flowing blood, which appears as a waisted double fan-shaped intensity pattern inside vessels in cross-sectional optical coherence tomography (OCT) images, was investigated for the first time. High resolution spectral domain OCT in the 1.3 m wavelength region is used to assess this inhomogeneous intravascular backscattering of light in an in vivo mouse model and flow phantom measurements. Based on a predicted alignment of the red ...
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    9. Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography

      Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography
      Topical corticosteroids are widely used to treat atopic dermatitis (AD), but their anti-inflammatory mode of action can be accompanied by several unwanted side effects including skin atrophy and telangiectasia. In this 8-week, investigator-blinded, intraindividual right-left comparison study with patients with mild-to-moderate AD, hydrocortisone 1% cream (HCT) was applied twice daily for 4 weeks on one side of forehead skin without clinical signs of AD and pimecrolimus 1% cream (PIM) on ...
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    10. 1st International Symposium on Optical Coherence Tomography at Ilmenau University of Technology, Germany, 13th September 2011

      1st International Symposium on Optical Coherence Tomography at Ilmenau University of Technology, Germany, 13th September 2011
      The possible applications for OCT (optical coherence tomography) have grown tremendously in recent years because of such technical innovations as stable broadband light sources. In this context we at the Biomedical Engineering Department at Ilmenau University of Technology are investigating new applications of OCT for medical diagnostics. With the symposium it is our intention to do two things for biomedical engineers and for scientists in optics: to give them the ...
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    11. Investigation of alveolar tissue deformations using OCT combined with fluorescence microscopy

      Investigation of alveolar tissue deformations using OCT combined with fluorescence microscopy
      In critical care medicine, artificial ventilation is a life saving tool providing sufficient blood oxygenation to patients suffering from respiratory failure. Essential for their survival is the use of protective ventilation strategies to prevent further lung damage due to ventilator induced lung injury (VILI). Since there is only little known about implications of lung tissue overdistension on the alveolar level, especially in the case of diseased lungs, this research deals ...
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    12. Improved OCT imaging of lung tissue using a prototype for total liquid ventilation

      Improved OCT imaging of lung tissue using a prototype for total liquid ventilation
      Optical coherence tomography (OCT) is used for imaging subpleural alveoli in animal models to gain information about dynamic and morphological changes of lung tissue during mechanical ventilation. The quality of OCT images can be increased if the refraction index inside the alveoli is matched to the one of tissue via liquid-filling. Thereby, scattering loss can be decreased and higher penetration depth and tissue contrast can be achieved. Until now, images ...
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    13. Enhanced joint spectral and time domain optical coherence tomography for quantitative flow velocity measurement

      Enhanced joint spectral and time domain optical coherence tomography for quantitative flow velocity measurement
      Recently, a new method called joint spectral and time domain optical coherence tomography (STdOCT) for flow velocity measurement in spectral domain OCT (SD OCT) was presented. This method analyzes the detected timeresolved interference fringe spectra by using a two-dimensional fast Fourier transformation (2D FFT) to determine directly the Doppler frequency shift instead of calculating the phase difference at each depth position of adjacent A-scans. There, it was found that STdOCT ...
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    14. Axial resolution improvement by spectral data fusion in simultaneous dual-band optical coherence tomography

      Axial resolution improvement by spectral data fusion in simultaneous dual-band optical coherence tomography
      A method for axial resolution improvement by adequate spectral data fusion of two parallel acquired disjunct wavelength bands in the 0.8 m and 1.3 m region in the field of simultaneous dual-band optical coherence tomography (OCT) is presented. The applied spectral domain dual-band OCT system is illuminated by a supercontinuum laser light source and allows simultaneous imaging at 800 nm and 1250 nm with free-space axial resolutions better ...
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    15. Optical coherence tomography for imaging of subpleural alveolar structure using a Fourier domain mode locked laser

      Optical coherence tomography for imaging of subpleural alveolar structure using a Fourier domain mode locked laser
      Optical coherence tomography (OCT) is a noninvasive imaging modality generating cross sectional and volumetric images of translucent samples. In Fourier domain OCT (FD OCT), the depth profile is calculated by a fast Fourier transformation of the interference spectrum, providing speed and SNR advantage and thus making FD OCT well suitable in biomedical applications. The interference spectrum can be acquired spectrally resolved in spectral domain OCT or time-resolved in optical frequency ...
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    16. 61-75 of 114 « 1 2 3 4 5 6 7 8 »
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  2. About Dresden University of Technology

    Dresden University of Technology

    Dresden University of Technology (Technische Universität Dresde) is the largest institute of higher education in the city of Dresden, the largest university in Saxony and one of the 10 largest universities in Germany with 34,993 students as of 2006. The name Technische Universität Dresden has only been used since 1961; the history of the university, however, goes back nearly 200 years to 1828. This makes it one of the oldest colleges of technology in Germany, and one of the country’s oldest Universitäten, which in German today refers to institutes of higher education which cover the entire curriculum. The university is member of TU 9, a consortium of the nine leading German Institutes of Technology. 

    Also see Clinical Sensoring and Monitoring Research Group at TU Dresden