1. Dresden University of Technology

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    1. Mentioned In 95 Articles

    2. Advanced analysis of domain walls in Mg doped LiNbO3 crystals with high resolution OCT

      Advanced analysis of domain walls in Mg doped LiNbO3 crystals with high resolution OCT
      The structure of domain walls (DW) in ferroelectric media is of great interest as this material is used for frequency doublers and other applications. We show that the structure of the DWs can nicely be visualized by high resolution optical coherence tomography (OCT). While the high group refractive index of lithium niobate allows a resolution much better than 1 m, the large dispersion can blur the image and has to ...
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    3. Improved Imaging of Magnetically Labeled Cells Using Rotational Magnetomotive Optical Coherence Tomography

      Improved Imaging of Magnetically Labeled Cells Using Rotational Magnetomotive Optical Coherence Tomography
      Abstract In this paper, we present a reliable and robust method for magnetomotive optical coherence tomography (MM-OCT) imaging of single cells labeled with iron oxide particles. This method employs modulated longitudinal and transverse magnetic fields to evoke alignment and rotation of anisotropic magnetic structures in the sample volume. Experimental evidence suggests that magnetic particles assemble themselves in elongated chains when exposed to a permanent magnetic field. Magnetomotion in the intracellular ...
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    4. Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain

      Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain
      In spectral domain optical coherence tomography (SD-OCT), any transverse motion component of a detected obliquely moving sample results in a nonlinear relationship between the Doppler phase shift and the axial sample velocity restricting phase-resolved Doppler OCT (PR-DOCT). The size of the deviation from the linear relation depends on the amount of the transverse velocity component, given by the Doppler angle, and the height of the absolute sample velocity. Especially for ...
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    5. Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats

      Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats
      Though artificial ventilation is an essential life-saving treatment, the mechanical behavior of lung tissue at the alveolar level is still unknown. Therefore, we need to understand the tissue response during artificial ventilation at this microscale in order to develop new and more protective ventilation methods. Optical coherence tomography (OCT) combined with intravital microscopy (IVM) is a promising tool for visualizing lung tissue dynamics with a high spatial and temporal resolution ...
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    6. Enamel Thickness before and after Orthodontic Treatment Analysed in Optical Coherence Tomography

      Enamel Thickness before and after Orthodontic Treatment Analysed in Optical Coherence Tomography
      Despite the continuous development of materials and techniques of adhesive bonding, the basic procedure remains relatively constant. The technique is based on three components: etching substance, adhesive system, and composite material. The use of etchants during bonding orthodontic brackets carries the risk of damage to the enamel. Therefore, the article examines the effect of the manner of enamel etching on its thickness before and after orthodontic treatment. The study was ...
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    7. Impact of a detector dead time in phase-resolved Doppler analysis using spectral domain optical coherence tomography

      Impact of a detector dead time in phase-resolved Doppler analysis using spectral domain optical coherence tomography
      For any oblique sample movement containing a transverse velocity component, the commonly used linear relationship between the phase shift and the axial velocity component is erroneous for spectrometer-based optical coherence tomography (spectral domain OCT, SD-OCT). We recently proposed a new Doppler model that assumes a continuous integration of the photocurrent. In this research, we extend the model for detectors with a shutter control by taking detector dead time into account ...
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    8. Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear

      Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear
      The treatment of otitis media requires classifying the effusion in the tympanic cavity for choosing appropriate therapeutic strategies. Otoscopic examination of the middle ear depends on the expertise of the physician and is often hampered in case of inflammatory alterations of the tympanic membrane. In otologic research, optical coherence tomography is an innovative non-invasive imaging technique utilized for visualizing the tympanic membrane. This ex vivo study presents the possibility of ...
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    9. PhD Student Position in Optical Coherence Tomography in Biomedical Research at the TU Dresden, Germany

      PhD Student Position in Optical Coherence Tomography in Biomedical Research at the TU Dresden, Germany
      Within the scope of the junior research group Optical Technologies in Medicine, new methods in optical imaging are transferred into medical and clinical application. The research is focused on optical coherence tomography and other optical methods for the diagnosis of different diseases. The PHD student will join a group of medical scientists, engineers, information and natural scientists. Requirements You hold, or to be about to receive before starting the contract ...
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    10. Improved non-invasive Optical Coherence Tomography detection of different engineered nanoparticles in food-mimicking matrices

      Improved non-invasive Optical Coherence Tomography detection of different engineered nanoparticles in food-mimicking matrices
      Food industry and regulators require fast and reliable analytical methods for quality control. This especially counts for the detection of engineered nanomaterials (ENMs) in food products. Respective EU regulation is in force, but the development of appropriate methods is still underway. This paper updates the scope of Optical Coherence Tomography (OCT) for ENM/food matrix analysis. A range of nanomaterials and composites Au@SiO 2 , Ag, Ag@SiO 2 and ...
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    11. NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

      NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice
      Aims Endothelial dysfunction is an early step in the development of atherosclerosis. Increased formation of superoxide anions by NADPH oxidase Nox1, 2, and 5 reduces nitric oxide availability and can promote endothelial dysfunction. In contrast, recent evidence supports a vasoprotective role of H 2 O 2 produced by main endothelial isoform Nox4. Therefore, we analysed the impact of genetic deletion of Nox4 on endothelial dysfunction and atherosclerosis in the low-density ...
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    12. Imaging of aortic valve dynamics in 4D OCT New insights into murine aortic valve diseases

      Imaging of aortic valve dynamics in 4D OCT  New insights into murine aortic valve diseases
      The mechanical components of the heart, especially the valves and leaflets, are enormous stressed during lifetime. Therefore, those structures undergo different pathophysiological tissue transformations which affect cardiac output and in consequence living comfort of affected patients. These changes may lead to calcific aortic valve stenosis (AVS), the major heart valve disease in humans. The knowledge about changes of the dynamic behaviour during the course of this disease and the possibility ...
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    13. Optimal processing of Doppler signals in OCT

      Optimal processing of Doppler signals in OCT
      Besides structural imaging, OCT can be used to estimate axial velocities of the sample resolved in depth by Doppler processing. In Fourier domain OCT (FD-OCT), this is accomplished by measuring the phase difference (i.e. phase shift) between timely separated A-scans at the same depth. In most cases, these data are disturbed by noise caused by intrinsic noise of the OCT system, specified by the SNR, and decorrelation noise caused ...
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    14. Imaging the tympanic membrane oscillation ex vivo with Doppler optical coherence tomography during simulated Eustachian catarrh

      Imaging the tympanic membrane oscillation ex vivo with Doppler optical coherence tomography during simulated Eustachian catarrh
      Recently, optical coherence tomography (OCT) was utilized in multiple studies for structural and functional imaging of the middle ear and the tympanic membrane. Since Doppler OCT allows both, the spatially resolved measurement of the tympanic membrane oscillation and high-resolution imaging, it is regarded as a promising tool for future in vivo applications. In this study, Doppler OCT is utilized for the visualization of the tympanic membrane oscillation in temporal bones ...
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    15. 4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo

      4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo
      The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain during lifetime. Like all highly stressed materials, also these biological components undergo fatigue and signs of wear, which impinge upon cardiac output and in the end on health and living comfort of affected patients. Thereby pathophysiological changes of the aortic valve leading to calcific aortic valve stenosis (AVS) as most frequent heart valve disease ...
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    16. Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy

      Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy
      Cell transplantation and stem cell therapy are promising approaches for regenerative medicine and are of interest to researchers and clinicians worldwide. However, currently, no imaging technique that allows three-dimensional in vivo inspection of therapeutically administered cells in host tissues is available. Therefore, we investigate magnetomotive optical coherence tomography (MM-OCT) of cells labeled with magnetic particles as a potential noninvasive cell tracking method. We develop magnetomotive imaging of mesenchymal stem cells ...
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  2. About Dresden University of Technology

    Dresden University of Technology

    Dresden University of Technology (Technische Universität Dresde) is the largest institute of higher education in the city of Dresden, the largest university in Saxony and one of the 10 largest universities in Germany with 34,993 students as of 2006. The name Technische Universität Dresden has only been used since 1961; the history of the university, however, goes back nearly 200 years to 1828. This makes it one of the oldest colleges of technology in Germany, and one of the country’s oldest Universitäten, which in German today refers to institutes of higher education which cover the entire curriculum. The university is member of TU 9, a consortium of the nine leading German Institutes of Technology. 

    Also see Clinical Sensoring and Monitoring Research Group at TU Dresden