1. Donald T. Miller

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    1. Mentioned In 47 Articles

    2. Method to investigate temporal dynamics of ganglion and other retinal cells in the living human eye

      Method to investigate temporal dynamics of ganglion and other retinal cells in the living human eye
      The inner retina is critical for visual processing, but much remains unknown about its neural circuitry and vulnerability to disease. A major bottleneck has been our inability to observe the structure and function of the cells composing these retinal layers in the living human eye. Here, we present a noninvasive method to observe both structural and functional information. Adaptive optics optical coherence tomography (AO-OCT) is used to resolve the inner ...
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    3. Measuring polarization changes in the human outer retina with polarization‐sensitive optical coherence tomography

      Measuring polarization changes in the human outer retina with polarization‐sensitive optical coherence tomography
      Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age‐related macular degeneration. However, earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization‐altering properties. To test this hypothesis, we developed a method based on polarization‐sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (25years) and 10 ...
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    4. Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography

      Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography
      Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (25 yr) and 10 older (54 ...
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    5. Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]

      Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]
      Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human ...
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    6. Indiana University Receives NIH Grant for Imaging Structure and Function of the Photoreceptor-RPE-Choriocapillaris Complex

      Indiana University Receives NIH Grant for Imaging Structure and Function of the Photoreceptor-RPE-Choriocapillaris Complex
      Indiana University Receives a 2017 NIH Grant for $461,610 for Imaging Structure and Function of the Photoreceptor-RPE-Choriocapillaris Complex. The principal investigator is Donald Miller. The program began in 2007 and ends in 2021. Below is a summary of the proposed work. Human vision starts when photoreceptors collect and respond to light. Photoreceptors do not function in isolation though, but share close interdependence with neighboring photoreceptors, retinal pigment epithelium (RPE ...
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    7. Tracking dynamics of photoreceptor disc shedding with adaptive optics-optical coherence tomography

      Tracking dynamics of photoreceptor disc shedding with adaptive optics-optical coherence tomography
      Absorption of light by photoreceptors initiates vision, but also leads to accumulation of toxic photo-oxidative compounds in the photoreceptor outer segment (OS). To prevent this buildup, small packets of OS discs are periodically pruned from the distal end of the OS, a process called disc shedding. Unfortunately dysfunction in any part of the shedding event can lead to photoreceptor and RPE dystrophy, and has been implicated in numerous retinal diseases ...
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    8. Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris [Invited]

      Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris [Invited]
      Histological studies have shown that morphometric changes at the microscopic level of choriocapillaris (CC) occur with aging and disease onset, and therefore may be sensitive biomarkers of outer retinal health. However, visualizing CC at this level in the living human eye is challenging because its microvascular is tightly interconnected and weakly reflecting. In this study, we address these challenges by developing and validating a method based on adaptive optics optical ...
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    9. Photoreceptor disc shedding in the living human eye

      Photoreceptor disc shedding in the living human eye
      Cone photoreceptors undergo a daily cycle of renewal and shedding of membranous discs in their outer segments (OS), the portion responsible for light capture. These physiological processes are fundamental to maintaining photoreceptor health, and their dysfunction is associated with numerous retinal diseases. While both processes have been extensively studied in animal models and postmortem eyes, little is known about them in the living eye, in particular human. In this study ...
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    10. A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

      A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future
      Purpose : Optical coherence tomography (OCT) has enabled virtual biopsy of the living human retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here, we review work done over the last 15 years to ...
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    11. Postdoctoral Fellow Position at the Advanced Ophthalmic Imaging Laboratory at Indian Universitiy

      Postdoctoral Fellow Position at the Advanced Ophthalmic Imaging Laboratory at Indian Universitiy
      The Advanced Ophthalmic Imaging Laboratory at Indiana University is looking to fill a postdoctoral fellow or research associateposition. The successful candidate will join a team of scientists and engineers that are developing the next-generation adaptive opticsoptical coherence tomography (AO-OCT) system for studying structure and function of the living human retina at the cellular level. The system will open up exciting new directions to study both normal and pathological vision. The ...
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    12. Imaging human retinal pigment epithelium cells using adaptive optics optical coherence tomography

      Imaging human retinal pigment epithelium cells using adaptive optics optical coherence tomography
      Retinal pigment epithelium (RPE) cells are vital to health of the outer retina, but are often compromised in ageing and major ocular diseases that lead to blindness. Early manifestation of RPE disruption occurs at the cellular level, and while biomarkers at this scale hold considerable promise, RPE cells have proven extremely challenging to image in the living human eye. We present a novel method based on optical coherence tomography (OCT ...
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    13. 1-15 of 47 1 2 3 »
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  2. About Donald T. Miller

    Donald T. Miller

    Donald Miller earned a B.S. in applied physics from Xavier University and a Ph.D. in optics from University of Rochester. This was followed by a National Research Council Research Associate position at Wright-Patterson Air Force Base in Dayton, Ohio. He joined the faculty at Indiana University School of Optometry in 1998 and currently holds the rank of Professor. Miller’s research focuses on the application of optical engineering and biomedical optics to the human eye. His group has pioneered the development of high-resolution optical systems for imaging the back of the eye based on the combined technologies of adaptive optics (AO) and optical coherence tomography (OCT). The cameras have opened a new window of opportunity to probe, noninvasively, the structure and function of the living retina at the cellular level in normal and diseased eyes in ways that have been traditionally limited to histology. He received a R&D; 100 Award for development of a MEMS-based Adaptive Optics Optical Coherence Tomography instrument in collaboration with colleagues at UC-Davis and Lawrence Livermore National Laboratory. Miller is actively involved in numerous optics and eye-related professional societies. He has chaired the OSA Adaptive Optics Topical Meeting three times and regularly serves on the program committee of the SPIE Ophthalmic Technologies Conference. He is a Fellow of OSA and SPIE.