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    1. Mentioned In 42 Articles

    2. Optical Coherence Tomography Segmentation Errors of the Retinal Nerve Fiber Layer Persist Over Time

      Optical Coherence Tomography Segmentation Errors of the Retinal Nerve Fiber Layer Persist Over Time
      Prcis: There are errors in automated segmentation of the retinal nerve fiber layer in glaucoma suspects or patients with mild glaucoma that appear to persist over time; however, automated segmentation has greater repeatability than manual segmentation. Purpose: To identify whether optical coherence tomography (OCT) segmentation errors in retinal nerve fiber layer (RNFL) thickness measurements persist longitudinally. Methods: This was a cohort study. We used spectral domain OCT (Spectralis, Heidelberg Engineering ...
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    3. Emanuel Hospital and Health Center Receives NIH Grant for IOP-Related Force and Failure in the Optical Nerve Head

      Emanuel Hospital and Health Center Receives NIH Grant for IOP-Related Force and Failure in the Optical Nerve Head
      Emanuel Hospital and Health Center Receives a 2019 NIH Grant for $579,552 for IOP-Related Force and Failure in the Optical Nerve Head. The principal investigator is Claude Burgoyne. The program began in 2098 and ends in 2021. Below is a summary of the proposed work. In the previous project period we completed our 3D histomorphometric characterization of connective tissue deformation and remodeling in early through end-stage monkey experimental glaucoma ...
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    4. Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

      Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study
      Purpose : To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods : A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal ...
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    5. Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.
      Purpose To assess glaucoma specialists detection of optic nerve head (ONH) rim tissue that is thin by optical coherence tomography (OCT) criteria. Design Reliability analysis Methods 5 clinicians marked the disc margin (DM) and rim margin (RM) on stereo-photos of 151 glaucoma or glaucoma suspect eyes obtained within 3 months of OCT imaging. The photo and OCT infrared image for each eye were colocalized and regionalized into twelve sectors relative ...
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    6. Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma

      Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma
      Clinical examination of the optic disc is a fundamental component of any ophthalmic evaluation, but it is especially important for diagnosis and management of glaucoma. The purpose of this article is to: (1) review the limitations inherent to clinical examination; (2) outline the rationale for adopting into clinical practice quantitative measures of the optic nerve head neuro‐retinal rim tissue integrity derived from current optical coherence tomography imaging approaches; (3 ...
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    7. A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease

      A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease
      Purpose : To compare morphologic changes on en face images derived from wide-field swept-source optical coherence tomography (ssOCT) to hypo- and hyperautofluorescent (hypoAF, hyperAF) areas on short-wavelength autofluorescence (SW-AF), and near-infrared (NIR)-AF in recessive Stargardt disease (STGD1). Methods : Wide-field ssOCT cube scans were obtained from 16 patients (16 eyes). Averaged B-scans and SW-AF images were obtained using Spectralis HRA+OCT. NIR-AF images were obtained from 6 eyes. The inner/outer ...
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    8. Emanuel Hospital and Health Center Receives NIH Grant for Optic Nerve Head SD-OCT Imaging in Glaucoma

      Emanuel Hospital and Health Center Receives NIH Grant  for Optic Nerve Head SD-OCT Imaging in Glaucoma
      Emanuel Hospital and Health Center Receives a 2017 NIH Grant for $507,846 for Optic Nerve Head SD-OCT Imaging in Glaucoma. The principal investigator is Claude Burgoyne. The program began in 2010 and ends in 2019. Below is a summary of the proposed work. As a result of discoveries made during the first project period, we propose a paradigm change for clinical assessment of the Optic Nerve Head (ONH), peripapillary ...
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    9. Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma

      Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma
      Purpose To characterize the error of optical coherence tomography (OCT) measurements of retinal nerve fiber layer (RNFL) thickness when using automated retinal layer segmentation algorithms without manual refinement. Design: cross-sectional study Methods Setting: glaucoma clinical practice. Study Population: 3490 scans from 412 eyes of 213 individuals with a diagnosis of glaucoma or glaucoma suspect. Observational Procedures: We used spectral domain OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany) to measure RNFL thickness ...
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    10. Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition

      Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition
      ... led by Balwantray C. Chauhan, Ph.D., Dalhousie University in Halifax (Canada), and Claude F. Burgoyne, M.D., Devers Eye Institute in Portland, OR (USA) performed with the SPECTRALIS imaging platform 1,2,3,4,5,6 . Their ...
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    11. In Vivo Detection of Laminar and Peripapillary Scleral Hypercompliance in Early Monkey Experimental Glaucoma

      In Vivo Detection of Laminar and Peripapillary Scleral Hypercompliance in Early Monkey Experimental Glaucoma
      Purpose : To compare optical coherence tomography (OCT) detected, optic nerve head (ONH) compliance within control and experimental glaucoma (EG) eyes of 15 monkeys at EG onset. Methods : Intraocular pressure (IOP) was chronically elevated in one eye of each animal using a laser. Experimental glaucoma onset was identified using confocal scanning laser tomography (CSLT). Optical coherence tomography ONH imaging (40 radial B-scans) was performed at 10 mm Hg before and after ...
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    12. Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental Glaucoma

      Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental Glaucoma
      Purpose : We compare spectral-domain optical coherence tomography (SDOCT) measurements of minimum rim width (MRW), minimum rim area (MRA), and peripapillary retinal nerve fiber layer thickness (RNFLT) to complete orbital optic nerve axon counts in nonhuman primates (NHP) with unilateral experimental glaucoma (EG). Methods : Biweekly SDOCT measurements of MRW, MRA, and RNFLT were acquired under manometric IOP control (10 mm Hg) in 51 NHP during baseline (mean SD, 5.0 1 ...
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    13. Changes in Retinal Nerve Fiber Layer Reflectance Intensity as a Predictor of Functional Progression in Glaucoma

      Changes in Retinal Nerve Fiber Layer Reflectance Intensity as a Predictor of Functional Progression in Glaucoma
      Purpose : We determined whether longitudinal changes in retinal nerve fiber layer (RNFL) reflectance provide useful prognostic information about longitudinal changes in function in glaucoma. Methods : The reflectance intensity of each pixel within spectral-domain optical coherence tomography (SD-OCT) circle scans was extracted by custom software. A repeatability cohort comprising 53 eyes of 27 participants (average visual field mean deviation [MD] 1.65 dB) was tested five times within a few weeks ...
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    14. Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

      Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method
      Purpose : We validated noninvasive Doppler-optical coherence tomography (OCT) blood flow measurements against the terminal microsphere method in a surgical induced optic nerve transection nonhuman primate model. Methods : In 6 nonhuman primates, total retinal blood flow (TRBF) was measured with a custom-built dual-beam bidirectional Doppler Fourier Domain (FD)-OCT. Peripapillary retinal nerve fiber layer thickness (RNFLT) was measured by Spectralis spectral-domain (SD)-OCT. Measurements were performed every 10 to 15 days ...
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    15. Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma
      ...ute, 1225 NE 2nd Ave, Portland, OR, 97232, United States 4. ^4Discoveries in Sight Research Laboratories, Devers Eye Institute and Legacy Research Institute, Legacy Health, Portland, OR, United States 5. ^5Optic ...
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  2. About Devers Eye Institute

    Devers Eye Institute

    Devers Eye Institute is a comprehensive medical eye center dedicated to offering excellence in all aspects of eye care. We are a private, non-profit, clinical and research institute—one of only a handful in the United States.