Postdoctoral Research Fellow position at Legacy Devers Eye Institute – Discoveries in Sight
...imaging technologies.
Legacy Devers Eye Institute – Discoveries in Sight:
Mentions:
Devers Eye Institute
Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results
Purpose To compare the three-dimensional (3D) morphology of the deep load-bearing structures of the human optic nerve head (ONH) as revealed in vivo by spectral domain optical coherence tomography (SDOCT) with ex vivo quantitative 3D histology. Methods SDOCT imaging of the ONH was performed in six eyes from three brain-dead organ donors on life-support equipment awaiting organ procurement (in vivo conditions). Following organ procurement (ex vivo conditions), the eyes were ...
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Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT Evolution to Reveal Early-Stage Changes in Glaucoma
Legacy Emanuel Hospital and Health Center Receives a 2020 NIH Grant for $543,351 for Advancing OCT Evolution to Reveal Early-Stage Chalnges in Glaucoma. The principal investigator is Brad Fortune. Below is a summary of the proposed work. Currently, diagnosis of glaucoma and patient management decisions are often informed by thinning of the optic nerve head (ONH) neuro-retinal rim, peripapillary retinal nerve fiber layer (RNFL), and macular inner retinal layers ...
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OCT Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening versus Bruch’s Membrane Opening Offset
...segmentations were performed by two observers, (PW and CH) within the Optic Nerve Head Research Laboratory of Devers Eye Institute. Quantification of all parameters was performed within custom software (Matlab version 7....
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Devers Eye Institute
OCT Structural Abnormality Detection in Glaucoma using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria
Purpose To evaluate the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. Design Retrospective cross-sectional study. Methods 196 GL, 150 GLS eyes and 303 Heathy eyes underwent PRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane ...
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Devers Eye Institute
Effect of Trabeculectomy on Optical Coherence Tomography (OCT) Measurements of the Optic Nerve Head Neuroretinal Rim Tissue
Purpose Ophthalmologists commonly perform glaucoma surgery to treat progressive glaucoma. Few studies have examined the stability of OCT neuroretinal rim parameters after glaucoma surgery for ongoing detection of glaucoma progression. Design Longitudinal cohort study. Participants 20 eyes (16 subjects) with primary open angle glaucoma who had undergone a trabeculectomy. Methods We calculated the change in OCT parameters (minimum rim area (MRA), minimum rim width (MRW), Bruchs membrane opening (BMO) area ...
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Devers Eye Institute
OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes
Purpose To assess anterior scleral canal opening (ASCO) offset relative to Bruchs membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Design Cross-sectional study Methods After OCT optic nerve head (ONH) and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented and planes, centroids, size and shape were calculated. Neural canal direction ...
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Optical Coherence Tomography Segmentation Errors of the Retinal Nerve Fiber Layer Persist Over Time
Prcis: There are errors in automated segmentation of the retinal nerve fiber layer in glaucoma suspects or patients with mild glaucoma that appear to persist over time; however, automated segmentation has greater repeatability than manual segmentation. Purpose: To identify whether optical coherence tomography (OCT) segmentation errors in retinal nerve fiber layer (RNFL) thickness measurements persist longitudinally. Methods: This was a cohort study. We used spectral domain OCT (Spectralis, Heidelberg Engineering ...
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Devers Eye Institute
Emanuel Hospital and Health Center Receives NIH Grant for IOP-Related Force and Failure in the Optical Nerve Head
Emanuel Hospital and Health Center Receives a 2019 NIH Grant for $579,552 for IOP-Related Force and Failure in the Optical Nerve Head. The principal investigator is Claude Burgoyne. The program began in 2018 and ends in 2021. Below is a summary of the proposed work. In the previous project period we completed our 3D histomorphometric characterization of connective tissue deformation and remodeling in early through end-stage monkey experimental glaucoma ...
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Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study
Purpose : To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods : A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal ...
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An Examination of the Frequency of Paravascular Defects and Epiretinal Membranes in Eyes With Early Glaucoma Using En-face Slab OCT Images
Purpose: To examine the frequency of paravascular defects (PDs) and macular epiretinal membranes (ERMs) in eyes categorized as having mild glaucoma or glaucoma suspect using en-face slab analysis of optical coherence tomography (OCT) scans. Materials and Methods: Fifty-seven glaucomatous eyes, 44 low-risk suspect eyes, and 101 healthy control eyes were included in the study. The 101 glaucomatous and suspect eyes had a mean deviation better than 6dB on the 24-2 ...
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Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.
Purpose To assess glaucoma specialists detection of optic nerve head (ONH) rim tissue that is thin by optical coherence tomography (OCT) criteria. Design Reliability analysis Methods 5 clinicians marked the disc margin (DM) and rim margin (RM) on stereo-photos of 151 glaucoma or glaucoma suspect eyes obtained within 3 months of OCT imaging. The photo and OCT infrared image for each eye were colocalized and regionalized into twelve sectors relative ...
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Devers Eye Institute
Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma
Clinical examination of the optic disc is a fundamental component of any ophthalmic evaluation, but it is especially important for diagnosis and management of glaucoma. The purpose of this article is to: (1) review the limitations inherent to clinical examination; (2) outline the rationale for adopting into clinical practice quantitative measures of the optic nerve head neuro‐retinal rim tissue integrity derived from current optical coherence tomography imaging approaches; (3 ...
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Devers Eye Institute
Study by ARVO authors finds vision research pays for itself
...at investments in vision research more than pay for themselves. ARVO President Claude Burgoyne, MD, FARVO, of Devers Eye Institute, and coauthors Philip Rosenfeld, MD, PhD of Bascom Palmer Eye Institute and Eric Swanson,...
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A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease
Purpose : To compare morphologic changes on en face images derived from wide-field swept-source optical coherence tomography (ssOCT) to hypo- and hyperautofluorescent (hypoAF, hyperAF) areas on short-wavelength autofluorescence (SW-AF), and near-infrared (NIR)-AF in recessive Stargardt disease (STGD1). Methods : Wide-field ssOCT cube scans were obtained from 16 patients (16 eyes). Averaged B-scans and SW-AF images were obtained using Spectralis HRA+OCT. NIR-AF images were obtained from 6 eyes. The inner/outer ...
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Devers Eye Institute is a comprehensive medical eye center dedicated to offering excellence in all aspects of eye care. We are a private, non-profit, clinical and research institute—one of only a handful in the United States.