1. Delft University of Technology

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    1. Mentioned In 66 Articles

    2. Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media

      Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media
      The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT ...
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    3. Deep-tissue label-free quantitative optical tomography

      Deep-tissue label-free quantitative optical tomography
      In vivo imaging of small animals is of wide interest to the biomedical community studying biological disease and developmental processes. However, optical imaging deep in tissue is severely limited by light scattering, posing restrictions on the imaging depth, image contrast, and spatial resolution. We demonstrate optical coherence projection tomography (OCPT) as a fast three-dimensional optical imaging technique for ballistic, non-scattered light, deep-tissue imaging. OCPT is based on a novel scanning ...
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    4. OCTA Multilayer and Multisector Peripapillary Microvascular Modeling for Diagnosing and Staging of Glaucoma

      OCTA Multilayer and Multisector Peripapillary Microvascular Modeling for Diagnosing and Staging of Glaucoma
      Purpose: To develop and assess an automatic procedure for classifying and staging glaucomatous vascular damage based on optical coherence tomography angiography (OCTA) imaging. Methods: OCTA scans (Zeiss Cirrus 5000 HD-OCT) from a random eye of 39 healthy subjects and 82 glaucoma patients were used to develop a new classification algorithm based on multilayer and multisector information. The averaged circumpapillary retinal nerve fiber layer (RNFL) thickness was also collected. Three models ...
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    5. Quantification of plant morphology and leaf thickness with optical coherence tomography

      Quantification of plant morphology and leaf thickness with optical coherence tomography
      Optical coherence tomography (OCT) can be a valuable imaging tool for in vivo and label-free digital plant phenotyping. However, for imaging leaves, air-filled cavities limit the penetration depth and reduce the image quality. Moreover, up to now quantification of leaf morphology with OCT has been done in one-dimensional or two-dimensional images only, and has often been limited to relative measurements. In this paper, we demonstrate a significant increase in OCT ...
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    6. Multi-scale optical coherence tomography imaging and visualization of Vermeer’s Girl with a Pearl Earring

      Multi-scale optical coherence tomography imaging and visualization of Vermeer’s Girl with a Pearl Earring
      We demonstrate multi-scale multi-parameter optical coherence tomography (OCT) imaging and visualization of Johannes Vermeers painting Girl with a Pearl Earring . Through automated acquisition, OCT image segmentation, and 3D volume stitching we realize OCT imaging at the scale of an entire painting. This makes it possible to image, with micrometer axial and lateral resolution, an entire painting over more than 5 orders of length scale. From the multi-scale OCT data we ...
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    7. Invasive Coronary Artery Imaging Using Optical Coherence Tomography: A Cost-effectiveness and Implementation Process Analysis (Thesis)

      Invasive Coronary Artery Imaging Using Optical Coherence Tomography: A Cost-effectiveness and Implementation Process Analysis (Thesis)
      The aim of this project was the implementation of optical coherence tomography (OCT), an invasive intracoronary imaging (ICI) tool used for the visualization of coronary arteries. The implementation was performed in a structured manner by: (1) A literature review into the current applications of OCT in relation to current standards; (2) A thesis feasibility study into clinical practices, professional views and other processes regarding ICI; (3) A Masters thesis including ...
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    8. Self-aligned micro-optic integrated photonic platform

      Self-aligned micro-optic integrated photonic platform
      In this work, we present the fabrication technology of a monolithically integrated photonic platform combining key components for optical coherence tomography (OCT) imaging, thereby including a photonic interferometer, a collimating lens, and a 45 reflecting mirror that directs the light from the interferometer to the collimator. The proposed integration process simplifies the fabrication of an interferometric system and inherently overcomes the complexity of costly alignment procedures while complying with the ...
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    9. Motorized capsule for shadow-free OCT imaging and synchronous beam control

      Motorized capsule for shadow-free OCT imaging and synchronous beam control
      We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments ...
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    10. Determination of mechanical properties of biofilms by modeling the deformation measured using optical coherence tomography

      Determination of mechanical properties of biofilms by modeling the deformation measured using optical coherence tomography
      The advantage of using non-invasive imaging such as optical coherence tomography (OCT) to asses material properties from deformed biofilm geometries can be compromised by the assumptions made on fluid forces acting on the biofilm. This study developed a method for the determination of elastic properties of biofilms by modelling the biofilm deformation recorded by OCT imaging with poroelastic fluid-structure interaction computations. Two-dimensional biofilm geometries were extracted from OCT scans of ...
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    11. Effect of biofilm structural deformation on hydraulic resistance during ultrafiltration: A numerical and experimental study

      Effect of biofilm structural deformation on hydraulic resistance during ultrafiltration: A numerical and experimental study
      Biofilm formation in membrane systems negatively impacts the filtration system performances. This study evaluated how biofilm compression driven by permeate flow increases the hydraulic resistance and leads to reduction in permeate flux. We analysed the effect of biofilm compression on hydraulic resistance and permeate flux through computational models supported by experimental data. Biofilms with homogeneous surface structure were subjected to step-wise changes in flux and transmembrane pressure during compression and ...
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    12. Optical Coherence Tomography within a single microsystem

      Optical Coherence Tomography within a single microsystem
      Optical Coherence Tomography (OCT) systems have huge potential for application beyond the traditional ophthalmology as general-purpose medical instrument for optical biopsy. The widening of the range of applications is expected to significantly increase production volume and, consequently, puts pressure on unit cost. This trend calls for a flexible and miniaturized system fabricated in a batch process. In this paper the different OCT configurations are compared for suitability in such an ...
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    13. Optical coherence computed tomography for quantitative 3D imaging of adult zebrafish

      Optical coherence computed tomography for quantitative 3D imaging of adult zebrafish
      Optical imaging in turbid media like biological tissue is limited by light scattering. We present optical coherence computed tomography (OCCT) as a novel optical imaging modality for ballistic 3D optical imaging of turbid media. In OCCT, coherence and confocal gated measurements from multiple lateral positions and angles are used to reconstruct quantitative 3D images of the optical attenuation and refractive index with tomographic reconstruction algorithms. OCCT allows for high resolution ...
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    14. Fourier-Domain Optical Coherence Tomography Signal Analysis and Numerical Modeling

      Fourier-Domain Optical Coherence Tomography Signal Analysis and Numerical Modeling
      In this work the theory of the optical coherence tomography (OCT) signal after sampling, in dispersive media, with noise, and for a turbid medium is presented. The analytical theory is demonstrated with a one-dimensional numerical OCT model for (single) reflectors, dispersive media, and turbid media. For dispersive media the deterioration of the OCT axial resolution is quantified analytically and numerically. The OCT signal to noise ratio (SNR) is analyzed in ...
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  2. About Delft University of Technology

    Delft University of Technology

    Delft University of Technology (Technische Universiteit Delft), also known as TU Delft, is the largest and oldest Dutch public technical university, located in Delft, Netherlands. With eight faculties and numerous research institutes it hosts over 15,000 students (undergraduate and postgraduate), more than 2,600 scientists (including more than 200 professors), over 1,800 doctoral students, and more than 2,000 people in the support and management staff.