1. Delft University of Technology

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    1. Mentioned In 54 Articles

    2. Optical coherence computed tomography for quantitative 3D imaging of adult zebrafish

      Optical coherence computed tomography for quantitative 3D imaging of adult zebrafish
      Optical imaging in turbid media like biological tissue is limited by light scattering. We present optical coherence computed tomography (OCCT) as a novel optical imaging modality for ballistic 3D optical imaging of turbid media. In OCCT, coherence and confocal gated measurements from multiple lateral positions and angles are used to reconstruct quantitative 3D images of the optical attenuation and refractive index with tomographic reconstruction algorithms. OCCT allows for high resolution ...
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    3. Fourier-Domain Optical Coherence Tomography Signal Analysis and Numerical Modeling

      Fourier-Domain Optical Coherence Tomography Signal Analysis and Numerical Modeling
      In this work the theory of the optical coherence tomography (OCT) signal after sampling, in dispersive media, with noise, and for a turbid medium is presented. The analytical theory is demonstrated with a one-dimensional numerical OCT model for (single) reflectors, dispersive media, and turbid media. For dispersive media the deterioration of the OCT axial resolution is quantified analytically and numerically. The OCT signal to noise ratio (SNR) is analyzed in ...
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    4. Feature Of The Week 09/10/2017: Thermo-elastic Optical Coherence Tomography

      Feature Of The Week 09/10/2017: Thermo-elastic  Optical Coherence Tomography
      The conventional OCT image contrast is derived from elastic scattering, and shows the internal structure of the sample. The determination of the tissue type in OCT images usually depends on the interpretation by the image reader. More accurate tissue type contrast may be achieved by new OCT-based imaging modalities, with sensitivity to other physical parameters than scattering alone. Phase-sensitive OCT can detect tissue motion on nanometer-to- micrometer length scales using ...
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    5. Thermo-elastic optical coherence tomography

      Thermo-elastic optical coherence tomography
      The absorption of nanosecond laser pulses induces rapid thermo-elastic deformation in tissue. A sub-micrometer scale displacement occurs within a few microseconds after the pulse arrival. In this Letter, we investigate the laser-induced thermo-elastic deformation using a 1.5 MHz phase-sensitive optical coherence tomography (OCT) system. A displacement image can be reconstructed, which enables a new modality of phase-sensitive OCT, called thermo-elastic OCT. An analysis of the results shows that the ...
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    6. Joint Segmentation of Retinal Layers and Focal Lesions in 3-D OCT Data of Topologically Disrupted Retinas

      Joint Segmentation of Retinal Layers and Focal Lesions in 3-D OCT Data of Topologically Disrupted Retinas
      Accurate quantification of retinal structures in 3-D optical coherence tomography data of eyes with pathologies provides clinically relevant information. We present an approach to jointly segment retinal layers and lesions in eyes with topology-disrupting retinal diseases by a loosely coupled level set framework. In the new approach, lesions are modeled as an additional space-variant layer delineated by auxiliary interfaces. Furthermore, the segmentation of interfaces is steered by local differences in ...
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    7. Optimization-based adaptive optics for optical coherence tomography (Thesis)

      Optimization-based adaptive optics for optical coherence tomography (Thesis)
      Optical coherence tomography (OCT) is a technique for non-invasive imaging based on low coherence interferometry. Its main application is found in ophthalmology, where it is used for 3D in vivo imaging of the cornea and the retina. OCT has evolved over the past decade as one of the most important ancillary tests in ophthalmic practice, providing great diagnostic value for disease screening and monitoring. In retinal OCT imaging, the lateral ...
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    8. Analysis and compensation for the effect of the catheter position on image intensities in intravascular optical coherence tomography

      Analysis and compensation for the effect of the catheter position on image intensities in intravascular optical coherence tomography
      Intravascular optical coherence tomography (IVOCT) is an imaging technique that is used to analyze the underlying cause of cardiovascular disease. Because a catheter is used during imaging, the intensities can be affected by the catheter position. This work aims to analyze the effect of the catheter position on IVOCT image intensities and to propose a compensation method to minimize this effect in order to improve the visualization and the automatic ...
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    9. Spatially-resolved in-situ quantification of biofouling using optical coherence tomography (OCT) and 3D image analysis in a spacer filled channel

      Spatially-resolved in-situ quantification of biofouling using optical coherence tomography (OCT) and 3D image analysis in a spacer filled channel
      The use of optical coherence tomography (OCT) to investigate biomass in membrane systems has increased with time. OCT is able to characterize the biomass in-situ and non-destructively. In this study, a novel approach to process three-dimensional (3D) OCT scans is proposed. The approach allows obtaining spatially-resolved detailed structural biomass information. The 3D biomass reconstruction enables analysis of the biomass only, obtained by subtracting the time zero scan to all images ...
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    10. Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study

      Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study
      Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a ...
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    11. A wafer-level miniaturized Michelson interferometer on glass substrate for Optical Coherence Tomography applications

      A wafer-level miniaturized Michelson interferometer on glass substrate for Optical Coherence Tomography applications
      The wafer-level fabrication of a Michelson interferometer using optical MEMS technologies is presented. The intended application is in Optical Coherence Tomography (OCT). The micro fabrication involves two steps: the 45 saw dicing of glass substrate and the subsequent deposition of a dielectric multilayer and metallic layers to obtain a beam splitter and waveguide micro mirrors, respectively. The Michelson interferometer was designed for use in the near-infrared range of 800900 nm ...
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    12. Transmission optical coherence tomography based measurement of optical material properties

      Transmission optical coherence tomography based measurement of optical material properties
      We present transmission optical coherence tomography (transmission OCT) as a versatile tool to measure optical material properties of turbid media. The transmission OCT signal is described in detail and it is demonstrated how the group refractive index ( n g ), group velocity dispersion (GVD) and optical attenuation can be determined from this signal. We experimentally validate the refractive index properties of glasses, liquids and glucose water solutions in terms of n ...
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    13. Model-based sensor-less wavefront aberration correction in optical coherence tomography

      Model-based sensor-less wavefront aberration correction in optical coherence tomography
      Several sensor-less wavefront aberration correction methods that correct nonlinear wavefront aberrations by maximizing the optical coherence tomography (OCT) signal are tested on an OCT setup. A conventional coordinate search method is compared to two model-based optimization methods. The first model-based method takes advantage of the well-known optimization algorithm (NEWUOA) and utilizes a quadratic model. The second model-based method (DONE) is new and utilizes a random multidimensional Fourier-basis expansion. The model-based ...
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    14. Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography

      Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography
      Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of the coronary artery pathologies and interventions. In contrast to the cross-sectional view, longitudinal sections and three-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements. We developed Heartbeat OCT, a new OCT method that overcomes these issues. This study aims to demonstrate in vivo Heartbeat OCT ...
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  2. About Delft University of Technology

    Delft University of Technology

    Delft University of Technology (Technische Universiteit Delft), also known as TU Delft, is the largest and oldest Dutch public technical university, located in Delft, Netherlands. With eight faculties and numerous research institutes it hosts over 15,000 students (undergraduate and postgraduate), more than 2,600 scientists (including more than 200 professors), over 1,800 doctoral students, and more than 2,000 people in the support and management staff.