1. Deepa K. Kasaragod

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    1. Mentioned In 34 Articles

    2. Machine-learning based segmentation of the optic nerve head using multi-contrast Jones matrix optical coherence tomography with semi-automatic training dataset generation

      Machine-learning based segmentation of the optic nerve head using multi-contrast Jones matrix optical coherence tomography with semi-automatic training dataset generation
      A pixel-by-pixel tissue classification framework using multiple contrasts obtained by Jones matrix optical coherence tomography (JM-OCT) is demonstrated. The JM-OCT is an extension of OCT that provides OCT, OCT angiography, birefringence tomography, degree-of-polarization uniformity tomography, and attenuation coefficient tomography, simultaneously. The classification framework consists of feature engineering, k -means clustering that generates a training dataset, training of a tissue classifier using the generated training dataset, and tissue classification by the ...
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    3. Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography

      Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography
      Polarization-sensitive optical coherence tomography (PS-OCT) allows the recording of depth-resolved polarimetric measurements. It has been reported that phase retardation and local birefringence images can noninvasively detect fibrotic area in blebs after glaucoma surgery. Evaluation of scar fibrosis in blebs is important not only for predicting bleb function, but also for planning revision trabeculectomy. Herein, we characterize the intensity, phase retardation, and local birefringence images of blebs using PS-OCT. A total ...
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    4. Simultaneous tissue birefringence and deformation measurement by polarization sensitive optical coherence elastography with active compression

      Simultaneous tissue birefringence and deformation measurement by polarization sensitive optical coherence elastography with active compression
      Polarization sensitive optical coherence tomography (PS-OCT) measures tissue birefringence, while optical coherence elastography (OCE) reveals the mechanical property of the tissue. Since both birefringence and mechanical properties are associated with tissue microstructures such as collagen, simultaneous PS-OCT and OCE measurement will provide useful insight for the tissue microstructures. In this paper, we present a combined PS-OCT and OCE technique. The PS-OCT is based on Jones matrix OCT theory. It measures ...
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    5. Generation and optimization of superpixels as image processing kernels for Jones matrix optical coherence tomography

      Generation and optimization of superpixels as image processing kernels for Jones matrix optical coherence tomography
      Jones matrix-based polarization sensitive optical coherence tomography (JM-OCT) simultaneously measures optical intensity, birefringence, degree of polarization uniformity, and OCT angiography. The statistics of the optical features in a local region, such as the local mean of the OCT intensity, are frequently used for image processing and the quantitative analysis of JM-OCT. Conventionally, local statistics have been computed with fixed-size rectangular kernels. However, this results in a trade-off between image sharpness ...
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    6. Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

      Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography
      A customized 1310-nm Jones-matrix optical coherence tomography (JM-OCT) for dermatological investigation was constructed and used for in vivo normal human skin tissue imaging. This system can simultaneously measure the threedimensional depth-resolved local birefringence, complex-correlation based OCT angiography (OCT-A), degree-ofpolarization- uniformity (DOPU) and scattering OCT intensity. By obtaining these optical properties of tissue, the morphology, vasculature, and collagen content of skin can be deduced and visualized. Structures in the deep layers ...
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    7. Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

      Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography
      A custom made dermatological Jones matrix optical coherence tomography (JM-OCT) is presented. It uses a passive-polarization-delay component based swept-source JM-OCT configuration, but is specially designed for in vivo human skin measurement. The center wavelength of its probe beam is 1310 nm and the A-line rate is 49.6 kHz. The JM-OCT is capable of simultaneously providing birefringence (local retardation) tomography, degree-of-polarization-uniformity tomography, complex-correlation-based optical coherence angiography, and conventional scattering OCT ...
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    8. Noise stochastic corrected maximum a posteriori estimator for birefringence imaging using polarization-sensitive optical coherence tomography

      Noise stochastic corrected maximum a posteriori estimator for birefringence imaging using polarization-sensitive optical coherence tomography
      This paper presents a noise-stochastic corrected maximum a posteriori estimator for birefringence imaging using Jones matrix optical coherence tomography. The estimator described in this paper is based on the relationship between probability distribution functions of the measured birefringence and the effective signal to noise ratio (ESNR) as well as the true birefringence and the true ESNR. The Monte Carlo method is used to numerically describe this relationship and adaptive 2D ...
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    9. Quantitative Evaluation of Phase Retardation in Filtering Blebs Using Polarization-Sensitive Optical Coherence Tomography

      Quantitative Evaluation of Phase Retardation in Filtering Blebs Using Polarization-Sensitive Optical Coherence Tomography
      Purpose : Polarization-sensitive optical coherence tomography (PS-OCT) can detect and evaluate scar fibrosis of the filtering blebs after glaucoma surgery. Although the change in phase retardation reportedly reflects bleb function, quantitative assessment of phase retardation in ocular tissues has not been conducted. We aimed to establish quantitative methods to investigate changes in phase retardation in the blebs after surgery using PS-OCT. Methods : Twenty-two blebs of 22 patients who had undergone glaucoma ...
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    10. Objective Evaluation of Functionality of Filtering Bleb Based on Polarization-Sensitive Optical Coherence Tomography

      Objective Evaluation of Functionality of Filtering Bleb Based on Polarization-Sensitive Optical Coherence Tomography
      Purpose : The fibrosis score is a new diagnostic score that we have developed to evaluate the function of bleb structures after glaucoma filtration surgery using polarization-sensitive optical coherence tomography (PS-OCT). This study aims to assess the efficacy of the fibrosis score in discriminating nonfunctional from the functional blebs. Methods : A total of 20 patients who had undergone glaucoma filtration surgery were imaged at different time periods after surgery using PS-OCT ...
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    11. Quantitative polarization and flow evaluation of choroid and sclera by multifunctional Jones matrix optical coherence tomography

      Quantitative polarization and flow evaluation of choroid and sclera by multifunctional Jones matrix optical coherence tomography
      Quantitative evaluation of optical properties of choroid and sclera are performed by multifunctional optical coherence tomography. Five normal eyes, five glaucoma eyes and one choroidal atrophy eye are examined. The refractive error was found to be correlated with choroidal birefringence, polarization uniformity, and flow in addition to scleral birefringence among normal eyes. The significant differences were observed between the normal and the glaucoma eyes, as for choroidal polarization uniformity, flow ...
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    12. Three-dimensional multifunctional optical coherence tomography for skin imaging

      Three-dimensional multifunctional optical coherence tomography for skin imaging
      Optical coherence tomography (OCT) visualizes cross-sectional microstructures of biological tissues. Recent developments of multifunctional OCT (MF-OCT) provides multiple optical contrasts which can reveal currently unknown tissue properties. In this contribution we demonstrate multifunctional OCT specially designed for dermatological investigation. And by utilizing it to measure four different body parts of in vivo human skin, three-dimensional scattering OCT, OCT angiography, polarization uniformity tomography, and local birefringence tomography images were obtained by ...
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    13. Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

      Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography
      A clinical grade prototype of posterior multifunctional Jones matrix optical coherence tomography (JM-OCT) is presented. This JM-OCT visualized depth-localized birefringence in addition to conventional cumulative phase retardation imaging through local Jones matrix analysis. In addition, it simultaneously provides a sensitivity enhanced scattering OCT, a quantitative polarization uniformity contrast, and OCT-based angiography. The probe beam is at 1- m wavelength band. The measurement speed and the depth-resolution were 100,000 A-lines ...
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    14. Repeatability of Corneal Phase Retardation Measurements by Polarization-Sensitive Optical Coherence Tomography

      Repeatability of Corneal Phase Retardation Measurements by Polarization-Sensitive Optical Coherence Tomography
      Purpose. Polarization-sensitive optical coherence tomography (PS-OCT) can evaluate internal tissue structures of the cornea, such as collagen fibers, by phase retardation measurement. In this study, we assessed the repeatability of corneal phase retardation measurements using anterior segment PS-OCT. Methods. A total of 173 eyes of 173 patients were measured using PS-OCT. In total, 58 eyes of young subjects with normal corneas, 28 eyes of old subjects with normal corneas, 26 ...
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    15. Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography

      Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography
      In many developing parts of the world, colposcopy supplemented by aceto-whitening remains the most widespread means of reliably diagnosing cervical dysplasia, potentially leading to cervical cancer. The use of aceto-whitening to enhance detection rates for Barretts esophagus is also emerging in recent years. Here we quantitatively study the aceto-whitening phenomenon using 1300 nm optical coherence tomography. By exposing a simple epithelial tissue model (excised rabbit cornea) to 0.5 M ...
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    16. Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography
      Purpose: Evaluation of bleb morphology using anterior segment optical coherence tomography (OCT) can offer important information regarding bleb function after glaucoma surgery. However, analysis of tissue properties, such as scar fibrosis of blebs, is difficult with conventional OCT. The birefringence of the blebs as susceptible measure of fibrosis scar was evaluated using polarization-sensitive OCT (PS-OCT) and its relation with bleb function was assessed. Methods: One hundred and fifty-three blebs of ...
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  2. About Deepa K. Kasaragod

    Deepa K. Kasaragod

    Deepa Kasaragod is a researcher in the Department of Material Sciences & Engineering, Kroto Research Institute at the University of Sheffield.