1. David Woolfson

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    1. Mentioned In 8 Articles

    2. Hydrogel-Forming Microneedle Arrays Can Be Effectively Inserted in Skin by Self-Application: A Pilot Study Centred on Pharmacist Intervention and a Patient Information Leaflet

      Hydrogel-Forming Microneedle Arrays Can Be Effectively Inserted in Skin by Self-Application: A Pilot Study Centred on Pharmacist Intervention and a Patient Information Leaflet

      Purpose To investigate, for the first time, the influence of pharmacist intervention and the use of a patient information leaflet on self-application of hydrogel-forming microneedle arrays by human volunteers without the aid of an applicator device. Methods A patient information leaflet was drafted and pharmacist counselling strategy devised. Twenty human volunteers applied 11 × 11 arrays of 400 μm hydrogel-forming microneedle arrays to their own skin following the instructions provided. Skin barrier function disruption was assessed using transepidermal water loss measurements and optical coherence tomography and results compared to those obtained when more experienced researchers applied the microneedles to the volunteers ...

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    3. Influence of a pore-forming agent on swelling, network parameters, and permeability of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: Application in transdermal delivery systems

      Influence of a pore-forming agent on swelling, network parameters, and permeability of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: Application in transdermal delivery systems
      ... Garland, 3. Katarzyna Migalska, 4. Ester Caffarel Salvador, 5. Rahamatullah Shaikh, 6. Helen O. McCarthy, 7. A. David Woolfson, 8. Ryan F....
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    4. Feature Of The Week 11/13/10: Researchers from Queen's University in Belfast use OCT to Study of the Effects of Microneedle Geometry on Skin Penetration and Drug Delivery

      Feature Of The Week 11/13/10: Researchers from Queen's University in Belfast use OCT to Study of the Effects of Microneedle Geometry on Skin Penetration and Drug Delivery
      Feature Of The Week 11/13/10: Researchers from Queen’s University in Belfast have used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height, and MN interspacing) and force of application have upon penetration characteristics of soluble poly(methyl vinyl ether-co-maleic anhydride, PMVE/MA) MN arrays into neonatal porcine skin in vitro. The results from OCT investigations were then used to design optimal and suboptimal MN-based drug delivery systems and evaluate their drug delivery profiles cross full thickness and dermatomed neonatal porcine skin in vitro. It was found that ...
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    5. Michelson Diagnostics’ VivoSight OCT Scanner used to Evaluate Microneedle Drug Delivery System

      Michelson Diagnostics’ VivoSight OCT Scanner used to Evaluate Microneedle Drug Delivery System
      ...Donnelly, Martin J. Garland, Desmond I.J. Morrow, Katarzyna Migalska, Thakur Raghu Raj Singh, Rita Majithiya, A. David Woolfson, “Optical coherence tomography is a valuable tool in the study of the effects of microneedle...
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    6. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution

      Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution
      In this study, we used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height, and MN interspacing) and force of application have upon penetration characteristics of soluble poly(methyl vinyl ether-co-maleic anhydride, PMVE/MA) MN arrays into neonatal porcine skin in vitro. The results from OCT investigations were then used to design optimal and suboptimal MN-based drug delivery systems and evaluate their drug delivery profiles cross full thickness and dermatomed neonatal porcine skin in vitro. It was found that increasing the force used for MN application resulted in a significant ...
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    7. Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique

      Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique
      Purpose  Design and evaluation of a novel laser-based method for micromoulding of microneedle arrays from polymeric materials under ambient conditions. The aim of this study was to optimise polymeric composition and assess the performance of microneedledevices that possess different geometries. Methods  A range of microneedle geometries was engineered into silicone micromoulds, and their physicochemical features were subsequently characterised. Results  Microneedles micromoulded from 20% w/w aqueous blends of the mucoadhesive copolymer Gantrez® AN-139 were surprisingly found to possess superior physical strength than those produced from commonly used pharma polymers. Gantrez® AN-139 microneedles, 600 μm and 900 μm in height, penetrated ...
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  2. About David Woolfson

    David Woolfson

    David Woolfson, professor, holds the Chair in Pharmaceutics and is Head of the School of Pharmacy at Queen's University Belfast. His research interests are in polymeric drug delivery systems for transepithelial applications, bioadhesion and biomaterials, with an emphasis on facilitated controlled drug delivery through polymeric systems, where physicochemical properties of the drug may present difficulties to efficient drug release. He has contributed to the development of the marketed pharmaceutical products, Femring vaginal ring for HRT (Warner Chilcott Inc.) and Ametop for percutaneous local anaesthesia (Smith and Nephew plc). Professor Woolfson is Chair of the British Pharmacopoeia Commission and Leader of the UK Delegation to the European Pharmacopoeia (EP) Commission. He is a member of the Scientific Advisory Board of CRC Books Inc.  He has published 3 books, approximately 400 scientific publications, holds several patents on drug delivery systems and biomaterials and has given numerous invited conference presentations.