1. David R. Hillman

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    1. Mentioned In 17 Articles

    2. Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure?

      Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure?
      ...ressure? Thomas K. Ansell , Peter K. McFawn , Robert A. McLaughlin , David D. Sampson , Peter R. Eastwood , David R. Hillman , Howard W. Mitchell , Peter B. Noble Journal of Applied Physiology Published 1 March 2015 Vo...
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    3. Effect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea

      Effect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea
      ...l of Anatomy, Physiology and Human Biology, University of Western Australia, Nedlands, WA 6009, Australia , * David R. Hillman Affiliations + West Australian Sleep Disorders Research Institute, Department of Pulmonary Ph...
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    4. Elastic Properties of the Central Airways in Obstructive Lung Diseases Measured Using Anatomical Optical Coherence Tomography

      Elastic Properties of the Central Airways in Obstructive Lung Diseases Measured Using Anatomical Optical Coherence Tomography
      Rationale: Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing. Objectives: To utilize anatomical optical coherence tomography (aOCT) to compare central airway elastic properties in control subjects and those with obstructive lung diseases. Methods: Following bronchodilation, airway lumen area (Ai) was measured using aOCT ...
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    5. Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography

      Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography
      Background Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity can occur at different airway generations and at branching points in the bronchial tree. Whilst heterogeneity has been detected by previous experimental approaches its spatial relationship either within or between airways is unknown. Methods In this study, distribution of airway ...
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    6. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

      Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function
      Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter ...
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    7. In vivo 4D imaging of the human lower airway using anatomical optical coherence tomography

      In vivo 4D imaging of the human lower airway using anatomical optical coherence tomography
      Anatomical optical coherence tomography (aOCT) is a long-range, fibre-optic endoscopic imaging modality capable of quantifying the size and shape of the human airway lumen. This paper presents the first application of respiratory gating to 3D aOCT volumetric data. A sequence of time-gated data volumes are generated, characterising the dynamic behaviour of a segment of the lower airway over an averaged respiratory cycle. The technique is demonstrated on in vivo data ...
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    8. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

      ...ons and emerging techniques J. P. Williamson^1^,2, A. L. James^1^,3^,4, M. J. Phillips^5, D. D. Sampson^6, D. R. Hillman^1^,3 and P. R. Eastwood^1^,2^,3 Depts of ^1 Pulmonary Physiology, and ^5 Respiratory Medicine, S...
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    9. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

      Airway dimensions are difficult to quantify bronchoscopically because of optical distortion and a limited ability to gauge depth. Anatomical optical coherence tomography (aOCT), a novel imaging technique, may overcome these limitations. This study evaluated the accuracy of aOCT against existing techniques in phantom, excised pig and in vivo human airways. Three comparative studies were performed: (i) micrometer-derived area measurements in ten plastic tubes were compared to aOCT-derived area; (ii) aOCT-derived ...
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    10. A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)

      A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)
      The present disclosure provides a method of providing quantitative information about a property of the lower airways of a lung using optical coherence tomography. The method comprises inserting a probe head of an anatomical optical coherence tomography device into the lower airways. Further, the method comprises directing light to, and receiving reflected light from, an internal wall portion of the lower airways. The light is suitable for optical coherence tomography ...
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    11. Effect of Body Posture on Pharyngeal Shape and Size in Adults With and Without Obstructive Sleep Apnea

      ...Alexandre Paduch, MSc2; Kathleen J. Maddison, BSc (Hons)1; Julian J. Armstrong, PhD2; David D. Sampson, PhD2; David R. Hillman, MD1; Peter R. Eastwood, PhD1,3 1West Australian Sleep Disorders Research Institute, Sir Char...
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    12. Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway

      Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway
      ...airway Robert A. McLaughlin, Jonathan P. Williamson, Martin J. Phillips, Julian J. Armstrong, Sven Becker, David R. Hillman, Peter R. Eastwood, and David D. Sampson Optics Express, Vol. 16, Issue 22, pp. 17521-17529 ยป...
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    13. Respiratory gating of endoscopic OCT images of the upper airway

      Robert A. McLaughlin, Julian J. Armstrong, Sven Becker et al. Anatomical optical coherence tomography (aOCT) is an endoscopic imaging modality that can be used to quantify size and shape of the upper airway. We report the application of respiratory gating to aOCT images. Our results show that respiratory gating can reduce motion artefact in upper airway images ... [Proc. SPIE 7004, 70045V (2008)] published Fri May 16, 2008.
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    14. Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea

      ...doscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population ... SAMPSON, DAVID R. HILLMAN, PETER R. EASTWOOD (2008) Evaluation of pharyngeal shape and size using anatomical optical co...
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    15. Anatomical optical coherence tomography: a safe and effective tool for quantitative long-term monitoring of upper airway size and shape

      J. J. Armstrong, S. Becker, R. A. McLaughlin et al. Anatomical optical coherence tomography (aOCT) is an endoscopic optical technique that enables continuous, quantitative assessment of hollow organ size and shape in three dimensions. It is a powerful alternative to X-ray computed tomography, magnetic resonance imaging, and video endoscopy for the as ... [Proc. SPIE Int. Soc. Opt. Eng. 6842, 68421N (2008)] published Fri Feb 8, 2008.
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  2. About David R. Hillman

    David R. Hillman

    David R. Hillman is with the Department of Pulmonary Physiology at Sir Charles Gairdner Hospital Australia and the West Australian Sleep Disorders Research Institute. Dr Hillman completed his specialist training in anaesthesia in 1981 before commencing a research fellowship in the Department of Pulmonary Physiology at Sir Charles Gairdner Hospital. In 1985 he was appointed to the hospital as a Clinical Physiologist and Anaesthetist. His time in these positions has coincided with a worldwide increase in knowledge of sleep and its disorders, particularly sleep apnoea. His research interests have increasingly centred on these problems. He has published over 50 scientific papers, and reviews regularly for international journals and national granting bodies.