1. David Huang

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    1. Mentioned In 369 Articles

    2. Keratoconus Detection using OCT Corneal and Epithelial Thickness Map Parameters and Patterns

      Keratoconus Detection using OCT Corneal and Epithelial Thickness Map Parameters and Patterns
      Purpose: To detect keratoconus using optical coherence tomography (OCT) corneal map parameters and patterns. Setting: Casey Eye Institute, Oregon Health Science University, Portland, Oregon, USA DESIGN:: Cross-sectional observational study. Methods: A spectral-domain OCT was used to acquire corneal and epithelial thickness maps in normal, manifest keratoconic, subclinical keratoconic, and forme fruste keratoconic (FFK) eyes. A two-step decision tree was designed. An eye will be classified as keratoconus if both decision ...
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    3. A Coincident Thinning Index for Keratoconus Identification Using OCT Pachymetry and Epithelial Thickness Maps

      A Coincident Thinning Index for Keratoconus Identification Using OCT Pachymetry and Epithelial Thickness Maps
      PURPOSE: To develop a coincident thinning (CTN) index to differentiate between keratoconic and healthy corneas using optical coherence tomography (OCT) measurements of pachymetry and epithelial thickness. METHODS: Pattern deviation maps of pachymetry and epithelial thickness were generated using Fourier-domain OCT images of the cornea. The co-localized thinning of the two maps was quantified using a novel CTN index, which was calculated from Gaussian fits of the regions of maximum relative ...
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    4. Scleral Lens Fitting Using Wide-Field OCT

      Scleral Lens Fitting Using Wide-Field OCT
      The purpose of this study is to see if OCT technology can optimize scleral contact lens fittings. Subjects with keratoconus, post-penetrating keratoplasty (PK), post-LASIK ectasia, post-radial keratotomy (RK), or a variety of anterior surface disorders requiring scleral lens fittings will be considered for enrollment. For each study eye, a clinically-selected scleral lens fit will be compared against an OCT-selected lens fit. The quality of each lens fit will be determined ...
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    5. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

      Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
      Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower ...
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    6. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma
      ...64,228 for Functional and Structural Optical Coherence Tomography for Glaucoma. The principal investigator is David Huang. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness. Early diagnos...
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    7. Sensorless adaptive-optics optical coherence tomographic angiography

      Sensorless adaptive-optics optical coherence tomographic angiography
      Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics (AO) can be used to compensate ocular aberrations when using high numerical aperture (NA), and thus improve image resolution. However, previously reported AO-OCTA instruments were large and complex, and have a small sub-millimeter field of view (FOV) that hinders the extraction of biomarkers with ...
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    8. Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography

      Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography
      Sensorless adaptive optics optical coherence tomography (AO-OCT) is a technology to image retinal tissue with high resolution by compensating ocular aberrations without wavefront sensors. In this Letter, a fast and robust hill-climbing algorithm is developed to optimize five Zernike modes in AO-OCT with a numerical aperture between that of conventional AO and commercial OCT systems. The merit function is generated in real time using graphics processing unit while axially tracking ...
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    9. Optical coherence tomography angiography avascular area association with one-year treatment requirement and disease progression in diabetic retinopathy

      Optical coherence tomography angiography avascular area association with one-year treatment requirement and disease progression in diabetic retinopathy
      Purpose To assess the association between optical coherence tomography angiography (OCTA) quantified avascular areas (AA) and diabetic retinopathy (DR) severity, progression and treatment requirement in the following year. Design Prospective cohort study. Methods We recruited diabetic patients from tertiary academic retina practice and obtained 3x3-mm macular OCTA scans with AngioVue system and standard 7-field color photographs at baseline and 1-year visit. A masked grader determined the DR severity from the ...
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    10. Systems and methods to remove shadowgraphic flow projections on OCT angiography

      Systems and methods to remove shadowgraphic flow projections on OCT angiography
      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.
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    11. Bulk motion subtraction in optical coherence tomography angiography

      Bulk motion subtraction in optical coherence tomography angiography
      Described herein is an algorithm to remove decorrelation noise due to bulk motion in optical coherence tomography angiography (OCTA). OCTA B-frames are divided into segments within which the bulk motion velocity could be assumed constant. This velocity is recovered using linear regression of decorrelation versus the logarithm of reflectance in axial lines (A-lines) identified as bulk tissue by percentile analysis. The fitting parameters are used to calculate a reflectance-adjusted threshold ...
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    12. Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases
      ...lication of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to ...
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    13. Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization

      Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization
      Purpose: To map and measure the depths of corneal neovascularization (NV) using 3-dimensional optical coherence tomography angiography (OCTA) at 2 different wavelengths. Methods: Corneal NV of varying severity, distribution, and underlying etiology was examined. Average NV depth and vessel density were measured using 840-nm spectral-domain OCTA and 1050-nm swept-source OCTA. The OCTA results were compared with clinical slit-lamp estimation of NV depth. Results: Twelve eyes with corneal NV from 12 ...
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    14. Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients

      Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients
      To construct an optical coherence tomography (OCT) nerve fiber layer (NFL) parameter that has maximal correlation and agreement with visual field (VF) mean deviation (MD). The NFL_MD parameter in dB scale was calculated from the peripapillary NFL thickness profile nonlinear transformation and VF area-weighted averaging. From the Advanced Imaging for Glaucoma study, 245 normal, 420 pre-perimetric glaucoma (PPG), and 289 perimetric glaucoma (PG) eyes were selected. NFL_MD had significantly higher ...
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    15. Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma

      Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma
      Purpose To simulate 24-2 visual field (VF) using optical coherence tomographic angiography (OCTA) for glaucoma evaluation. Design Cross-sectional study. Methods One eye each of 39 glaucoma and 31 age-matched normal participants was scanned using 4.5-mm OCTA scans centered on the disc. The peripapillary retinal nerve fiber layer plexus capillary density (NFLP_CD, %area) was measured. The NFLP_CD and 24-2 VF maps were divided into 8 corresponding sectors using an extension ...
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  2. About David Huang

    David Huang

    David Huang is Peterson Professor of Ophthalmology, professor of biomedical engineering, and director of the Center for Ophthalmic Optics and Lasers (www.COOLLab.net) in the Casey Eye Institute at the Oregon Health and Science University in Portland. The COOL lab conducts research on retinal diseases, anterior eye disease, glaucoma, and other optic nerve diseases. He is a co-inventor of OCT and has contributed to polarization-sensitive, swept-source, spectroscopic, and anterior eye OCT as well as OCT angiography. He is also an inventor of laser therapeutic devices and mobile diagnostic technology, and a founder of Gobiquity Mobile Health (www.gobiquity.com), which makes mobile diagnostic apps for professional and home use. Huang shared the 2012 António Champalimaud Vision Award and received the Association for Research in Vision and Ophthalmology’s Jonas Friedenwald Award and the American Academy of Ophthalmology’s Senior Achievement Award. He is a fellow of the National Academy of Inventors.

  3. Quotes

    1. Among the developments in the past 2 years, OCTA is by far the most important...Clinically, OCTA represents a paradigm change in angiography. It requires no dye injection, is faster (no waiting for dye transit), noninvasive, cheaper, and it can be used at every visit for screening and monitoring. OCTA will be used a lot more that fluorescein angiography ever was.
      In Ophthalmic imaging modalities: a lot of change in 2 years
    2. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      In Co-invented by OHSU's Dr. David Huang 25 years ago, OCT technology helps stop blindness
    3. OCT is a big saver of healthcare dollars – the guidance of anti-vascular endothelial growth factor therapy in age-related macular degeneration alone saves billions of dollars per year by avoiding unnecessary injections.
      In Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment
    4. OCT is the most commonly used eye imaging test in the management of the leading causes of blindness today: macular degeneration, diabetic retinopathy and glaucoma. I am proud to be a key contributor to the technology that is preserving vision for people around the world.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    5. Seeing the blood flow in many layers of the retina is incredibly important because the most important causes of blindness in the world are due to abnormal blood circulation.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    6. There are a few circumstances where mapping the posterior surface is also useful, for example, in post-LASIK cataract surgery intraocular lens calculations, where measuring the anterior surface alone is not sufficient to really accurately measure the net corneal power.
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    7. Confocal microscopy of the cornea has been around for a long time but it still doesn’t have a lot of specificity in looking at microorganisms...Some sort of in vivo staining or fluorescence that allows us to really distinguish infections or microorganisms with confocal imaging would be great
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    8. OCT has higher resolution than any of the anterior segment modalities....I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.
      In OCT devices increasingly finding use outside retinal practice
    9. OCT has higher resolution than any of the anterior segment modalities...I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.”
      In OCT devices increasingly finding use outside retinal practice
    10. It just requires special scanning software that could easily be put on the OCT machines that most retinal specialists have.
      In Shining Light on Diabetes-Related Blindness