1. David Huang

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    1. Mentioned In 261 Articles

    2. Hematocrit dependence of flow signal in optical coherence tomography angiography

      Hematocrit dependence of flow signal in optical coherence tomography angiography
      The hematocrit dependence of flow signal (split-spectrum amplitude decorrelation angiography-SSADA decorrelation value) was investigated in this paper. Based on the normalized field temporal correlation function and concentration dependent particle scattering properties, the relationship between hematocrit and flow signal was analytically derived. Experimental verification of the relationship was performed with custom-designed microfluidic chips and human blood with 45%, 40% and 32% hematocrit. It was found that, in large flow channels and ...
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    3. Optical coherence tomography angiography of non-exudative choroidal neovascularization

      Optical coherence tomography angiography of non-exudative choroidal neovascularization
      Age-related macular degeneration (AMD) has been classified in two groups, neovascular and non-neovascular, which historically has been synonymous with exudative and non-exudative, respectively. Neovascular AMD occurs when pathologic blood vessels, choroidal neovascularization (CNV), arise from the choroid and extend above Bruchs membrane toward the outer retina. Often these vessels are exudative in nature, resulting in leakage of fluid, lipid exudate, or blood causing vision loss. The exudation from CNV allows ...
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    4. Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography

      Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography
      The choriocapillaris plays an important role in supporting the metabolic demands of the retina. Studies of the choriocapillaris in disease states with optical coherence tomography angiography (OCTA) have proven insightful. However, image artifacts complicate the identification and quantification of the choriocapillaris in degenerative diseases such as choroideremia. Here, we demonstrate a supervised machine learning approach to detect intact choriocapillaris based on training with results from an expert grader. We trained ...
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    5. Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography

      Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography
      Purpose To evaluate the morphological structure of ill-defined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). Methods A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. En ...
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    6. Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors

      Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors
      Purpose To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. Design Cross-sectional observational clinical study. Participants Patients with iris lesions and healthy volunteers. Methods Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months. Main ...
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    7. Two-dimensional phase unwrapping in Doppler Fourier domain optical coherence tomography

      Two-dimensional phase unwrapping in Doppler Fourier domain optical coherence tomography
      For phase-related imaging modalities using interferometric techniques, it is important to develop effective method to recover phase information that is mathematically wrapped. In this paper, we propose and demonstrate a two-dimensional (2D) method to achieve effective phase unwrapping in Doppler Fourier-domain (FD) optical coherence tomography (OCT), and recover the discontinuous phase distribution in retinal blood flow successfully for the first time in Doppler OCT studies. The proposed method is based ...
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    8. Visualization of 3 Distinct Retinal Plexuses by Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Visualization of 3 Distinct Retinal Plexuses by Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Importance Projection artifacts in optical coherence tomography angiography (OCTA) blur the retinal vascular plexuses together and limit visualization of the individual plexuses. Objective To describe projection-resolved (PR) OCTA in eyes with diabetic retinopathy (DR) and healthy eyes. Design, Setting, and Participants In this case-control study, patients with DR and healthy controls were enrolled in this observational study from January 26, 2015, to December 4, 2015, at a tertiary academic center ...
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    9. Automated Quantification of Nonperfusion in Three Retinal Plexuses Using Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Automated Quantification of Nonperfusion in Three Retinal Plexuses Using Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Purpose : The purpose of this study was to evaluate an automated algorithm for detecting avascular area (AA) in optical coherence tomography angiograms (OCTAs) separated into three individual plexuses using a projection-resolved technique. Methods : A 3 3 mm macular OCTA was obtained in 13 healthy and 13 mild nonproliferative diabetic retinopathy (NPDR) participants. A projection-resolved algorithm segmented OCTA into three vascular plexuses: superficial, intermediate, and deep. An automated algorithm detected AA ...
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    10. Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology

      Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology
      Artifacts introduced by eye motion in optical coherence tomography angiography (OCTA) affect the interpretation of images and the quantification of parameters with clinical value. Eradication of such artifacts in OCTA remains a technical challenge. We developed an algorithm that recognizes five different types of motion artifacts and used it to evaluate the performance of three motion removal technologies. On en face maximum projection of flow images, the summed flow signal ...
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    11. Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography

      Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography
      Purpose : To compensate for reflectance variation when quantifying vessel density by optical coherence tomography angiography (OCTA). Methods : Healthy participants received 66-mm macular and 4.54.5-mm optic nerve head (ONH) angiography scans on a 70-kHz spectral-domain optical coherence tomography system. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute the OCTA signal. Mean reflectance projection and maximum decorrelation projection were used to create en face OCT and OCTA images ...
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    12. OSA Centennial Snapshots: OCT and the Flowering of Biophotonics

      OSA Centennial Snapshots: OCT and the Flowering of Biophotonics
      The birth, commercialization and ultimate impact of OCT stand out as landmark accomplishments even amid the abundant advances in biophotonics during the 1980s and 1990s. Twenty-five years ago this month, the editors of Science accepted for publication a research paper titled Optical Coherence Tomography. That three-word phrase (and its punchier abbreviation, OCT) heralded a revolution in ophthalmologyone that would spawn a billion-dollar-a-year market, and affect millions of people.
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    13. Calibration of optical coherence tomography angiography with a microfluidic chip

      Calibration of optical coherence tomography angiography with a microfluidic chip
      A microfluidic chip with microchannels ranging from 8 to 96 m 96m was used to mimic blood vessels down to the capillary level. Blood flow within the microfluidic channels was analyzed with split-spectrum amplitude-decorrelation angiography (SSADA)-based optical coherence tomography (OCT) angiography. It was found that the SSADA decorrelation value was related to both blood flow speed and channel width. SSADA could differentiate nonflowing blood inside the microfluidic channels from ...
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    14. 1-15 of 261 1 2 3 4 ... 16 17 18 »
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  2. About David Huang

    David Huang

    David Huang is Peterson Professor of Ophthalmology, professor of biomedical engineering, and director of the Center for Ophthalmic Optics and Lasers (www.COOLLab.net) in the Casey Eye Institute at the Oregon Health and Science University in Portland. The COOL lab conducts research on retinal diseases, anterior eye disease, glaucoma, and other optic nerve diseases. He is a co-inventor of OCT and has contributed to polarization-sensitive, swept-source, spectroscopic, and anterior eye OCT as well as OCT angiography. He is also an inventor of laser therapeutic devices and mobile diagnostic technology, and a founder of Gobiquity Mobile Health (www.gobiquity.com), which makes mobile diagnostic apps for professional and home use. Huang shared the 2012 António Champalimaud Vision Award and received the Association for Research in Vision and Ophthalmology’s Jonas Friedenwald Award and the American Academy of Ophthalmology’s Senior Achievement Award. He is a fellow of the National Academy of Inventors.

  3. Quotes

    1. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      In Co-invented by OHSU's Dr. David Huang 25 years ago, OCT technology helps stop blindness
    2. OCT is a big saver of healthcare dollars – the guidance of anti-vascular endothelial growth factor therapy in age-related macular degeneration alone saves billions of dollars per year by avoiding unnecessary injections.
      In Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment
    3. OCT is the most commonly used eye imaging test in the management of the leading causes of blindness today: macular degeneration, diabetic retinopathy and glaucoma. I am proud to be a key contributor to the technology that is preserving vision for people around the world.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    4. Seeing the blood flow in many layers of the retina is incredibly important because the most important causes of blindness in the world are due to abnormal blood circulation.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    5. There are a few circumstances where mapping the posterior surface is also useful, for example, in post-LASIK cataract surgery intraocular lens calculations, where measuring the anterior surface alone is not sufficient to really accurately measure the net corneal power.
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    6. Confocal microscopy of the cornea has been around for a long time but it still doesn’t have a lot of specificity in looking at microorganisms...Some sort of in vivo staining or fluorescence that allows us to really distinguish infections or microorganisms with confocal imaging would be great
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    7. OCT has higher resolution than any of the anterior segment modalities....I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.
      In OCT devices increasingly finding use outside retinal practice
    8. OCT has higher resolution than any of the anterior segment modalities...I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.”
      In OCT devices increasingly finding use outside retinal practice
    9. It just requires special scanning software that could easily be put on the OCT machines that most retinal specialists have.
      In Shining Light on Diabetes-Related Blindness
    10. People with poor blood flow don't respond well to some of the laser treatments used for retinopathy, and they are at a higher risk for proliferative retinopathy.
      In Shining Light on Diabetes-Related Blindness