1. David Huang

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    1. Mentioned In 321 Articles

    2. Quantitative evaluation of retinal artery occlusion using optical coherence tomography angiography: A case report

      Quantitative evaluation of retinal artery occlusion using optical coherence tomography angiography: A case report
      Rationale: Retinal artery occlusion (RAO) results in painless, catastrophic vision loss in a period of seconds. Optical coherence tomography angiography (OCTA) can image retinal microcirculation, which is helpful to evaluate treatment response during the follow-up period. Using a single case with central RAO, we report its retinal perfusion changes before and after treatment using OCTA. Patient concerns: A 36-year-old Chinese man came to our clinic with a sudden, painless loss ...
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    3. Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University

      Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University
      ...al processing, and image processing are also desirable. Please Contact Dr. Yifan Jian at jian@ohsu.edu or Dr. David Huang at huangd@ohsu.edu or details. Applications, including a statement of research interests, a curren...
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    4. Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography

      Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography
      Advances in the retinal layer segmentation of structural optical coherence tomography (OCT) images have allowed the separation of capillary plexuses in OCT angiography (OCTA). With the increased scanning speeds of OCT devices and wider field images (10 mm on fast-axis), greater retinal curvature and anatomic variations have introduced new challenges. In this study, we developed a novel automated method to segment seven retinal layer boundaries and two retinal plexuses in ...
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    5. Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography

      Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography
      Purpose : To evaluate if projection-resolved optical coherence tomographic angiography (PR-OCTA) reduces projection artifact with less attenuation of choroidal neovascularization (CNV) flow signal compared to conventional OCTA with slab subtraction. Methods : In this retrospective cross-sectional study, participants with subfoveal treatment-nave CNV secondary to age-related macular degeneration underwent OCTA. Scans were exported for custom processing including manual segmentation as necessary, application of slab subtraction and PR-OCTA algorithm, and calculation of CNV vascular ...
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    6. Deep learning for the segmentation of preserved photoreceptors on en face optical coherence tomography in two inherited retinal diseases

      Deep learning for the segmentation of preserved photoreceptors on en face optical coherence tomography in two inherited retinal diseases
      The objective quantification of photoreceptor loss in inherited retinal degenerations (IRD) is essential for measuring disease progression, and is now especially important with the growing number of clinical trials. Optical coherence tomography (OCT) is a non-invasive imaging technology widely used to recognize and quantify such anomalies. Here, we implement a versatile method based on a convolutional neural network to segment the regions of preserved photoreceptors in two different IRDs (choroideremia ...
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    7. Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes

      Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes
      Importance Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants Cross-sectional study at a ...
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    8. Systems and methods of choroidal neovascularization detection using optical coherence tomography angiography

      Systems and methods of choroidal neovascularization detection using optical coherence tomography angiography
      Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.
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    9. Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography

      Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography
      Purpose : To describe an automated algorithm to quantify the foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA), and to compare its performance for diagnosis of diabetic retinopathy (DR) and association with best-corrected visual acuity (BCVA) to that of extrafoveal avascular area (EAA). Methods : We obtained 3 3-mm macular OCTA scans in diabetic patients with various levels of DR and healthy controls. An algorithm based on a generalized gradient ...
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    10. Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT

      Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT
      Phase-based optical coherence tomography (OCT), such as OCT angiography (OCTA) and Doppler OCT, is sensitive to the confounding phase shift introduced by subject bulk motion. Traditional bulk motion compensation methods are limited by their accuracy and computing cost-effectiveness. In this Letter, to the best of our knowledge, we present a novel bulk motion compensation method for phase-based functional OCT. Bulk motion associated phase shift can be directly derived by solving ...
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    11. Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti
      Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may ...
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    12. OCT in Diagnosis of Irregular Corneas

      OCT in Diagnosis of Irregular Corneas
      This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: Develop an OCT-based system to classify and evaluate corneal-shape irregularities. Develop OCT metrics for more sensitive detection of keratoconus progression. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK ...
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    13. Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti
      Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may ...
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    14. Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

      Automated spectroscopic retinal oximetry with visible-light optical coherence tomography
      Accurate, quantitative assessment of retinal blood oxygen saturation ( sO 2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO 2 within the retinal arteries (A- sO 2 ) and veins (V- sO 2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was ...
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    15. Aqueous cell differentiation in anterior uveitis using optical coherence tomography

      Aqueous cell differentiation in anterior uveitis using optical coherence tomography
      Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from OCT image data are disclosed. In one example approach, determining a percentage composition of detected aqueous cells may comprise calculating a percentage of the detected aqueous cells which are polymorphonuclear and calculating a percentage of detected aqueous cells which are mononuclear.
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    16. 1-15 of 321 1 2 3 4 ... 20 21 22 »
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  2. About David Huang

    David Huang

    David Huang is Peterson Professor of Ophthalmology, professor of biomedical engineering, and director of the Center for Ophthalmic Optics and Lasers (www.COOLLab.net) in the Casey Eye Institute at the Oregon Health and Science University in Portland. The COOL lab conducts research on retinal diseases, anterior eye disease, glaucoma, and other optic nerve diseases. He is a co-inventor of OCT and has contributed to polarization-sensitive, swept-source, spectroscopic, and anterior eye OCT as well as OCT angiography. He is also an inventor of laser therapeutic devices and mobile diagnostic technology, and a founder of Gobiquity Mobile Health (www.gobiquity.com), which makes mobile diagnostic apps for professional and home use. Huang shared the 2012 António Champalimaud Vision Award and received the Association for Research in Vision and Ophthalmology’s Jonas Friedenwald Award and the American Academy of Ophthalmology’s Senior Achievement Award. He is a fellow of the National Academy of Inventors.

  3. Quotes

    1. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      In Co-invented by OHSU's Dr. David Huang 25 years ago, OCT technology helps stop blindness
    2. OCT is a big saver of healthcare dollars – the guidance of anti-vascular endothelial growth factor therapy in age-related macular degeneration alone saves billions of dollars per year by avoiding unnecessary injections.
      In Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment
    3. OCT is the most commonly used eye imaging test in the management of the leading causes of blindness today: macular degeneration, diabetic retinopathy and glaucoma. I am proud to be a key contributor to the technology that is preserving vision for people around the world.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    4. Seeing the blood flow in many layers of the retina is incredibly important because the most important causes of blindness in the world are due to abnormal blood circulation.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    5. There are a few circumstances where mapping the posterior surface is also useful, for example, in post-LASIK cataract surgery intraocular lens calculations, where measuring the anterior surface alone is not sufficient to really accurately measure the net corneal power.
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    6. Confocal microscopy of the cornea has been around for a long time but it still doesn’t have a lot of specificity in looking at microorganisms...Some sort of in vivo staining or fluorescence that allows us to really distinguish infections or microorganisms with confocal imaging would be great
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    7. OCT has higher resolution than any of the anterior segment modalities....I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.
      In OCT devices increasingly finding use outside retinal practice
    8. OCT has higher resolution than any of the anterior segment modalities...I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.”
      In OCT devices increasingly finding use outside retinal practice
    9. It just requires special scanning software that could easily be put on the OCT machines that most retinal specialists have.
      In Shining Light on Diabetes-Related Blindness
    10. People with poor blood flow don't respond well to some of the laser treatments used for retinopathy, and they are at a higher risk for proliferative retinopathy.
      In Shining Light on Diabetes-Related Blindness