1. David Huang

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    1. Mentioned In 250 Articles

    2. Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology

      Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology
      Artifacts introduced by eye motion in optical coherence tomography angiography (OCTA) affect the interpretation of images and the quantification of parameters with clinical value. Eradication of such artifacts in OCTA remains a technical challenge. We developed an algorithm that recognizes five different types of motion artifacts and used it to evaluate the performance of three motion removal technologies. On en face maximum projection of flow images, the summed flow signal ...
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    3. Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography

      Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography
      Purpose : To compensate for reflectance variation when quantifying vessel density by optical coherence tomography angiography (OCTA). Methods : Healthy participants received 66-mm macular and 4.54.5-mm optic nerve head (ONH) angiography scans on a 70-kHz spectral-domain optical coherence tomography system. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute the OCTA signal. Mean reflectance projection and maximum decorrelation projection were used to create en face OCT and OCTA images ...
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    4. OSA Centennial Snapshots: OCT and the Flowering of Biophotonics

      OSA Centennial Snapshots: OCT and the Flowering of Biophotonics
      The birth, commercialization and ultimate impact of OCT stand out as landmark accomplishments even amid the abundant advances in biophotonics during the 1980s and 1990s. Twenty-five years ago this month, the editors of Science accepted for publication a research paper titled Optical Coherence Tomography. That three-word phrase (and its punchier abbreviation, OCT) heralded a revolution in ophthalmologyone that would spawn a billion-dollar-a-year market, and affect millions of people.
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    5. Calibration of optical coherence tomography angiography with a microfluidic chip

      Calibration of optical coherence tomography angiography with a microfluidic chip
      A microfluidic chip with microchannels ranging from 8 to 96 m 96m was used to mimic blood vessels down to the capillary level. Blood flow within the microfluidic channels was analyzed with split-spectrum amplitude-decorrelation angiography (SSADA)-based optical coherence tomography (OCT) angiography. It was found that the SSADA decorrelation value was related to both blood flow speed and channel width. SSADA could differentiate nonflowing blood inside the microfluidic channels from ...
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    6. Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography

      Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography
      Purpose : We observed and analyzed the morphologic characteristics of polypoidal lesions and abnormal branching vascular network (BVN) in patients with polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA). Methods : A retrospective observational case series was done of patients with PCV. All patients were scanned with a 70-kHz spectral-domain OCT system using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images of ...
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    7. Quantification of choroidal neovascularization vessel length using optical coherence tomography angiography

      Quantification of choroidal neovascularization vessel length using optical coherence tomography angiography
      Quantification of choroidal neovascularization (CNV) as visualized by optical coherence tomography angiography (OCTA) may have importance clinically when diagnosing or tracking disease. Here, we present an automated algorithm to quantify the vessel skeleton of CNV as vessel length. Initial segmentation of the CNV on en face angiograms was achieved using saliency-based detection and thresholding. A level set method was then used to refine vessel edges. Finally, a skeleton algorithm was ...
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    8. Foreword: 25 Years of Optical Coherence Tomography

      Foreword: 25 Years of Optical Coherence Tomography
      This special issue commemorates the 25th anniversary of the development of optical coherence tomography (OCT). OCT has had a transformative impact in the field of ophthalmology and vision research, contributing to fundamental understanding of disease pathogenesis, drug discovery and development, and everyday clinical decision making in all ophthalmic subspecialties. The role of OCT in research and clinical care continues to accelerate, as judged by the cumulative number of publications in ...
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    9. Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography

      Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography
      Purpose : To use multiplane en face Doppler optical coherence tomography (OCT) to measure the change in total retinal blood flow (TRBF) in response to hyperoxia. Methods : One eye of each healthy human participant ( n = 8) was scanned with a commercial high-speed (70-kHz) spectral OCT system. Three repeated scans were captured at baseline and after 10 minutes of oxygen (hyperoxia) by open nasal mask. The procedure was performed twice on day ...
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    10. Comparison of Newer IOL Power Calculation Methods for Eyes With Previous Radial Keratotomy

      Comparison of Newer IOL Power Calculation Methods for Eyes With Previous Radial Keratotomy
      Purpose : To evaluate the accuracy of the optical coherence tomographybased (OCT formula) and Barrett True K (True K) intraocular lens (IOL) calculation formulas in eyes with previous radial keratotomy (RK). Methods : In 95 eyes of 65 patients, using the actual refraction following cataract surgery as target refraction, the predicted IOL power for each method was calculated. The IOL prediction error (PE) was obtained by subtracting the predicted IOL power from ...
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    11. Relationship Between Retinal Perfusion and Retinal Thickness in Healthy Subjects: An Optical Coherence Tomography Angiography Study

      Relationship Between Retinal Perfusion and Retinal Thickness in Healthy Subjects: An Optical Coherence Tomography Angiography Study
      Purpose : To investigate the relationship between retinal perfusion and retinal thickness in the peripapillary and macular areas of healthy subjects. Methods : Using spectral-domain optic coherence tomography and split-spectrum amplitude decorrelation angiography (SSADA) algorithm, retinal perfusion and retinal thicknesses in the macular and peripapillary areas were measured in healthy volunteers, and correlations among these variables were analyzed. Results : Overall, 64 subjects (121 eyes) including 28 males and 36 females with a ...
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    12. Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography

      Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography
      Purpose : We investigated the feasibility of glaucoma detection by measuring retinal surface contour variability (RSCV) using optical coherence tomography (OCT). Methods : The peripapillary region in one eye of each participant was scanned over an 8 8 mm area with a swept source OCT prototype. The retinal surface contour was sampled at approximately 1.5- to 3.5-mm radius circles centered on the optic nerve head. The RSCV is defined as ...
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    13. Optical Coherence Tomography Angiography

      Optical Coherence Tomography Angiography
      Optical coherence tomography angiography (OCTA) is a noninvasive approach that can visualize blood vessels down to the capillary level. With the advent of high-speed OCT and efficient algorithms, practical OCTA of ocular circulation is now available to ophthalmologists. Clinical investigations that used OCTA have increased exponentially in the past few years. This review will cover the history of OCTA and survey its most important clinical applications. The salient problems in ...
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    14. Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes

      Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes
      Purpose : The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. Methods : Two hundred sixty-one eyes of 164 healthy, glaucoma suspect, and open-angle glaucoma (OAG) participants from the Diagnostic Innovations in Glaucoma Study with good quality OCT-A images were included. Retinal vasculature information was summarized as a vessel density map ...
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    15. Split-spectrum phase-gradient optical coherence tomography angiography

      Split-spectrum phase-gradient optical coherence tomography angiography
      A phase gradient angiography (PGA) method is proposed for optical coherence tomography (OCT). This method allows the use of phase information to map the microvasculature in tissue without the correction of bulk motion and laser trigger jitter induced phase artifacts. PGA can also be combined with the amplitude/intensity to improve the performance. Split-spectrum technique can further increase the signal to noise ratio by more than two times. In-vivo imaging ...
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  2. About David Huang

    David Huang

    David Huang joined the Oregon Health & Science University (OHSU) Casey Eye Institute in 2010 as a Professor of Ophthalmology. Dr. Huang earned the MD degree from Harvard University and a PhD in Medical Engineering and Medical Physics from Massachusetts Institute of Technology. He received ophthalmology residency training at USC and fellowship training in cornea, external disease and refractive surgery at Emory University School of Medicine. Before joining the OHSU faculty, Dr. Huang was on the staff of the Cole Eye Institute of the Cleveland Clinic and later on the faculty of Doheny Eye Institute of University of Southern California. Dr. Huang has been named one of best doctors in America by his peers (www.bestdoctors.com) and among the top LASIK surgeons by www.trustedlasiksurgeons.com based on research experience and premier patient care. Dr. Huang is known for his innovations in applying laser and optical technology to eye diseases. He is a co-inventor of optical coherence tomography (OCT), an imaging technology that has been applied to the measurement of eye structures with unprecedented precision. He continues his research in applying OCT to corneal and cataract surgery, glaucoma and retinal diseases

  3. Quotes

    1. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      In Co-invented by OHSU's Dr. David Huang 25 years ago, OCT technology helps stop blindness
    2. OCT is a big saver of healthcare dollars – the guidance of anti-vascular endothelial growth factor therapy in age-related macular degeneration alone saves billions of dollars per year by avoiding unnecessary injections.
      In Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment
    3. OCT is the most commonly used eye imaging test in the management of the leading causes of blindness today: macular degeneration, diabetic retinopathy and glaucoma. I am proud to be a key contributor to the technology that is preserving vision for people around the world.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    4. Seeing the blood flow in many layers of the retina is incredibly important because the most important causes of blindness in the world are due to abnormal blood circulation.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    5. There are a few circumstances where mapping the posterior surface is also useful, for example, in post-LASIK cataract surgery intraocular lens calculations, where measuring the anterior surface alone is not sufficient to really accurately measure the net corneal power.
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    6. Confocal microscopy of the cornea has been around for a long time but it still doesn’t have a lot of specificity in looking at microorganisms...Some sort of in vivo staining or fluorescence that allows us to really distinguish infections or microorganisms with confocal imaging would be great
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    7. OCT has higher resolution than any of the anterior segment modalities....I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.
      In OCT devices increasingly finding use outside retinal practice
    8. OCT has higher resolution than any of the anterior segment modalities...I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.”
      In OCT devices increasingly finding use outside retinal practice
    9. It just requires special scanning software that could easily be put on the OCT machines that most retinal specialists have.
      In Shining Light on Diabetes-Related Blindness
    10. People with poor blood flow don't respond well to some of the laser treatments used for retinopathy, and they are at a higher risk for proliferative retinopathy.
      In Shining Light on Diabetes-Related Blindness