1. David Huang

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    1. Mentioned In 311 Articles

    2. Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography

      Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography
      Purpose : To describe an automated algorithm to quantify the foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA), and to compare its performance for diagnosis of diabetic retinopathy (DR) and association with best-corrected visual acuity (BCVA) to that of extrafoveal avascular area (EAA). Methods : We obtained 3 3-mm macular OCTA scans in diabetic patients with various levels of DR and healthy controls. An algorithm based on a generalized gradient ...
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    3. Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT

      Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT
      Phase-based optical coherence tomography (OCT), such as OCT angiography (OCTA) and Doppler OCT, is sensitive to the confounding phase shift introduced by subject bulk motion. Traditional bulk motion compensation methods are limited by their accuracy and computing cost-effectiveness. In this Letter, to the best of our knowledge, we present a novel bulk motion compensation method for phase-based functional OCT. Bulk motion associated phase shift can be directly derived by solving ...
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    4. Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti
      Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may ...
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    5. OCT in Diagnosis of Irregular Corneas

      OCT in Diagnosis of Irregular Corneas
      This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: Develop an OCT-based system to classify and evaluate corneal-shape irregularities. Develop OCT metrics for more sensitive detection of keratoconus progression. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK ...
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    6. Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti
      Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may ...
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    7. Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

      Automated spectroscopic retinal oximetry with visible-light optical coherence tomography
      Accurate, quantitative assessment of retinal blood oxygen saturation ( sO 2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO 2 within the retinal arteries (A- sO 2 ) and veins (V- sO 2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was ...
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    8. Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography

      Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography
      Purpose : To devise a method to quantify nerve fibers over their arcuate courses over an extended peripapillary area using optical coherence tomography (OCT). Methods : Participants were imaged with 8 8-mm volumetric OCT scans centered at the optic disc. A new quantity, nerve fiber flux (NFF), represents the cross-sectional area transected perpendicular to the nerve fibers. The peripapillary area was divided into 64 tracks with equal flux. An iterative algorithm traced ...
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    9. Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography

      Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography
      Purpose: To investigate the changes in the retinal vasculature in different parts of the fundus in eyes with primary angle closure glaucoma (PACG). Methods: Healthy subjects and those with PACG were enrolled. Optical coherence tomography and a split-spectrum amplitude decorrelation angiography algorithm were used to quantify the retinal vessel densities in the parafoveal and peripapillary areas. Results: Thirty-nine eyes from 24 PACG patients and 39 eyes from 20 age- and ...
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    10. Post-Doctoral Fellowship on Ophthalmic Imaging and Lasers at Oregon Science & Health University

      Post-Doctoral Fellowship on Ophthalmic Imaging and Lasers at Oregon Science & Health University
      ...essing, image processing, and laser-tissue interaction are also desirable. Please contact center director Dr. David Huang huangd@ohsu.edu for details. A postdoctoral research fellowship/research associate position is imm...
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    11. Post-Doctoral Fellowship on Image Processing (OCT and OCTA) at Oregon Health & Science University

      Post-Doctoral Fellowship on Image Processing (OCT and OCTA) at Oregon Health & Science University
      A postdoctoral research fellowship is immediately available in the Center for Ophthalmic Optics and Lasers, Casey Eye Institute, Oregon Health Science University. The researcher on this position will work alongside experts in clinical and engineering disciplines to develop image processing algorithms for artifact reduction, registration, segmentation, detection, analysis and modelling of OCT and OCT angiography data. PhD degree in Computer Science, Biomedical Engineering, Electrical Engineering, Physics, Optics or a related ...
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    12. Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning

      Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning
      Optical coherence tomography (OCT) can demonstrate early deterioration of the photoreceptor integrity caused by inherited retinal degeneration diseases (IRD). A machine learning method based on random forests was developed to automatically detect continuous areas of preserved ellipsoid zone structure (an easily recognizable part of the photoreceptors on OCT) in sixteen eyes of patients with choroideremia (a type of IRD). Pseudopodial extensions protruding from the preserved ellipsoid zone areas are detected ...
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    13. Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma

      Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma
      Purpose To report a case of age-related hypertrophy of the nonpigmented ciliary epithelium (ARH-NPCE) clinically resembling a ciliary body melanoma and report the optical coherence tomography angiography (OCTA) findings associated with this lesion. Observations A 51-year-old male was referred for evaluation of a deeply pigmented ciliary body mass with extension through the iris root. Iridocyclectomy was performed due to concern for ciliary body melanoma. Histopathologic analysis was instead consistent with ...
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    14. Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy

      Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy
      Purpose To compare patient and Medicare savings from the use of optical coherence tomography (OCT) in guiding therapy for neovascular age-related macular degeneration (nvAMD) to the research investments made in developing OCT by the National Institutes of Health (NIH) and the National Science Foundation (NSF). Design Observational cohort study. Methods Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology codes on intravitreal injections (67028), retinal OCT ...
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    15. 1-15 of 311 1 2 3 4 ... 19 20 21 »
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  2. About David Huang

    David Huang

    David Huang is Peterson Professor of Ophthalmology, professor of biomedical engineering, and director of the Center for Ophthalmic Optics and Lasers (www.COOLLab.net) in the Casey Eye Institute at the Oregon Health and Science University in Portland. The COOL lab conducts research on retinal diseases, anterior eye disease, glaucoma, and other optic nerve diseases. He is a co-inventor of OCT and has contributed to polarization-sensitive, swept-source, spectroscopic, and anterior eye OCT as well as OCT angiography. He is also an inventor of laser therapeutic devices and mobile diagnostic technology, and a founder of Gobiquity Mobile Health (www.gobiquity.com), which makes mobile diagnostic apps for professional and home use. Huang shared the 2012 António Champalimaud Vision Award and received the Association for Research in Vision and Ophthalmology’s Jonas Friedenwald Award and the American Academy of Ophthalmology’s Senior Achievement Award. He is a fellow of the National Academy of Inventors.

  3. Quotes

    1. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      In Co-invented by OHSU's Dr. David Huang 25 years ago, OCT technology helps stop blindness
    2. OCT is a big saver of healthcare dollars – the guidance of anti-vascular endothelial growth factor therapy in age-related macular degeneration alone saves billions of dollars per year by avoiding unnecessary injections.
      In Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment
    3. OCT is the most commonly used eye imaging test in the management of the leading causes of blindness today: macular degeneration, diabetic retinopathy and glaucoma. I am proud to be a key contributor to the technology that is preserving vision for people around the world.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    4. Seeing the blood flow in many layers of the retina is incredibly important because the most important causes of blindness in the world are due to abnormal blood circulation.
      In OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
    5. There are a few circumstances where mapping the posterior surface is also useful, for example, in post-LASIK cataract surgery intraocular lens calculations, where measuring the anterior surface alone is not sufficient to really accurately measure the net corneal power.
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    6. Confocal microscopy of the cornea has been around for a long time but it still doesn’t have a lot of specificity in looking at microorganisms...Some sort of in vivo staining or fluorescence that allows us to really distinguish infections or microorganisms with confocal imaging would be great
      In Versatile corneal, anterior segment imaging technologies improve accuracy
    7. OCT has higher resolution than any of the anterior segment modalities....I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.
      In OCT devices increasingly finding use outside retinal practice
    8. OCT has higher resolution than any of the anterior segment modalities...I think eventually any function that a topography, ultrasound or slit scanning can do, OCT can do better.”
      In OCT devices increasingly finding use outside retinal practice
    9. It just requires special scanning software that could easily be put on the OCT machines that most retinal specialists have.
      In Shining Light on Diabetes-Related Blindness
    10. People with poor blood flow don't respond well to some of the laser treatments used for retinopathy, and they are at a higher risk for proliferative retinopathy.
      In Shining Light on Diabetes-Related Blindness