Articles that mention David A. Boas -Optical Coherence Tomography News

David A. Boas

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1. Mentioned In 35 Articles
2. Shear-Induced Diffusion of Red Blood Cells Measured with Dynamic Light Scattering-Optical Coherence Tomography
  
  Explore Wiley Online Library Jul 12 2017
  
  Quantitative measurements of intravascular microscopic dynamics, such as absolute blood flow velocity, shear stress, and the diffusion coefficient of red blood cells (RBCs), are fundamental to understanding the blood flow behavior within the microcirculation, and for understanding why diffuse correlation spectroscopy (DCS) measurements of blood flow are dominantly sensitive to the diffusive motion of RBCs. Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle ...
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  Mentions: Massachusetts General Hospital Harvard University David A. Boas
3. Polarization-sensitive optical coherence tomography of the human brain connectome
  
  Explore Home: SPIE.org Jan 27 2017 Neurology
  
  The human brain is composed of approximately 100 billion neurons that communicate through an intricate network of axons and dendrites. 1 The difficulty of tracing these 3D neuronal pathways, however, has been a critical barrier for standard histology (the study of microscopic anatomy) over the past 100 years. Indeed, there is still no technology that can be used to acquire microscopic images in undistorted 3D space for mapping human brain ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
4. Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography
  
  Explore SPIE | Journal Jan 27 2017
  
  Optical coherence tomography (OCT) has been used to measure capillary red blood cell (RBC) flux. However, one important technical issue is that the accuracy of this method is subject to the temporal resolution (tt) of the repeated RBC-passage B-scans. A ceiling effect arises due to an insufficientttlimiting the maximum RBC-flux that can be measured. In this letter, we first present simulations demonstrating thatt=1.5mst=1.5mspermits measuring RBC-flux up ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
5. Optical coherence tomography imaging of capillary reperfusion after ischemic stroke
  
  Explore OSA | OSA Publishing Nov 16 2016 Neurology
  
  Although progress has been made for recanalization therapies after ischemic stroke, post-treatment imaging studies show that tissue reperfusion cannot be attained despite satisfactory recanalization in a significant percentage of patients. Hence, investigation of microcirculatory changes in both surface and deep cortical levels after ischemia reperfusion is important for understanding the post-stroke blood flow dynamics. In this study, we applied optical coherence tomography (OCT) imaging of cerebral blood flow for the ...
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  Mentions: Massachusetts General Hospital Harvard University Brown University
6. Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes
  
  Explore Optical Coherence Tomography News Jul 5 2016 Funding
  
  Massachusetts General Hosptial Receives a 2016 NIH Grant for $616,222 for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes. The principal investigator is David Boas. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
7. Polarization sensitive optical coherence microscopy for brain imaging
  
  Explore OSA | OSA Publishing May 9 2016 Neurology
  
  Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 m axial and 1.3 m transverse resolution to investigate fiber ...
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  Mentions: Harvard University Taner Akkin Hui Wang
8. BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)
  
  Explore Optical Coherence Tomography News May 9 2016
  
  The Bi-annual Biophotonics and Imaging Summer School (BIGSS16) will be held 5-9 September 2016 in Galway, Ireland. It is a five ECTS accredited course with leading professors teaching. Sessions are approx. four hours each to give a substantial grounding in the main topics of Biophotonics. The location is in the picturesque village of Ballyvaughanin the Burren . This will be augmented with hands on training at NUI Galway. Fee: 800 including ...
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  Mentions: University of Toronto Baylor College of Medicine Adrian G. Podoleanu
9. Massachusetts General Hospital Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Micro-vascular Changes
  
  Explore Optical Coherence Tomography News Sep 8 2015 Neurology , Funding
  
  Massachusetts General Hospital Receives a 2015 NIH Grant for $600,376 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Micro-vascular Changes. The principal investigator is David Boas. The program began in 2015 and 2019. Below is summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
10. Reducing stroke damage may be next application for OCT technology now widely used in eye and vision healthcare
  
  Explore Home: SPIE.org Jul 6 2015 Neurology
  
  An optical technology already widely used in ophthalmology and other medical fields holds potential to reveal how blood flows in the brain during stroke, providing information that could someday guide new treatments and reduce stroke-induced damage to the brain. A new article published in the journal Neurophotonics describes work at the University of Washington (UW) using optical coherence tomography (OCT) to render high-resolution images and information about blood-flow dynamics over ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
11. Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging
  
  Explore Optical Coherence Tomography News May 6 2015 Microscopy , Neurology , Funding
  
  Massachusetts General Hospital Receives a 2015 NIH Grant for $285,859 for High Resolution Optical Imaging. The principal investigator is David Boas. The program began in 2015 and ends in 2015. Below is a summary of the proposed work. This core will support the theme of functional coupling between glial, endothelial, and neuronal cells by using both in vivo and in vitro novel optical imaging to dissect the mechanisms of ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
12. Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography
  
  Explore SPIE | Journal Mar 18 2015
  
  Computing microvascular cerebral blood flow ( CBF ) in real cortical angiograms is challenging. Here, we investigated whether the use of Doppler optical coherence tomography (DOCT) flow measurements in individual vessel segments can help in reconstructing CBF across the entire vasculature of a truncated cortical angiogram. A CBF computational framework integrating DOCT measurements is presented. Simulations performed on a synthetic angiogram showed that the addition of DOCT measurements, especially close to large ...
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  Mentions: Massachusetts General Hospital Harvard University Polytechnique Montreal
13. Optical coherence tomography visualizes neurons in human entorhinal cortex
  
  Explore SPIE | Journal Feb 15 2015 Neurology
  
  The cytoarchitecture of the human brain is of great interest in diverse fields: neuroanatomy, neurology, neuroscience, and neuropathology. Traditional histology is a method that has been historically used to assess cell and fiber content in the ex vivo human brain. However, this technique suffers from significant distortions. We used a previously demonstrated optical coherence microscopy technique to image individual neurons in several square millimeters of en-face tissue blocks from layer ...
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  Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University
14. SPIE Launches Neurophotonics Journal With Special Section On BRAIN Initiative
  
  Explore Photonics Online Jul 31 2014 Neurology
  
  The new peer-reviewed journal Neurophotonics, published by SPIE, the international society for optics and photonics, will facilitate further collaboration on technological advances in optogenetics, photoacoustics, spectroscopy, and more. This will have significant medical and cognitive applications, and contribute to a comprehensive understanding of the brain. The inaugural issue includes a special section on the the U.S. BRAIN Initiative. The advanced optical methods and applications for imaging and manipulation of ...
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  Mentions: Massachusetts General Hospital Harvard University David A. Boas
15. SPIE launches 'Neurophotonics' journal with special section on BRAIN Initiative
  
  Explore Home: SPIE.org Jul 29 2014
  
  The advanced optical methods and applications for imaging and manipulation of the brain that are driving a revolution in the neurosciences were the inspiration behind Neurophotonic s , a new peer-reviewed journal published by SPIE, the international society for optics and photonics . The first issue coincides with the launch of the BRAIN Initiative in the United States, and a special section features articles that lay out a vision for and provide ...
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  Mentions: Massachusetts General Hospital Harvard University David A. Boas
16. Cross-validation of serial optical coherence scanning and diffusion tensor imaging: A study on neural fiber maps in human medulla oblongata
  
  Explore ScienceDirect Jun 24 2014 Neurology
  
  We established a strategy to perform cross-validation of serial optical coherence scanner imaging (SOCS) and diffusion tensor imaging (DTI) on a postmortem human medulla. Following DTI, the sample was serially scanned by SOCS, which integrates a vibratome slicer and a multi-contrast optical coherence tomography rig for large-scale three-dimensional imaging at microscopic resolution. The DTI dataset was registered to the SOCS space. An average correlation coefficient of 0.9 was found ...
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  Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University
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