Articles that mention David A. Boas -Optical Coherence Tomography News

David A. Boas

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1. Mentioned In 41 Articles
2. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
  
  Explore SPIE Digital Library Feb 27 2018
  
  Quantitative measurement of blood flow velocity in capillaries is challenging due to their small size (around 5-10 m), and the discontinuity and single-file feature of RBCs flowing in a capillary. In this work, we present a phase-resolved Optical Coherence Tomography (OCT) method for accurate measurement of the red blood cell (RBC) speed in cerebral capillaries. To account for the discontinuity of RBCs flowing in capillaries, we applied an M-mode scanning ...
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  Mentions: Massachusetts General Hospital Harvard University David A. Boas
3. Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography
  
  Explore SPIE Digital Library Feb 17 2018
  
  Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements ...
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  Mentions: Massachusetts General Hospital Harvard University Boston University
4. Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography
  
  Explore OSA | OSA Publishing Nov 18 2017 Neurology
  
  Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
5. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
  
  Explore Optical Coherence Tomography News Sep 26 2017 Funding
  
  Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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  Mentions: National Institutes of Health Boston University David A. Boas
6. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
  
  Explore OSA | OSA Publishing Sep 9 2017
  
  We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity in cerebral capillaries. OCT data were acquired with an M-mode scanning strategy (repeated A-scans) to account for the single-file passage of RBCs in a capillary, which were then high-pass filtered to remove the stationary component of the signal to ensure an accurate measurement of phase shift ...
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  Mentions: Massachusetts General Hospital Harvard University Boston University
7. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
  
  Explore Optical Coherence Tomography News Sep 5 2017 Funding
  
  Boston University Receives a 2017 NIH Grant for $616,301 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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  Mentions: National Institutes of Health Boston University David A. Boas
8. Shear-Induced Diffusion of Red Blood Cells Measured with Dynamic Light Scattering-Optical Coherence Tomography
  
  Explore Wiley Online Library Jul 12 2017
  
  Quantitative measurements of intravascular microscopic dynamics, such as absolute blood flow velocity, shear stress, and the diffusion coefficient of red blood cells (RBCs), are fundamental to understanding the blood flow behavior within the microcirculation, and for understanding why diffuse correlation spectroscopy (DCS) measurements of blood flow are dominantly sensitive to the diffusive motion of RBCs. Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle ...
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  Mentions: Massachusetts General Hospital Harvard University David A. Boas
9. Polarization-sensitive optical coherence tomography of the human brain connectome
  
  Explore Home: SPIE.org Jan 27 2017 Neurology
  
  The human brain is composed of approximately 100 billion neurons that communicate through an intricate network of axons and dendrites. 1 The difficulty of tracing these 3D neuronal pathways, however, has been a critical barrier for standard histology (the study of microscopic anatomy) over the past 100 years. Indeed, there is still no technology that can be used to acquire microscopic images in undistorted 3D space for mapping human brain ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
10. Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography
  
  Explore SPIE | Journal Jan 27 2017
  
  Optical coherence tomography (OCT) has been used to measure capillary red blood cell (RBC) flux. However, one important technical issue is that the accuracy of this method is subject to the temporal resolution (tt) of the repeated RBC-passage B-scans. A ceiling effect arises due to an insufficientttlimiting the maximum RBC-flux that can be measured. In this letter, we first present simulations demonstrating thatt=1.5mst=1.5mspermits measuring RBC-flux up ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
11. Optical coherence tomography imaging of capillary reperfusion after ischemic stroke
  
  Explore OSA | OSA Publishing Nov 16 2016 Neurology
  
  Although progress has been made for recanalization therapies after ischemic stroke, post-treatment imaging studies show that tissue reperfusion cannot be attained despite satisfactory recanalization in a significant percentage of patients. Hence, investigation of microcirculatory changes in both surface and deep cortical levels after ischemia reperfusion is important for understanding the post-stroke blood flow dynamics. In this study, we applied optical coherence tomography (OCT) imaging of cerebral blood flow for the ...
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  Mentions: Massachusetts General Hospital Harvard University Brown University
12. Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes
  
  Explore Optical Coherence Tomography News Jul 5 2016 Funding
  
  Massachusetts General Hosptial Receives a 2016 NIH Grant for $616,222 for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes. The principal investigator is David Boas. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
13. Polarization sensitive optical coherence microscopy for brain imaging
  
  Explore OSA | OSA Publishing May 9 2016 Neurology
  
  Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 m axial and 1.3 m transverse resolution to investigate fiber ...
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  Mentions: Harvard University Taner Akkin Hui Wang
14. BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)
  
  Explore Optical Coherence Tomography News May 9 2016
  
  The Bi-annual Biophotonics and Imaging Summer School (BIGSS16) will be held 5-9 September 2016 in Galway, Ireland. It is a five ECTS accredited course with leading professors teaching. Sessions are approx. four hours each to give a substantial grounding in the main topics of Biophotonics. The location is in the picturesque village of Ballyvaughanin the Burren . This will be augmented with hands on training at NUI Galway. Fee: 800 including ...
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  Mentions: University of Toronto Baylor College of Medicine Adrian G. Podoleanu
15. Massachusetts General Hospital Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Micro-vascular Changes
  
  Explore Optical Coherence Tomography News Sep 8 2015 Neurology , Funding
  
  Massachusetts General Hospital Receives a 2015 NIH Grant for $600,376 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Micro-vascular Changes. The principal investigator is David Boas. The program began in 2015 and 2019. Below is summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
16. Reducing stroke damage may be next application for OCT technology now widely used in eye and vision healthcare
  
  Explore Home: SPIE.org Jul 6 2015 Neurology
  
  An optical technology already widely used in ophthalmology and other medical fields holds potential to reveal how blood flows in the brain during stroke, providing information that could someday guide new treatments and reduce stroke-induced damage to the brain. A new article published in the journal Neurophotonics describes work at the University of Washington (UW) using optical coherence tomography (OCT) to render high-resolution images and information about blood-flow dynamics over ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
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