Articles that mention David A. Boas -Optical Coherence Tomography News

David A. Boas

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1. Mentioned In 43 Articles
2. Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography
  
  Explore SPIE Digital Library Mar 19 2019
  
  Optical coherence tomography angiography (OCTA) has been widely used for ien face/i visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the tail artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (ig/isub1/sub-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating ...
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  Mentions: Boston University David A. Boas
3. Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21
  
  Explore Home - Springer Oct 24 2018 Neurology
  
  Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence microscopy (OCM) is higher resolution (i.e., 1.25 m) and is capable of detecting neurons. In a previous report, we compared the correspondence of OCM acquired imaging of neurons with traditional Nissl stained histology in entorhinal cortex layer ...
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  Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Boston University
4. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
  
  Explore SPIE Digital Library Feb 27 2018
  
  Quantitative measurement of blood flow velocity in capillaries is challenging due to their small size (around 5-10 m), and the discontinuity and single-file feature of RBCs flowing in a capillary. In this work, we present a phase-resolved Optical Coherence Tomography (OCT) method for accurate measurement of the red blood cell (RBC) speed in cerebral capillaries. To account for the discontinuity of RBCs flowing in capillaries, we applied an M-mode scanning ...
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  Mentions: Massachusetts General Hospital Harvard University David A. Boas
5. Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography
  
  Explore SPIE Digital Library Feb 17 2018
  
  Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements ...
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  Mentions: Massachusetts General Hospital Harvard University Boston University
6. Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography
  
  Explore OSA | OSA Publishing Nov 18 2017 Neurology
  
  Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
7. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
  
  Explore Optical Coherence Tomography News Sep 26 2017 Funding
  
  Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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  Mentions: National Institutes of Health Boston University David A. Boas
8. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
  
  Explore OSA | OSA Publishing Sep 9 2017
  
  We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity in cerebral capillaries. OCT data were acquired with an M-mode scanning strategy (repeated A-scans) to account for the single-file passage of RBCs in a capillary, which were then high-pass filtered to remove the stationary component of the signal to ensure an accurate measurement of phase shift ...
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  Mentions: Massachusetts General Hospital Harvard University Boston University
9. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
  
  Explore Optical Coherence Tomography News Sep 5 2017 Funding
  
  Boston University Receives a 2017 NIH Grant for $616,301 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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  Mentions: National Institutes of Health Boston University David A. Boas
10. Shear-Induced Diffusion of Red Blood Cells Measured with Dynamic Light Scattering-Optical Coherence Tomography
  
  Explore Wiley Online Library Jul 12 2017
  
  Quantitative measurements of intravascular microscopic dynamics, such as absolute blood flow velocity, shear stress, and the diffusion coefficient of red blood cells (RBCs), are fundamental to understanding the blood flow behavior within the microcirculation, and for understanding why diffuse correlation spectroscopy (DCS) measurements of blood flow are dominantly sensitive to the diffusive motion of RBCs. Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle ...
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  Mentions: Massachusetts General Hospital Harvard University David A. Boas
11. Polarization-sensitive optical coherence tomography of the human brain connectome
  
  Explore Home: SPIE.org Jan 27 2017 Neurology
  
  The human brain is composed of approximately 100 billion neurons that communicate through an intricate network of axons and dendrites. 1 The difficulty of tracing these 3D neuronal pathways, however, has been a critical barrier for standard histology (the study of microscopic anatomy) over the past 100 years. Indeed, there is still no technology that can be used to acquire microscopic images in undistorted 3D space for mapping human brain ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
12. Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography
  
  Explore SPIE | Journal Jan 27 2017
  
  Optical coherence tomography (OCT) has been used to measure capillary red blood cell (RBC) flux. However, one important technical issue is that the accuracy of this method is subject to the temporal resolution (tt) of the repeated RBC-passage B-scans. A ceiling effect arises due to an insufficientttlimiting the maximum RBC-flux that can be measured. In this letter, we first present simulations demonstrating thatt=1.5mst=1.5mspermits measuring RBC-flux up ...
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  Mentions: Massachusetts General Hospital Harvard University Hui Wang
13. Optical coherence tomography imaging of capillary reperfusion after ischemic stroke
  
  Explore OSA | OSA Publishing Nov 16 2016 Neurology
  
  Although progress has been made for recanalization therapies after ischemic stroke, post-treatment imaging studies show that tissue reperfusion cannot be attained despite satisfactory recanalization in a significant percentage of patients. Hence, investigation of microcirculatory changes in both surface and deep cortical levels after ischemia reperfusion is important for understanding the post-stroke blood flow dynamics. In this study, we applied optical coherence tomography (OCT) imaging of cerebral blood flow for the ...
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  Mentions: Massachusetts General Hospital Harvard University Brown University
14. Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes
  
  Explore Optical Coherence Tomography News Jul 5 2016 Funding
  
  Massachusetts General Hosptial Receives a 2016 NIH Grant for $616,222 for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes. The principal investigator is David Boas. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
15. Polarization sensitive optical coherence microscopy for brain imaging
  
  Explore OSA | OSA Publishing May 9 2016 Neurology
  
  Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 m axial and 1.3 m transverse resolution to investigate fiber ...
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  Mentions: Harvard University Taner Akkin Hui Wang
16. BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)
  
  Explore Optical Coherence Tomography News May 9 2016
  
  The Bi-annual Biophotonics and Imaging Summer School (BIGSS16) will be held 5-9 September 2016 in Galway, Ireland. It is a five ECTS accredited course with leading professors teaching. Sessions are approx. four hours each to give a substantial grounding in the main topics of Biophotonics. The location is in the picturesque village of Ballyvaughanin the Burren . This will be augmented with hands on training at NUI Galway. Fee: 800 including ...
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  Mentions: University of Toronto Baylor College of Medicine Adrian G. Podoleanu
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