1. David A. Boas

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    1. Mentioned In 51 Articles

    2. Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters

      Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters
      Significance: The optical properties of biological samples provide information about the structural characteristics of the tissue and any changes arising from pathological conditions. Optical coherence tomography (OCT) has proven to be capable of extracting tissue's optical properties using a model that combines the exponential decay due to tissue scattering and the axial point spread function that arises from the confocal nature of the detection system, particularly for higher numerical ...
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    3. Massachusetts General Hospital Receives NIH Grant for Volumetric Optical Coherence Tomography of Human Cerebellar Circuitry

      Massachusetts General Hospital Receives NIH Grant for Volumetric Optical Coherence Tomography of Human Cerebellar Circuitry
      Massachusetts General Hospital Receives a 2020 NIH Grant for $248,993 for Volumetric Optical Coherence Tomography of Human Cerebellar Circuitry. The principal investigator is Hui Wang. Below is a summary of the proposed work. The goal in seeking a K99/R00 Pathway to Independence Award is to establish myself as an independent principal investigator to study the structural-functional relationship of the brain circuitry in normal and brain disorders. The proposed ...
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    4. Human Brain Imaging by Optical Coherence Tomography (Book Chapter)

      Human Brain Imaging by Optical Coherence Tomography (Book Chapter)
      The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating ...
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    5. Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain

      Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain
      In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction methods. We find that, if the reconstruction approach is chosen carefully, single-shell dMRI data can yield the same accuracy as multi-shell data, and only moderately lower accuracy than a full Cartesian-grid ...
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    6. Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography

      Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography
      ...ns in real time,” Appl. Phys. Lett. 90(16), 164105 (2007). [Crossref] C. Yu, A. D. Aguirre, R. Lana, D. Anna, D. A. Boas, and J. G. Fujimoto, “Optical coherence tomography (OCT) reveals depth-resolved dynamics during fun...
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    7. MATLAB code and data processing guide for Dynamic Light Scattering-Optical Coherence Tomography

      MATLAB code and data processing guide for Dynamic Light Scattering-Optical Coherence Tomography
      This guide is for post data processing of DLSOCT, which outputs axial velocity (Vz), transverse velocity (Vx), total velocity(V), the ratio of static component (Ms), the ratio of dynamic component (Mf), and fitting accuracy (R). The speed upper limit is determined by OCT system Aline rate and 3Dvoxel size.
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    8. Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

      Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography
      Optical coherence tomography angiography (OCTA) has been widely used for ien face/i visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the tail artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (ig/isub1/sub-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating ...
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    9. Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21

      Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21
      Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence microscopy (OCM) is higher resolution (i.e., 1.25 m) and is capable of detecting neurons. In a previous report, we compared the correspondence of OCM acquired imaging of neurons with traditional Nissl stained histology in entorhinal cortex layer ...
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    10. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography

      Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
      Quantitative measurement of blood flow velocity in capillaries is challenging due to their small size (around 5-10 m), and the discontinuity and single-file feature of RBCs flowing in a capillary. In this work, we present a phase-resolved Optical Coherence Tomography (OCT) method for accurate measurement of the red blood cell (RBC) speed in cerebral capillaries. To account for the discontinuity of RBCs flowing in capillaries, we applied an M-mode scanning ...
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    11. Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography

      Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography
      Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements ...
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    12. Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography

      Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography
      Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the ...
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    13. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
      Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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    14. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography

      Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
      We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity in cerebral capillaries. OCT data were acquired with an M-mode scanning strategy (repeated A-scans) to account for the single-file passage of RBCs in a capillary, which were then high-pass filtered to remove the stationary component of the signal to ensure an accurate measurement of phase shift ...
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    15. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
      Boston University Receives a 2017 NIH Grant for $616,301 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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  2. About David A. Boas

    David A. Boas

    David A. Boas is a Professor in Radiology at Harvard Medical School Associate Physicist at Massachusetts General Hospital Director, Optical Imaging Core & Lab at Martinos Center Department of Radiology, MGH