1. David A. Boas

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    1. Mentioned In 39 Articles

    2. Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography

      Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography
      Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the ...
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    3. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
      Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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    4. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography

      Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
      We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity in cerebral capillaries. OCT data were acquired with an M-mode scanning strategy (repeated A-scans) to account for the single-file passage of RBCs in a capillary, which were then high-pass filtered to remove the stationary component of the signal to ensure an accurate measurement of phase shift ...
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    5. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
      Boston University Receives a 2017 NIH Grant for $616,301 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability ...
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    6. Shear-Induced Diffusion of Red Blood Cells Measured with Dynamic Light Scattering-Optical Coherence Tomography

      Shear-Induced Diffusion of Red Blood Cells Measured with Dynamic Light Scattering-Optical Coherence Tomography
      Quantitative measurements of intravascular microscopic dynamics, such as absolute blood flow velocity, shear stress, and the diffusion coefficient of red blood cells (RBCs), are fundamental to understanding the blood flow behavior within the microcirculation, and for understanding why diffuse correlation spectroscopy (DCS) measurements of blood flow are dominantly sensitive to the diffusive motion of RBCs. Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle ...
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    7. Polarization-sensitive optical coherence tomography of the human brain connectome

      Polarization-sensitive optical coherence tomography of the human brain connectome
      The human brain is composed of approximately 100 billion neurons that communicate through an intricate network of axons and dendrites. 1 The difficulty of tracing these 3D neuronal pathways, however, has been a critical barrier for standard histology (the study of microscopic anatomy) over the past 100 years. Indeed, there is still no technology that can be used to acquire microscopic images in undistorted 3D space for mapping human brain ...
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    8. Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography

      Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography
      Optical coherence tomography (OCT) has been used to measure capillary red blood cell (RBC) flux. However, one important technical issue is that the accuracy of this method is subject to the temporal resolution (tt) of the repeated RBC-passage B-scans. A ceiling effect arises due to an insufficientttlimiting the maximum RBC-flux that can be measured. In this letter, we first present simulations demonstrating thatt=1.5mst=1.5mspermits measuring RBC-flux up ...
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    9. Optical coherence tomography imaging of capillary reperfusion after ischemic stroke

      Optical coherence tomography imaging of capillary reperfusion after ischemic stroke
      Although progress has been made for recanalization therapies after ischemic stroke, post-treatment imaging studies show that tissue reperfusion cannot be attained despite satisfactory recanalization in a significant percentage of patients. Hence, investigation of microcirculatory changes in both surface and deep cortical levels after ischemia reperfusion is important for understanding the post-stroke blood flow dynamics. In this study, we applied optical coherence tomography (OCT) imaging of cerebral blood flow for the ...
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    10. Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes

      Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes
      Massachusetts General Hosptial Receives a 2016 NIH Grant for $616,222 for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes. The principal investigator is David Boas. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ...
      Read Full Article
    11. Polarization sensitive optical coherence microscopy for brain imaging

      Polarization sensitive optical coherence microscopy for brain imaging
      Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 m axial and 1.3 m transverse resolution to investigate fiber ...
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    12. BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)

      BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)
      The Bi-annual Biophotonics and Imaging Summer School (BIGSS16) will be held 5-9 September 2016 in Galway, Ireland. It is a five ECTS accredited course with leading professors teaching. Sessions are approx. four hours each to give a substantial grounding in the main topics of Biophotonics. The location is in the picturesque village of Ballyvaughanin the Burren . This will be augmented with hands on training at NUI Galway. Fee: 800 including ...
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    13. Massachusetts General Hospital Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Micro-vascular Changes

      Massachusetts General Hospital Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Micro-vascular Changes
      Massachusetts General Hospital Receives a 2015 NIH Grant for $600,376 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Micro-vascular Changes. The principal investigator is David Boas. The program began in 2015 and 2019. Below is summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map ...
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    14. Reducing stroke damage may be next application for OCT technology now widely used in eye and vision healthcare

      Reducing stroke damage may be next application for OCT technology now widely used in eye and vision healthcare
      An optical technology already widely used in ophthalmology and other medical fields holds potential to reveal how blood flows in the brain during stroke, providing information that could someday guide new treatments and reduce stroke-induced damage to the brain. A new article published in the journal Neurophotonics describes work at the University of Washington (UW) using optical coherence tomography (OCT) to render high-resolution images and information about blood-flow dynamics over ...
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    15. Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging
      Massachusetts General Hospital Receives a 2015 NIH Grant for $285,859 for High Resolution Optical Imaging. The principal investigator is David Boas. The program began in 2015 and ends in 2015. Below is a summary of the proposed work. This core will support the theme of functional coupling between glial, endothelial, and neuronal cells by using both in vivo and in vitro novel optical imaging to dissect the mechanisms of ...
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    16. Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography

      Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography
      Computing microvascular cerebral blood flow ( CBF ) in real cortical angiograms is challenging. Here, we investigated whether the use of Doppler optical coherence tomography (DOCT) flow measurements in individual vessel segments can help in reconstructing CBF across the entire vasculature of a truncated cortical angiogram. A CBF computational framework integrating DOCT measurements is presented. Simulations performed on a synthetic angiogram showed that the addition of DOCT measurements, especially close to large ...
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  2. About David A. Boas

    David A. Boas

    David A. Boas is a Professor in Radiology at Harvard Medical School Associate Physicist at Massachusetts General Hospital Director, Optical Imaging Core & Lab at Martinos Center Department of Radiology, MGH