1. Daniel Woods

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    1. Mentioned In 8 Articles

    2. Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Background Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4 μm resolution, comparable with microscopy (‘virtual biopsy’). The present study evaluated OCT to detect and quantify skin fibrosis in SSc. Methods We performed 458 OCT scans of hands and forearms on 21 SSc patients and 22 healthy controls. We compared the findings with histology from three skin biopsies and by correlation with clinical assessment of the skin ...

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    3. Monitoring sinew contraction during formation of tissue-engineered fibrin-based ligament constructs

      Monitoring sinew contraction during formation of tissue-engineered fibrin-based ligament constructs

      The ability to study the gross morphological changes occurring during tissue formation is vital to producing tissue-engineered structures of clinically relevant dimensions in vitro. Here, we have used non-destructive methods of digital imaging and optical coherence tomography to monitor the early-stage formation and subsequent maturation of fibrin-based tissue-engineered ligament constructs. In addition, the effect of supplementation with essential promoters of collagen synthesis, ascorbic acid (AA) and proline (P), have been assessed. Contraction of the cell-seeded fibrin gel occurs unevenly within the first 5 days of culture around two fixed anchor points before forming a longitudinal ligament-like construct. AA+P supplementation ...

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    4. Michelson Diagnostics’ VivoSight OCT Scanner used to Evaluate Microneedle Drug Delivery System

      Michelson Diagnostics’ VivoSight OCT Scanner used to Evaluate Microneedle Drug Delivery System
      ...ry development. It is the only clinical technology that can image the needles in situ, in real time,” said Dr Daniel Woods, Senior Imaging Scientist at Michelson Diagnostics Ltd., adding “The high resolution and extended...
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    5. Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow independent of flow direction

      Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow independent of flow direction
      Optical coherence tomography (OCT) allows non-invasive imaging of sub-surface structures in vivo, ideally without a need for target preparation. In conventional OCT, the contrast for blood vessels depends on a variety of factors and can be challenging. Speckle variance has been recognized as a method to enhance contrast for blood flow without the application of contrast agents in OCT images. Here, we demonstrate the possibility of extracting blood flow information from a volumetric OCT datasets that was obtained routinely from a human participant. We used a commercially available OCT system with a clinical CE-mark. The light source has a central ...
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    6. From Talbot bands to no mirror terms in Fourier domain OCT: a quest on the fundamental origin of the sensitivity decay with depth

      We show that the decay of sensitivity with depth in Fourier Domain (FD)-OCT can be explained based on the superposition of wavetrain lengths after dispersion (diffraction). The more coherent the dispersed waves are, the slower the decay of sensitivity. An asymmetry in the decay curve with the optical path difference (OPD) can be introduced via an "intrinsic" delay which has the effect of shifting axially the two wavetrains relative to each other, originating from the object and reference beam of an interferometer. In this way, an equivalent Talbot Bands set-up is implemented, characterized by no mirror terms for the ...
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    7. Controlling the shape of Talbot bands visibility

      Controlling the shape of Talbot bands visibility
      We present a theoretical model to predict the sensitivity variation versus optical path difference (OPD) in Fourier domain spectral interferometry using configurations which produce Talbot bands. Such configurations require that the two interfering beams use different parts of the diffraction grating in the interrogating spectrometer. So far, the power distribution within the two beams in a Talbot bands experiment was considered uniform. In this report, we show that by manipulating the power distribution within the two interfering beams, the OPD value where maximum sensitivity is achieved can be conveniently tuned, as well as the sensitivity variation with OPD. Furthermore, creating ...
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  2. About Daniel Woods

    Daniel Woods

    Daniel Woods has joined as Senior Imaging Scientist at Michelson Diagnostics and will provide additional technical expertise for customers in Medical and Biological fields. Dan previously worked in the University of Leiden Medical Center where he designed speckle flowmetry technologies for obstetric surgeries. He has eight years experience in the field of OCT, and received his PhD from the Biomedical Optics group at the University of Kent at Canterbury. The optical processing techniques he designed there are still generating new publications to this day.

  3. Quotes

    1. The successful use of OCT in this study could prove to be a key development for polymeric micro-needle research, accelerating their commercial exploitation...The VivoSight system is a unique tool for transdermal drug delivery development. It is the only clinical technology that can image the needles in situ, in real time...The high resolution and extended penetration depth of VivoSight mean that researchers can really understand how the needles interact with the skin.
      In Michelson Diagnostics’ VivoSight OCT Scanner used to Evaluate Microneedle Drug Delivery System