1. Daniel Woods

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    1. Mentioned In 10 Articles

    2. In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching

      In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching
      Stratum corneum and epidermal layers change in terms of thickness and roughness with gender, age and anatomical site. Knowledge of the mechanical and tribological properties of skin associated with these structural changes are needed to aid in the design of exoskeletons, prostheses, orthotics, body mounted sensors used for kinematics measurements and in optimum use of wearable on-body devices. In this case study, optical coherence tomography (OCT) and digital image correlation ...
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    3. Processing Optical Coherence Tomography Scans Of A Subject'S Skin

      Processing Optical Coherence Tomography Scans Of A Subject'S Skin
      A method of processing optical coherence tomography (OCT) scans of a subject's skin (7), the skin (7) having a surface(8), the method comprising capturing a plurality of scans through the subject's skin(7), the scans representing an OCT signal in slices through the user's skin (7) in parallel planes, the scans being offset from one another along a direction perpendicular to the parallel planes, the method ...
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    4. Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma
      Background Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4 m resolution, comparable with microscopy (virtual biopsy). The present study evaluated OCT to detect and quantify skin fibrosis in SSc. Methods We performed 458 OCT scans of ...
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    5. Monitoring sinew contraction during formation of tissue-engineered fibrin-based ligament constructs

      Monitoring sinew contraction during formation of tissue-engineered fibrin-based ligament constructs
      The ability to study the gross morphological changes occurring during tissue formation is vital to producing tissue-engineered structures of clinically relevant dimensions in vitro. Here, we have used non-destructive methods of digital imaging and optical coherence tomography to monitor the early-stage formation and subsequent maturation of fibrin-based tissue-engineered ligament constructs. In addition, the effect of supplementation with essential promoters of collagen synthesis, ascorbic acid (AA) and proline (P), have been ...
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    6. Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow independent of flow direction

      Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow independent of flow direction
      Optical coherence tomography (OCT) allows non-invasive imaging of sub-surface structures in vivo, ideally without a need for target preparation. In conventional OCT, the contrast for blood vessels depends on a variety of factors and can be challenging. Speckle variance has been recognized as a method to enhance contrast for blood flow without the application of contrast agents in OCT images. Here, we demonstrate the possibility of extracting blood flow information ...
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    7. From Talbot bands to no mirror terms in Fourier domain OCT: a quest on the fundamental origin of the sensitivity decay with depth

      We show that the decay of sensitivity with depth in Fourier Domain (FD)-OCT can be explained based on the superposition of wavetrain lengths after dispersion (diffraction). The more coherent the dispersed waves are, the slower the decay of sensitivity. An asymmetry in the decay curve with the optical path difference (OPD) can be introduced via an "intrinsic" delay which has the effect of shifting axially the two wavetrains relative ...
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    8. Controlling the shape of Talbot bands visibility

      Controlling the shape of Talbot bands visibility
      We present a theoretical model to predict the sensitivity variation versus optical path difference (OPD) in Fourier domain spectral interferometry using configurations which produce Talbot bands. Such configurations require that the two interfering beams use different parts of the diffraction grating in the interrogating spectrometer. So far, the power distribution within the two beams in a Talbot bands experiment was considered uniform. In this report, we show that by manipulating ...
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  2. About Daniel Woods

    Daniel Woods

    Daniel Woods has joined as Senior Imaging Scientist at Michelson Diagnostics and will provide additional technical expertise for customers in Medical and Biological fields. Dan previously worked in the University of Leiden Medical Center where he designed speckle flowmetry technologies for obstetric surgeries. He has eight years experience in the field of OCT, and received his PhD from the Biomedical Optics group at the University of Kent at Canterbury. The optical processing techniques he designed there are still generating new publications to this day.

  3. Quotes

    1. The successful use of OCT in this study could prove to be a key development for polymeric micro-needle research, accelerating their commercial exploitation...The VivoSight system is a unique tool for transdermal drug delivery development. It is the only clinical technology that can image the needles in situ, in real time...The high resolution and extended penetration depth of VivoSight mean that researchers can really understand how the needles interact with the skin.
      In Michelson Diagnostics’ VivoSight OCT Scanner used to Evaluate Microneedle Drug Delivery System