1. Daniel Szlag

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    1. Mentioned In 28 Articles

    2. Imaging of cortical structures and microvasculature using extended-focus optical coherence tomography at 1.3  μm

      Imaging of cortical structures and microvasculature using extended-focus optical coherence tomography at 1.3  μm
      Extended-focus optical coherence tomography (xf-OCT) is a variant of optical coherence tomography (OCT) wherein the illumination and/or detection modes are engineered to provide a constant diffractionless lateral resolution over an extended depth of field (typically 3 to 10 10 the Rayleigh range). xf-OCT systems operating at 800 nm have been devised and used in the past to image brain structures at high-resolution in vivo , but are limited to 500 ...
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    3. In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range

      In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range
      Visible light optical coherence tomography has shown great interest in recent years for spectroscopic and high-resolution retinal and cerebral imaging. Here, we present an extended-focus optical coherence microscopy system operating from the visible to the near-infrared wavelength range for high axial and lateral resolution imaging of cortical structures in vivo . The system exploits an ultrabroad illumination spectrum centered in the visible wavelength range ( c =650nm, 250nm) offering a submicron axial ...
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    4. Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy

      Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy
      Fast, label-free, high-resolution, three-dimensional imaging platforms are crucial for high-throughput in vivo time-lapse studies of the anatomy of Caenorhabditis elegans , one of the most commonly used model organisms in biomedical research. Despite the needs, methods combining all these characteristics have been lacking. Here, we present label-free imaging of live Caenorhabditis elegans with three-dimensional sub-micrometer resolution using visible optical coherence microscopy (visOCM). visOCM is a versatile optical imaging method which we ...
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    5. Massively parallel data processing for quantitative total flow imaging with optical coherence microscopy and tomography

      Massively parallel data processing for quantitative total flow imaging with optical coherence microscopy and tomography
      We present an application of massively parallel processing of quantitative flow measurements data acquired using spectral optical coherence microscopy (SOCM). The need for massive signal processing of these particular datasets have been a major hurdle for many applications based on SOCM. In view of this difficulty, we implemented and adapted quantitative total flow estimation algorithms on graphics processing units (GPU) and achieved a 150 fold reduction in processing time when ...
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    6. Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain

      Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain
      We propose a new method and optical instrumentation for mouse brain imaging based on extended-focus optical coherence microscopy. This in vivo imaging technique allows the evaluation of the cytoarchitecture at cellular level and the circulation system dynamics in three dimensions. This minimally invasive and non-contact approach is performed without the application of contrasting agents. The optical design achieved a resolution of 2.2 m over a distance of 800 m ...
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    7. Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy

      Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy
      We used Optical Coherence Microscopy (OCM) to monitor structural and functional changes due to ischemic stroke in small animals brains in vivo. To obtain lateral resolution of 2.2 m over the range of 600 m we used extended focus configuration of OCM instrument involving Bessel beam. It provided access to detailed 3D information about the changes in brain vascular system up to the level of capillaries across I and ...
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    8. Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers

      Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers
      The identification of a beta-cell tracer is a major quest in diabetes research. However, since MRI, PET and SPECT cannot resolve individual islets, optical techniques are required to assess the specificity of these tracers. We propose to combine Optical Coherence Microscopy (OCM) with fluorescence detection in a single optical platform to facilitate these initial screening steps from cell culture up to living rodents. OCM can image islets and vascularization without ...
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    9. Quantitative lateral and axial flow imaging with optical coherence microscopy and tomography

      Quantitative lateral and axial flow imaging with optical coherence microscopy and tomography
      Optical coherence tomography (OCT) and optical coherence microscopy (OCM) allow the acquisition of quantitative three-dimensional axial flow by estimating the Doppler shift caused by moving scatterers. Measuring the velocity of red blood cells is currently the principal application of these methods. In many biological tissues, blood flow is often perpendicular to the optical axis, creating the need for a quantitative measurement of lateral flow. Previous work has shown that lateral ...
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    10. Feature Of The Week 11/25/12: Nicolaus Copernicus University Presents Work on Four-Dimensional OCT Imaging Using Graphics Processing Units

      Feature Of The Week 11/25/12: Nicolaus Copernicus University Presents Work on Four-Dimensional OCT Imaging Using Graphics Processing Units
      Nicolaus Copernicus University present the application of graphics processing unit (GPU) programming for real-time three-dimensional (3-D) Fourier domain optical coherence tomography (FdOCT) imaging with implementation of flow visualization algorithms. One of the limitations of FdOCT is data processing time, which is generally longer than data acquisition time. Utilizing additional algorithms, such as Doppler analysis, further increases computation time. The general purpose computing on GPU (GPGPU) has been used successfully for ...
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    11. Four-dimensional structural and Doppler optical coherence tomography imaging on graphics processing units

      Four-dimensional structural and Doppler optical coherence tomography imaging on graphics processing units
      The authors present the application of graphics processing unit (GPU) programming for real-time three-dimensional (3-D) Fourier domain optical coherence tomography (FdOCT) imaging with implementation of flow visualization algorithms. One of the limitations of FdOCT is data processing time, which is generally longer than data acquisition time. Utilizing additional algorithms, such as Doppler analysis, further increases computation time. The general purpose computing on GPU (GPGPU) has been used successfully for structural ...
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    12. Optical Coherence Tomography Apparatus And Method With Speckle Suppression

      Optical Coherence Tomography Apparatus And Method With Speckle Suppression
      The invention relates to an optical coherence tomography apparatus and method. It improves speckle suppression by modifying the scanning trajectory (18) of the probing light beam so that groups of A scans close to the imaged segments (22) can be recorded and averaged. The invention facilitates effective speckle suppression combined with high resolution and little dependence of sample motions during the measurement.
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    13. Multi-parametric imaging of murine brain using spectral and time domain optical coherence tomography

      Multi-parametric imaging of murine brain using spectral and time domain optical coherence tomography
      Examination of brain functions in small animal models may help improve the diagnosis and treatment of neurological conditions. Transcranial imaging of small rodents brains poses a major challenge for optical microscopy. Another challenge is to reduce the measurement time. We describe methods and algorithms for three-dimensional assessment of blood flow in the brains of small animals, through the intact skull, using spectral and time domain optical coherence tomography. By introducing ...
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    14. 1-15 of 28 1 2 »
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  2. About Daniel Szlag

    Daniel Szlag

    Daniel Szlag is a PhD Student in the Medical Physics Group at Nicholaus Copernicus University. Daniel Szlag was born in 1983 in Poland. In 2007, he received his MSc degree in Computer Metrology and Control at NCU. He also completed the 3-year studies of Applied Informatics. After he started his PhD study and in 2008 he joined the Medical Physics Group. He is a participant in the research project of EURYI. He also is an employee in the Research & Development Office Optopol Technology S. A. He works on improvement of software and hardware control of OCT devices. He also works on the OCM project and blood flows in the eye. He is interested in applied informatics, electronics and data processing.