1. Daniel M. Siegel

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    1. Mentioned In 18 Articles

    2. Commentary on the Diagnostic Utility of Non-invasive Imaging Devices for Field Cancerization

      Commentary on the Diagnostic Utility of Non-invasive Imaging Devices for Field Cancerization
      In this issue of Experimental Dermatology , Marneffe and collegues present a practical algorithmic guide to differentiating actinic keratosis (AK) from normal skin and squamous cell carcinoma (SCC) using high-definition optical coherence tomography (HD-OCT), outlining steps and markers to guide both novice and more experienced skin cancer experts (1).
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    3. Commentary on the Diagnostic Utility of Non-invasive Imaging Devices for Field Cancerization

      Commentary on the Diagnostic Utility of Non-invasive Imaging Devices for Field Cancerization
      In this issue of Experimental Dermatology , Marneffe and collegues present a practical algorithmic guide to differentiating actinic keratosis (AK) from normal skin and squamous cell carcinoma (SCC) using high-definition optical coherence tomography (HD-OCT), outlining steps and markers to guide both novice and more experienced skin cancer experts (1).
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    4. Defining Field Cancerization of the Skin Using Noninvasive Optical Coherence Tomography Imaging to Detect and Monitor Actinic Keratosis in Ingenol Mebutate 0.015%-Treated Patients

      Defining Field Cancerization of the Skin Using Noninvasive Optical Coherence Tomography Imaging to Detect and Monitor Actinic Keratosis in Ingenol Mebutate 0.015%-Treated Patients
      Objective: The objective of this study was to assess the ability of optical coherence tomography to detect clinical and subclinical actinic keratoses confirmed by histopathology. The efficacy of ingenol mebutate treatment of actinic keratosis was also evaluated using optical coherence tomography, and correlation of treatment efficacy with severity of local skin reactions was determined. Design: Single-arm, open-label, split-face study. Setting: Hospital outpatient clinic. Participants: Male subjects (N=30) with seven ...
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    5. Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns

      Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns
      Non-invasive imaging devices are currently being utilized in research and clinical settings to help visualize, characterize, anddiagnose cancers of the skin. Speckle-variance optical coherence tomography (svOCT) is one such technology that offers considerable promise for non-invasive, real time detection of skin cancers given its added ability to show changes in microvasculature. We present four early lesions of the face namely sebaceous hyperplasia, basal cell skin cancer, pigmented actinic keratosis, and ...
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    6. Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy
      Objective : To determine the diagnostic accuracy of optical coherence tomography for basal cell carcinoma and the proportion of biopsies that could be avoided if optical coherence tomography is used to rule-in surgery. Design : Multicenter, prospective, observational study. Setting : Dermatology clinics. Participants : Consecutive patients with clinically challenging pink lesions suspicious for basal cell carcinoma. Measurements : Clinical, dermoscopic, and optical coherence tomography images were obtained for all subjects. At each stage, the ...
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    7. Positive results from multi-centre, prospective clinical trial for diagnosis of basal cell carcinoma using Michelson Diagnostics’ VivoSight OCT Presented at AAD

      Positive results from multi-centre, prospective clinical trial for diagnosis of basal cell carcinoma using Michelson Diagnostics’ VivoSight OCT Presented at AAD
      ...ing in Dermatology

      Authors: Orit Markowitz, MD, FAAD; Robert Bard, MD; Theresa Cao, DO; Gerald Messer; Daniel M. Siegel, MD, MS, FAAD ; Dan Sperling, MD; Martina Ulrich, MD; Julia Welzel, MD

      Session Info: T...

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    8. Optical Coherence Tomography Dermatology Image Atlas

      Optical Coherence Tomography Dermatology Image Atlas
      A OCT poster from recent European Academy of Dermatology and Venereology Meeting. See PDF HERE. Optical Coherence Tomography is a low-intensity laser based imaging technique that can image up to 2mm beneath the skin. The OCT probe moves across a lesion creating a continuous black and white movie of multiple vertical sections, similar to a the vertical orientation of histology and provides more cellular resolution than seen with ultrasound technology.
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    9. Optical Coherence Tomography Imaging of Onychomycosis

      Optical Coherence Tomography Imaging of Onychomycosis
      A OCT poster from recentEuropean Academy of Dermatology and Venereology Meeting.Optical coherence tomography (OCT) is a non-invasive imaging technique that uses a low-power infrared laser light to image up to 2mm beneath the skins surface. This allows the clinician to obtain real-time images of the architecture of the skin, without any pre-treatment or gels. OCT has shown to be a useful diagnostic tool for conditions of the nail, such ...
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    10. Breakthrough 3-D optical imaging possible in vivo

      Breakthrough 3-D optical imaging possible in vivo
      National report — A series of technological innovations has led to near-real-time, in vivo, three-dimensional optical imaging of skin up to a depth of 1 mm – with potentially a depth of up to 2 mm with clearing methods. The resolution is approaching that of histology biopsy. Initial use is likely to be in a research setting; broad clinical use will require both validation and the marketing of a device that is ...
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    11. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between Spectral-Domain and Time-Domain Optical Coherence Tomography

      Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between Spectral-Domain and Time-Domain Optical Coherence Tomography
      Objective: To compare the performance of a spectral-domain optical coherence tomography (OCT) device and a time-domain OCT device to detect retinal nerve fiber layer (RNFL) progression in glaucoma patients.Design: Prospective study.Participants: One hundred twenty-eight eyes of 81 glaucoma patients.Methods: Patients were followed up at 4-month intervals for at least 24 months for RNFL imaging and visual field examination. Both eyes were imaged by the Cirrus HD-OCT (Carl ...
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    12. 1-15 of 18 1 2 »
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  2. About Daniel M. Siegel

    Daniel M. Siegel

    Daniel Mark Siegel is a professor of dermatology at State University of New York Downstate Medical Center College of Medicine.

  3. Quotes

    1. OCT holds a lot of promise, and I think this brings it a step forward...I think it is great that people are pushing the technology...Will it replace biopsy? I'm not sure yet...Are we seeing basal cell carcinoma? Are we seeing melanoma? Are we seeing squamous cell carcinoma? Or are we simply seeing thickened epidermis because we have psoriasis?
      In Breakthrough 3-D optical imaging possible in vivo