1. Daniël M. de Bruin

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    1. Mentioned In 63 Articles

    2. Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study

      Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
      Purpose Knowledge on tumor stage and grade is paramount for treatment decision in Upper Urinary Tract Urothelial Carcinoma (UUT-UC), but cannot be accurately assessed by current techniques. Optical Coherence Tomography (OCT) is a technique, which can hypothetically provide the urologist with real-time intra-operative information on tumor grade and stage. In this pilot study the first results of OCT in grading and staging of UUT-UC are presented. Material Methods Eight consecutive ...
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    3. Optical biopsy of epithelial cancers by optical coherence tomography (OCT)

      Optical biopsy of epithelial cancers by optical coherence tomography (OCT)
      Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study ...
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    4. Successful treatment of a long tapered lesion with two overlapping ABSORB® bioresorbable vascular scaffolds of different diameters: Evaluation by three-dimensional optical coherence tomography

      Successful treatment of a long tapered lesion with two overlapping ABSORB® bioresorbable vascular scaffolds of different diameters: Evaluation by three-dimensional optical coherence tomography
      ... Medical Center, University of Amsterdam, Amsterdam, The Netherlands + Contributed equally to this paper. , * D. Martijn de Bruin Affiliations + Department of Biomedical Engineering and Physics, Academic Medical Center, ...
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    5. Optical coherence tomography in vulvar intraepithelial neoplasia

      Optical coherence tomography in vulvar intraepithelial neoplasia
      Vulvar squamous cell carcinoma (VSCC) is a gynecological cancer with an incidence of two to three per 100,000 women. VSCC arises from vulvar intraepithelial neoplasia (VIN), which is diagnosed through painful punch biopsy. In this study, optical coherence tomography (OCT) is used to differentiate between normal and VIN tissue. We hypothesize that (a) epidermal layer thickness measured in OCT images is different in normal tissue and VIN, and (b ...
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    6. Feature Of The Week 9/2/12: Academic Medical Center at The University of Amsterdam Investigates Comparison of RNFL Thickness Measurements by SD-OCT Systems Using a Phantom Eye Model

      Feature Of The Week 9/2/12: Academic Medical Center at The University of Amsterdam Investigates Comparison of RNFL Thickness Measurements by SD-OCT Systems Using a Phantom Eye Model
      We developed a multi-layered phantom eye model that distinguishes instrumental from biological variation, to quantify differences in retinal nerve fiber layer (RNFL) thickness measurements by various spectral-domain optical coherence tomography (SD-OCT) systems. The eye model comprised a glass lens, water as vitreous and silicone elastomer based layers mimicking the retina (top layer thickness = 49 m). We tested 3 RTVue OptoVue, 3 Cirrus Zeiss, 3 3DOCT-1000 Topcon and 3 Spectralis Heidelberg ...
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    7. Comparison of retinal nerve fiber layer thickness measurements by spectral-domain optical coherence tomography systems using a phantom eye model

      Comparison of retinal nerve fiber layer thickness measurements by spectral-domain optical coherence tomography systems using a phantom eye model
      To quantify differences in nerve fiber layer thickness measurements by various spectral-domain optical coherence tomography (SD-OCT) systems, we developed a phantom eye model. We tested twelve SD-OCT systems of four manufacturers. All systems combined overestimated the 49 m thick phantom RNFL thickness on average by 18 m. Within brands, thickness measurements differed statistically significant for one Topcon, one RTVue and one Cirrus. Between brands, thickness determined with RTVue and Topcon ...
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    8. Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase I in vivo human study

      Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase I in vivo human study
      Optical Coherence Tomography (OCT) was developed in the early 1990s for ophthalmological application and is currently widely accepted in ophthalmology for retinal imaging purposes. In kidneys, the first experiments were performed on transplant kidneys to investigate the ability of OCT to assess ischaemic damage of kidneys. An ex vivo pilot study on the ability of OCT to differentiate normal renal tissue from malignant renal tissue, showed positive results and here ...
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    9. In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography

      In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography
      Conventional imaging modalities are unable to depict the early degeneration of articular cartilage in osteoarthritis, especially in small joints. Optical coherence tomography has previously been used successfully in high-resolution imaging of cartilage tissue. This pilot cadaver study demonstrates the use of intra-articular optical coherence tomography in imaging of articular cartilage of the first carpometacarpal joint, producing high resolution images of the articular surface in which cartilage thickness and surface characteristics ...
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    10. Biphasic Oxidation of Oxy-Hemoglobin in Bloodstains

      Biphasic Oxidation of Oxy-Hemoglobin in Bloodstains
      Background: In forensic science, age determination of bloodstains can be crucial in reconstructing crimes. Upon exiting the body, bloodstains transit from bright red to dark brown, which is attributed to oxidation of oxy-hemoglobin (HbO2) to methemoglobin (met-Hb) and hemichrome (HC). The fractions of HbO2, met-Hb and HC in a bloodstain can be used for age determination of bloodstains. In this study, we further analyze the conversion of HbO2 to met-Hb ...
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    11. Feature Of The Week 2/6/11: Investigation into using Optical Coherence Tomography for Grading Urothelial Carcinoma - Recent Work from Academic Medical Center Amsterdam and University of Twente

      Feature Of The Week 2/6/11: Investigation into using Optical Coherence Tomography for Grading Urothelial Carcinoma - Recent Work from Academic Medical Center Amsterdam and University of Twente
      Feature Of The Week 2/6/11: Achieving the goal of a real-time in-situ high-resolution optical biopsy using OCT would be a tremendous boost to medicine and mankind. However is it quite a complex and difficult challenge that has not been fully realized to date. Many people believe this challenge will be realized in the not too distant future as understanding, approaches, and technology is improved due to progress at ...
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    12. Advanced Diagnostics in Renal Mass Using Optical Coherence Tomography: A Preliminary Report

      Advanced Diagnostics in Renal Mass Using Optical Coherence Tomography: A Preliminary Report
      Objective: To avoid unnecessary surgical treatment of small renal masses (≤4cm), a more accurate diagnostic method would be desirable since radiological differentiation between malignant and benign is difficult and nondiagnostic biopsies account from 9% to 37%. Optical coherence tomography (OCT) measures backscattered light versus depth, with an attenuation coefficient (μt) that may vary among different histological types. We hypothesize that quantitative measurements of μt using OCT can differentiate between normal ...
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    13. Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder

      Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder
      .... Cauberg Academic Medical Center, Department of Urology, P. O. Box 22660, 1100 DD Amsterdam, The Netherlands Daniël M. de Bruin and Dirk J. Faber Academic Medical Center, Department of Biomedical Engineering and Physics...
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    14. Optical phantoms of varying geometry based on thin building blocks with controlled optical properties

      Optical phantoms of varying geometry based on thin building blocks with controlled optical properties
      Current innovations in optical imaging, measurement techniques, and data analysis algorithms express the need for reliable testing and comparison methods. We present the design and characterization of silicone elastomer-based optical phantoms. Absorption is included by adding a green dye and scattering by adding TiO2 or SiO2 particles. Optical coherence tomography measurements demonstrate a linear dependence of the attenuation coefficient with scatterer concentration in the absence of absorbers. Optical transmission spectroscopy ...
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    15. Carbonized blood deposited on fibres during 810, 940 and 1,470 nm endovenous laser ablation: thickness and absorption by optical coherence tomography

      Carbonized blood deposited on fibres during 810, 940 and 1,470 nm endovenous laser ablation: thickness and absorption by optical coherence tomography
      Endovenous laser ablation (EVLA) is commonly used to treat saphenous varicosities. Very high temperatures at the laser fibre tip have been reported during EVLA. We hypothesized that the laser irradiation deposits a layer of strongly absorbing carbonized blood of very high temperature on the fibre tip. We sought to prove the existence of these layers and study their properties by optical transmission, optical coherence tomography (OCT) and microscopy. We analysed ...
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    16. Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging

      To compare the optical properties of the human retina, 3-D volumetric images of the same eye are acquired with two nearly identical optical coherence tomography (OCT) systems at center wavelengths of 845 and 1060 nm using optical frequency domain imaging (OFDI). To characterize the contrast of individual tissue layers in the retina at these two wavelengths, the 3-D volumetric data sets are carefully spatially matched. The relative scattering intensities from ...
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    17. 46-60 of 63 « 1 2 3 4 5 »
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  2. About Daniël M. de Bruin

    Daniël M. de Bruin

    Daniël M. de Bruin is in the Department of Biomedical Engineering and Physics at the Academic Medical Center Amsterdam, The Netherlands.