1. Daniël M. de Bruin

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    1. Mentioned In 49 Articles

    2. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

      Explore JRP-JMIR Research Protocols Urology
      Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)
      Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis ...
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      Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin

    3. Feasibility of Optical Coherence Tomography (OCT) for Intra-Operative Detection of Blood Flow during Gastric Tube Reconstruction

      Explore MDPI Open Access Journals Platform Gastroenterology
      Feasibility of Optical Coherence Tomography (OCT) for Intra-Operative Detection of Blood Flow during Gastric Tube Reconstruction
      In this study; an OCT-based intra-operative imaging method for blood flow detection during esophagectomy with gastric tube reconstruction is investigated. Change in perfusion of the gastric tube tissue can lead to ischemia; with a high morbidity and mortality as a result. Anastomotic leakage (incidence 520%) is one of the most severe complications after esophagectomy with gastric tube reconstruction. Optical imaging techniques provide for minimal-invasive and real-time visualization tools that can ...
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      Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin

    4. Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

      Explore SPIE Digital Library Gastroenterology
      Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models
      Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10m) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose ...
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      Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen

    5. Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound

      Explore SPIE Digital Library Urology
      Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound
      Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen. Visualization software (AMIRA) was used ...
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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen

    6. Can we predict necrosis intra-operatively? Real-time optical quantitative perfusion imaging in surgery: study protocol for a prospective, observational, in vivo pilot study

      Explore Pilot and Feasibility Studies
      Can we predict necrosis intra-operatively? Real-time optical quantitative perfusion imaging in surgery: study protocol for a prospective, observational, in vivo pilot study
      Background Compromised perfusion as a result of surgical intervention causes a reduction of oxygen and nutrients in tissue and therefore decreased tissue vitality. Quantitative imaging of tissue perfusion during reconstructive surgery, therefore, may reduce the incidence of complications. Non-invasive optical techniques allow real-time tissue imaging, with high resolution and high contrast. The objectives of this study are, first, to assess the feasibility and accuracy of optical coherence tomography (OCT), sidestream ...
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      Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin

    7. Visibility of Fiducial Markers used for Image-Guided Radiation Therapy on Optical Coherence Tomography for Registration with CT: an Esophageal Phantom Study

      Explore Wiley Online Library Gastroenterology
      Visibility of Fiducial Markers used for Image-Guided Radiation Therapy on Optical Coherence Tomography for Registration with CT: an Esophageal Phantom Study
      Purpose Optical coherence tomography (OCT) is of interest to visualize microscopic esophageal tumor extensions to improve tumor delineation for radiation therapy (RT) planning. Fiducial marker placement is a common method to ensure target localization during planning and treatment. Visualization of these fiducial markers on OCT permits integrating OCT and computed tomography (CT) images used for RT planning via image registration. We studied the visibility of 13 (8 types) commercially available ...
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      Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam Dirk J. Faber

    8. Optical coherence tomography for identification and quantification of human airway wall layers

      Explore Journals | PLOS Pulmonology
      Optical coherence tomography for identification and quantification of human airway wall layers
      Background High-resolution computed tomography has limitations in the assessment of airway wall layers and related remodeling in obstructive lung diseases. Near infrared-based optical coherence tomography (OCT) is a novel imaging technique that combined with bronchoscopy generates highly detailed images of the airway wall. The aim of this study is to identify and quantify human airway wall layers both ex-vivo and in-vivo by OCT and correlate these to histology. Methods Patients ...
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      Mentions: National Institutes of Health Academic Medical Center at the University of Amsterdam St. Jude Medical

    9. Applicability of quantitative optical imaging techniques for intraoperative perfusion diagnostics: a comparison of laser speckle contrast imaging, sidestream dark-field microscopy, and optical coherence tomography

      Explore SPIE Digital Library
      Applicability of quantitative optical imaging techniques for intraoperative perfusion diagnostics: a comparison of laser speckle contrast imaging, sidestream dark-field microscopy, and optical coherence tomography
      . Patient morbidity and mortality due to hemodynamic complications are a major problem in surgery. Optical techniques can image blood flow in real-time and high-resolution, thereby enabling perfusion monitoring intraoperatively. We tested the feasibility and validity of laser speckle contrast imaging (LSCI), optical coherence tomography (OCT), and sidestream dark-field microscopy (SDF) for perfusion diagnostics in a phantom model using whole blood. Microvessels with diameters of 50, 100, and 400 m were ...
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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen

    10. Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy

      Explore Elsevier Health Urology
      Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy
      Purposes Biopsies and cytology are cornerstones in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). However, a high rate of non-diagnostic biopsies, tumor upgrading and -staging after nephroureterectomy is observed. In this prospective in vivo study we aimed to evaluate the diagnostic accuracy of OCT for grading and staging of UTUC Material Methods Twenty-six patients underwent diagnostic URS including biopsies and OCT imaging, followed by nephroureterectomy or segmental ureter ...
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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen

    11. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Explore Wiley Online Library Oncology , Urology
      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling
      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm 1 ; 3.85 mm 1 ; p 0.0001) for all patients ...
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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber VU University Amsterdam

    12. Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer

      Explore tct.sagepub.com Urology
      Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer
      Objective: To design and demonstrate a customized tool to generate histologic sections of the prostate that directly correlate with needle-based optical coherence tomography pullback measurements. Materials and Methods: A customized tool was created to hold the prostatectomy specimens during optical coherence tomography measurements and formalin fixation. Using the tool, the prostate could be sliced into slices of 4 mm thickness through the optical coherence tomography measurement trajectory. In this way ...
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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber VU University Amsterdam

    13. Percutaneous Needle Based Optical Coherence Tomography for the Differentiation of Renal Masses: a Pilot Cohort

      Explore The Journal of Urology Urology
      Percutaneous Needle Based Optical Coherence Tomography for the Differentiation of Renal Masses: a Pilot Cohort
      To view the full text, please login as a subscribed user or purchase a subscription . Click here to view the full text on ScienceDirect. The aim of this study is to determine the ability of percutaneous needle based Optical Coherence Tomography (OCT) to differentiate renal masses, by using the attenuation coefficient (OCT, mm-1) as a quantitative measure. Percutaneous needle based OCT of the kidney was performed in patients presenting with ...
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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen

    14. Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient

      Explore SPIE | Journal
      Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient
      The learning curve and interobserver variance of attenuation coefficient ( OCT ) determination from optical coherence tomography (OCT) images were quantified. The OCT of normal and diseased vulvar tissues was determined at five time points by three novice students and three OCT experts who reached consensus for reference. Students received feedback between time points. Eventually, variance in OCT was smaller in images of diseased tissue than in images of normal vulvar tissue ...
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      Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber

    15. Assesment of apoptosis induced changes in scattering using optical coherence tomography

      Explore Wiley Online Library
      Assesment of apoptosis induced changes in scattering using optical coherence tomography
      The aim of this study is to identify changes in scattering with optical coherence tomography (OCT) and relate these measurements with mitochondrial changes during the initiation of apoptosis. Human retinal pigment epithelial cells were cultured and apoptosis was induced using 10% alcohol. Using the attenuation coefficient and backscattering, changes were measured during cell death in a cell-pellet and monolayer respectively. To confirm apoptosis, fluorescent activated cell sorting was used. Mitochondrial ...
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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen

    16. Beyond Endoscopy-Ultrasound, Optical Coherence Tomography and Confocal Laser Endomicroscopy (Book Chapter)

      Explore Home - Springer Gastroenterology , Textbooks
      Beyond Endoscopy-Ultrasound, Optical Coherence Tomography and Confocal Laser Endomicroscopy (Book Chapter)
      One of the main challenges in endoscopic diagnosis and treatment of upper urinary tract urothelial carcinoma is the complicated anatomy and the small size of the upper urinary tract, resulting in high demands on the armamentarium and expertise of the urologist. Difficulties to reach the complete collecting system could result in an incomplete visual inspection.
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      Mentions: Academic Medical Center at the University of Amsterdam Daniël M. de Bruin Theo M. de Reijke
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  4. About Daniël M. de Bruin

    Daniël M. de Bruin

    Daniël M. de Bruin is in the Department of Biomedical Engineering and Physics at the Academic Medical Center Amsterdam, The Netherlands.

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