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Daniël M. de Bruin
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Mentioned In 63 Articles
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Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation
Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT ...Read Full Article -
En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients
The increase histopathological evaluation of prostatectomy specimens rises the workload on pathologists. Automated histopathology systems, preferably directly on unstained specimens, would accelerate the pathology workflow. In this study, we investigate the potential of quantitative analysis of Optical Coherence Tomography (OCT) to separate benign from malignant prostate tissue automatically. Twenty fixated prostates were cut, from which 54 slices were scanned by OCT. Quantitative OCT metrics (attenuation coefficient, residue, goodness‐of‐fit ...Read Full Article -
Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU
Introduction: Differentiating ARDS from other forms of respiratory failure can be difficult. By advancing an optic fiber through a diagnostic bronchoscope, followed by an automatic pullback mechanism, OCT enables real-time 3D imaging of the alveolar compartment and peripheral airways. Aim: To investigate feasibility of bronchoscopic OCT, and to describe different OCT patterns of the alveolar compartment in mechanically ventilated patients. Methods: Observational study of OCT imaging in mechanically ventilated patients ...Read Full ArticleMentions: Daniël M. de Bruin -
Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix
Introduction: Airway diseases are characterized by structural airway remodeling, including extracellular matrix (ECM) changes. Although a key feature, no diagnostic test currently assesses airway remodeling other than invasive airway biopsies. Real-time optical coherence tomography (OCT) generates infrared-based cross-sectional images of airway segments. Previously we reported that OCT identifies and quantifies airway wall layers. We hypothesized that OCT is able to detect collagen deposition areas within the airway wall ECM. Methods ...Read Full ArticleMentions: Daniël M. de Bruin -
Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study
Objective Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design Using needle-based introduction of the OCT probe, the articular surface ...Read Full Article -
The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure ...Read Full Article -
Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study
Radiation therapy for patients with non-small-cell lung cancer is hampered by acute radiation-induced toxicity in the esophagus. This study aims to validate that optical coherence tomography (OCT), a minimally invasive imaging technique with high resolution (~10 m), is able to visualize and monitor acute radiation-induced esophageal damage (ARIED) in mice. We compare our findings with histopathology as the gold standard. Irradiated mice receive a single dose of 40 Gy at ...Read Full Article -
Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)
Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with thermal energy. The extent of treatment effect is largely unknown. Optical coherence tomography (OCT) is a high resolution imaging technique, using near-infrared light, that generates near-histology cross sectional images of the airway wall. Aim: Assess the extent of acute airway wall effects of BT with OCT and compare these to the untreated right ...Read Full Article -
Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review
Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT ...Read Full Article -
One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen
Optical coherence tomography (OCT), enables high‐resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one‐to‐one registration is needed. The primary aim of this study ...Read Full Article -
Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma
Background: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images. Objective: To assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects ...Read Full Article -
Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study
Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate ...Read Full Article -
Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients
iagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation ...Read Full Article -
Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)
Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis ...Read Full Article
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About Daniël M. de Bruin
Daniël M. de Bruin is in the Department of Biomedical Engineering and Physics at the Academic Medical Center Amsterdam, The Netherlands.