1. Dalhousie University

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    1. Mentioned In 32 Articles

    2. Colocalization of optical coherence tomography angiography with histology in the mouse retina

      Colocalization of optical coherence tomography angiography with histology in the mouse retina
      Optical coherence tomography angiography (OCT-A) allows in vivo , non-invasive, functional imaging of retinal perfusion. The purpose of this study was to determine the reliability of OCT-A in visualizing the complete retinal vasculature by comparing in vivo OCT-A images to matched ex vivo tissue in mice. Adult female C57BL/6 mice were imaged to obtain OCT-A images of the superficial vascular complex, intermediate capillary plexus and deep capillary plexus. Z-stack fluorescence ...
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    3. Effects of axial length on retinal nerve fiber layer and macular ganglion cell-inner plexiform layer measured by spectral-domain OCT

      Effects of axial length on retinal nerve fiber layer and macular ganglion cell-inner plexiform layer measured by spectral-domain OCT
      Purpose: To evaluate the influence of ocular axial length on circumpapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in healthy eyes after correcting for ocular magnification effect. Methods: In this cross-sectional study, we evaluated 120 eyes from 60 volunteer participants (myopes, emmetropes, and hyperopes). The thickness of the circumpapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer were measured using the spectral optical coherence tomography (OCT ...
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    4. Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects

      Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects
      Background/aims Quantitative analysis of optical coherence tomography angiography (OCT-A) images requires a reproducible approach that accounts for sectoral loss. The objective of this study was to determine whether an index that accounts for both global (perfusion density, PD) and asymmetric loss of perfusion, rather than PD alone, more reliably measures loss of perfusion in patients with glaucoma. Methods We analysed macular OCT-A scans of 95 glaucoma patients and 59 ...
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    5. Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage

      Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage
      Purpose To understand the added value of Bruchs membrane opening-minimum rim width (BMO-MRW) measurements to conventional circumpapillary retinal nerve fibre layer (cpRNFL) thickness measurements on optical coherence tomography (OCT) imaging for discriminating between perimetric glaucoma and healthy eyes, evaluated through a qualitative evaluation. Methods 384 healthy eyes and 188 glaucoma eyes were evaluated, and glaucoma eyes were categorised as perimetric (n=107) based on a history of 3 consecutive abnormal ...
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    6. A Novel Use of Optical Coherence Tomography for the Assessment of Ocular Torsion (Thesis)

      A Novel Use of Optical Coherence Tomography for the Assessment of Ocular Torsion (Thesis)
      Abnormal ocular torsion is most frequently the result paresis of the fourth cranial nerve. The presence of torsion can be a barrier to fusion, in which case, surgical intervention is required for a patient to have single vision. Clinically, ocular torsion can be measured either subjectively or objectively, the latter traditionally using the relationship between the fovea and the optic disc. However, previous literature has shown inconsistencies between torsion a ...
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    7. Influence of Bruch’s Membrane Opening Area in Diagnosing Glaucoma with Neuroretinal Parameters from Optical Coherence Tomography

      Influence of Bruch’s Membrane Opening Area in Diagnosing Glaucoma with Neuroretinal Parameters from Optical Coherence Tomography
      Purpose To determine whether the glaucoma diagnostic accuracy of age and Bruchs membrane opening area (BMOA) adjusted normative classifications of minimum rim width (MRW) and retinal nerve fibre layer thickness (RNFLT) is dependent on BMOA, in a European descent population. Design Retrospective, cross-sectional study. Methods We included 182 glaucoma patients and 166 healthy controls for the primary study, and 105 glaucoma patients in a second sample used for a replication ...
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    8. OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes
      Purpose To assess anterior scleral canal opening (ASCO) offset relative to Bruchs membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Design Cross-sectional study Methods After OCT optic nerve head (ONH) and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented and planes, centroids, size and shape were calculated. Neural canal direction ...
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    9. Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage

      Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage
      Purpose : We implemented optical coherence tomography angiography (OCT-A) in mice to: (1) develop quantitative parameters from OCT-A images, (2) measure the reproducibility of the parameters, and (3) determine the impact of experimental models of inner and outer retinal damage on OCT-A findings. Methods : OCT-A images were acquired with a customized system (Spectralis Multiline OCT2). To assess reproducibility, imaging was performed five times over 1 month. Inner retinal damage was induced ...
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    10. Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls

      Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls
      Hypothesis: Ears with otosclerotic stapes fixation will exhibit lower-than-normal levels of ossicular mobility as measured by Optical Coherence Tomography Doppler Vibrometry (OCT-DV). Background: OCT-DV measures the vibration of middle ear structures in response to sound non-invasively through the intact tympanic membrane. This allows, in particular, direct measurement of the vibration at the lenticular process of the incus which is expected to be lower in patients with otosclerotic stapes fixation. Methods ...
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    11. Visibility of Optic Nerve Head Structures With Spectral-domain and Swept-source Optical Coherence Tomography

      Visibility of Optic Nerve Head Structures With Spectral-domain and Swept-source Optical Coherence Tomography
      Purpose: To compare the visibility of deep optic nerve head (ONH) structures and the visible area of the anterior surface of the lamina cribrosa (ASLC) with spectral-domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT). Materials and Methods: In total, 33 glaucoma patients were imaged with SD-OCT (Spectralis, 24 radial B-scans centered on the ONH) and SS-OCT (Atlantis, 12 radial and a horizontal and vertical raster scan pattern containing 5 ...
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    12. Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics

      Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics
      We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in ...
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  2. About Dalhousie University

    Dalhousie University

    Dalhousie University is a university located in Halifax, Nova Scotia, Canada. As the largest post-secondary educational institution in the Maritime Provinces it offers a wide array of programmes, including a Medical Programme and the Dalhousie Law School.