1. Cynthia A. Toth

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    1. Mentioned In 134 Articles

    2. Macular Microvascular Findings in Familial Exudative Vitreoretinopathy on Optical Coherence Tomography Angiography

      Macular Microvascular Findings in Familial Exudative Vitreoretinopathy on Optical Coherence Tomography Angiography
      BACKGROUND AND OBJECTIVE: To describe depth-resolved macular microvasculature abnormalities in patients with familial exudative vitreoretinopathy (FEVR) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Twenty-two eyes (11 eyes of six patients with FEVR and 11 control eyes) were imaged with OCTA. Graders qualitatively analyzed the OCTA images of the superficial and deep vascular complexes for abnormal vascular features and compared to fluorescein angiography (FA). RESULTS: Seven of 11 eyes ...
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    3. Handbook of Pediatric Retinal OCT and the Eye-Brain Connection 1st Edition (Textbook)

      Handbook of Pediatric Retinal OCT and the Eye-Brain Connection 1st Edition (Textbook)
      Optical Coherence Tomography (OCT) plays a vital role in pediatric retina diagnosis , often revealing unrecognized retinal disorders and connections to brain injury, disease, and delayed neurodevelopment. Handbook of Pediatric Retinal OCT and the Eye-Brain Connection provides authoritative, up-to-date guidance in this promising area , showing how to optimize imaging in young children and infants, how to accurately interpret these images, and how to identify links between these images and brain and ...
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    4. Best Clinical Practice for Age-Related Macular Degeneration Imaging

      Best Clinical Practice for Age-Related Macular Degeneration Imaging
      Purpose: To identify best clinical practices for macular degeneration imaging. Methods: We reviewed best clinical practices for imaging patients with age-related macular degeneration. These recommendations are based on different levels of evidence (I-III). Results: The type of imaging needed depends to some degree on the clinical scenario: first visit vs follow-up visit vs poorly responsive patient. Conclusions: Imaging technologies that may be useful include optical coherence tomography, fundus photography, fundus ...
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    5. Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope

      Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope
      Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. The system includes a display having first and second display portions, configured to display first images in the first display portion, and configured to display second images in the second display portion. The first image and the second image are projected ...
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    6. Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care
      ...r Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care. The principal investigator is Cynthia Toth. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Retinopath...
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    7. Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease

      Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease
      Importance Coats disease is a rare pediatric vitreoretinopathy that can cause devastating visual and anatomic outcomes. Objective To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic findings in Coats disease. Design, Setting, and Participants This retrospective cohort study was conducted in a single tertiary institution (Duke Eye Center) and identified 28 children with Coats disease through a review of medical records from December 2002 to ...
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    8. Depth-Based, Motion-Stabilized Colorization of Microscope-Integrated Optical Coherence Tomography Volumes for Microscope-Independent Microsurgery

      Depth-Based, Motion-Stabilized Colorization of Microscope-Integrated Optical Coherence Tomography Volumes for Microscope-Independent Microsurgery
      Purpose : We develop and assess the impact of depth-based, motion-stabilized colorization (color) of microscope-integrated optical coherence tomography (MIOCT) volumes on microsurgical performance and ability to interpret surgical volumes. Methods : Color was applied in real-time as gradients indicating axial position and stabilized based on calculated center of mass. In a test comparing colorization versus grayscale visualizations of prerecorded intraoperative volumes from human surgery, ophthalmologists ( N = 7) were asked to identify retinal ...
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    9. Intraoperative OCT Guidance of Intraocular Surgery II

      Intraoperative OCT Guidance of Intraocular Surgery II
      The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes. The investigators believe this technology will enable novel ophthalmic and other microsurgeries not possible due to current limitations in surgical visualization.
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    10. Vascular Findings In A Small Retinoblastoma Tumor Using OCT-A

      Vascular Findings In A Small Retinoblastoma Tumor Using OCT-A
      Retinoblastoma (RB) is the most common primary intraocular malignancy of children. 1 Improvements in screening tactics and treatment methods have dramatically increased both patient and globe survival. 1,2 Imaging modalities such as fluorescein angiography (FA) have demonstrated retinal vascular abnormalities in both large and small caliber retinal vessels in eyes with retinoblastoma, 1 and optical coherence tomography (OCT) can reveal or confirm otherwise subclinical lesions. 2 OCT angiography (OCT-A ...
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    11. Imaging infant retinal vasculature with optical coherence tomography angiography

      Imaging infant retinal vasculature with optical coherence tomography angiography
      Study of infant retinal vascular development has been limited to histopathological reports. We report herein depth-resolved visualization of full-term infant parafoveal microvasculature and their similarity to that of young children using a portable optical coherence tomography angiography system.
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    12. Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease

      Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease
      Purpose : To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease. Methods : Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 2016 were reviewed for SD-OCT features. Central subfield (CSF) SD-OCT findings were analyzed relative to VA (logarithm of the minimum angle of resolution) at baseline and final visit (when follow-up 6 months) and across visits ...
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    13. Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning

      Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning
      The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by synchronization with retinal birefringence scanning (RBS). OCT is performed without knowing whether or not the subject is looking at the intended target. The present invention combines OCT retinal imaging, such as, but not limited to, time domain OCT, SDOCT, or ...
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    14. Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography

      Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography
      Purpose : We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. Methods : A MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging an object of known size in model eyes. This method then was applied to subretinal blebs created by injection of diluted triamcinolone. Bleb volumes obtained ...
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    15. 1-15 of 134 1 2 3 4 5 6 7 8 9 »
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  2. About Cynthia A. Toth

    Cynthia A. Toth

    Cynthia A. Toth, MD, is a Professor of Ophthalmology Vitreoretinal Diseases and Surgery and Professor of Biomedical Engineering at Duke. Clinical Interests: Medical and surgical diseases of the retina and vitreous, especially macular diseases, surgical treatments for macular degeneration, retinopathy of prematurity, proliferative vitroeoretinal disorders, retinal detachment and laser eye injury, choroidal neovascular membranes and subretinal hemorrhage, macular translocation surgery. Research Interests: Dr. Toth specializes in the evaluation and surgical treatment of vitreoretinal diseases in adults and children. She has pioneered the development of macular translocation surgery for age-related macular degeneration (AMD). Her particular clinical interests and skills also include the surgical treatment of macular diseases, retinal detachment, proliferative diabetic retinopathy, proliferative vitreoretinopathy (PVR), and retinopathy of prematurity (ROP). Dr. Toth’s primary research interests include improving diagnostic methods and therapy for macular degeneration and the development and application of optical coherence tomography for macular diseases. She has been repeatedly honored among the Best Doctors in America.

  3. Quotes

    1. Now, for the first time, we can take the SD OCT system into the neonatal intensive care unit and hold it over the infant's eye without touching the eye and image the retina while the infant is lying in the bed.
      In Mapping a baby’s retina for signs of blindness
    2. SD OCT reveals the retina in greater detail than was ever before realized, allowing us to observe disease at almost the cellular level
      In New device finds early signs of eye disease in preemies
    3. We can see just amazing things in these young children's eyes that we never suspected.
      In Testing tool to better detect premature baby eye disease
    4. One benefit of SD-OCT is the creation of the summed voxel projection [SVP], which is helpful for orientation of individual OCT scans. One can collapse three-dimensional OCT volumes along the depth axis to form a two-dimensional plane, summing pixels to calculate one representative pixel intensity alone each line in the projection.
      In Spectral-domain optical coherence tomography an improvement over previous optical coherence tomography systems