1. Cynthia A. Toth

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    1. Mentioned In 149 Articles

    2. Local anatomic precursors to new onset geographic atrophy in age-related macular degeneration as defined on optical coherence tomography

      Explore Ophthalmology Retina Ophthalmology
      Local anatomic precursors to new onset geographic atrophy in age-related macular degeneration as defined on optical coherence tomography
      Purpose In macula-wide analyses, spectral domain optical coherence tomography (SDOCT) features such as drusen volume, hyperreflective foci and OCT-reflective drusen substructures independently predict onset of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). We sought to identify SDOCT features in the location of new GA prior to its onset. Design Retrospective study Subjects Age-Related Eye Disease Study 2 Ancillary SDOCT Study Participants Methods We analyzed longitudinally-captured SDOCT and color ...
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      Mentions: Duke University Cynthia A. Toth Sina Farsiu

    3. Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Explore American Journal of Ophthalmology Ophthalmology
      Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials
      Purpose To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-VEGF through pixel-mapping analysis of baseline OCT. Design Cross-sectional analysis. Setting Multicenter clinical trial. Patient population 68 eyes from the Comparison of Age-Related Macular Degeneration Treatments Trials. Intervention Treatment with anti-VEGF agents. Main outcome measure The percentage of MA or FS pixels with each OCT feature at baseline, and the odds ratio (OR ...
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      Mentions: Duke University Cynthia A. Toth Gui-Shuang Ying

    4. Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System

      Explore TVST Journal Ophthalmology
      Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System
      Purpose : To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods : Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thickness on OCT scans of the right eye of 10 healthy adults. Three OCT systems were used: handheld Leica Envisu, investigational handheld swept-source OCT (UC3), and Heidelberg Spectralis ...
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      Mentions: Heidelberg Engineering Duke University Cynthia A. Toth

    5. Macular Optical Coherence Tomography Characteristics at 36 weeks Postmenstrual Age in Infants Examined for Retinopathy of Prematurity

      Explore ScienceDirect Ophthalmology
      Macular Optical Coherence Tomography Characteristics at 36 weeks Postmenstrual Age in Infants Examined for Retinopathy of Prematurity
      Objective To report our ability to capture, grade reliably and analyze bedside macular optical coherence tomography (OCT) images from preterm infants and relate OCT findings to biological factors and retinopathy of prematurity (ROP) status at a single time window in the STudy of Eye imaging in Preterm infantS (BabySTEPS). Design Prospective observational study Participants Preterm infants eligible for ROP screening, with parental consent for research and a 361 weeks postmenstrual ...
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      Mentions: Joseph A. Izatt Duke University Sharon F. Freedman

    6. Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

      Explore TVST Journal Ophthalmology
      Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity
      Abstract Purpose : To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (ROP). Methods : In this exploratory study, we selected images from eyes with a range of ROP vascular disease, prospectively acquired from preterm infants using an investigational, noncontact, handheld, bedside swept-source OCT ...
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      Mentions: Joseph A. Izatt Duke University Sharon F. Freedman

    7. Lightweight Learning-based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images

      Explore American Journal of Ophthalmology Ophthalmology
      Lightweight Learning-based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images
      Purpose Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available to measure the volume of therapeutics successfully administered to the subretinal location during surgery. Here we introduce the first automatic method for quantifying the volume of subretinal blebs, using porcine eyes injected with ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    8. Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients

      Explore Journal of AAPOS Ophthalmology
      Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients
      Handheld optical coherence tomography (OCT) makes it possible to acquire intraoperative and clinical imaging in infants and children for whom standard OCT is not possible. In patients with a retinal pathology who are left aphakic after surgery, however, image clarity is affected by insufficient refractive correction with handheld OCT. We describe a technique for supplementing the refractive power of the handheld OCT device with an aphakic contact lens to improve ...
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      Mentions: Duke University Cynthia A. Toth

    9. OCULAR MANIFESTATIONS OF PORETTI-BOLTSHAUSER SYNDROME: FINDINGS FROM MULTIMODAL IMAGING AND ELECTROPHYSIOLOG

      Explore LWW Online Ophthalmology
      OCULAR MANIFESTATIONS OF PORETTI-BOLTSHAUSER SYNDROME: FINDINGS FROM MULTIMODAL IMAGING AND ELECTROPHYSIOLOG
      Background/Purpose: Poretti-Boltshauser syndrome is a rare, nonprogressive neurologic syndrome with characteristic cerebellar cysts on neuroimaging due to mutations in LAMA1 . The ophthalmic findings in Poretti-Boltshauser syndrome are not well described. Here, we report the ophthalmic findings from multimodal imaging and electrophysiology of a patient with genetically confirmed Poretti-Boltshauser syndrome . Methods: A 3-year-old boy with confirmed mutations in LAMA1 underwent examination under anesthesia with electroretinography and multimodal imaging including fundus ...
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      Mentions: Duke University Cynthia A. Toth

    11. Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA

      Explore Healio.com Ophthalmology
      Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA
      BACKGROUND AND OBJECTIVE: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. PATIENTS AND METHODS: Single-center, prospective, cross-sectional, consecutive case-series of children with previously treated retinoblastoma who underwent portable OCTA of posterior retinoblastoma lesions. RESULTS: Eight tumors from seven eyes of five children with retinoblastoma were included. Tumors with types 1 (calcified remnant, n = 3), 2 ...
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      Mentions: Duke University Cynthia A. Toth Miguel A. Materin

    12. HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF X-LINKED RETINOSCHISIS IN EARLY CHILDHOOD

      Explore LWW Online Ophthalmology
      HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF X-LINKED RETINOSCHISIS IN EARLY CHILDHOOD
      Background/Purpose: Using handheld spectral domain optical coherence tomography (SDOCT) imaging to investigate in vivo microanatomic retinal changes and their progression over time in young children with juvenile X-linked retinoschisis (XLRS). Methods: This retrospective analysis was of handheld SD OCT images obtained under a prospective research protocol in children who had established XLRS diagnosis based on genetic testing or clinical history. Three OCT graders performed standardized qualitative and quantitative assessment ...
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      Mentions: Duke University Cynthia A. Toth

    13. Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography

      Explore Home - Springer Ophthalmology
      Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography
      Purpose Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be especially advantageous in the diagnosis and monitoring of children with CNV. Methods Eight eyes from eight patients aged 12 months to 18 years were imaged with the investigational Spectralis OCTA (version 6.9, Heidelberg Engineering, Heidelberg, Germany) and ...
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      Mentions: Optovue Duke University Cynthia A. Toth

    14. Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years

      Explore ScienceDirect Ophthalmology
      Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years
      Purpose Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) can be used with sedation in children not amenable to traditional imaging. Purpose: to report GCC and RNFL measurements in normal children using HH-OCT. Design Prospective observational study of normal children 5-years of age ...
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      Mentions: Duke University Sharon F. Freedman Cynthia A. Toth

    15. Duke University Receives NIH Grant for Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants.

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Duke University Receives NIH Grant for Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants.
      ...dside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants. The principal investigator is Cynthia Toth. The program began in 2018 and ends in 2020. Below is a summary of the proposed work.

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      Mentions: National Institutes of Health Duke University Cynthia A. Toth

    16. Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children

      Explore American Journal of Ophthalmology Ophthalmology
      Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children
      Purpose Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) can be used with sedation in children not amenable to traditional imaging. Purpose: to report GCC and RNFL measurements in normal children using HH-OCT. Design Prospective observational study of normal children 5-years of age ...
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      Mentions: Duke University Sharon F. Freedman Cynthia A. Toth
    17. 1-15 of 149 1 2 3 4 5 6 7 8 9 10 »
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  4. About Cynthia A. Toth

    Cynthia A. Toth

    Cynthia A. Toth, MD, is a Professor of Ophthalmology Vitreoretinal Diseases and Surgery and Professor of Biomedical Engineering at Duke. Clinical Interests: Medical and surgical diseases of the retina and vitreous, especially macular diseases, surgical treatments for macular degeneration, retinopathy of prematurity, proliferative vitroeoretinal disorders, retinal detachment and laser eye injury, choroidal neovascular membranes and subretinal hemorrhage, macular translocation surgery. Research Interests: Dr. Toth specializes in the evaluation and surgical treatment of vitreoretinal diseases in adults and children. She has pioneered the development of macular translocation surgery for age-related macular degeneration (AMD). Her particular clinical interests and skills also include the surgical treatment of macular diseases, retinal detachment, proliferative diabetic retinopathy, proliferative vitreoretinopathy (PVR), and retinopathy of prematurity (ROP). Dr. Toth’s primary research interests include improving diagnostic methods and therapy for macular degeneration and the development and application of optical coherence tomography for macular diseases. She has been repeatedly honored among the Best Doctors in America.

  5. Related Topics

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      143 articles also mentioned Duke University
    2. Correlation Of Pathologic Features In Spectral Domain Optical Coherence Tomography With Conventional Retinal Studies.
      73 articles also mentioned Joseph A. Izatt
    3. Fast detection and segmentation of drusen in retinal optical coherence tomography images
      50 articles also mentioned Sina Farsiu
    4. Methods, Systems And Computer Program Products For Mixed-Density Optical Coherence Tomography (Oct) Imaging (Wo 2008/137077)
      32 articles also mentioned Leica
    5. Insights into Advanced Retinopathy of Prematurity Using Handheld Spectral Domain Optical Coherence Tomography Imaging
      27 articles also mentioned Ramiro S. Maldonado
    6. Caveats to Obtaining Retinal Topography With Optical Coherence Tomography
      25 articles also mentioned Oscar Carrasco-Zevallos

  6. Quotes

    1. Now, for the first time, we can take the SD OCT system into the neonatal intensive care unit and hold it over the infant's eye without touching the eye and image the retina while the infant is lying in the bed.
      In Mapping a baby’s retina for signs of blindness
    2. SD OCT reveals the retina in greater detail than was ever before realized, allowing us to observe disease at almost the cellular level
      In New device finds early signs of eye disease in preemies
    3. We can see just amazing things in these young children's eyes that we never suspected.
      In Testing tool to better detect premature baby eye disease
    4. One benefit of SD-OCT is the creation of the summed voxel projection [SVP], which is helpful for orientation of individual OCT scans. One can collapse three-dimensional OCT volumes along the depth axis to form a two-dimensional plane, summing pixels to calculate one representative pixel intensity alone each line in the projection.
      In Spectral-domain optical coherence tomography an improvement over previous optical coherence tomography systems