1. Cynthia A. Toth

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    1. Mentioned In 127 Articles

    2. Depth-Based, Motion-Stabilized Colorization of Microscope-Integrated Optical Coherence Tomography Volumes for Microscope-Independent Microsurgery

      Explore TVST Journal Ophthalmology
      Depth-Based, Motion-Stabilized Colorization of Microscope-Integrated Optical Coherence Tomography Volumes for Microscope-Independent Microsurgery
      Purpose : We develop and assess the impact of depth-based, motion-stabilized colorization (color) of microscope-integrated optical coherence tomography (MIOCT) volumes on microsurgical performance and ability to interpret surgical volumes. Methods : Color was applied in real-time as gradients indicating axial position and stabilized based on calculated center of mass. In a test comparing colorization versus grayscale visualizations of prerecorded intraoperative volumes from human surgery, ophthalmologists ( N = 7) were asked to identify retinal ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    4. Intraoperative OCT Guidance of Intraocular Surgery II

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Intraoperative OCT Guidance of Intraocular Surgery II
      The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes. The investigators believe this technology will enable novel ophthalmic and other microsurgeries not possible due to current limitations in surgical visualization.
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      Mentions: Duke University Cynthia A. Toth National Eye Institute

    5. Vascular Findings In A Small Retinoblastoma Tumor Using OCT-A

      Explore Ophthalmology Retina Ophthalmology
      Vascular Findings In A Small Retinoblastoma Tumor Using OCT-A
      Retinoblastoma (RB) is the most common primary intraocular malignancy of children. 1 Improvements in screening tactics and treatment methods have dramatically increased both patient and globe survival. 1,2 Imaging modalities such as fluorescein angiography (FA) have demonstrated retinal vascular abnormalities in both large and small caliber retinal vessels in eyes with retinoblastoma, 1 and optical coherence tomography (OCT) can reveal or confirm otherwise subclinical lesions. 2 OCT angiography (OCT-A ...
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      Mentions: Duke University Cynthia A. Toth

    6. Imaging infant retinal vasculature with optical coherence tomography angiography

      Explore ScienceDirect Ophthalmology
      Imaging infant retinal vasculature with optical coherence tomography angiography
      Study of infant retinal vascular development has been limited to histopathological reports. We report herein depth-resolved visualization of full-term infant parafoveal microvasculature and their similarity to that of young children using a portable optical coherence tomography angiography system.
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      Mentions: Duke University Sharon F. Freedman Cynthia A. Toth

    7. Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease

      Explore IOVS Journal Ophthalmology
      Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease
      Purpose : To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease. Methods : Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 2016 were reviewed for SD-OCT features. Central subfield (CSF) SD-OCT findings were analyzed relative to VA (logarithm of the minimum angle of resolution) at baseline and final visit (when follow-up 6 months) and across visits ...
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      Mentions: Duke University Cynthia A. Toth

    8. Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning

      Explore uspto.gov Patents
      Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning
      The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by synchronization with retinal birefringence scanning (RBS). OCT is performed without knowing whether or not the subject is looking at the intended target. The present invention combines OCT retinal imaging, such as, but not limited to, time domain OCT, SDOCT, or ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    9. Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography

      Explore TVST Journal Ophthalmology
      Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography
      Purpose : We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. Methods : A MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging an object of known size in model eyes. This method then was applied to subretinal blebs created by injection of diluted triamcinolone. Bleb volumes obtained ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    10. VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY

      Explore LWW Online Ophthalmology
      VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY
      Purpose: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. Methods: In this prospective study, we analyzed a subgroup of patients with proliferative diabetic retinopathy complications who required vitrectomy and who were imaged by the research swept-source microscope-integrated optical coherence tomography system. In near real time, images were displayed in stereo heads-up display facilitating intraoperative surgeon feedback. Postoperative ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    11. Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology

      Explore TVST Journal Ophthalmology
      Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology
      Purpose : We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. Methods : A prototype swept source OCT system with a LWD (defined as distance from the last optical element of the imaging system to the eye) of 350 mm with custom fixation targets was developed to facilitate imaging of children ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    12. Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration

      Explore Ophthalmology Ophthalmology
      Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration
      Purpose Appearance of geographic atrophy (GA) on color photography (CP) is preceded by specific features on spectral-domain optical coherence tomography (SD OCT). We aimed to build SD OCTbased risk assessment models for 5-year new onset of GA and central GA on CP. Design Prospective, longitudinal study. Participants Age-Related Eye Disease Study 2 Ancillary SD OCT study participants with age-related macular degeneration (AMD) with bilateral large drusen or noncentral GA and ...
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      Mentions: Duke University Cynthia A. Toth Sina Farsiu

    13. Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery
      ... independent clinician-scientist. Dr. Ehlers has assembled an outstanding mentorship team (Drs. Peter Kaiser, Cynthia Toth, and William J. Dupps). The mentors' experience in instrument design, biomedical engineering, tra...
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      Mentions: National Institutes of Health Case Western Reserve University Cleveland Clinic

    14. HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS

      Explore LWW Online Ophthalmology
      HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS
      Purpose: The authors investigated feasibility of undilated handheld spectral domain optical coherence tomography (SDOCT) retinal imaging in preterm infants and children with neurologic abnormalities. Methods: Under an institutional review board-approved protocol, the authors attempted handheld SDOCT imaging of the retina, choroid, and optic nerve in infants and young children without pupil dilation. Scans were analyzed for quality and successful capture of foveal, optic nerve, and retinal structural parameters and abnormalities ...
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      Mentions: Duke University Cynthia A. Toth Ramiro S. Maldonado

    15. Optical Coherence Tomography and Wide-Field Fluorescein Angiography in Retinopathy of Prematurity (Book Chapter)

      Explore Home - Springer Ophthalmology , Textbooks
      Optical Coherence Tomography and Wide-Field Fluorescein Angiography in Retinopathy of Prematurity (Book Chapter)
      The advent and adaptation of many imaging modalities promise to revolutionize our understanding of retinopathy of prematurity (ROP) by improving the detection, diagnosis, and monitoring of response to treatment of this disease. Diagnosis and classification of ROP traditionally relies on an eye exam by an ophthalmologist expert in this area who characterizes extent and character of retinal vascularization via indirect ophthalmoscopy. Many tools now exist that allow for data acquisition ...
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      Mentions: Duke University Cynthia A. Toth Ramiro S. Maldonado

    16. Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease

      Explore The JAMA Network Ophthalmology
      Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease
      Importance Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal diseases. To date, these two technologies have not been applied in combination to evaluate retinal vascular disease in the operating suite. Objective To conduct microscope-integrated, swept-source OCTA (MIOCTA) in children with retinal vascular disease. Design, Setting, and ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth
    17. 1-15 of 127 1 2 3 4 5 6 7 8 9 »
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  4. About Cynthia A. Toth

    Cynthia A. Toth

    Cynthia A. Toth, MD, is a Professor of Ophthalmology Vitreoretinal Diseases and Surgery and Professor of Biomedical Engineering at Duke. Clinical Interests: Medical and surgical diseases of the retina and vitreous, especially macular diseases, surgical treatments for macular degeneration, retinopathy of prematurity, proliferative vitroeoretinal disorders, retinal detachment and laser eye injury, choroidal neovascular membranes and subretinal hemorrhage, macular translocation surgery. Research Interests: Dr. Toth specializes in the evaluation and surgical treatment of vitreoretinal diseases in adults and children. She has pioneered the development of macular translocation surgery for age-related macular degeneration (AMD). Her particular clinical interests and skills also include the surgical treatment of macular diseases, retinal detachment, proliferative diabetic retinopathy, proliferative vitreoretinopathy (PVR), and retinopathy of prematurity (ROP). Dr. Toth’s primary research interests include improving diagnostic methods and therapy for macular degeneration and the development and application of optical coherence tomography for macular diseases. She has been repeatedly honored among the Best Doctors in America.

  5. Related Topics

    1. Kinetic acoustic ocular examination apparatus and method
      121 articles also mentioned Duke University
    2. Correlation Of Pathologic Features In Spectral Domain Optical Coherence Tomography With Conventional Retinal Studies.
      68 articles also mentioned Joseph A. Izatt
    3. Fast detection and segmentation of drusen in retinal optical coherence tomography images
      47 articles also mentioned Sina Farsiu
    4. Methods, Systems And Computer Program Products For Mixed-Density Optical Coherence Tomography (Oct) Imaging (Wo 2008/137077)
      28 articles also mentioned Bioptigen
    5. Insights into Advanced Retinopathy of Prematurity Using Handheld Spectral Domain Optical Coherence Tomography Imaging
      27 articles also mentioned Ramiro S. Maldonado
    6. Caveats to Obtaining Retinal Topography With Optical Coherence Tomography
      23 articles also mentioned Oscar Carrasco-Zevallos

  6. Quotes

    1. Now, for the first time, we can take the SD OCT system into the neonatal intensive care unit and hold it over the infant's eye without touching the eye and image the retina while the infant is lying in the bed.
      In Mapping a baby’s retina for signs of blindness
    2. SD OCT reveals the retina in greater detail than was ever before realized, allowing us to observe disease at almost the cellular level
      In New device finds early signs of eye disease in preemies
    3. We can see just amazing things in these young children's eyes that we never suspected.
      In Testing tool to better detect premature baby eye disease
    4. One benefit of SD-OCT is the creation of the summed voxel projection [SVP], which is helpful for orientation of individual OCT scans. One can collapse three-dimensional OCT volumes along the depth axis to form a two-dimensional plane, summing pixels to calculate one representative pixel intensity alone each line in the projection.
      In Spectral-domain optical coherence tomography an improvement over previous optical coherence tomography systems