1. Cynthia A. Toth

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    1. Mentioned In 120 Articles

    2. Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography

      Explore TVST Journal Ophthalmology
      Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography
      Purpose : We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. Methods : A MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging an object of known size in model eyes. This method then was applied to subretinal blebs created by injection of diluted triamcinolone. Bleb volumes obtained ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    3. VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY

      Explore LWW Online Ophthalmology
      VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY
      Purpose: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. Methods: In this prospective study, we analyzed a subgroup of patients with proliferative diabetic retinopathy complications who required vitrectomy and who were imaged by the research swept-source microscope-integrated optical coherence tomography system. In near real time, images were displayed in stereo heads-up display facilitating intraoperative surgeon feedback. Postoperative ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    4. Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology

      Explore TVST Journal Ophthalmology
      Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology
      Purpose : We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. Methods : A prototype swept source OCT system with a LWD (defined as distance from the last optical element of the imaging system to the eye) of 350 mm with custom fixation targets was developed to facilitate imaging of children ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    5. Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration

      Explore Ophthalmology Ophthalmology
      Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration
      Purpose Appearance of geographic atrophy (GA) on color photography (CP) is preceded by specific features on spectral-domain optical coherence tomography (SD OCT). We aimed to build SD OCTbased risk assessment models for 5-year new onset of GA and central GA on CP. Design Prospective, longitudinal study. Participants Age-Related Eye Disease Study 2 Ancillary SD OCT study participants with age-related macular degeneration (AMD) with bilateral large drusen or noncentral GA and ...
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      Mentions: Duke University Cynthia A. Toth Sina Farsiu

    6. Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery
      ... independent clinician-scientist. Dr. Ehlers has assembled an outstanding mentorship team (Drs. Peter Kaiser, Cynthia Toth, and William J. Dupps). The mentors' experience in instrument design, biomedical engineering, tra...
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      Mentions: National Institutes of Health Case Western Reserve University Cleveland Clinic

    7. HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS

      Explore LWW Online Ophthalmology
      HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS
      Purpose: The authors investigated feasibility of undilated handheld spectral domain optical coherence tomography (SDOCT) retinal imaging in preterm infants and children with neurologic abnormalities. Methods: Under an institutional review board-approved protocol, the authors attempted handheld SDOCT imaging of the retina, choroid, and optic nerve in infants and young children without pupil dilation. Scans were analyzed for quality and successful capture of foveal, optic nerve, and retinal structural parameters and abnormalities ...
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      Mentions: Duke University Cynthia A. Toth Ramiro S. Maldonado

    8. Optical Coherence Tomography and Wide-Field Fluorescein Angiography in Retinopathy of Prematurity (Book Chapter)

      Explore Home - Springer Ophthalmology , Textbooks
      Optical Coherence Tomography and Wide-Field Fluorescein Angiography in Retinopathy of Prematurity (Book Chapter)
      The advent and adaptation of many imaging modalities promise to revolutionize our understanding of retinopathy of prematurity (ROP) by improving the detection, diagnosis, and monitoring of response to treatment of this disease. Diagnosis and classification of ROP traditionally relies on an eye exam by an ophthalmologist expert in this area who characterizes extent and character of retinal vascularization via indirect ophthalmoscopy. Many tools now exist that allow for data acquisition ...
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      Mentions: Duke University Cynthia A. Toth Ramiro S. Maldonado

    9. Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease

      Explore The JAMA Network Ophthalmology
      Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease
      Importance Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal diseases. To date, these two technologies have not been applied in combination to evaluate retinal vascular disease in the operating suite. Objective To conduct microscope-integrated, swept-source OCTA (MIOCTA) in children with retinal vascular disease. Design, Setting, and ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    11. Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries

      Explore Indian Journal of Ophthalmology (IJO) Ophthalmology
      Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries
      We report the first use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT) capable of live four-dimensional (4D) (three-dimensional across time) imaging intraoperatively to directly visualize tube shunt placement and trabeculectomy surgeries in two patients with severe open-angle glaucoma and elevated intraocular pressure (IOP) that was not adequately managed by medical intervention or prior surgery. We performed tube shunt placement and trabeculectomy surgery and used SS-MIOCT to visualize and record surgical ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    12. Review of intraoperative optical coherence tomography: technology and applications [Invited]

      Explore OSA | OSA Publishing
      Review of intraoperative optical coherence tomography: technology and applications [Invited]
      During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeons depth perception and visualization of instruments and sub-surface anatomy. Surgical procedures outside microsurgery, such as breast tumor resections, may also benefit from visualization of the sub-surface tissue structures. The widespread clinical adoption of optical coherence tomography (OCT) in ophthalmology and its growing prominence in other fields, such as cancer imaging, has motivated the development ...
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      Mentions: Joseph A. Izatt Duke University Cynthia A. Toth

    14. Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery

      Explore Healio.com Ophthalmology
      Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery
      The authors report the use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT), capable of live four-dimensional (three-dimensional across time) intraoperative imaging, to directly visualize suture depth during lateral rectus resection. Key surgical steps visualized in this report included needle depth during partial and full-thickness muscle passes along with scleral passes.
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      Mentions: Joseph A. Izatt Duke University Sharon F. Freedman

    16. Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration

      Explore Elsevier Health Ophthalmology
      Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration
      Purpose Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tomographyreflective drusen substructures (ODS) and examine their associations with age-related macular degeneration (AMD)related features and AMD progression. Design Retrospective analysis in a prospective study. Participants Patients with intermediate AMD (n = 349) enrolled in the multicenter Age-Related ...
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      Mentions: Duke University Cynthia A. Toth Stephanie J. Chiu
    17. 1-15 of 120 1 2 3 4 5 6 7 8 »
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  4. About Cynthia A. Toth

    Cynthia A. Toth

    Cynthia A. Toth, MD, is a Professor of Ophthalmology Vitreoretinal Diseases and Surgery and Professor of Biomedical Engineering at Duke. Clinical Interests: Medical and surgical diseases of the retina and vitreous, especially macular diseases, surgical treatments for macular degeneration, retinopathy of prematurity, proliferative vitroeoretinal disorders, retinal detachment and laser eye injury, choroidal neovascular membranes and subretinal hemorrhage, macular translocation surgery. Research Interests: Dr. Toth specializes in the evaluation and surgical treatment of vitreoretinal diseases in adults and children. She has pioneered the development of macular translocation surgery for age-related macular degeneration (AMD). Her particular clinical interests and skills also include the surgical treatment of macular diseases, retinal detachment, proliferative diabetic retinopathy, proliferative vitreoretinopathy (PVR), and retinopathy of prematurity (ROP). Dr. Toth’s primary research interests include improving diagnostic methods and therapy for macular degeneration and the development and application of optical coherence tomography for macular diseases. She has been repeatedly honored among the Best Doctors in America.

  5. Related Topics

    1. Kinetic acoustic ocular examination apparatus and method
      114 articles also mentioned Duke University
    2. Correlation Of Pathologic Features In Spectral Domain Optical Coherence Tomography With Conventional Retinal Studies.
      65 articles also mentioned Joseph A. Izatt
    3. Fast detection and segmentation of drusen in retinal optical coherence tomography images
      46 articles also mentioned Sina Farsiu
    4. Insights into Advanced Retinopathy of Prematurity Using Handheld Spectral Domain Optical Coherence Tomography Imaging
      27 articles also mentioned Ramiro S. Maldonado
    5. Methods, Systems And Computer Program Products For Mixed-Density Optical Coherence Tomography (Oct) Imaging (Wo 2008/137077)
      27 articles also mentioned Bioptigen
    6. Caveats to Obtaining Retinal Topography With Optical Coherence Tomography
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  6. Quotes

    1. Now, for the first time, we can take the SD OCT system into the neonatal intensive care unit and hold it over the infant's eye without touching the eye and image the retina while the infant is lying in the bed.
      In Mapping a baby’s retina for signs of blindness
    2. SD OCT reveals the retina in greater detail than was ever before realized, allowing us to observe disease at almost the cellular level
      In New device finds early signs of eye disease in preemies
    3. We can see just amazing things in these young children's eyes that we never suspected.
      In Testing tool to better detect premature baby eye disease
    4. One benefit of SD-OCT is the creation of the summed voxel projection [SVP], which is helpful for orientation of individual OCT scans. One can collapse three-dimensional OCT volumes along the depth axis to form a two-dimensional plane, summing pixels to calculate one representative pixel intensity alone each line in the projection.
      In Spectral-domain optical coherence tomography an improvement over previous optical coherence tomography systems