1. Costas D. Pitris

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    1. Mentioned In 24 Articles

    2. Tissue dispersion measurement techniques using optical coherence tomography

      Tissue dispersion measurement techniques using optical coherence tomography
      Dispersion, a result of wavelength-dependent index of refraction variations, causes pulse-width broadening with detrimental effects in many pulsed-laser applications. It is also considered to be one of the major causes of resolution degradation in Optical Coherence Tomography (OCT). However, dispersion is material dependent and, in tissue, Group Velocity Dispersion (GVD) could be used, for example, to detect changes associated with early cancer and result in more accurate disease diagnosis. In ...
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    3. Using speckle to measure tissue dispersion in optical coherence tomography

      Using speckle to measure tissue dispersion in optical coherence tomography
      In Optical Coherence tomography (OCT), dispersion mismatches cause degradation of the image resolution. However, dispersion is specific to the material that is causing the effect and can therefore carry useful information regarding the composition of the samples. In this summary, we propose a novel technique for estimating the dispersion in tissue which uses the image speckle to calculate the PSF degradation and is therefore applicable to any tissue and can ...
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    4. Lateral resolution improvement of oversampled OCT images using Capon estimation of weighted subvolume contribution

      Lateral resolution improvement of oversampled OCT images using Capon estimation of weighted subvolume contribution
      A novel technique for lateral resolution improvement in optical coherence tomography (OCT) is presented. The proposed method is based on lateral oversampling of the image. The locations and weights of multiple high spatial resolution sub-volumes are calculated using a Capon estimator assuming each contributes a weighted portion to the detected signal. This technique is independent of the delivery optics and the depth of field. Experimental results demonstrate that it is ...
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    5. Correlation of the derivative as a robust estimator of scatterer size in optical coherence tomography (OCT)

      Correlation of the derivative as a robust estimator of scatterer size in optical coherence tomography (OCT)
      The size-dependent spectral variations, predicted by Mie theory, have already been considered as a contrast enhancement mechanism in optical coherence tomography. In this work, a new spectroscopic metric, the bandwidth of the correlation of the derivative, was developed for estimating scatterer size which is more robust and accurate compared to existing methods. Its feasibility was demonstrated using phantoms containing polystyrene microspheres as well as images of normal and cancerous human ...
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    6. Development of a new, robust and accurate, spectroscopic metric for scatterer size estimation in optical coherence tomography (OCT) images

      Development of a new, robust and accurate, spectroscopic metric for scatterer size estimation in optical coherence tomography (OCT) images
      The modulations appearing on the backscattering spectrum originating from a scatterer are related to its diameter as described by Mie theory for spherical particles. Many metrics for Spectroscopic Optical Coherence Tomography (SOCT) take advantage of this observation in order to enhance the contrast of Optical Coherence Tomography (OCT) images. However, none of these metrics has achieved high accuracy when calculating the scatterer size. In this work, Mie theory was used ...
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    7. Lateral resolution improvement in Optical Coherence Tomography (OCT) images

      Lateral resolution improvement in Optical Coherence Tomography (OCT) images
      A novel method for lateral resolution improvement of Optical Coherence Tomography (OCT) images, which is independent of the focusing of the delivery optics and the depth of field, is presented. This method was inspired by radar range oversampling techniques. It is based on the lateral oversampling of the image and the estimation of the locations of the multiple scatterers which contribute to the signal. The information in the oversampled images ...
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    8. University of Cyprus receives a grant of 163,780 Euro ($208,844) enhancing the resolution of Optical Coherence Tomography.

      University of Cyprus receives a grant of 163,780 Euro ($208,844) enhancing the resolution of Optical Coherence Tomography.
      ...am is a two-year program, starting in Sept. 2012 and ending in Aug. 2014. The principle investigator is Prof. Costas Pitris with post-doctoral associate Evgenia Bousi. A brief description of the project is given below. ...
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    9. Axial resolution improvement by modulated deconvolution in Fourier domain optical coherence tomography

      Axial resolution improvement by modulated deconvolution in Fourier domain optical coherence tomography
      A novel technique for axial resolution improvement in Fourier domain optical coherence tomography (FDOCT) is presented. The technique is based on the deconvolution of modulated optical coherence tomography signals. In FDOCT, the real part of the Fourier transform of the interferogram is modulated by a frequency which depends on the position of the interferogram in k space. A slight numerical k shift results in a different modulation frequency. By adding ...
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    10. Lateral resolution improvement in oversampled Optical Coherence Tomography images assuming weighted oversampled multi-scatterer contributions

      Lateral resolution improvement in oversampled Optical Coherence Tomography images assuming weighted oversampled multi-scatterer contributions
      A novel method for lateral resolution improvement of Optical Coherence Tomography (OCT) images, which is independent of the focusing of the delivery optics and the depth of field, is presented. This method was inspired by radar range oversampling techniques. It is based on the lateral oversampling of the image and the estimation of the locations of the multiple scatterers which contribute to the signal. The information in the oversampled images ...
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    11. Handbook of Biomedical Optics (Book)

      Handbook of Biomedical Optics (Book)
      Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and ...
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  2. About Costas D. Pitris

    Costas D. Pitris

    Constantinos D. Pitris has completed his studies at the University of Texas at Austin (BS Honors in Electrical Engineering, 1993, MS in Electrical Engineering, 1995), Massachusetts Institute of Technology (Ph.D. in Electrical and Medical Engineering, 2000), and Harvard Medical School (MD Magna Cum Laude in Medicine, 2002). He has worked as a research assistant at the University of Texas and Massachusetts Institute of Technology and as a postdoctoral associate at the Wellman Laboratories of Photomedicine of the Massachusetts General Hospital and Harvard Medical School. His main research interests cover the areas of optics and medical diagnostics. He has been a Lecturer and, currently, an Assistant Professor in the faculty of Electrical and Computer Engineering at the University of Cyprus since June 2002.