1. Costas D. Pitris

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    1. Mentioned In 19 Articles

    2. Lateral resolution improvement in Optical Coherence Tomography (OCT) images

      Lateral resolution improvement in Optical Coherence Tomography (OCT) images

      A novel method for lateral resolution improvement of Optical Coherence Tomography (OCT) images, which is independent of the focusing of the delivery optics and the depth of field, is presented. This method was inspired by radar range oversampling techniques. It is based on the lateral oversampling of the image and the estimation of the locations of the multiple scatterers which contribute to the signal. The information in the oversampled images is used to estimate the locations of multiple scatterers assuming each contributes a weighted portion to the detected signal, the weight determined by the location of the scatterer and the ...

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    3. University of Cyprus receives a grant of 163,780 Euro ($208,844) enhancing the resolution of Optical Coherence Tomography.

      University of Cyprus receives a grant of 163,780 Euro ($208,844) enhancing the resolution of Optical Coherence Tomography.
      ...am is a two-year program, starting in Sept. 2012 and ending in Aug. 2014. The principle investigator is Prof. Costas Pitris with post-doctoral associate Evgenia Bousi. A brief description of the project is given below. ...
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    4. Axial resolution improvement by modulated deconvolution in Fourier domain optical coherence tomography

      Axial resolution improvement by modulated deconvolution in Fourier domain optical coherence tomography

      A novel technique for axial resolution improvement in Fourier domain optical coherence tomography (FDOCT) is presented. The technique is based on the deconvolution of modulated optical coherence tomography signals. In FDOCT, the real part of the Fourier transform of the interferogram is modulated by a frequency which depends on the position of the interferogram in k space. A slight numerical k shift results in a different modulation frequency. By adding two shifted signals, beating can appear in the A-scan. When the amount of shifting is appropriately selected, deconvolution of the resulting depth profile, using suitable modulated kernels, yields a narrower ...

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    5. Lateral resolution improvement in oversampled Optical Coherence Tomography images assuming weighted oversampled multi-scatterer contributions

      Lateral resolution improvement in oversampled Optical Coherence Tomography images assuming weighted oversampled multi-scatterer contributions

      A novel method for lateral resolution improvement of Optical Coherence Tomography (OCT) images, which is independent of the focusing of the delivery optics and the depth of field, is presented. This method was inspired by radar range oversampling techniques. It is based on the lateral oversampling of the image and the estimation of the locations of the multiple scatterers which contribute to the signal. The information in the oversampled images is used to estimate the locations of multiple scatterers assuming each contributes a weighted portion to the detected signal, the weight determined by the location of the scatterer and the ...

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    6. Handbook of Biomedical Optics (Book)

      Handbook of Biomedical Optics (Book)

      Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques

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    7. AM-FM techniques in the analysis of optical coherence tomography signals

      The subtle tissue changes associated with the early stages of malignancies, such as cancer, are not clearly discernible even at the current, improved, resolution of optical coherence tomography (OCT) systems. However, these changes directly affect the spectral content of the OCT image that contains information regarding these unresolvable features. Spectral analysis of OCT signals has recently been shown to provide additional information, resulting in improved contrast, directly related to scatterer size changes. Amplitude modulation-frequency modulation (AM-FM) analysis, a fast and accurate technique for the estimation of the instantaneous frequency, phase, and amplitude of a signal, can also be applied to ...

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    8. Spectral Analysis of Optical Coherence Tomography Signals (Thesis)

      Spectral Analysis of Optical Coherence Tomography Signals (Thesis)

      More than 85% of all cancers originate in the epithelium that lines the internal surfaces of organs throughout the body. Before they become invasive, at stages known as dysplasia and carcinoma in situ, early cancer cells alter the epithelial-cell architecture. More specially, the number of cells, and therefore the number ofnuclei, increases. The nuclei themselves become enlarged and hyperchromatic, i.e. their chromatin changes and colours more darkly when stained during histopathology. Nuclear sizes change from the normal 5 - 10 um to 1:5 - 2 x the size, i.e.10 - 20 um. Currently, these early changes are only detectable ...

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    9. In vivo ultrahigh-resolution optical coherence tomography.

      Ultrahigh-resolution optical coherence tomography (OCT) by use of state of the art broad-bandwidth femtosecond laser technology is demonstrated and applied to in vivo subcellular imaging. Imaging is performed with a Kerr-lens mode-locked Ti:sapphire laser with double-chirped mirrors that emits sub-two-cycle pulses with bandwidths of up to 350 nm, centered at 800 nm. Longitudinal resolutions of ~1mum and transverse resolution of 3mum, with a 110-dB dynamic range, are achieved in biological tissue. To overcome depth-of-field limitations we perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth. To our knowledge this is ...
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    10. 1-15 of 19 1 2 »
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  2. About Costas D. Pitris

    Costas D. Pitris

    Constantinos D. Pitris has completed his studies at the University of Texas at Austin (BS Honors in Electrical Engineering, 1993, MS in Electrical Engineering, 1995), Massachusetts Institute of Technology (Ph.D. in Electrical and Medical Engineering, 2000), and Harvard Medical School (MD Magna Cum Laude in Medicine, 2002). He has worked as a research assistant at the University of Texas and Massachusetts Institute of Technology and as a postdoctoral associate at the Wellman Laboratories of Photomedicine of the Massachusetts General Hospital and Harvard Medical School. His main research interests cover the areas of optics and medical diagnostics. He has been a Lecturer and, currently, an Assistant Professor in the faculty of Electrical and Computer Engineering at the University of Cyprus since June 2002.