1. Cornell University

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    1. Mentioned In 67 Articles

    2. Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle

      Explore OSA | OSA Publishing
      Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle
      Multiple scattering is a major barrier that limits the optical imaging depth in scattering media. In order to alleviate this effect, we demonstrate aberration-diverse optical coherence tomography (AD-OCT), which exploits the phase correlation between the deterministic signals from single-scattered photons to suppress the random background caused by multiple scattering and speckle. AD-OCT illuminates the sample volume with diverse aberrated point spread functions, and computationally removes these intentionally applied aberrations. After ...
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      Mentions: Cornell University Steven G. Adie

    3. Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography

      Explore Nature Publishing Group Ophthalmology
      Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography
      Optical coherence tomography angiography (OCT-A) is a non-invasive alternative to fluorescein angiography that allows for the study of the retinal and choroidal vasculatures. In this retrospective cohort study of 28 patients with retinitis pigmentosa (RP), we used OCT-A to quantify changes in perfusion density, foveal avascular zone (FAZ) area, and choriocapillaris blood flow over time and correlated these variables with ellipsoid zone (EZ) line width and best-corrected visual acuity (BCVA ...
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      Mentions: Cornell University Columbia University Stanford University

    4. Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics

      Explore OSA | OSA Publishing Microscopy
      Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics
      Optical coherence microscopy (OCM) is a promising modality for high resolution imaging, but has limited ability to capture large-scale volumetric information about dynamic biological processes with cellular resolution. To enhance the throughput of OCM, we implemented a hybrid adaptive optics (hyAO) approach that combines computational adaptive optics with an intentionally aberrated imaging beam generated via hardware adaptive optics. Using hyAO, we demonstrate the depth-equalized illumination and collection ability of an ...
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      Mentions: Cornell University Steven G. Adie

    5. Photonic force optical coherence elastography for three-dimensional mechanical microscopy

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      Photonic force optical coherence elastography for three-dimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low-numerical aperture optical beam can apply transversely localized force over an extended depth range. Here we present photonic force optical coherence elastography (PF-OCE ...
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      Mentions: Cornell University University of Western Australia Steven G. Adie

    6. Optical Coherence Tomography Angiography to Evaluate Ischemia in Diabetic Eyes

      Explore The JAMA Network Ophthalmology
      Optical Coherence Tomography Angiography to Evaluate Ischemia in Diabetic Eyes
      The retinal vasculature consists of a superficial vascular plexus (SVP), an intermediate capillary plexus (ICP), and a deep capillary plexus (DCP). There is also a fourth regional vascular network, the radial peripapillary capillary plexus (RPCP). The RPCP runs in parallel with the nerve fiber layer, the SVP is located within the ganglion cell layer and the deeper plexuses, and the ICP and DCP are above and below the inner nuclear ...
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      Mentions: Cornell University

    7. SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN COATS DISEASE

      Explore LWW Online Ophthalmology
      SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN COATS DISEASE
      Purpose: To evaluate microstructural retinal abnormalities on spectral domain optical coherence tomography (SD-OCT) imaging of eyes with Coats disease . Methods: This is a multicenter, retrospective study in which SD-OCT images of patients with treatment-naive Coats disease were correlated with clinical examination and visual acuity and, when available, followed longitudinally over time. Results: Macular SD-OCT of 27 eyes with Coats disease revealed intraretinal edema (59%), intraretinal exudates (67%), subretinal fluid (37 ...
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      Mentions: Cornell University

    8. Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography

      Explore OSA | OSA Publishing
      Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography
      A weakly focused laser beam can exert sufficient radiation pressure to manipulate microscopic particles over a large depth range. However, depth-resolved continuous measurement of radiation-pressure force profiles over an extended range about the focal plane has not been demonstrated despite decades of research on optical manipulation. Here, we present a method for continuous measurement of axial radiation-pressure forces from a weakly focused beam on polystyrene micro-beads suspended in viscous fluids ...
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      Mentions: Cornell University Steven G. Adie

    9. Photonic force optical coherence elastography for threedimensional mechanical microscopy

      Explore arxiv.org
      Photonic force optical coherence elastography for threedimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low numerical aperture optical beam can apply transversely localized force over an extended depth range. We propose photonic force optical coherence elastography (PF-OCE ...
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      Mentions: Cornell University University of Western Australia Steven G. Adie

    10. Hybrid Deep Learning on Single Wide-field Optical Coherence Tomography Scans Accurately Classifies Glaucoma Suspects

      Explore LWW Online Ophthalmology
      Hybrid Deep Learning on Single Wide-field Optical Coherence Tomography Scans Accurately Classifies Glaucoma Suspects
      Purpose: Existing summary statistics based upon optical coherence tomographic (OCT) scans and/or visual fields (VFs) are suboptimal for distinguishing between healthy and glaucomatous eyes in the clinic. This study evaluates the extent to which a hybrid deep learning method (HDLM), combined with a single wide-field OCT protocol, can distinguish eyes previously classified as either healthy suspects or mild glaucoma. Methods: In total, 102 eyes from 102 patients, with or ...
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      Mentions: Cornell University Columbia University Robert Ritch

    12. Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain

      Explore Optical Coherence Tomography News Neurology , Funding
      Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain
      ...rm our ability for large-scale, volumetric recording of mouse brain activity.

      Cornell University Receives a 2017 NIH Grant for $244,625 for Development of Hybrid Adaptive Optics for Multim...

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      Mentions: National Institutes of Health Cornell University Steven G. Adie

    13. Space Flight–Associated Neuro-ocular Syndrome

      Explore The JAMA Network Neurology , Ophthalmology
      Space Flight–Associated Neuro-ocular Syndrome
      New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flightassociated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the ...
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      Mentions: Cornell University Baylor College of Medicine University of Texas Medical Branch

    15. Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy

      Explore OSA | OSA Publishing Microscopy
      Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy
      Traction force microscopy (TFM) is a method used to study the forces exerted by cells as they sense and interact with their environment. Cell forces play a role in processes that take place over a wide range of spatiotemporal scales, and so it is desirable that TFM makes use of imaging modalities that can effectively capture the dynamics associated with these processes. To date, confocal microscopy has been the imaging ...
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      Mentions: Cornell University Steven G. Adie
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  4. About Cornell University

    Cornell University

    Cornell University is a private university located in Ithaca, New York, U.S. Its two medical campuses are in New York City and Education City, Qatar. Cornell is a member of the Ivy League. Cornell was founded in 1865 by Ezra Cornell and Andrew Dickson White as a coeducational, non-sectarian institution where admission was offered irrespective of religion or race. Inaugurated shortly after the American Civil War, its founders intended that the new university would teach and make contributions in all fields of knowledge — from the classics to the sciences and from the theoretical to the applied. Also see Wiel Cornell Medical College.

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