1. Cornell University

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    1. Mentioned In 106 Articles

    2. Retinal vessel multifractals predict pial collateral status in patients with acute ischemic stroke

      Retinal vessel multifractals predict pial collateral status in patients with acute ischemic stroke
      Objectives Pial collateral blood flow is a major determinant of the outcomes of acute ischemic stroke. This study was undertaken to determine whether retinal vessel metrics can predict the pial collateral status and stroke outcomes in patients. Methods Thirty-five patients with acute stroke secondary to middle cerebral artery (MCA) occlusion underwent grading of their pial collateral status from computed tomography angiography and retinal vessel analysis from retinal fundus images. Results ...
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    3. Noninvasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series

      Noninvasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series
      Background: Cutaneous metastases (CM) are clinically challenging, requiring an invasive biopsy for confirmation. A novel, RCM-OCT device combines the advantage of high-resolution reflectance confocal microscopy (RCM) images and deeper optical coherence tomography (OCT) images to aid in non-invasive diagnosis. Objective: Characterize CM using RCM-OCT device. Methods: Seven patients with suspicious CM were consented and imaged with RCM-OCT device. CM features were defined by comparing with histopathology. Tumor depths were measured ...
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    4. Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging

      Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging
      Quantitative characterisation of micro-scale mechanical properties of the extracellular matrix (ECM) and dynamic cell-ECM interactions can significantly enhance fundamental discoveries and their translational potential in the rapidly growing field of mechanobiology. However, quantitative 3D imaging of ECM mechanics with cellular-scale resolution and dynamic monitoring of cell-mediated changes to pericellular viscoelasticity remain a challenge for existing mechanical characterisation methods. Here, we present light-sheet photonic force optical coherence elastography (LS-pfOCE) to address ...
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    5. Investigation of multiple scattering in space and spatial-frequency domains: with application to the analysis of aberration-diverse optical coherence tomography

      Investigation of multiple scattering in space and spatial-frequency domains: with application to the analysis of aberration-diverse optical coherence tomography
      Optical microscopy suffers from multiple scattering (MS), which limits the optical imaging depth into scattering media. We previously demonstrated aberration-diverse optical coherence tomography (AD-OCT) for MS suppression, based on the principle that for datasets acquired with different aberration states of the imaging beam, MS backgrounds become decorrelated while single scattering (SS) signals remain correlated, so that a simple coherent average can be used to enhance the SS signal over the ...
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    6. OPTICAL COHERENCE ELASTOGRAPHIC AND TOMOGRAPHIC MICROSCOPY FOR RESOLUTION-ENHANCED MICROMECHANICAL AND STRUCTURAL IMAGING OF BIOLOGICAL SYSTEMS

      OPTICAL COHERENCE ELASTOGRAPHIC AND TOMOGRAPHIC MICROSCOPY FOR RESOLUTION-ENHANCED MICROMECHANICAL AND STRUCTURAL IMAGING OF BIOLOGICAL SYSTEMS
      Optical microscopy has had a revolutionary impact in the biomedical sciences. Among other modalities, optical coherence tomography (OCT) offers a unique capability for label-free structural imaging of biological systems at cellular resolution over millimeter-scale volumetric field-of-view. The rapidly growing field of mechanobiology has presented immense opportunities for not only structural microscopy, but also functional imaging of biomechanical properties with emerging optical elastography techniques. Importantly, attention has been given to the ...
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    7. Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging

      Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging
      Spatial resolution in conventional optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise ratio (SNR) by exploiting ...
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    8. Manually scanned single fiber optical coherence tomography for skin cancer characterization

      Manually scanned single fiber optical coherence tomography for skin cancer characterization
      Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. Within dermatology, it has found applications for in vivo diagnostic imaging purposes, as well as to guide Mohs micrographic surgery (MMS), due to its ability to visualize skin morphology up to several millimeters in depth. However, standard OCT probes have a large footprint and capture an extended area of the skin, making it difficult to ...
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    9. Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT

      Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT
      Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography (OCT) imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein). Methods: Case report and review of the relevant literature. Patients: Single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services. Results: A patient with a novel homozygous mutation in the ...
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    10. Real-time deep learning assisted skin layer delineation in dermal optical coherence tomography

      Real-time deep learning assisted skin layer delineation in dermal optical coherence tomography
      We present deep learning assisted optical coherence tomography (OCT) imaging for quantitative tissue characterization and differentiation in dermatology. We utilize a manually scanned single fiber OCT (sfOCT) instrument to acquire OCT images from the skin. The focus of this study is to train a U-Net for automatic skin layer delineation. We demonstrate that U-Net allows quantitative assessment of epidermal thickness automatically. U-Net segmentation achieves high accuracy for epidermal thickness estimation ...
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    11. Cornell University Receives a NIH Grant for Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain

      Cornell University Receives a NIH Grant for Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain
      ... large-scale, deep imaging at high spatiotemporal resolution is needed.

      Cornell University Receives a 2021 NIH Grant for $1,982,304 for Real-time Aberration Sensor for Large-S...

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    12. Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer

      Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer
      Background: Optical coherence tomography (OCT) is a novel imaging modality that provides microstructural information of different tissue layers using near-infrared light. This prospective, multicenter phase II trial aimed to assess the accuracy of OCT-assisted cystoscopy for bladder tumor staging. Methods: Patients with primary or recurrent bladder tumors (Ta,T1) identified by outpatient cystoscopy were included. The primary objective was to assess the accuracy and positive predictive value of for determining ...
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  2. About Cornell University

    Cornell University

    Cornell University is a private university located in Ithaca, New York, U.S. Its two medical campuses are in New York City and Education City, Qatar. Cornell is a member of the Ivy League. Cornell was founded in 1865 by Ezra Cornell and Andrew Dickson White as a coeducational, non-sectarian institution where admission was offered irrespective of religion or race. Inaugurated shortly after the American Civil War, its founders intended that the new university would teach and make contributions in all fields of knowledge — from the classics to the sciences and from the theoretical to the applied. Also see Wiel Cornell Medical College.