1. Cornell University

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    1. Mentioned In 99 Articles

    2. Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging

      Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging
      Spatial resolution in conventional optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise ratio (SNR) by exploiting ...
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    3. Manually scanned single fiber optical coherence tomography for skin cancer characterization

      Manually scanned single fiber optical coherence tomography for skin cancer characterization
      Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. Within dermatology, it has found applications for in vivo diagnostic imaging purposes, as well as to guide Mohs micrographic surgery (MMS), due to its ability to visualize skin morphology up to several millimeters in depth. However, standard OCT probes have a large footprint and capture an extended area of the skin, making it difficult to ...
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    4. Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT

      Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT
      Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography (OCT) imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein). Methods: Case report and review of the relevant literature. Patients: Single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services. Results: A patient with a novel homozygous mutation in the ...
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    5. Real-time deep learning assisted skin layer delineation in dermal optical coherence tomography

      Real-time deep learning assisted skin layer delineation in dermal optical coherence tomography
      We present deep learning assisted optical coherence tomography (OCT) imaging for quantitative tissue characterization and differentiation in dermatology. We utilize a manually scanned single fiber OCT (sfOCT) instrument to acquire OCT images from the skin. The focus of this study is to train a U-Net for automatic skin layer delineation. We demonstrate that U-Net allows quantitative assessment of epidermal thickness automatically. U-Net segmentation achieves high accuracy for epidermal thickness estimation ...
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    6. Cornell University Receives a NIH Grant for Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain

      Cornell University Receives a NIH Grant for Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain
      ... large-scale, deep imaging at high spatiotemporal resolution is needed.

      Cornell University Receives a 2021 NIH Grant for $1,982,304 for Real-time Aberration Sensor for Large-S...

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    7. Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer

      Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer
      Background: Optical coherence tomography (OCT) is a novel imaging modality that provides microstructural information of different tissue layers using near-infrared light. This prospective, multicenter phase II trial aimed to assess the accuracy of OCT-assisted cystoscopy for bladder tumor staging. Methods: Patients with primary or recurrent bladder tumors (Ta,T1) identified by outpatient cystoscopy were included. The primary objective was to assess the accuracy and positive predictive value of for determining ...
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    8. Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging

      Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging
      Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) imaging system. Methods: A retrospective, single-center, consecutive case series evaluated patients between September 2019 and October 2020 with UWF SS-OCT (modified Optos P200TxE, Optos PLC) as part of routine retinal care. The logistics of image acquisition, interpretability of images captured, nature of the peripheral abnormality ...
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    9. Role of Optical Coherence Tomography for Predicting Postoperative Visual Outcomes After Repair of Macula-Off Rhegmatogenous Retinal Detachment

      Role of Optical Coherence Tomography for Predicting Postoperative Visual Outcomes After Repair of Macula-Off Rhegmatogenous Retinal Detachment
      Purpose: To identify any prognostic associations between preoperative optical coherence tomography (OCT) findings and postoperative visual outcomes in patients with macula-off rhegmatogenous retinal detachment (RRD). Methods: Retrospective, single-center study of patients diagnosed with macula-off RRD whom underwent surgical reattachment from 2012-2017. OCT images were analyzed by two retina surgeons. Outcome measures included "good" final vision (best corrected visual acuity of 20/40 or better), "poor" final vision (best corrected visual ...
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    10. Traction force optical coherence microscopy: a new method to study the dynamic mechanical behavior of cells and multicellular collectives within scattering media (Thesis)

      Traction force optical coherence microscopy: a new method to study the dynamic mechanical behavior of cells and multicellular collectives within scattering media (Thesis)
      Mechanobiology is a prominent research field which seeks to elucidate the role of physical forces and mechanical interactions throughout various biological processes, including morphogenesis, wound healing, and cancer metastasis, among others. Traction force microscopy (TFM) is an important family of experimental techniques used by mechanobiologists to study and quantify the forces that cells exert upon their surroundings. Recent years have seen a growing demand for TFM methods capable of studying ...
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    11. Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography

      Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
      ...achusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; 2Retina Service, Weill Cornell Medical College, New York, NY, USA *These authors contributed equally to this work Correspondenc...
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    12. Visibility of microvessels in Optical Coherence Tomography Angiography depends on angular orientation

      Visibility of microvessels in Optical Coherence Tomography Angiography depends on angular orientation
      OCT Angiography (OCTA) is a widespread tool for depth‐resolved imaging of chorioretinal vasculature with single microvessel resolution. To improve the clinical interpretation of OCTA, the conditions affecting visualization of microvessels must be defined. Here we inject a scattering plasma tracer (Intralipid) during OCTA imaging of the anesthetized rat eye. In the retina, we find that interlaminar (vertical) vessels that connect laminae have one‐fourth to one‐third the OCTA ...
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    13. Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling

      Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling
      Obesity increases the risk and worsens the prognosis for breast cancer due, in part, to altered adipose stromal cell (ASC) behavior. Whether ASCs from obese individuals increase migration of breast cancer cells relative to their lean counterparts, however, remains unclear. To test this connection, multicellular spheroids composed of MCF10A‐derived tumor cell lines of varying malignant potential and lean or obese ASCs are embedded into collagen scaffolds mimicking the elastic ...
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    14. Optical Coherence Tomography Findings in the Junctional Scotoma of Traquair

      Optical Coherence Tomography Findings in the Junctional Scotoma of Traquair
      A 43-year-old woman presented with a right-sided visual field defect in the right eye. The visual acuity was normal and there was a right relative afferent pupillary defect. Formal visual field testing revealed a junctional scotoma of Traquair. The fundus examination showed optic atrophy in the right eye and optical coherence tomography demonstrated unilateral band atrophy. Neuroimaging revealed a sellar and suprasellar cystic pituitary adenoma for which she underwent a ...
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  2. About Cornell University

    Cornell University

    Cornell University is a private university located in Ithaca, New York, U.S. Its two medical campuses are in New York City and Education City, Qatar. Cornell is a member of the Ivy League. Cornell was founded in 1865 by Ezra Cornell and Andrew Dickson White as a coeducational, non-sectarian institution where admission was offered irrespective of religion or race. Inaugurated shortly after the American Civil War, its founders intended that the new university would teach and make contributions in all fields of knowledge — from the classics to the sciences and from the theoretical to the applied. Also see Wiel Cornell Medical College.