Bilateral Optic Disc Edema in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With COVID-19: The Value and Limitations of Optical Coherence Tomography: Response
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Cornell University
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Cornell University
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Mentioned In 102 Articles
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Investigation of multiple scattering in space and spatial-frequency domains: with application to the analysis of aberration-diverse optical coherence tomography
Optical microscopy suffers from multiple scattering (MS), which limits the optical imaging depth into scattering media. We previously demonstrated aberration-diverse optical coherence tomography (AD-OCT) for MS suppression, based on the principle that for datasets acquired with different aberration states of the imaging beam, MS backgrounds become decorrelated while single scattering (SS) signals remain correlated, so that a simple coherent average can be used to enhance the SS signal over the ...Read Full ArticleMentions: Cornell University -
OPTICAL COHERENCE ELASTOGRAPHIC AND TOMOGRAPHIC MICROSCOPY FOR RESOLUTION-ENHANCED MICROMECHANICAL AND STRUCTURAL IMAGING OF BIOLOGICAL SYSTEMS
Optical microscopy has had a revolutionary impact in the biomedical sciences. Among other modalities, optical coherence tomography (OCT) offers a unique capability for label-free structural imaging of biological systems at cellular resolution over millimeter-scale volumetric field-of-view. The rapidly growing field of mechanobiology has presented immense opportunities for not only structural microscopy, but also functional imaging of biomechanical properties with emerging optical elastography techniques. Importantly, attention has been given to the ...Read Full ArticleMentions: Cornell University -
Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging
Spatial resolution in conventional optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise ratio (SNR) by exploiting ...Read Full ArticleMentions: Cornell University -
Manually scanned single fiber optical coherence tomography for skin cancer characterization
Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. Within dermatology, it has found applications for in vivo diagnostic imaging purposes, as well as to guide Mohs micrographic surgery (MMS), due to its ability to visualize skin morphology up to several millimeters in depth. However, standard OCT probes have a large footprint and capture an extended area of the skin, making it difficult to ...Read Full ArticleMentions: Cornell University -
Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT
Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography (OCT) imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein). Methods: Case report and review of the relevant literature. Patients: Single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services. Results: A patient with a novel homozygous mutation in the ...Read Full ArticleMentions: Cornell University -
Real-time deep learning assisted skin layer delineation in dermal optical coherence tomography
We present deep learning assisted optical coherence tomography (OCT) imaging for quantitative tissue characterization and differentiation in dermatology. We utilize a manually scanned single fiber OCT (sfOCT) instrument to acquire OCT images from the skin. The focus of this study is to train a U-Net for automatic skin layer delineation. We demonstrate that U-Net allows quantitative assessment of epidermal thickness automatically. U-Net segmentation achieves high accuracy for epidermal thickness estimation ...Read Full ArticleMentions: Cornell University -
Optical Coherence Tomography Findings in Presumed Digoxin Retinal Toxicity
We present novel OCT findings of presumed acute digoxin photoreceptor toxicity in the setting of concurrent amiodarone use. Discontinuation of medications resulted in symptom abatement, vision improvement, and reversal of OCT findings.Read Full ArticleMentions: Cornell University -
Cornell University Receives a NIH Grant for Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain
... large-scale, deep imaging at high spatiotemporal resolution is needed.Read Full ArticleCornell University Receives a 2021 NIH Grant for $1,982,304 for Real-time Aberration Sensor for Large-S...
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Cornell University Receives NIH Grant for Ultrahigh-Resolution Quantitative Optical Coherence Elastography of the Tumor Microenvironment In Vivo
...hanobiology research, and broadly impact other areas of mechanobiology.Read Full ArticleCornell University Receives a 2021 NIH Grant for $400,639 for Ultrahigh-Resolution Quantitative Optical Cohere...
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Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer
Background: Optical coherence tomography (OCT) is a novel imaging modality that provides microstructural information of different tissue layers using near-infrared light. This prospective, multicenter phase II trial aimed to assess the accuracy of OCT-assisted cystoscopy for bladder tumor staging. Methods: Patients with primary or recurrent bladder tumors (Ta,T1) identified by outpatient cystoscopy were included. The primary objective was to assess the accuracy and positive predictive value of for determining ...Read Full Article -
Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging
Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) imaging system. Methods: A retrospective, single-center, consecutive case series evaluated patients between September 2019 and October 2020 with UWF SS-OCT (modified Optos P200TxE, Optos PLC) as part of routine retinal care. The logistics of image acquisition, interpretability of images captured, nature of the peripheral abnormality ...Read Full Article -
Role of Optical Coherence Tomography for Predicting Postoperative Visual Outcomes After Repair of Macula-Off Rhegmatogenous Retinal Detachment
Purpose: To identify any prognostic associations between preoperative optical coherence tomography (OCT) findings and postoperative visual outcomes in patients with macula-off rhegmatogenous retinal detachment (RRD). Methods: Retrospective, single-center study of patients diagnosed with macula-off RRD whom underwent surgical reattachment from 2012-2017. OCT images were analyzed by two retina surgeons. Outcome measures included "good" final vision (best corrected visual acuity of 20/40 or better), "poor" final vision (best corrected visual ...Read Full ArticleMentions: Cornell University -
Traction force optical coherence microscopy: a new method to study the dynamic mechanical behavior of cells and multicellular collectives within scattering media (Thesis)
Mechanobiology is a prominent research field which seeks to elucidate the role of physical forces and mechanical interactions throughout various biological processes, including morphogenesis, wound healing, and cancer metastasis, among others. Traction force microscopy (TFM) is an important family of experimental techniques used by mechanobiologists to study and quantify the forces that cells exert upon their surroundings. Recent years have seen a growing demand for TFM methods capable of studying ...Read Full ArticleMentions: Cornell University -
Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
...achusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; 2Retina Service, Weill Cornell Medical College, New York, NY, USA *These authors contributed equally to this work Correspondenc...Read Full Article
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About Cornell University
Cornell University is a private university located in Ithaca, New York, U.S. Its two medical campuses are in New York City and Education City, Qatar. Cornell is a member of the Ivy League. Cornell was founded in 1865 by Ezra Cornell and Andrew Dickson White as a coeducational, non-sectarian institution where admission was offered irrespective of religion or race. Inaugurated shortly after the American Civil War, its founders intended that the new university would teach and make contributions in all fields of knowledge — from the classics to the sciences and from the theoretical to the applied. Also see Wiel Cornell Medical College.