1. Constance R. Chu

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    1. Mentioned In 14 Articles

    2. Stanford University Receives NIH Grant for Enhanced Clinical Diagnosis of Early Osteoarthritis

      Stanford University Receives NIH Grant for Enhanced Clinical Diagnosis of Early Osteoarthritis
      Stanford University Received a 2013 NIH Grant for $482,301 for Enhanced Clinical Diagnosis of Early Osteoarthritis. The principal investigator is Costance Chu. The program began in 2005 and ends in 2016. Below is a summary of the proposed work. Osteoarthritis is a leading cause of disability, and a major public health issue. Progressive loss of articular cartilage due to injury and degeneration are important etiological factors in the development ...
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    3. Novel Quantitative Imaging for Early Detection of Joint Tissue Injury to Support Early Treatment Strategies

      Novel Quantitative Imaging for Early Detection of Joint Tissue Injury to Support Early Treatment Strategies
      The Cartilage Restoration Center at the University of Pittsburgh conducts research using novel imaging technologies to detect early microstructural changes to articular joint tissues in degenerative and traumatic injury-induced articular cartilage and meniscus disease. Identification of early changes to joint tissues permits the identification of patients who could potentially benefit from therapeutic interventions. Quantitative strategies for the diagnosis and staging of joint tissue degeneration prior to the breakdown of the ...
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    4. Knee-deep in pain: With osteoarthritis and other knee injuries, doctors stress the importance of proper analysis, treatment and exercise

      Knee-deep in pain: With osteoarthritis and other knee injuries, doctors stress the importance of proper analysis, treatment and exercise
      ... replacement surgery is expensive and painful, and recovery from it is time consuming. So researchers such as Constance Chu, director of the Cartilage Restoration Center at UPMC, are searching hard for ways to detect det...
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    5. Arthroscopic Optical Coherence Tomography in Diagnosis of Early Arthritis

      Arthroscopic Optical Coherence Tomography in Diagnosis of Early Arthritis
      Osteoarthritis (OA) is a progressive, debilitating disease that is increasing in prevalence. The pathogenesis of OA is likely multifactorial but ultimately leads to progressive breakdown of collagen matrix and loss of chondrocytes. Current clinical modalities employed to evaluate cartilage health and diagnose osteoarthritis in orthopaedic surgery include, radiography, MRI, and arthroscopy. While these assessment methods can show cartilage fissuring and loss, they are limited in ability to diagnose cartilage injury ...
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    6. Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears

      Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears
      Objective: Quantitative and nondestructive methods for clinical diagnosis and staging of articular cartilage degeneration are important to evaluation of potential disease modifying treatments for osteoarthritis. Optical Coherence Tomography (OCT) is a novel imaging technology that can generate microscopic resolution cross-sectional images of articular cartilage in near real time. This study tests the hypotheses that OCT can be used clinically to identify early cartilage degeneration, and that OCT correlates with MRI ...
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    7. Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content

      Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content
      Optical coherence tomography (OCT) and T2 mapping are emerging clinical imaging technologies with potential to detect subsurface changes in cartilage retaining a macroscopically intact articular surface. This study tests the hypothesis that OCT correlates with magnetic resonance imaging (MRI) T2 values, and that OCT signal is sensitive to cartilage matrix degeneration. Forty-five osteochondral cores were harvested from five human tibial plateau explants after MRI T2 mapping. Cores underwent OCT imaging ...
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  2. About Constance R. Chu

    Constance R. Chu

    Constance Chu , MD, is In Orthopedic Surgery at Stanford University School of Medicine.

  3. Quotes

    1. All of our best efforts create inferior tissue to what we are born with...Just because we can't get [the tissue] perfect unless it's through transplant doesn't mean we shouldn't keep trying to improve the repair.
      In The Latest Front In the War on Arthritis