1. Columbia University

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    1. Mentioned In 207 Articles

    2. Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography

      Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography
      Purpose : Our purpose was to compare the effectiveness of detecting progressive retinal nerve fiber layer (RNFL) thickness changes using widefield scans compared to circumpapillary circle scans derived from optic disc volume scans when using a manual region-of-interest (ROI) approach . Methods : In a prospective observational study, a total of 125 eyes diagnosed clinically with glaucoma or suspected glaucoma that had both widefield (12 9 mm) and optic disc (6 6 mm ...
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    3. Adapting a commercial spectral domain optical coherence tomography system for time-locked displacement and physiological measurements

      Adapting a commercial spectral domain optical coherence tomography system for time-locked displacement and physiological measurements
      Measuring vibration within the cochlear partition is important to understand sound transduction and nonlinear amplification within the cochlea. Here we describe the customization of a commercially available Spectral Domain Optical Coherence Tomography system, the Thorlabs Telesto, for displacement measurements in the cochlea using a technique called Spectral Domain Phase Microscopy (SDPM). The paper describes the SDOCT data analysis pipeline composed of background subtraction, interpolation, and spectral shaping of the raw ...
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    4. The Effectiveness of Excimer Laser Angioplasty to Treat Coronary In-Stent Restenosis With Peri-stent Calcium as Assessed by Optical Coherence Tomography

      The Effectiveness of Excimer Laser Angioplasty to Treat Coronary In-Stent Restenosis With Peri-stent Calcium as Assessed by Optical Coherence Tomography
      ..., New York, NY; Center for Interventional Vascular Therapy, Division of Cardiology, Presbyterian Hospital and Columbia University, New York, NY; St. Francis Hospital-The Heart Center, Roslyn, NY.; 11. Clinical Trials Cen...
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    5. Bifurcation and Ostial Optical Coherence Tomography Mapping (BOOM) – Case Description of a Novel Bifurcation Stent Technique

      Bifurcation and Ostial Optical Coherence Tomography Mapping (BOOM) – Case Description of a Novel Bifurcation Stent Technique
      Stent placement guided by angiography alone is often inexact, but of increased importance with bifurcation percutaneous coronary intervention (PCI). We describe a novel technique using optical coherence tomography (OCT)-guided angiographic co-registration termed Bifurcation and Ostial OCT Mapping (BOOM). The technique is based on the precise identification and mapping of the side-branch ostium using co-registration to minimize protrusion of stent struts into the main branch while ensuring full coverage of ...
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    6. Evaluation of a Qualitative Approach for Detecting Glaucomatous Progression Using Wide-Field Optical Coherence Tomography Scans

      Evaluation of a Qualitative Approach for Detecting Glaucomatous Progression Using Wide-Field Optical Coherence Tomography Scans
      Purpose : To determine the effectiveness of detecting glaucomatous progression by a qualitative evaluation of wide-field (12 9 mm) scans on optical coherence tomography imaging. This method was compared to a conventional quantitative analysis of the global circumpapillary retinal nerve fiber layer (cpRNFL) thickness. Methods : A total of 409 eyes with a clinical diagnosis of glaucoma or suspected glaucoma for which two wide-field scans were obtained at least 1 year apart ...
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    7. Optical coherence tomography reveals complex motion between the basilar membrane and organ of corti in the gerbil cochlea

      Optical coherence tomography reveals complex motion between the basilar membrane and organ of corti in the gerbil cochlea
      The mechanical basis of auditory transduction within the mammalian cochlea is not fully understood but relies on complex mechanical interactions between different structures within the Organ of Corti (OoC). We used spectral domain phase microscopy, a functional extension of optical coherence tomography (OCT), to measure the sound-evoked motion in response to Zwuis frequency complexes,in vivo, in the basal region of the gerbil cochlea. Because OCT allows for measurements from ...
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    8. Evaluation of a Region-of-Interest Approach for Detecting Progressive Glaucomatous Macular Damage on Optical Coherence Tomography

      Evaluation of a Region-of-Interest Approach for Detecting Progressive Glaucomatous Macular Damage on Optical Coherence Tomography
      Purpose : To evaluate a manual region-of-interest (ROI) approach for detecting progressive macular ganglion cell complex (GCC) changes on optical coherence tomography (OCT) imaging. Methods : One hundred forty-six eyes with a clinical diagnosis of glaucoma or suspected glaucoma with macular OCT scans obtained at least 1 year apart were evaluated. Changes in the GCC thickness were identified using a manual ROI approach (ROI M ), whereby region(s) of observed or suspected ...
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    9. Heterogeneity study of the human cervix between the internal os and the external os using optical coherence tomography

      Heterogeneity study of the human cervix between the internal os and the external os using optical coherence tomography
      The regional heterogeneity study of cervical ultrastructure is critical to understand the cervical functions like cervical softening and dilation. To better understand why the internal os initiates the premature remodeling, we present the heterogeneity study of collagen fiber network, tissue optical property, and mechanical property between the internal os and external os using optical coherence tomography (OCT) and indentation test. Pregnant (n=1) and non-pregnant patients (n=8) were consented ...
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    10. Detecting Glaucomatous Progression With a Region-of-Interest Approach on Optical Coherence Tomography: A Signal-to-Noise Evaluation

      Detecting Glaucomatous Progression With a Region-of-Interest Approach on Optical Coherence Tomography: A Signal-to-Noise Evaluation
      Purpose : To compare two region-of-interest (ROI) approaches and a global thickness approach for capturing progressive circumpapillary retinal nerve fiber layer (cpRNFL) changes on optical coherence tomography (OCT) imaging. Methods : Progressive cpRNFL thickness changes were evaluated in 164 eyes with a clinical diagnosis of glaucoma or suspected glaucoma; all eyes underwent optic disc OCT imaging on two visits at least 1 year apart. Such changes were evaluated with a manual ROI ...
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    11. Optical coherence tomography in gastroenterology: a review and future outlook

      Optical coherence tomography in gastroenterology: a review and future outlook
      Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease ...
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    12. High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)

      High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)
      In the past decades, the performance of swept source optical coherence tomography (SS-OCT) has experienced an unprecedented improvement which is mainly driven by the rapidly evolving laser technologies: the state-of-art SS-OCT is now tens of dB more sensitive, six orders of magnitude faster, and seeing ten times deeper than the original version of time domain OCT. Regardless of the abovementioned progress, the phase instability is always considered the biggest weakness ...
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    13. Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)

      Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)
      Over the past 25 years of development and innovation, optical coherence tomography (OCT) has successfully fills the gap between the ex vivo high-resolution optical microscopy technologies and in vivo low-resolution medical imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound (US). Ultrahigh resolution (UHR) OCT categorizes OCT systems with an axial resolution below 3 m in tissue. With the improved resolution, UHR OCT may impart the knowledge of ...
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    14. Optical Coherence Tomography: A Novel Imaging Method for Post-lumpectomy Breast Margin Assessment—A Multi-reader Study

      Optical Coherence Tomography: A Novel Imaging Method for Post-lumpectomy Breast Margin Assessment—A Multi-reader Study
      Rationale and Objectives This study aimed to assess whether different breast cancer subspecialty physicians can be trained to distinguish non-suspicious from suspicious areas of post-lumpectomy specimen margin in patients with breast cancer using optical coherence tomography (OCT) images (a near-infrared based imaging technique) with final histology as the reference standard. Materials and Methods This institutional review board-exempt, Health Insurance Portability and Accountability Act-compliant study was performed on 63 surgically excised ...
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    15. Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

      Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography
      A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multi-contrast imaging of human myocardium in one-shot measurement. The intensity contrast and functional contrasts, including the ratio between the cross- and co- polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate micro-structures in the myocardium ...
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    16. 1-15 of 207 1 2 3 4 ... 12 13 14 »
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  2. About Columbia University

    Columbia University

    Columbia University.  From its beginnings in a schoolhouse in lower Manhattan, Columbia University has grown to encompass two principal campuses: the historic, neoclassical campus in the Morningside Heights neighborhood and the modern Medical Center further uptown, in Washington Heights. Today, Columbia is one of the top academic and research institutions in the world, conducting pathbreaking research in medicine, science, the arts, and the humanities. It includes three undergraduate schools, thirteen graduate and professional schools, and a school of continuing education.