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    1. Mentioned In 284 Articles

    2. Optical Coherence Tomography Angiography of the Choriocapillaris in Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of the Choriocapillaris in Age-Related Macular Degeneration
      The advent of optical coherence tomography angiography (OCTA) has allowed for remarkable advancements in our understanding of the role of the choriocapillaris in age-related macular degeneration (AMD). As a relatively new imaging modality, techniques to analyze and quantify choriocapillaris images are still evolving. Quantification of the choriocapillaris requires careful consideration of many factors, including the type of OCTA device, segmentation of the choriocapillaris slab, image processing techniques, and thresholding method ...
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    3. Morphology and phenotype characteristics of atherosclerotic plaque in patients with acute coronary syndrome

      Morphology and phenotype characteristics of atherosclerotic plaque in patients with acute coronary syndrome
      Background: Contemporary optical coherence tomography (OCT) findings in patients with acute coronary syndromes (ACS) are still subject of controversy. We sought to use OCT to evaluate plaque morphology and phenotype classification in patients with ACS. Methods: Using optical coherence tomography, culprit lesions were morphologically classified as plaque rupture, plaque erosion, calcified nodule, thin-cap fibroatheroma, thick-cap fibroatheroma (TCFA) or fibrotic, fibrocalcific or fibrolipidic plaque. Quantitative and qualitative analyses also included cholesterol ...
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    4. Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study

      Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study
      Background Aims Tethered capsule endomicroscopy (TCE) involves swallowing small tethered pill that implements optical coherence tomography (OCT) imaging, procuring high resolution images of the whole esophagus. Here, we demonstrate and evaluate the feasibility and safety of TCE and a portable OCT imaging system in patients with Barretts esophagus (BE) in a multi-center (5-site) clinical study. Methods Untreated patients with BE as per endoscopic biopsy diagnosis were eligible to participate in ...
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    5. Global optical coherence tomography measures for detecting the progression of glaucoma have fundamental flaws

      Global optical coherence tomography measures for detecting the progression of glaucoma have fundamental flaws
      Objective To understand the problems involved in using global OCT measures for detecting progression in early glaucoma. Subjects/Methods Eyes from 76 patients and 28 healthy controls (HC) had a least two OCT scans at least 1 year apart. To determine the 95% confidence intervals (CI), 151 eyes (49 HC and 102 patients) had at least two scans within 6 months. All eyes had 24-2 mean deviation -6dB. The average ...
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    6. Did the OCT Show Progression Since the Last Visit?

      Did the OCT Show Progression Since the Last Visit?
      Identifying progression is of fundamental importance to the management of glaucoma. It is also a challenge. The most sophisticated, and probably the most useful, commercially available clinical tool for identifying progression is the Guided Progression Analysis (GPA), which was initially developed to identify progression using 24-2 visual field tests. More recently it has been extended to retinal nerve fiber layer (RNFL) and ganglion cell + inner plexiform layer (GCIPL) thicknesses measured ...
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    7. Robust and Interpretable Convolutional Neural Networks to Detect Glaucoma in Optical Coherence Tomography Images

      Robust and Interpretable Convolutional Neural Networks to Detect Glaucoma in Optical Coherence Tomography Images
      Recent studies suggest that deep learning systems can now achieve performance on par with medical experts in diagnosis of disease. A prime example is in the field of ophthalmology, where convolutional neural networks (CNNs) have been used to detect retinal and ocular diseases. However, this type of artificial intelligence (AI) has yet to be adopted clinically due to questions regarding robustness of the algorithms to datasets collected at new clinical ...
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    8. Historic Effort to 'End Blindness" Marks a Major Milestone with Leading Scientist Recognized for Pioneering Work at VIP Ceremony Featuring Tribute To Ruth Bader Ginsburg

      Historic Effort to 'End Blindness" Marks a Major Milestone with Leading Scientist Recognized for Pioneering Work at VIP Ceremony Featuring Tribute To Ruth Bader Ginsburg
      ... Hospital F.M. Kirby Neurobiology Center Dr. Simon John, The Jackson Laboratory, Department of Ophthalmology, Columbia University • Dr. Botond Roska, Institute of Molecular and Clinical Ophthalmology Basel Dr. Masayo Tak...
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    9. Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study

      Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study
      Background: Detecting coronary vulnerable plaques in vivo and assessing their vulnerability have been great challenges for clinicians and the research community. Intravascular ultrasound (IVUS) is commonly used in clinical practice for diagnosis and treatment decisions. However, due to IVUS limited resolution (about 150-200 m), it is not sufficient to detect vulnerable plaques with a threshold cap thickness of 65 m. Optical Coherence Tomography (OCT) has a resolution of 15-20 m ...
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    10. Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Universal Approach for Optimization of Stent Implantation

      Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Universal Approach for Optimization of Stent Implantation
      Despite consistent clinical data supporting the use of intravascular imaging with percutaneous coronary intervention, utilization remains low. A practical and standardized approach to incorporating intravascular imaging with percutaneous coronary intervention may overcome the barriers to utilization. This review focuses on basic image interpretation with intravascular ultrasound and optical coherence tomography and proposes an algorithmic approach to stent sizing and optimization. Incorporation of this strategic method for percutaneous coronary intervention may ...
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    11. Reasons why OCT Global Circumpapillary Retinal Nerve Fiber Layer Thickness is a Poor Measure of Glaucomatous Progression

      Reasons why OCT Global Circumpapillary Retinal Nerve Fiber Layer Thickness is a Poor Measure of Glaucomatous Progression
      Purpose: To assess the effects of local defects, segmentation errors, and improper image alignment on the performance of the commonly used optical coherence tomography (OCT) measure of progression, that is the change in global (average) circumpapillary retinal nerve fiber layer (cpRNFL) thickness (G). Methods: One hundred fifty eyes suspected of, or with, early glaucoma had OCT circle and cube scans obtained using eye tracking on two occasions at least 1 ...
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    12. Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT
      Automatic quantification and visualization of 3-D collagen fiber architecture using Optical Coherence Tomography (OCT) has previously relied on polarization information and/or prior knowledge of tissue-specific fiber architecture. This study explores image processing, enhancement, segmentation, and detection algorithms to map 3-D collagen fiber architecture from OCT images alone. 3-D fiber mapping, histogram analysis, and 3-D tractography revealed fiber groupings and macro-organization previously unseen in uterine tissue samples. We applied our ...
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    13. Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography

      Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography
      Purpose: To demonstrate the clinical and research value of a simplified technique enabling alignment of functional microperimetry data with retinal structure imaged by eye-tracked optical coherence tomography (OCT) in eyes with macular disease. Methods: Normal and diseased eyes underwent sequential Spectralis OCT macular raster scans and Macular Integrity Assessment (MAIA) microperimetry using both standard central 10 analysis and custom scan patterns. The microperimetry data were imported into Spectralis research software ...
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    14. Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity

      Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity
      The mammalian hearing organ, the cochlea, contains an active amplifier to boost the vibrational response to low level sounds. Hallmarks of this active process are sharp location-dependent frequency tuning and compressive nonlinearity over a wide stimulus range. The amplifier relies on outer hair cell (OHC) generated forces driven in part by the endocochlear potential (EP), the ̴ +80 mV potential maintained in scala media, generated by the stria vascularis. We transiently ...
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    15. 1-15 of 284 1 2 3 4 ... 17 18 19 »
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  2. About Columbia University

    Columbia University

    Columbia University.  From its beginnings in a schoolhouse in lower Manhattan, Columbia University has grown to encompass two principal campuses: the historic, neoclassical campus in the Morningside Heights neighborhood and the modern Medical Center further uptown, in Washington Heights. Today, Columbia is one of the top academic and research institutions in the world, conducting pathbreaking research in medicine, science, the arts, and the humanities. It includes three undergraduate schools, thirteen graduate and professional schools, and a school of continuing education.