1. Colin Hopper

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    1. Mentioned In 22 Articles

    2. Rapid ex vivo examination of Mohs specimens using optical coherence tomography

      Rapid ex vivo examination of Mohs specimens using optical coherence tomography
      Background Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo . Objective : The aim of this prospective ...
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    3. Optical diagnostic techniques for use in lesions of the head and neck: review of the latest developments

      Optical diagnostic techniques for use in lesions of the head and neck: review of the latest developments
      Optical biopsy systems are a potential adjunct to the histopathological assessment of tissue specimens; they are not invasive and can give an immediate result. We review the most common optical biopsy techniques used to detect lesions of the head and neck: elastic scattering spectroscopy, microendoscopy, narrow band imaging, fluorescence, and optical coherence tomography, and discuss their clinical use.
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    4. Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

      Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study
      Background Optical coherence tomography (OCT) is an evolving optical technology that is capable of delivering real-time, high-resolution signatures of tissue. Objectives The purpose of this immediate ex vivo prospective clinical study was: (1) to assess the sensitivity and specificity of OCT on biopsy material in identifying potentially malignant and malignant oral lesions, (2) to determine the inter-observer agreement in the analysis of specific image parameters, and (3) to find out ...
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    5. Structural validation of oral mucosal tissue using optical coherence tomography

      Structural validation of oral mucosal tissue using optical coherence tomography
      Background Optical coherence tomography (OCT) is a non-invasive optical technology using near-infrared light to produce cross-sectional tissue images with lateral resolution. Objectives The overall aims of this study was to generate a bank of normative and pathological OCT data of the oral tissues to allow identification of cellular structures of normal and pathological processes with the aim to create a diagnostic algorithm which can be used in the early detection ...
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    6. Optical coherence tomography of the tongue papillae for patients suffering from taste disorders following chemoradiotherapy

      Optical coherence tomography of the tongue papillae for patients suffering from taste disorders following chemoradiotherapy
      Background: In vivo optical coherence tomography (OCT) is a relatively new, non-invasive method for assessment of the oral cavity epithelium. The penetration depth of approximately 2mm allows visualization of tongue papillae structures and assesses their geometry.
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    7. Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series

      Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series
      Background: Guiding and monitoring treatment during and after photodynamic therapy (PDT) of skin cancer is often difficult. Objectives: We investigated the applicability of in vivo optical coherence tomography (OCT) in guiding and monitoring PDT in patients with skin cancer.
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    8. Optical coherence tomography in the evaluation of tongue papillae in healthy individuals

      Optical coherence tomography in the evaluation of tongue papillae in healthy individuals
      Although there have been several investigations involving the morphological features and the pathological changes in tongue papillae, highly accurate and sensitive tools in which morphology, volume and geometry of tongue papillae can be easily identified have not been developed yet.
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    9. Qualitative optical coherence tomography for normal and pathologic skin lesions

      Qualitative optical coherence tomography for normal and pathologic skin lesions
      The pre-clinical application of optical coherence tomography (OCT) on ex vivo skin lesions has validated this tool structurally and metrically. However, knowledge of in vivo normal and pathological skin architectural and morphological properties would be of significant interest in dermatological practice.
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    10. First published application of Optical Coherence Tomography for in vivo mapping of non-melanoma skin cancer

      First published application of Optical Coherence Tomography for in vivo mapping of non-melanoma skin cancer
      ...better clinical outcomes for patients.   References   1. Zaid Hamdoon, Waseem Jerjes, Tahwinder Upile and Colin Hopper "Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study" Photodiagn...
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    11. Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study

      Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study
      Photodynamic therapy (PDT) has been identified as a successful therapy for skin cancer. This case study investigates the role of optical coherence tomography (OCT) in lesion (squamous cell carcinoma) mapping, assisting the surgeon to correctly deliver PDT and monitor the outcome. Optical coherence tomographic images were acquired pre-treatment to assess tumour extent and margins to enable guidance of the PDT. Tomographic images taken post-PDT up to 6 months revealed complete ...
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    12. Michelson Diagnostics Reports First Quantitative Results on Cancer Diagnosis Using Multi-beam OCT imaging

      Michelson Diagnostics Reports First Quantitative Results on Cancer Diagnosis Using Multi-beam OCT imaging
      ...), held in San Francisco, 23-24 January, as part of SPIE Photonics West.   The presenting authors, Professor Colin Hopper, Dr Waseem Jerjes, and Zaid Hamdoon of University College Hospital London, concluded from the stu...
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    13. 1-15 of 22 1 2 »
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  2. About Colin Hopper

    Colin Hopper

    Colin Hopper, M.D., Head, Unit of Oral and Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences at the University College London Eastman Dental Institute.  Since 1991 Mr Hopper has been working in the National Medical Centre. In this position he has lead a variety of research projects on the use of photodynamic therapy in the treatment of oral squamous cell carcinoma. This program is currently one of the largest in the world with over 400 treatments using the three main photosensitizers. Mr Hopper is the principal investigator on a series of ethically approved projects. His work has resulted in a number of publications and helped establish a clear role for this treatment in a variety of neoplastic conditions in the head and neck. This work has advanced rapidly by the development of interstitial treatment of tumours using image guidance systems developed with the department of imaging and medical physics. This has become a national referral service and approval of PDT for treat of cancer has been recognised as such in 2002. Other related areas of research are fluorescence diagnostics (optical techniques for tissue interrogation) and the use of PDT in the treatment of non-malignant conditions such as neurofibromatosis.

  3. Quotes

    1. This case study is part of a larger programme of ground-breaking research at our unit into using OCT imaging for clinical benefit of cancer patients...As well as improving PDT, mapping skin cancer lesions with OCT should improve delivery of other treatments. We are looking to integrate OCT into our routine clinical pathway.
      In OCT mapping tracks skin cancer during PDT
    2. These ex-vivo results are very encouraging and we expect the in-vivo results to be even better, due to better contrast on perfused tissue.
      In Michelson Diagnostics Reports First Quantitative Results on Cancer Diagnosis Using Multi-beam OCT imaging
    3. If we can catch it early, the incipient tumour is small and can be easily excised, for a complete cure in most cases. but if it has been allowed to develop, the treatment is expensive, invasive, often disfiguring surgery, with a poor prognosis. We really need a fast, non-invasive way to scan the many lumps that develop in the mouths of users of tobacco, alcohol and betel nut, to see when one is developing a cancer – now, it really looks like OCT imaging is the answer
      In Michelson Diagnostics Reports First Quantitative Results on Cancer Diagnosis Using Multi-beam OCT imaging
    4. We are very excited about the breakthrough in image quality that this system offers.
      In Successful OCT Imaging Of Oral Cancer Tissue Announced By MDL And UCH, UK
    5. We are very excited about the breakthrough in image quality that this system offers.
      In OCT market set for rapid growth