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1. Mentioned In 209 Articles
2. OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration
  
  Explore ScienceDirect Oct 25 2022 Ophthalmology
  
  No established biomarkers currently exist for therapeutic efficacy and durability of antiVEGF therapy in neovascular age-related macular degeneration (nAMD). This study evaluated radiomic-based quantitative OCT biomarkers that may be predictive of anti-VEGF treatment response and durability. Design Assessment of baseline biomarkers using machine learning (ML) classifiers to predict tolerance to anti-VEGF therapy. Participants Eighty-one participants with treatment-nave nAMD from the OSPREY study, including 15 super responders (patients who achieved and ...
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  Mentions: Case Western Reserve University Cleveland Clinic
3. Intraoperative OCT Guidance of Intraocular Surgery (MIOCT)
  
  Explore Home - ClinicalTrials.gov Aug 23 2022 Ophthalmology , Clinical Trials
  
  ...etinal and anterior segment surgery. A total of 722 subjects will be enrolled at 2 sites, Duke Eye Center and Cole Eye Institute. Of those, there will be 500 retina subjects and 222 anterior segment subjects. There will ...
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  Mentions: Duke University Cleveland Clinic Leica
4. Automated Machine Learning Detection of Hydroxychloroquine Toxicity and Prediction of Future Toxicity Using Higher Order OCT Biomarkers
  
  Explore Elsevier Jun 14 2022 Ophthalmology
  
  Objective: Despite guidelines for HCQ toxicity screening, there are clear challenges to accurate detecting and interpretation. In the current report, the feasibility of automated machine-learning (ML) -based detection of hydroxychloroquine (HCQ) retinopathy and prediction of progression to toxicity in eyes without preexisting toxicity is described. Design: Retrospective longitudinal cohort study. Subjects and methods: This was an IRB-approved retrospective longitudinal image analysis study of 388 subjects on hydroxychloroquine. Multi-layer compartmental retinal ...
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  Mentions: Cleveland Clinic
5. Cleveland Clinic Receives NIH Grant for Broad Bandwidth Transducers for High Resolution Information Rich IVUS
  
  Explore Optical Coherence Tomography News Jun 14 2022 Cardiology , Funding
  
  ...nnovations and enable creation of a product to disrupt intracoronary imaging.
  Cleveland Clinic Received a 2022 NIH Grant for $390,345 for Broad Bandwidth Transducers for High Resolution In...
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  Mentions: National Institutes of Health Cleveland Clinic
6. The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis
  
  Explore Taylor & Francis Online May 23 2022 Ophthalmology
  
  Purpose: Modalities such as optical coherence tomography (OCT) and OCT angiography (OCTA) have improved the diagnostic utility of fundus imaging in management of uveitis. The purpose of this study is to review role of OCT and OCTA in differential diagnosis of certain posterior uveitic entities. Methods: Narrative review. Results: In this review, we have comprehensively summarized the utility of OCT and OCTA in helping the clinician diagnose common but challenging ...
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  Mentions: Cleveland Clinic
7. Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry AMD-The Importance of Outer Retinal Integrity
  
  Explore ScienceDirect May 16 2022 Ophthalmology
  
  Objective: The purpose of the study was to perform a post-hoc analysis to explore the effect of baseline anatomic characteristics identified on optical coherence tomography (OCT) on best-corrected visual acuity (BCVA) response with risuteganib from the completed Phase 2 study in subjects with dry age-related macular degeneration. Design: Post-hoc analysis of a randomized, double-masked, placebo-controlled Phase 2 study SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Eyes with intermediate dry AMD with BCVA ...
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  Mentions: Duke University Cleveland Clinic
8. Grading Anterior Chamber Inflammation with Anterior Segment Optical Coherence Tomography: An Overview
  
  Explore Taylor & Francis Online Apr 22 2022 Ophthalmology
  
  The objective grading of anterior chamber inflammation (ACI) has remained a challenge in the field of uveitis. While the grading criteria produced by the Standardization of Uveitis Nomenclature (SUN) International Workshop have been widely adopted, limitations exist including interobserver variability and grading confined to discrete categories rather than a continuous measurement. Since the earliest iterations of optical coherence tomography (OCT), ACI has been assessed using anterior segment OCT and shown ...
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  Mentions: Cleveland Clinic
9. Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction
  
  Explore ScienceDirect Apr 19 2022 Cardiology
  
  Objectives The purpose of this study was to determine the effect of evolocumab on optical coherence tomography (OCT) measures of plaque composition. Background The proprotein convertase subtilisin kexin type-9 inhibitor evolocumab produced coronary atheroma regression in statin-treated patients. Methods Patients with a nonST-segment elevation myocardial infarction were treated with monthly evolocumab 420 mg (n = 80) or placebo (n = 81) for 52 weeks. Patients underwent serial OCT and intravascular ultrasound imaging ...
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  Mentions: Cleveland Clinic University of Bern Semmelweis University
10. Plaque microstructures during metformin therapy in type 2 diabetic subjects with coronary artery disease: optical coherence tomography analysis
  
  Explore Home Mar 15 2022 Cardiology
  
  Background: While metformin is recommended as a first-line cardioprotective therapy for type 2 diabetic patients, whether it exerts direct effects on atherosclerotic plaque remains uncertain. The current study characterized coronary plaque microstructures in type 2 diabetic patients who received metformin. Methods: We retrospectively analyzed 409 non-culprit lipid plaques in 313 type 2 diabetic patients with coronary artery disease (CAD) by using frequency-domain optical coherence tomography (FD-OCT) imaging. FD-OCT derived plaque ...
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  Mentions: Cleveland Clinic
11. Optical Coherence Tomography Findings in Infectious Posterior Uveitis
  
  Explore Taylor & Francis Online Mar 3 2022 Ophthalmology
  
  Purpose To describe and illustrate the main optical coherence tomography (OCT) findings of infectious uveitis. Methods Narrative review. Results Posterior segment OCT in patients with infectious uveitis reveals posterior hyaloid face precipitates, superficial retinal precipitates and infiltrates, foveolitis, retinitis, neuro-retinitis, choroidal granulomas, and choroiditis as main imaging biomarkers. Some of these features are specific to the underlying causing etiology and may support the diagnosis and the initiation of treatment. Some ...
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  Mentions: Case Western Reserve University Cleveland Clinic Università Vita-Salute San Raffaele
12. Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study
  
  Explore Journals | PLOS Feb 15 2022 Ophthalmology
  
  Purpose: To evaluate the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity (BCVA) outcomes in neovascular age-related macular degeneration (nARMD) patients using baseline swept-source optical coherence tomography (SS-OCT) and OCT-angiography (OCT-A) data. Methods: In this phase IV, retrospective, proof of concept, single center study, SS-OCT data from 17 previously treated nARMD eyes was used to assess retinal layer thicknesses, as well as quantify intraretinal ...
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  Mentions: Cleveland Clinic University of Cambridge Voxeleron
13. Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis
  
  Explore BJO Online Feb 12 2022 Ophthalmology
  
  Background/aims: To establish a consensus in the nomenclature for reporting optical coherence tomography angiography (OCTA findings in uveitis. Methods: The modified Delphi process consisted of two rounds of electronic questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-one items were included for discussion. The three main areas of discussion were: wide field OCTA (WF-OCTA), nomenclature of OCTA findings and OCTA signal attenuation assessment and measurement. Seventeen specialists in uveitis ...
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  Mentions: Cleveland Clinic
14. Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study
  
  Explore Gastrointestinal Endoscopy Jan 20 2022 Gastroenterology , Oncology
  
  Background and Aims Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation. Since these alterations predate the development of dysplasia, we aimed to utilize nanoNAM to identify patients with Barretts esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Methods This is a nested ...
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  Mentions: University of Pittsburgh Cleveland Clinic
15. Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction
  
  Explore journals.healio.com Jan 5 2022 Ophthalmology
  
  Background and objective: To evaluate the utility of spectral-domain optical coherence tomography biomarkers to predict the development of subfoveal geographic atrophy (sfGA). Patients and methods: This was a retrospective cohort analysis including 137 individuals with dry age-related macular degeneration without sfGA with 5 years of follow-up. Multiple spectral-domain optical coherence tomography quantitative metrics were generated, including ellipsoid zone (EZ) integrity and subretinal pigment epithelium (sub-RPE) compartment features. Results: Reduced mean ...
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  Mentions: Cleveland Clinic
16. Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography
  
  Explore Nature Publishing Group Dec 9 2021 Ophthalmology
  
  o analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three ...
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  Mentions: Cleveland Clinic Topcon Medical Systems Nanyang Technological University
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