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    1. Mentioned In 204 Articles

    2. Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry AMD-The Importance of Outer Retinal Integrity

      Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry AMD-The Importance of Outer Retinal Integrity
      Objective: The purpose of the study was to perform a post-hoc analysis to explore the effect of baseline anatomic characteristics identified on optical coherence tomography (OCT) on best-corrected visual acuity (BCVA) response with risuteganib from the completed Phase 2 study in subjects with dry age-related macular degeneration. Design: Post-hoc analysis of a randomized, double-masked, placebo-controlled Phase 2 study SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Eyes with intermediate dry AMD with BCVA ...
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    3. Grading Anterior Chamber Inflammation with Anterior Segment Optical Coherence Tomography: An Overview

      Grading Anterior Chamber Inflammation with Anterior Segment Optical Coherence Tomography: An Overview
      The objective grading of anterior chamber inflammation (ACI) has remained a challenge in the field of uveitis. While the grading criteria produced by the Standardization of Uveitis Nomenclature (SUN) International Workshop have been widely adopted, limitations exist including interobserver variability and grading confined to discrete categories rather than a continuous measurement. Since the earliest iterations of optical coherence tomography (OCT), ACI has been assessed using anterior segment OCT and shown ...
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      Mentions: Cleveland Clinic
    4. Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction

      Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction
      Objectives The purpose of this study was to determine the effect of evolocumab on optical coherence tomography (OCT) measures of plaque composition. Background The proprotein convertase subtilisin kexin type-9 inhibitor evolocumab produced coronary atheroma regression in statin-treated patients. Methods Patients with a nonST-segment elevation myocardial infarction were treated with monthly evolocumab 420 mg (n = 80) or placebo (n = 81) for 52 weeks. Patients underwent serial OCT and intravascular ultrasound imaging ...
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    5. Plaque microstructures during metformin therapy in type 2 diabetic subjects with coronary artery disease: optical coherence tomography analysis

      Plaque microstructures during metformin therapy in type 2 diabetic subjects with coronary artery disease: optical coherence tomography analysis
      Background: While metformin is recommended as a first-line cardioprotective therapy for type 2 diabetic patients, whether it exerts direct effects on atherosclerotic plaque remains uncertain. The current study characterized coronary plaque microstructures in type 2 diabetic patients who received metformin. Methods: We retrospectively analyzed 409 non-culprit lipid plaques in 313 type 2 diabetic patients with coronary artery disease (CAD) by using frequency-domain optical coherence tomography (FD-OCT) imaging. FD-OCT derived plaque ...
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      Mentions: Cleveland Clinic
    6. Optical Coherence Tomography Findings in Infectious Posterior Uveitis

      Optical Coherence Tomography Findings in Infectious Posterior Uveitis
      Purpose To describe and illustrate the main optical coherence tomography (OCT) findings of infectious uveitis. Methods Narrative review. Results Posterior segment OCT in patients with infectious uveitis reveals posterior hyaloid face precipitates, superficial retinal precipitates and infiltrates, foveolitis, retinitis, neuro-retinitis, choroidal granulomas, and choroiditis as main imaging biomarkers. Some of these features are specific to the underlying causing etiology and may support the diagnosis and the initiation of treatment. Some ...
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    7. Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study

      Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study
      Purpose: To evaluate the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity (BCVA) outcomes in neovascular age-related macular degeneration (nARMD) patients using baseline swept-source optical coherence tomography (SS-OCT) and OCT-angiography (OCT-A) data. Methods: In this phase IV, retrospective, proof of concept, single center study, SS-OCT data from 17 previously treated nARMD eyes was used to assess retinal layer thicknesses, as well as quantify intraretinal ...
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    8. Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis

      Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis
      Background/aims: To establish a consensus in the nomenclature for reporting optical coherence tomography angiography (OCTA findings in uveitis. Methods: The modified Delphi process consisted of two rounds of electronic questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-one items were included for discussion. The three main areas of discussion were: wide field OCTA (WF-OCTA), nomenclature of OCTA findings and OCTA signal attenuation assessment and measurement. Seventeen specialists in uveitis ...
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      Mentions: Cleveland Clinic
    9. Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study

      Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study
      Background and Aims Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation. Since these alterations predate the development of dysplasia, we aimed to utilize nanoNAM to identify patients with Barretts esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Methods This is a nested ...
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    10. Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction

      Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction
      Background and objective: To evaluate the utility of spectral-domain optical coherence tomography biomarkers to predict the development of subfoveal geographic atrophy (sfGA). Patients and methods: This was a retrospective cohort analysis including 137 individuals with dry age-related macular degeneration without sfGA with 5 years of follow-up. Multiple spectral-domain optical coherence tomography quantitative metrics were generated, including ellipsoid zone (EZ) integrity and subretinal pigment epithelium (sub-RPE) compartment features. Results: Reduced mean ...
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      Mentions: Cleveland Clinic
    11. Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography

      Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography
      o analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three ...
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    12. ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

      ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma
      Importance: Although the diagnosis of vitreoretinal lymphoma (VRL) can be challenging, early detection is critical for visual prognosis. Objective: To analyze the spectrum of optical coherence tomography (OCT) findings in patients with biopsy-proven VRL and correlate these features with clinical parameters. Design: Retrospective cross-sectional study SETTING: Multicenter chart review from 13 retina, uveitis and ocular oncology clinics worldwide over an 11-year period (2008-2019). Participants: Patients with a diagnosis of biopsy-proven ...
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    13. The Emerging Role of Intraoperative OCT for Retinal Surgery: Image-guided technologies are rapidly advancing

      The Emerging Role of Intraoperative OCT for Retinal Surgery: Image-guided technologies are rapidly advancing
      O ptical coherence tomography (OCT) is a quick and noninvasive imaging modality capable of discerning high-resolution morphologic features of the retina and surrounding structures. 1 Over the past 20 years, OCT has evolved to become an integral component of ophthalmic diagnosis, management, and therapeutic monitoring, with an estimated tens of millions of images captured per year. 2 During this time, improvements in OCT technology have enabled the transition from an ...
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    14. Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes

      Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes
      BACKGROUND AND OBJECTIVES: To characterize the clinical and ellipsoid zone (EZ) integrity outcomes in surgical intervention for symptomatic vitreomacular traction (VMT), and to evaluate the utility of intraoperative optical coherence tomography (OCT) during VMT surgery. PATIENTS AND METHODS: This was a post-hoc analysis of eyes in the DISCOVER study undergoing pars plana vitrectomy (PPV) with intraoperative OCT for VMT-related macular disease. Data were collected prospectively on feasibility and utility of ...
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      Mentions: Cleveland Clinic
    15. Student becomes teacher: training faster deep learning lightweight networks for automated identification of optical coherence tomography B-scans of interest using a student-teacher framework

      Student becomes teacher: training faster deep learning lightweight networks for automated identification of optical coherence tomography B-scans of interest using a student-teacher framework
      This work explores a student-teacher framework that leverages unlabeled images to train lightweight deep learning models with fewer parameters to perform fast automated detection of optical coherence tomography B-scans of interest. Twenty-seven lightweight models (LWMs) from four families of models were trained on expert-labeled B-scans (70 K) as either abnormal or normal, which established a baseline performance for the models. Then the LWMs were trained from random initialization using a ...
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    16. Depth-resolved Corneal Biomechanical Changes Measured Via Optical Coherence Elastography Following Corneal Crosslinking

      Depth-resolved Corneal Biomechanical Changes Measured Via Optical Coherence Elastography Following Corneal Crosslinking
      Purpose: To evaluate depth-resolved changes of corneal biomechanical properties in eyes with corneal ectasia after corneal crosslinking (CXL) using optical coherence elastography. Methods: In a prospective pilot series of eyes with corneal ectasia, a custom high-speed swept source optical coherence tomography system was used to image the cornea before and 3 months after CXL during a low-speed applanating deformation while monitoring applanation force. Cross-correlation was applied to track frame-by-frame two-dimensional ...
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    17. 1-15 of 204 1 2 3 4 ... 12 13 14 »
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  2. About Cleveland Clinic

    Cleveland Clinic

    Cleveland Clinic is a multispecialty academic medical center located in Cleveland, Ohio, United States. The Cleveland Clinic was established in 1921 by four physicians for the purpose of providing patient care, research, and medical education in an ideal medical setting. One of the largest private medical centers in the world, the Cleveland Clinic saw more than 2,900,000 patient visits in 2005, with 53,000 hospital admissions.  Cleveland Clinic Cole Eye Institute is a state-of-the-art eye care facility with world-class ophthalmologists specializing in eye disease. We diagnose and treat the entire spectrum of conditions of the eye, including eye diseases such as macular degeneration, cataracts, glaucoma, and diabetic retinopathy. Our eye doctors offer such treatments as cataract surgery, photodynamic therapy, and eye surgery for age-related macular degeneration