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    1. Mentioned In 209 Articles

    2. OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration

      OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration
      No established biomarkers currently exist for therapeutic efficacy and durability of antiVEGF therapy in neovascular age-related macular degeneration (nAMD). This study evaluated radiomic-based quantitative OCT biomarkers that may be predictive of anti-VEGF treatment response and durability. Design Assessment of baseline biomarkers using machine learning (ML) classifiers to predict tolerance to anti-VEGF therapy. Participants Eighty-one participants with treatment-nave nAMD from the OSPREY study, including 15 super responders (patients who achieved and ...
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    3. Automated Machine Learning Detection of Hydroxychloroquine Toxicity and Prediction of Future Toxicity Using Higher Order OCT Biomarkers

      Automated Machine Learning Detection of Hydroxychloroquine Toxicity and Prediction of Future Toxicity Using Higher Order OCT Biomarkers
      Objective: Despite guidelines for HCQ toxicity screening, there are clear challenges to accurate detecting and interpretation. In the current report, the feasibility of automated machine-learning (ML) -based detection of hydroxychloroquine (HCQ) retinopathy and prediction of progression to toxicity in eyes without preexisting toxicity is described. Design: Retrospective longitudinal cohort study. Subjects and methods: This was an IRB-approved retrospective longitudinal image analysis study of 388 subjects on hydroxychloroquine. Multi-layer compartmental retinal ...
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      Mentions: Cleveland Clinic
    4. The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis

      The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis
      Purpose: Modalities such as optical coherence tomography (OCT) and OCT angiography (OCTA) have improved the diagnostic utility of fundus imaging in management of uveitis. The purpose of this study is to review role of OCT and OCTA in differential diagnosis of certain posterior uveitic entities. Methods: Narrative review. Results: In this review, we have comprehensively summarized the utility of OCT and OCTA in helping the clinician diagnose common but challenging ...
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      Mentions: Cleveland Clinic
    5. Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry AMD-The Importance of Outer Retinal Integrity

      Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry AMD-The Importance of Outer Retinal Integrity
      Objective: The purpose of the study was to perform a post-hoc analysis to explore the effect of baseline anatomic characteristics identified on optical coherence tomography (OCT) on best-corrected visual acuity (BCVA) response with risuteganib from the completed Phase 2 study in subjects with dry age-related macular degeneration. Design: Post-hoc analysis of a randomized, double-masked, placebo-controlled Phase 2 study SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Eyes with intermediate dry AMD with BCVA ...
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    6. Grading Anterior Chamber Inflammation with Anterior Segment Optical Coherence Tomography: An Overview

      Grading Anterior Chamber Inflammation with Anterior Segment Optical Coherence Tomography: An Overview
      The objective grading of anterior chamber inflammation (ACI) has remained a challenge in the field of uveitis. While the grading criteria produced by the Standardization of Uveitis Nomenclature (SUN) International Workshop have been widely adopted, limitations exist including interobserver variability and grading confined to discrete categories rather than a continuous measurement. Since the earliest iterations of optical coherence tomography (OCT), ACI has been assessed using anterior segment OCT and shown ...
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      Mentions: Cleveland Clinic
    7. Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction

      Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction
      Objectives The purpose of this study was to determine the effect of evolocumab on optical coherence tomography (OCT) measures of plaque composition. Background The proprotein convertase subtilisin kexin type-9 inhibitor evolocumab produced coronary atheroma regression in statin-treated patients. Methods Patients with a nonST-segment elevation myocardial infarction were treated with monthly evolocumab 420 mg (n = 80) or placebo (n = 81) for 52 weeks. Patients underwent serial OCT and intravascular ultrasound imaging ...
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    8. Plaque microstructures during metformin therapy in type 2 diabetic subjects with coronary artery disease: optical coherence tomography analysis

      Plaque microstructures during metformin therapy in type 2 diabetic subjects with coronary artery disease: optical coherence tomography analysis
      Background: While metformin is recommended as a first-line cardioprotective therapy for type 2 diabetic patients, whether it exerts direct effects on atherosclerotic plaque remains uncertain. The current study characterized coronary plaque microstructures in type 2 diabetic patients who received metformin. Methods: We retrospectively analyzed 409 non-culprit lipid plaques in 313 type 2 diabetic patients with coronary artery disease (CAD) by using frequency-domain optical coherence tomography (FD-OCT) imaging. FD-OCT derived plaque ...
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      Mentions: Cleveland Clinic
    9. Optical Coherence Tomography Findings in Infectious Posterior Uveitis

      Optical Coherence Tomography Findings in Infectious Posterior Uveitis
      Purpose To describe and illustrate the main optical coherence tomography (OCT) findings of infectious uveitis. Methods Narrative review. Results Posterior segment OCT in patients with infectious uveitis reveals posterior hyaloid face precipitates, superficial retinal precipitates and infiltrates, foveolitis, retinitis, neuro-retinitis, choroidal granulomas, and choroiditis as main imaging biomarkers. Some of these features are specific to the underlying causing etiology and may support the diagnosis and the initiation of treatment. Some ...
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    10. Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study

      Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study
      Purpose: To evaluate the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity (BCVA) outcomes in neovascular age-related macular degeneration (nARMD) patients using baseline swept-source optical coherence tomography (SS-OCT) and OCT-angiography (OCT-A) data. Methods: In this phase IV, retrospective, proof of concept, single center study, SS-OCT data from 17 previously treated nARMD eyes was used to assess retinal layer thicknesses, as well as quantify intraretinal ...
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    11. Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis

      Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis
      Background/aims: To establish a consensus in the nomenclature for reporting optical coherence tomography angiography (OCTA findings in uveitis. Methods: The modified Delphi process consisted of two rounds of electronic questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-one items were included for discussion. The three main areas of discussion were: wide field OCTA (WF-OCTA), nomenclature of OCTA findings and OCTA signal attenuation assessment and measurement. Seventeen specialists in uveitis ...
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      Mentions: Cleveland Clinic
    12. Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study

      Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study
      Background and Aims Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation. Since these alterations predate the development of dysplasia, we aimed to utilize nanoNAM to identify patients with Barretts esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Methods This is a nested ...
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    13. Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction

      Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction
      Background and objective: To evaluate the utility of spectral-domain optical coherence tomography biomarkers to predict the development of subfoveal geographic atrophy (sfGA). Patients and methods: This was a retrospective cohort analysis including 137 individuals with dry age-related macular degeneration without sfGA with 5 years of follow-up. Multiple spectral-domain optical coherence tomography quantitative metrics were generated, including ellipsoid zone (EZ) integrity and subretinal pigment epithelium (sub-RPE) compartment features. Results: Reduced mean ...
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      Mentions: Cleveland Clinic
    14. Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography

      Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography
      o analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three ...
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  2. About Cleveland Clinic

    Cleveland Clinic

    Cleveland Clinic is a multispecialty academic medical center located in Cleveland, Ohio, United States. The Cleveland Clinic was established in 1921 by four physicians for the purpose of providing patient care, research, and medical education in an ideal medical setting. One of the largest private medical centers in the world, the Cleveland Clinic saw more than 2,900,000 patient visits in 2005, with 53,000 hospital admissions.  Cleveland Clinic Cole Eye Institute is a state-of-the-art eye care facility with world-class ophthalmologists specializing in eye disease. We diagnose and treat the entire spectrum of conditions of the eye, including eye diseases such as macular degeneration, cataracts, glaucoma, and diabetic retinopathy. Our eye doctors offer such treatments as cataract surgery, photodynamic therapy, and eye surgery for age-related macular degeneration