1. Claude F. Burgoyne

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    1. Mentioned In 20 Articles

    2. The Effect of Age on Optic Nerve Axon Counts, SDOCT Scan Quality, and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in Rhesus Monkeys

      The Effect of Age on Optic Nerve Axon Counts, SDOCT Scan Quality, and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in Rhesus Monkeys

      Purpose: To evaluate the effect of age on optic nerve axon counts, spectral-domain optical coherence tomography (SDOCT) scan quality, and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in healthy monkey eyes. Methods: In total, 83 healthy rhesus monkeys were included in this study (age range: 1.2–26.7 years). Peripapillary RNFLT was measured by SDOCT. An automated algorithm was used to count 100% of the axons and measure their cross-sectional area in postmortem optic nerve tissue samples ( N = 46). Simulation experiments were done to determine the effects of optical changes on measurements of RNFLT. An objective, fully-automated method ...

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    3. Anatomic vs. Acquired Image Frame Discordance in Spectral Domain Optical Coherence Tomography Minimum Rim Measurements

      Anatomic vs. Acquired Image Frame Discordance in Spectral Domain Optical Coherence Tomography Minimum Rim Measurements

      Purpose To quantify the effects of using the fovea to Bruch's membrane opening (FoBMO) axis as the nasal-temporal midline for 30° sectoral (clock-hour) spectral domain optical coherence tomography (SDOCT) optic nerve head (ONH) minimum rim width (MRW) and area (MRA) calculations. Methods The internal limiting membrane and BMO were delineated within 24 radial ONH B-scans in 222 eyes of 222 participants with ocular hypertension and glaucoma. For each eye the fovea was marked within the infrared reflectance image, the FoBMO angle (θ) relative to the acquired image frame (AIF) horizontal was calculated, the ONH was divided into 30°sectors using ...

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    4. Emanuel Hospital Receives NIH Grant for Studying the Optical Nerve Head Using SD-OCT Imaging in Glaucoma

      Emanuel Hospital Receives NIH Grant for Studying the Optical Nerve Head Using SD-OCT Imaging in Glaucoma

      Emanuel Hospital Received a 2013 NIH Grant for $344.250 to study the Optical Nerve Head Using SD-OCT Imaging in Glaucoma. The principal investigator is Claude Burgoyne. The program began in 2010 and ends in 2014. Below is a summary of the proposed work. The primary goal of this project is to test three hypotheses regarding glaucomatous damage to the visual system. First, that clinically detectable neural, glial and connective tissue alterations occur deep in the optic nerve head (ONH) at a very early stage in the pathophysiology of glaucomatous damage to the visual system. Second, that the location and ...

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    5. Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Purpose. To determine if the detection of spectral domain optical coherence tomography (SDOCT) optic nerve head (ONH) change precedes the detection of Confocal Scanning Laser Tomography (CSLT) ONH surface, SDOCT retinal nerve fiber layer (RNFL), Scanning Laser Perimetry (SLP) and multifocal electroretinography (mfERG) change in 8 experimental glaucoma (EG) eyes. Methods. Both eyes from 8 monkeys were tested at least 3 times at baseline, and then every 2 weeks following laser-induced chronic unilateral IOP elevation. Event and trend-based definitions of onset in both the control and EG eyes for a total of 11 SDOCT neural and connective tissue, CSLT surface ...

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    6. Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier Than RNFL Thickness Changes in Experimental Glaucoma

      Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier Than RNFL Thickness Changes in Experimental Glaucoma
      ...) Retardance Changes Occur Earlier Than RNFL Thickness Changes in Experimental Glaucoma 1. Brad Fortune, 2. Claude F. Burgoyne, 3. Grant Cull, 4. Juan Reynaud and 5. Lin Wang 1. Discoveries in Sight Research Labo...
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    7. Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter

      Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter
      ...ons + Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada , * Claude F. Burgoyne, MD Affiliations + Devers Eye Institute, Portland, Oregon Received 27 May 2012; received in...
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    8. Relationship between Orbital Optic Nerve Axon Counts and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomograph

      Relationship between Orbital Optic Nerve Axon Counts and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomograph

      Purpose: To determine the relationship between total optic nerve axon counts and peripapillary retinal nerve fiber layer thickness (RNFLT) measured in vivo by spectral domain optical coherence tomography (SDOCT). Methods: Twenty-two rhesus macaques had three or more baseline measurements in both eyes of peripapillary RNFLT made by SDOCT (Spectralis, Heidelberg Engineering GmbH). Laser photocoagulation was then applied to the trabecular meshwork of one eye to induce chronic unilateral IOP elevation. SDOCT measurements of RNFLT continued approximately every two weeks until the pre-defined study endpoint was reached in each animal. At endpoint, animals were sacrificed and the optic nerve was sampled ...

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    9. Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging of the Normal and Glaucomatous Nonhuman Primate Optic Nerve Head

      Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging of the Normal and Glaucomatous Nonhuman Primate Optic Nerve Head
      Purpose. To test whether the enhanced depth imaging (EDI) modality improves anterior and posterior lamina cribrosa surface (ALCS and PLCS) visibility compared with conventional spectral-domain optical coherence tomography (SD-OCT). Methods. Conventional and EDI SD-OCT scans were obtained 30 minutes after IOP was manometrically lowered to 10 mm Hg in both eyes of 14 nonhuman primates (NHPs) with unilateral experimental glaucoma (EG). Thirteen horizontal and seven vertical radial B-scans of each SD-OCT data set were delineated by one operator masked to image type. Delineated ALCS and PLCS points were projected to 1 of 100 equal-sized subregions of the neural canal opening ...
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    10. Optic Disc Margin Anatomy in Patients with Glaucoma and Normal Controls with Spectral Domain Optical Coherence Tomography

      Optic Disc Margin Anatomy in Patients with Glaucoma and Normal Controls with Spectral Domain Optical Coherence Tomography
      ...Alexandre S.C. Reis, MD^1^, ^2, * Glen P. Sharpe, MSc^1, * Hongli Yang, PhD^3, * Marcelo T. Nicolela, MD^1, * Claude F. Burgoyne, MD^3, * Balwantray C. Chauhan, PhD^1^, Corresponding author contact information ^, E-mail ...
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    11. Spectral Domain Optical Coherence Tomography (SDOCT) Enhanced Depth Imaging (EDI) of the Normal and Glaucomatous Non-human Primate (NHP) Optic Nerve Head (ONH)

      Spectral Domain Optical Coherence Tomography (SDOCT) Enhanced Depth Imaging (EDI) of the Normal and Glaucomatous Non-human Primate (NHP) Optic Nerve Head (ONH)
      ...ng Qi^2, 3. Christy Hardin^1, 4. Stuart K. Gardiner^1, 5. Nicholas G. Strouthidis^3, 6. Brad Fortune^1 and 7. Claude F. Burgoyne^1 1. ^1Devers Eye Institute, Portland, OR; 2. ^2NYU Polytechnic Institute, Brooklyn, NY 3. ...
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    12. The Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head As Detected by Spectral Domain Optical Coherence Tomography

      The Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head As Detected by Spectral Domain Optical Coherence Tomography
      Purpose To determine whether acutely elevated IOP alters optic nerve head (ONH) structural parameters characterized in vivo using spectral domain optical coherence tomography (SDOCT). Methods Five rhesus macaques were tested under isoflurane anaesthesia. SDOCT images of the ONH of both eyes were acquired 30 minutes after IOP was stabilized to 10 mmHg and after 60 minutes to 45 mmHg. The internal limiting membrane, Bruch's Membrane/retinal pigment epithelium, neural canal opening (NCO) and anterior lamina cribrosa surface (ALCS) were delineated using custom software. Differences in SDOCT structural parameters between the two IOP levels were assessed using generalized estimating equations ...
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    13. Optical Coherence Tomography Used $500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What’s to Come?

      Optical Coherence Tomography Used $500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What’s to Come?

      The field of optical coherence tomography (OCT) has blossomed dramatically since some of the first work by various researchers around the world in the late 1980s and early 1990s. Since then there have been dozens of companies created, hundreds of research groups working on OCT, thousands of research articles published, millions of patients scanned with OCT, hundreds of millions of venture capital and corporate R&D dollars invested, hundreds of millions of dollars in company acquisitions, and billions of dollars of revenue created. The United States government and other governments around the world have been big supporters of funding for ...

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    14. Frontiers and Controversies in Structural and Functional Ocular Imaging

      Frontiers and Controversies in Structural and Functional Ocular Imaging

      Heidelberg Engineering has designed, manufactured and distributed diagnostic instruments for eye care professionals for 20 years. In celebration of this milestone the company held a two-day symposium in Heidelberg, Germany, demonstrating the integral part the company has played and continues to play in worldwide research and clinical practice. “Frontiers and controversies in structural and functional ocular imaging” featured a plethora of experts from all over the world discussing their research and results in imaging and diagnostics. In this supplement Ophthalmology Times Europe and Heidelberg Engineering present the highlights of the 20th Anniversary symposium.

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    15. Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Optic Nerve Head and Peripapillary Retina in Experimental Glaucoma

      Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Optic Nerve Head and Peripapillary Retina in Experimental Glaucoma
      Purpose: To investigate whether longitudinal changes deep within the optic nerve head (ONH) are detectable by spectral domain optical coherence tomography (SDOCT) in experimental glaucoma (EG) and whether these changes are detectable at the onset of Heidelberg Retina Tomography (HRT) defined surface topography depression. Methods: Longitudinal SDOCT imaging (Heidelberg Spectralis) was performed in both eyes of 9 rhesus macaques every 1-3 weeks. One eye of each underwent trabecular laser-induced IOP elevation. Four masked operators delineated internal limiting membrane, retinal nerve fiber layer (RNFL), Bruch's Membrane/retinal pigment epithelium, neural canal opening (NCO) and anterior lamina cribrosa surface (ALCS) using ...
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  2. About Claude F. Burgoyne

    Claude F. Burgoyne

    Claude F. Burgoyne is a Senior Scientist and Research Director in the Optic Nerve Head Research Laboratory at Devers Eye Institute at the Devers Eye Institute in Portland Oregon.