1. Claude Boccara

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    1. Mentioned In 62 Articles

    2. High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography

      High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography
      Full-field optical coherence tomography (FF-OCT) is a powerful tool for nondestructive assessment of biological tissue, i.e., for the structural examination of tissue in depth at a cellular resolution. Mostly known as a microscopy device for ex vivo analysis, FF-OCT has also been adapted to endoscopy setups since it shows good potential for in situ cancer diagnosis and biopsy guidance. Nevertheless, all the attempts to perform endoscopic FF-OCT imaging did ...
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    3. Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by temporal analysis of interferometric signals

      Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by temporal analysis of interferometric signals
      We developed a new endogenous approach to reveal subcellular metabolic contrast in fresh ex vivo tissues taking advantage of the time dependence of the full field optical coherence tomography interferometric signals. This method reveals signals linked with local activity of the endogenous scattering elements which can reveal cells where other imaging techniques fail or need exogenous contrast agents. We benefit from the micrometric transverse resolution of full field OCT to ...
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    4. Optical tissue sectioning using full field optical coherence tomography

      Optical tissue sectioning using full field optical coherence tomography
      According to a first aspect, the invention relates to a multimodal optical sectioning microscope (200, 400, 600) for full-field imaging of a volumic and scattering sample comprising: --a full-field OCT system for providing an image of a first section in depth of the sample comprising an illumination sub-system (201, 401, 601) and a full-field imaging interferometer with a detection sub system (208, 408, 608) and an optical conjugation device for ...
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    5. Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography

      Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography
      Background: Full-field optical coherence tomography (FFOCT) is a real-time imaging technique that rapidly generates images reminiscent of histology without any tissue processing, warranting its exploration for evaluation of ex vivo kidney tissue. Methods: Fresh tissue sections from tumor and adjacent nonneoplastic kidney ( n = 25 nephrectomy specimens; clear cell renal cell carcinoma (CCRCC) = 12, papillary RCC (PRCC) = 4, chromophobe RCC (ChRCC) = 4, papillary urothelial carcinoma (PUC) = 1, angiomyolipoma (AML) = 2 and ...
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    6. Method and device for high resolution full field interference microscopy

      Method and device for high resolution full field interference microscopy
      The invention relates to an incoherent light full field interference microscopy device for the imaging of a volumetric scattering sample (106). The device comprises an interference device (100) between a reference wave (401), produced by reflection of an incident wave by a reflective surface (105) of a reference arm of the interference device, and an object wave (402) produced by backscattering of the incident wave by a slice of the ...
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    7. Anisotropic polyvinyl alcohol hydrogel phantom for shear wave elastography in fibrous biological soft tissue: a multimodality characterization

      Anisotropic polyvinyl alcohol hydrogel phantom for shear wave elastography in fibrous biological soft tissue: a multimodality characterization
      Shear wave elastography imaging techniques provide quantitative measurement of soft tissues elastic properties. Tendons, muscles and cerebral tissues are composed of fibers, which induce a strong anisotropic effect on the mechanical behavior. Currently, these tissues cannot be accurately represented by existing elastography phantoms. Recently, a novel approach for orthotropic hydrogel mimicking soft tissues has been developed (Millon et al 2006 J. Biomed. Mater. Res. B 30511). The mechanical anisotropy is ...
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  2. About Claude Boccara

    Claude Boccara

    A. Claude Boccara was Dean of Research at ESPCI-ParisTech. Among the optical methods he has developed new microscopies to increase depth and lateral resolution. Recently, ultimate measurements have found new fields of application going from detection of gravitational waves to 3-D imaging though scattering media. He has published more than 300 scientific articles (ISI/ Boccara A* or Boccara C) in international journals. In 2007 he founded the start-up LLTech devoted to medical imaging and diagnostics.

  3. Quotes

    1. The system provides pictures of excellent quality that you can browse easily from the centimeter down to the micrometer scale. I confess having been amazed by the results. This new tool already makes my fellows biologists and physicians enthusiastic: its worth trying it, you will like it.
      In LLTech launches the ultra high resolution - micron level - 3D Light-CT scanner for research
    2. "The CT principle involves using light with a relatively broad spectrum, and the broader the spectrum is, the better the sectioning ability of the technique...That illumination commonly comes from a superluminescent diode or an ultrashort pulsed laser, but Light-CT is completely different.
      In LLTech brings optical biopsies to operating theaters: Coherence tomography technique allows surgeons to see biopsy results in 3D and almost real-time.