1. Claude Boccara

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    1. Mentioned In 60 Articles

    2. The multiple scattering limit in optical microscopy

      The multiple scattering limit in optical microscopy
      Optical microscopy offers a unique insight of biological structures with a sub-micrometer resolution and a minimum invasiveness. However, the inhomogeneities of the specimen itself can induce multiple scattering of light and optical aberrations which limit the observation to depths close to the surface. To predict quantitatively the penetration depth in microscopy, we theoretically derive the single-to-multiple scattering ratio in reflection. From this key quantity, the multiple scattering limit is deduced ...
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    3. Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

      Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography
      Purpose : To use cell motility as a contrast agent in retinal explants. Methods : Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. Results : Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen ...
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    4. Fast subsurface fingerprint imaging with full-field optical coherence tomography system equipped with a silicon camera

      Fast subsurface fingerprint imaging with full-field optical coherence tomography system equipped with a silicon camera
      Images recorded below the surface of a finger can have more details and be of higher quality than conventional surface fingerprint images. This is particularly true when the quality of the surface fingerprints is compromised by, for example, moisture or surface damage. However, there is an unmet need for a cost effective fingerprint sensor that could record high-quality images at sufficient depth below the surface and in short-enough time. To ...
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    5. Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

      Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging
      Full-field optical coherence tomography (FF-OCT) is a variant of OCT that is able to register 2D en face views of scattering samples at a given depth. Thanks to its superior resolution, it can quickly reveal information similar to histology without the need to physically section the sample. Sensitivity and specificity levels of diagnosis performed with FF-OCT are 80% to 95% of the equivalent histological diagnosis performances and could therefore benefit ...
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    6. Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning

      Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning
      For a large number of cancer surgeries, the lack of reliable intraoperative diagnosis leads to reoperations or bad outcomes for the patients. To deliver better diagnosis, we developed Dynamic Full Field OCT (D-FFOCT) as a complement to FFOCT. FFOCT already presents interesting results for cancer diagnosis e.g. Mohs surgery and reaching 96% accuracy on prostate cancer. D-FFOCT accesses the dynamic processes of metabolism and gives new tools to diagnose ...
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    7. Retinal imaging with adaptive optics full-field OCT

      Retinal imaging with adaptive optics full-field OCT
      Adaptive optics full-filed OCT (FFOCT) with a transmissive liquid crystal spatial light modulator (LCSLM) as wavefront corrector is used without strict plane conjugation for low order aberrations corrections. We validated experimentally that FFOCT resolution is independent of aberrations and only reduce the signal level. A signal based sensorless algorithm was thus applied for wavefront distortion compensation. Image quality improvements by the wavefront sensorless control of the LCSLM were evaluated on ...
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    8. Dynamic multimodal full-field optical coherence tomography and fluorescence structured illumination microscopy

      Dynamic multimodal full-field optical coherence tomography and fluorescence structured illumination microscopy
      We report on the development of a configuration of a multimodal full-field optical coherence tomography (FF-OCT) and fluorescence microscope. Our system can simultaneously acquire FF-OCT and structured illumination microscopy images. Dynamic parallel evolution of tissue microstructures and biochemical environments can be visualized. We use high numerical aperture objectives to optimize the combination of the two modalities. We imaged the propagation of mechanical waves initiated by calcium waves in a heart ...
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    9. En face coherence microscopy [Invited]

      En face coherence microscopy [Invited]
      En face coherence microscopy or flying spot or full field optical coherence tomography or microscopy (FF-OCT/FF-OCM) belongs to the OCT family because the sectioning ability is mostly linked to the source coherence length. In this article we will focus our attention on the advantages and the drawbacks of the following approaches: en face versus B scan tomography in terms of resolution, coherent versus incoherent illumination and influence of aberrations ...
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    10. Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography

      Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography
      Optical coherence tomography (OCT) can map the stiffness of biological tissue by imaging mechanical perturbations (shear waves) propagating in the tissue. Most shear wave elastography (SWE) techniques rely on active shear sources to generate controlled displacements that are tracked at ultrafast imaging rates. Here, we propose a noise-correlation approach to retrieve stiffness information from the imaging of diffuse displacement fields using low-frame rate spectral-domain OCT. We demonstrated the method on ...
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    11. Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport

      Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport
      ...pectrum microscopy,” Cell 158(4), 822–832 (2014). [Crossref] [PubMed] C. Apelian, F. Harms, O. Thouvenin, and A. C. Boccara, “Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in ti...
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    12. Adaptive optics full-field optical coherence tomography

      Adaptive optics full-field optical coherence tomography
      We describe a simple and compact full-field optical coherence tomography (FFOCT) setup coupled to a transmissive liquid crystal spatial light modulator (LCSLM) to induce or correct aberrations. To reduce the system complexity, strict pupil conjugation was abandoned because low-order aberrations are often dominant. We experimentally confirmed a recent theoretical and experimental demonstration that the image resolution was almost insensitive to aberrations that mostly induce a reduction of the signal level ...
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    13. Full-field spatially incoherent illumination interferometry: a spatial resolution almost insensitive to aberrations

      Full-field spatially incoherent illumination interferometry: a spatial resolution almost insensitive to aberrations
      We show that with spatially incoherent illumination, the point spread function (PSF) width/spatial resolution of an imaging interferometer like that used in full-field optical coherence tomography (OCT) is almost insensitive to aberrations. In these systems, aberrations mostly induce a reduction of the signal level that leads to a loss of the signal-to-noise ratio without broadening the system PSF. This is demonstrated by comparison with traditional scanning OCT and wide-field ...
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    14. High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography

      High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography
      Full-field optical coherence tomography (FF-OCT) is a powerful tool for nondestructive assessment of biological tissue, i.e., for the structural examination of tissue in depth at a cellular resolution. Mostly known as a microscopy device for ex vivo analysis, FF-OCT has also been adapted to endoscopy setups since it shows good potential for in situ cancer diagnosis and biopsy guidance. Nevertheless, all the attempts to perform endoscopic FF-OCT imaging did ...
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    15. Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by temporal analysis of interferometric signals

      Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by temporal analysis of interferometric signals
      We developed a new endogenous approach to reveal subcellular metabolic contrast in fresh ex vivo tissues taking advantage of the time dependence of the full field optical coherence tomography interferometric signals. This method reveals signals linked with local activity of the endogenous scattering elements which can reveal cells where other imaging techniques fail or need exogenous contrast agents. We benefit from the micrometric transverse resolution of full field OCT to ...
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  2. About Claude Boccara

    Claude Boccara

    A. Claude Boccara was Dean of Research at ESPCI-ParisTech. Among the optical methods he has developed new microscopies to increase depth and lateral resolution. Recently, ultimate measurements have found new fields of application going from detection of gravitational waves to 3-D imaging though scattering media. He has published more than 300 scientific articles (ISI/ Boccara A* or Boccara C) in international journals. In 2007 he founded the start-up LLTech devoted to medical imaging and diagnostics.

  3. Quotes

    1. The system provides pictures of excellent quality that you can browse easily from the centimeter down to the micrometer scale. I confess having been amazed by the results. This new tool already makes my fellows biologists and physicians enthusiastic: its worth trying it, you will like it.
      In LLTech launches the ultra high resolution - micron level - 3D Light-CT scanner for research
    2. "The CT principle involves using light with a relatively broad spectrum, and the broader the spectrum is, the better the sectioning ability of the technique...That illumination commonly comes from a superluminescent diode or an ultrashort pulsed laser, but Light-CT is completely different.
      In LLTech brings optical biopsies to operating theaters: Coherence tomography technique allows surgeons to see biopsy results in 3D and almost real-time.