1. Claude Boccara

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    1. Mentioned In 77 Articles

    2. Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves

      Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
      Cell-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers, and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in ...
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    3. Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies

      Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies
      Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as oesophageal papillae, gastric pits, duodenal villi and colonic crypts. In dynamic FFOCT mode, we imaged ...
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    4. Full-field optical coherence tomography for the diagnosis of giant cell arteritis

      Full-field optical coherence tomography for the diagnosis of giant cell arteritis
      Histopathological examination of temporal artery biopsy (TAB) remains the gold standard for the diagnosis of giant cell arteritis (GCA) but is associated with essential limitations that emphasize the need for an upgraded pathological process. This study pioneered the use of full-field optical coherence tomography (FF-OCT) for rapid and automated on-site pathological diagnosis of GCA. Sixteen TABs (12 negative and 4 positive for GCA) were selected according to major histopathological criteria ...
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    5. Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves

      Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
      High-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in ...
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    6. Compact and Mobile Full-Field Optical Coherence Tomography Sensor for Subsurface Fingerprint Imaging

      Compact and Mobile Full-Field Optical Coherence Tomography Sensor for Subsurface Fingerprint Imaging
      Conventional fingerprint sensors that are deployed in real-life applications lack the ability to peer inside a finger beyond the external surface. Subsurface information can provide complimentary biometric characteristics associated with the finger. The subsurface fingerprints can also be employed when the quality of the external/surface fingerprints is affected. One of the most promising technologies for imaging below the surface of an external fingerprint is full-field optical coherent tomography (FF-OCT ...
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    7. Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT

      Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT
      In todays clinics, a cellular-resolution view of the cornea can be achieved only with an in vivo confocal microscope (IVCM) in contact with the eye. Here, we present a common-path Full-field/Spectral-domain OCT microscope (FF/SD OCT), which, for the first time, enables cell-detail imaging of the entire ocular surface (central and peripheral cornea, limbus, sclera, tear film) without contact and in real time. The device, that has been successfully ...
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    8. Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view

      Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view
      Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine [1, 2, 3], but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is normally achieved with adaptive optics (AO) and scanning methods, which considerably reduce the useful FOV and increase the system complexity. An alternative technique is time-domain Full-Field Optical Coherence Tomography (FF-OCT) [4, 5], which ...
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    9. High-throughput dark-field full-field optical coherence tomography

      High-throughput dark-field full-field optical coherence tomography
      Full-field optical coherence tomography (FF-OCT) can rapidly acquire 2D en face OCT images through a scattering medium. However, the standard interferometer configurations waste almost 75% of light. In addition, specular reflections can saturate the detector, limiting FF-OCT performance. Here, we report on a high-throughput dark-field (HTDF) FF-OCT configuration that efficiently uses the available light budget and allows suppressing specular reflections. Specifically, we demonstrate that images acquired with the HTDF FF-OCT ...
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    10. High-resolution in-vivo human retinal imaging using full-field OCT with optical stabilization of axial motion

      High-resolution in-vivo human retinal imaging using full-field OCT with optical stabilization of axial motion
      Time-domain full-field OCT (FF-OCT) represents an imaging modality capable of recording high-speed en-face sections of a sample at a given depth. One of the biggest challenges to transfer this technique to image in-vivo human retina is the presence of continuous involuntary head and eye axial motion during image acquisition. In this paper, we demonstrate a solution to this problem by implementing an optical stabilization in an FF-OCT system. This was ...
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    11. Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

      Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids
      Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue, but lacks functional information. We present dynamic full-field optical coherence tomography to image living human induced pluripotent stem cell-derived retinal organoids non-invasively. Colored images with an endogenous contrast linked to organelle motility are generated, with sub-micrometer spatial resolution and millisecond temporal resolution, opening an avenue to identify specific cell types in living tissue via their function.
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    12. Distortion matrix concept for deep imaging in optical coherence microscopy

      Distortion matrix concept for deep imaging in optical coherence microscopy
      In optical imaging, light propagation is affected by the inhomogeneities of the medium. Sample-induced aberrations and multiple scattering can strongly degrade the image resolution and contrast. Based on a dynamic correction of the incident and/or reflected wave-fronts, adaptive optics has been employed to compensate for those aberrations. However, it mainly applies to spatiallyinvariant aberrations or to thin aberrating layers. Here, we propose a global and non-invasive approach based on ...
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    13. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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    14. The clinical usefulness of optical coherence tomography during cancer interventions

      The clinical usefulness of optical coherence tomography during cancer interventions
      Introduction Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which has been widely evaluated during the past decades. This review aims to determine the clinical usefulness of OCT during cancer interventions focussing on qualitative features ...
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    15. 1-15 of 77 1 2 3 4 5 »
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  2. About Claude Boccara

    Claude Boccara

    A. Claude Boccara was Dean of Research at ESPCI-ParisTech. Among the optical methods he has developed new microscopies to increase depth and lateral resolution. Recently, ultimate measurements have found new fields of application going from detection of gravitational waves to 3-D imaging though scattering media. He has published more than 300 scientific articles (ISI/ Boccara A* or Boccara C) in international journals. In 2007 he founded the start-up LLTech devoted to medical imaging and diagnostics.

  3. Quotes

    1. The system provides pictures of excellent quality that you can browse easily from the centimeter down to the micrometer scale. I confess having been amazed by the results. This new tool already makes my fellows biologists and physicians enthusiastic: its worth trying it, you will like it.
      In LLTech launches the ultra high resolution - micron level - 3D Light-CT scanner for research
    2. "The CT principle involves using light with a relatively broad spectrum, and the broader the spectrum is, the better the sectioning ability of the technique...That illumination commonly comes from a superluminescent diode or an ultrashort pulsed laser, but Light-CT is completely different.
      In LLTech brings optical biopsies to operating theaters: Coherence tomography technique allows surgeons to see biopsy results in 3D and almost real-time.