1. Chuanqing Zhou

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    1. Mentioned In 21 Articles

    2. Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography
      We report on the investigation of spectral leakages impact on the reconstruction of Fourier-domain optical coherence tomography (FD-OCT). We discuss the shift-variant nature introduced by the spectral leakage and develop a novel spatial-domain FD-OCT image formation model. A proof-of-concept phantom experiment is conducted to validate our model. Compared with previous models, the proposed framework could better describe the image formation process, especially when the fineness of the axial structure approaches ...
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    3. Weakly Supervised Deep Learning Based Optical Coherence Tomography Angiography

      Weakly Supervised Deep Learning Based Optical Coherence Tomography Angiography
      Optical coherence tomography angiography (OCTA) is a promising imaging modality for microvasculature studies. Deep learning networks have been widely applied in the field of OCTA reconstruction, benefiting from its powerful mapping capability among images. However, these existing deep learning-based methods depend on high-quality labels, which are hard to acquire considering imaging hardware limitations and practical data acquisition conditions. In this paper, we proposed an unprecedented weakly supervised deep learning-based pipeline ...
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    4. Beyond Fourier transform: break the axial resolution limit in optical coherence tomography

      Beyond Fourier transform: break the axial resolution limit in optical coherence tomography
      Optical coherence tomography (OCT) is a volumetric imaging modality that empowers the clinicians and scientists to noninvasively visualize and examine the microscopic cross-sectional architectures of biological samples. By taking advantages of the coherence gating, OCT could achieve micrometer-level axial sectioning with high sensitivity. In the past decade, substantial efforts have been made to push the axial resolution of Fourier-domain OCT (FD-OCT) further into the sub-micron regime via physically extending the ...
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    5. In vivo time-serial evaluation of laser-induced choroidal neovascularization in rats simultaneously using photoacoustic microscopy and optical coherence tomography

      In vivo time-serial evaluation of laser-induced choroidal neovascularization in rats simultaneously using photoacoustic microscopy and optical coherence tomography
      Determination of the precise location and degree of condition of the Choroidal neovascularization (CNV) lesion is essential for diagnosation Neovascular age-related macular degeneration (AMD) and evaluation the efficacy of treatment. Given the complimentary contrast mechanisms of Photoacoustic microscopy (PAM) and Optical coherence tomography (OCT), the combination of PAM and OCT imaging could potentially provide much sensitive and specific detection of CNV. In this paper, we validated the opportunity to evaluate ...
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    6. Response to Comment on “Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography”

      Response to Comment on “Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography”
      We noticed that Spahr et al. commented on our latest paper Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography. In their comments, they concluded that the measured retinal pulse wave velocity (rPWV) in our paper was highly surprising and contradictory to theoretical predictions and previously published results. However, we have some different opinions regarding their comments.
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      Mentions: Chuanqing Zhou
    7. Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography

      Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography
      The human eyes provide a natural window for noninvasive measurement of the pulse wave velocity (PWV) of small arteries. By measuring the retinal PWV, the stiffness of small arteries can be assessed, which may better detect early vascular diseases. Therefore, retinal PWV measurement has attracted increasing attention. In this study, a jump-scanning method was proposed for non-invasive measurement of retinal PWV using spectral-domain OCT. The jump-scanning method uses the phase-resolved ...
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    8. Dual band dual focus optical coherence tomography for imaging the whole eye segment

      Dual band dual focus optical coherence tomography for imaging the whole eye segment
      We developed an improved dual band dual focus spectral domain optical coherence tomography (SD-OCT) for in vivo 2D/3D imaging of the whole eye segment, including the whole anterior segment and retina. The system featured two OCT channels with two different bands centered at 840 nm and 1050 nm, which were designed to image the retina and the anterior segments of the eye, respectively. By combing the two probe light ...
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    9. PEGylated Aucore–Agshell Nanorods as Optical Coherence Tomography Signal Nanoamplifiers

      PEGylated Aucore–Agshell Nanorods as Optical Coherence Tomography Signal Nanoamplifiers
      Optimizing contrast enhancement in optical coherence tomography (OCT) is essential for producing specific image signals and realizing its potential use in various biomedical imaging fields besides ophthalmology and cardiology. Using nanoparticles as selective signal nanoamplifiers will be helpful to highlight the lesion sites and identify cancerous changes that are difficult to diagnose currently. In this study, a quantitatively detailed analysis on the improvement of contrast enhancement and penetration depth of ...
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    10. Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography

      Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography
      To research retinal stretching or distortion with accommodation, accommodation-induced changes in retinal thickness (RT) in the macular area were investigated in a population of young adults ( n = 23 ) by using a dual-channel spectral domain optical coherence tomography (SD-OCT) system manufactured in-house for this study. This dual-channel SD-OCT is capable of imaging the cornea and retina simultaneously with an imaging speed of 24 kHz A-line scan rate, which can provide the ...
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    11. Evaluation of ultrasound and glucose synergy effect on the optical clearing and light penetration for human colon tissue using SD-OCT

      Evaluation of ultrasound and glucose synergy effect on the optical clearing and light penetration for human colon tissue using SD-OCT
      Topical application optical clearing agents (OCAs) can effectively enhance the tissue optical clearing on the human colon tissue, which has been demonstrated in our previous studies. Nevertheless, the strong light scattering still limits the diffusion rate of OCAs and penetration depth of light into the tissue. In this study, in order to further increase the diffusion of the OCA of glucose into tissue, we employ a method to improve the ...
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    12. Noninvasive Imaging and Measurement of Accommodation Using Dual-Channel SD-OCT

      Noninvasive Imaging and Measurement of Accommodation Using Dual-Channel SD-OCT
      Purpose : To investigate the feasibility and practicality of real-time noninvasive imaging and measurement of ocular accommodation (05D with one diopter step) using dual-channel , dual-focus spectral domain optical coherence tomography ( SD-OCT ). Materials and Methods : A custom-built, dual-channel , dual-focus SD-OCT was used to image the anterior segment, including the cornea, iris, and anterior and posterior lens surfaces. Three consecutive measurements were taken in each accommodative session for each subject. Changes in ocular ...
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    13. Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography

      Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography
      Recent reports have suggested that spectral domain optical coherence tomography (SD-OCT) is a useful tool for quantifying the permeability of hyperosmotic agents in various tissues. We report our preliminary results on quantification of glucose diffusion and assessment of the optical attenuation change due to the diffusion of glucose in normal and adenomatous human colon tissues in vitro by using a SD-OCT and then calculated the permeability coefficients (PC) and optical ...
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  2. About Chuanqing Zhou

    Chuanqing Zhou

    Chuanqing Zhou, obtained his Ph. D. degree in biomedical engineering from Shanghai Jiao Tong University in 2007. He is currently working in Shanghai Jiao Tong University as Associate Professor. He has published more than 40 papers in the peer reviewed journals and 2 book chapters, and holds 3 patents in the field of ophthalmology and visual prosthesis. His research interest includes Biomedical Optics, Ophthalmology and Visual Optics.